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Supramolecular Chemistry Volume 15, 2003 - Issue 7-8
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Original Articles

Triazine Dendrimers for Drug Delivery: Evaluation of Solubilization Properties, Activity in Cell Culture, and In Vivo Toxicity of a Candidate Vehicle

Wen Zhang Department of Chemistry, Texas A&M University, 77845-3255, College Station, TX, USA
,
Jing Jiang Departments of Medical Pharmacology and Toxicology, Texas A&M University, 77845-3255, College Station, TX, USA
,
Chunhua Qin Departments of Veterinary Physiology and Pharmacology, Texas A&M University, 77845-3255, College Station, TX, USA
,
Lisa M. Pérez Department of Chemistry, Texas A&M University, 77845-3255, College Station, TX, USA
,
Alan R. Parrish Departments of Medical Pharmacology and Toxicology, Texas A&M University, 77845-3255, College Station, TX, USA
,
Stephen H. Safe Departments of Veterinary Physiology and Pharmacology, Texas A&M University, 77845-3255, College Station, TX, USA
&
Eric E. Simanek Department of Chemistry, Texas A&M University, 77845-3255, College Station, TX, USACorrespondence[email protected]
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Pages 607-616 | Received 02 Nov 2002, Accepted 17 Dec 2002, Published online: 17 Oct 2011

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Eric E Simanek, Alan E Enciso & Giovanni M Pavan. (2013) Computational design principles for the discovery of bioactive dendrimers: [s]-triazines and other examples. Expert Opinion on Drug Discovery 8:9, pages 1057-1069.
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Articles from other publishers (37)

