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Research Article

The Design and Exogenous Delivery of siRNA for Post-transcriptional Gene Silencing

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Pages 315-340 | Published online: 03 Oct 2008

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Read on this site (6)

Aditya Kiran Gatta, Raghu Chandrashekhar Hariharapura, Nayanabhirama Udupa, Meka Sreenivasa Reddy & Venkata Rao Josyula. (2018) Strategies for improving the specificity of siRNAs for enhanced therapeutic potential. Expert Opinion on Drug Discovery 13:8, pages 709-725.
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Shubiao Zhang, Defu Zhi & Leaf Huang. (2012) Lipid-based vectors for siRNA delivery. Journal of Drug Targeting 20:9, pages 724-735.
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Saghir Akhtar. (2010) Cationic nanosystems for the delivery of small interfering ribonucleic acid therapeutics: a focus on toxicogenomics. Expert Opinion on Drug Metabolism & Toxicology 6:11, pages 1347-1362.
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Andrew J. Hollins, Yadollah Omidi, Ibrahim F. Benter & Saghir Akhtar. (2007) Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity. Journal of Drug Targeting 15:1, pages 83-88.
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Y. Omidi, A.J. Hollins, R.M. Drayton & S. Akhtar. (2005) Polypropylenimine dendrimer-induced gene expression changes: The effect of complexation with DNA, dendrimer generation and cell type. Journal of Drug Targeting 13:7, pages 431-443.
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Raymond M Schiffelers, Inge van Rooy & Gert Storm. (2005) siRNA-mediated inhibition of angiogenesis. Expert Opinion on Biological Therapy 5:3, pages 359-368.
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Articles from other publishers (52)

Mathieu Martino, Adil Mouahid, Michelle Sergent, Camille Desgrouas, Catherine Badens & Elisabeth Badens. (2023) Supercritical millifluidic process for siRNA encapsulation in nanoliposomes for potential Progeria treatment (ex-vivo assays). Journal of Drug Delivery Science and Technology, pages 104804.
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Hanspeter Naegeli. 2023. Present Knowledge in Food Safety. Present Knowledge in Food Safety 938 958 .
Fereshteh Karamali, Sanaz Behtaj, Shahnaz Babaei-Abraki, Hanieh Hadady, Atefeh Atefi, Soraya Savoj, Sareh Soroushzadeh, Samaneh Najafian, Mohammad Hossein Nasr Esfahani & Henry Klassen. (2022) Potential therapeutic strategies for photoreceptor degeneration: the path to restore vision. Journal of Translational Medicine 20:1.
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Molly Darlington, Jordan D. Reinders, Amit Sethi, Albert L. Lu, Partha Ramaseshadri, Joshua R. Fischer, Chad J. Boeckman, Jay S. Petrick, Jason M. Roper, Kenneth E. Narva & Ana M. Vélez. (2022) RNAi for Western Corn Rootworm Management: Lessons Learned, Challenges, and Future Directions. Insects 13:1, pages 57.
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Tahirah Yasmin, Maisha Adiba, Abdullah Al Saba & AHM Nurun Nabi. (2022) In Silico Design of siRNAs for Silencing CLEC5A Receptor as a Potential Therapeutic Approach Against Dengue and Japanese Encephalitis Virus Infection in Human. Bioinformatics and Biology Insights 16, pages 117793222211421.
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Krishna Baxi, Sujata Sawarkar, Munira Momin, Vainav Patel & Trinette Fernandes. (2020) Vaginal siRNA delivery: overview on novel delivery approaches. Drug Delivery and Translational Research 10:4, pages 962-974.
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Thais B. Rodrigues & Jay S. Petrick. (2020) Safety Considerations for Humans and Other Vertebrates Regarding Agricultural Uses of Externally Applied RNA Molecules. Frontiers in Plant Science 11.
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Maria Abdul Ghafoor Raja, Haliza Katas & Muhammad Wahab Amjad. (2019) Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA. Asian Journal of Pharmaceutical Sciences 14:5, pages 497-510.
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Loutfy H. Madkour. 2019. Nucleic Acids as Gene Anticancer Drug Delivery Therapy. Nucleic Acids as Gene Anticancer Drug Delivery Therapy 75 86 .
Muhammad Wahab Amjad, Prashant Kesharwani, Mohd Cairul Iqbal Mohd Amin & Arun K. Iyer. (2017) Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy. Progress in Polymer Science 64, pages 154-181.
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Jay S. Petrick, Gregory E. Frierdich, Stephanie M. Carleton, Colton R. Kessenich, Andre Silvanovich, Yuanji Zhang & Michael S. Koch. (2016) Corn rootworm-active RNA DvSnf7: Repeat dose oral toxicology assessment in support of human and mammalian safety. Regulatory Toxicology and Pharmacology 81, pages 57-68.
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Vijay Bhooshon Kumar, Himadri Medhi, Zhang Yong