Muhammad Asadullah Khan, Rui Peng, CanLi Liu & Zhen Chen. (2022) Synthesis, dynamics and applications (cytotoxicity and biocompatibility) of dendrimers: A mini-review. European Polymer Journal 181, pages 111708.
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Mohamed Haider, Khaled Zaki Zaki, Mariam Rafat El Hamshary, Zahid Hussain, Gorka Orive & Haidy Osama Ibrahim. (2022) Polymeric nanocarriers: A promising tool for early diagnosis and efficient treatment of colorectal cancer. Journal of Advanced Research 39, pages 237-255.
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Eric E. Simanek. (2021) Two Decades of Triazine Dendrimers. Molecules 26:16, pages 4774.
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Keerti Jain, Narendra Kumar Jain & Prashant Kesharwani. 2021. Dendrimer-Based Nanotherapeutics. Dendrimer-Based Nanotherapeutics 95 123 .
Andrzej S. Skwarecki, Michał G. Nowak & Maria J. Milewska. (2020) Synthetic strategies in construction of organic macromolecular carrier–drug conjugates. Organic & Biomolecular Chemistry 18:30, pages 5764-5783.
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Evandro Paulo Soares Martins, Edeltrudes de Oliveira Lima, Felipe Terra Martins, Mário Luiz Araújo de Almeida Vasconcellos & Gerd Bruno Rocha. (2019) Synthesis, spectroscopic characterization, DFT studies, and preliminary antimicrobial evaluation of new antimony(III) and bismuth(III) complexes derived from 1,3,5-triazine. Journal of Molecular Structure 1183, pages 373-383.
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Kholood Dahlous, Zainab Almarhoon, Ahmed-Yacine Badjah-Hadj-Ahmed, Zeid AL Othman & Ayman El-Faham. (2018) Microwave Irradiation Assists the Synthesis of a Novel Series of bis-Arm s-Triazine Oxy-Schiff Base and Oxybenzylidene Barbiturate Derivatives. Molecules 23:11, pages 2976.
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Vijay Mishra & Prashant Kesharwani. (2016) Dendrimer technologies for brain tumor. Drug Discovery Today 21:5, pages 766-778.
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Neelesh Kumar Mehra, Keerti Jain & N. K. Jain. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 8062 8073 .
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Lin-ping Wu, Mario Ficker, Jørn B. Christensen, Panagiotis N. Trohopoulos & Seyed Moein Moghimi. (2015) Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges. Bioconjugate Chemistry 26:7, pages 1198-1211.
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Eric E. Simanek & Alan E. Enciso. 2014. Cationic Polymers in Regenerative Medicine. Cationic Polymers in Regenerative Medicine 249 267 .
Dzmitry Shcharbin, Anna Janaszewska, Barbara Klajnert-Maculewicz, Barbara Ziemba, Volha Dzmitruk, Inessa Halets, Svetlana Loznikova, Natallia Shcharbina, Katarzyna Milowska, Maksim Ionov, Antos Shakhbazau & Maria Bryszewska. (2014) How to study dendrimers and dendriplexes III. Biodistribution, pharmacokinetics and toxicity in vivo. Journal of Controlled Release 181, pages 40-52.
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Jongdoo Lim & Eric E. Simanek. (2012) Triazine dendrimers as drug delivery systems: From synthesis to therapy. Advanced Drug Delivery Reviews 64:9, pages 826-835.
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Jongdoo Lim, Giovanni M. Pavan, Onofrio Annunziata & Eric E. Simanek. (2012) Experimental and Computational Evidence for an Inversion in Guest Capacity in High-Generation Triazine Dendrimer Hosts. Journal of the American Chemical Society 134:4, pages 1942-1945.
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M. Malkoch, E. Malmström & A.M. Nyström. 2012. Polymer Science: A Comprehensive Reference. Polymer Science: A Comprehensive Reference 113 176 .
Cédric‐Olivier Turrin & Anne‐Marie Caminade. 2011. Dendrimers. Dendrimers 463 484 .
Su-Tang Lo, Stephan Stern, Jeffrey D. Clogston, Jiwen Zheng, Pavan P. Adiseshaiah, Marina Dobrovolskaia, Jongdoo Lim, Anil K. Patri, Xiankai Sun & Eric E. Simanek. (2010) Biological Assessment of Triazine Dendrimer: Toxicological Profiles, Solution Behavior, Biodistribution, Drug Release and Efficacy in a PEGylated, Paclitaxel Construct. Molecular Pharmaceutics 7:4, pages 993-1006.
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Jongdoo Lim, Vincent J. Venditto & Eric E. Simanek. (2010) Synthesis and characterization of a triazine dendrimer that sequesters iron(III) using 12 desferrioxamine B groups. Bioorganic & Medicinal Chemistry 18:15, pages 5749-5753.
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Keerti Jain, Prashant Kesharwani, Umesh Gupta & N.K. Jain. (2010) Dendrimer toxicity: Let's meet the challenge. International Journal of Pharmaceutics 394:1-2, pages 122-142.
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Eric E. Simanek, Hanan Abdou, Sanjiv Lalwani, Jongdoo Lim, Meredith Mintzer, Vincent J. Venditto & Brandon Vittur. (2009) The 8 year thicket of triazine dendrimers: strategies, targets and applications. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 466:2117, pages 1445-1468.
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Vincent J. Venditto & Eric E. Simanek. (2010) Cancer Therapies Utilizing the Camptothecins: A Review of the in Vivo Literature . Molecular Pharmaceutics 7:2, pages 307-349.
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Kristin L. Aillon, Yumei Xie, Nashwa El-Gendy, Cory J. Berkland & M. Laird Forrest. (2009) Effects of nanomaterial physicochemical properties on in vivo toxicity. Advanced Drug Delivery Reviews 61:6, pages 457-466.
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Wen Zhang, Sanjiv Lalwani, Abdellatif Chouai & Eric E. Simanek. (2009) Synthesis and Characterization of Anionic Triazine Dendrimers with a Labile Disulfide Core. Israel Journal of Chemistry 49:1, pages 23-30.
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Ioannis D. Kostas, Fotini J. Andreadaki, Elaine A. Medlycott, Garry S. Hanan & Eric Monflier. (2009) Synthesis of a halo-methylphenylene periphery-functionalized triazine-based dendritic molecule with a 3,3′-dimethyl-biphenyl linker using tris(halo-methylphenylene)triazines as building blocks. Tetrahedron Letters 50:16, pages 1851-1854.
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Sean T. Zuckerman & Weiyuan John Kao. 2009. Nanotechnology in Drug Delivery. Nanotechnology in Drug Delivery 193 228 .
Karlos X. Moreno & Eric E. Simanek. (2008) Identification of diamine linkers with differing reactivity and their application in the synthesis of melamine dendrimers. Tetrahedron Letters 49:7, pages 1152-1154.
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Lovorka Degoricija, Michael A. Carnahan, C. Starck Johnson, Terry Kim & Mark W. Grinstaff. (2006) Synthesis and Characterization of Bola-Type Amphiphilic Dendritic Macromolecules. Macromolecules 39:26, pages 8952-8958.
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Umesh Gupta, Hrushikesh Bharat Agashe, Abhay Asthana & Narendra K. Jain. (2006) A review of in vitro–in vivo investigations on dendrimers: the novel nanoscopic drug carriers. Nanomedicine: Nanotechnology, Biology and Medicine 2:2, pages 66-73.
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Mackay B. Steffensen, Emily Hollink, Frank Kuschel, Monika Bauer & Eric E. Simanek. (2006) Dendrimers based on [1,3,5]‐triazines. Journal of Polymer Science Part A: Polymer Chemistry 44:11, pages 3411-3433.
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Sivakumar V. Aathimanikandan, Elamprakash N. Savariar & S. Thayumanavan. (2005) Temperature-Sensitive Dendritic Micelles. Journal of the American Chemical Society 127:42, pages 14922-14929.
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Jongdoo Lim & Eric E. Simanek. (2005) Toward the Next-Generation Drug Delivery Vehicle:  Synthesis of a Dendrimer with Four Orthogonally Reactive Groups. Molecular Pharmaceutics 2:4, pages 273-277.
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M.F. Neerman, A.P. Umali, H.-T. Chen, S.D. Waghela, A.R. Parrish & E.E. Simanek. (2005) Biological evaluation of dendrimers based on melamine. Journal of Drug Delivery Science and Technology 15:1, pages 31-39.
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Francesca Corbellini, Ronald M. A. Knegtel, Peter D. J. Grootenhuis, Mercedes Crego-Calama & David N. Reinhoudt. (2005) Water-Soluble Molecular Capsules: Self-Assembly and Binding Properties. Chemistry - A European Journal 11:1, pages 298-307.
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Michael F. Neerman, Hui-Ting Chen, Alan R. Parrish & Eric E. Simanek. (2004) Reduction of Drug Toxicity Using Dendrimers Based on Melamine. Molecular Pharmaceutics 1:5, pages 390-393.
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Hui-Ting Chen, Michael F. Neerman, Alan R. Parrish & Eric E. Simanek. (2004) Cytotoxicity, Hemolysis, and Acute in Vivo Toxicity of Dendrimers Based on Melamine, Candidate Vehicles for Drug Delivery. Journal of the American Chemical Society 126:32, pages 10044-10048.
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Michael F. Neerman, Wen Zhang, Alan R. Parrish & Eric E. Simanek. (2004) In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery. International Journal of Pharmaceutics 281:1-2, pages 129-132.
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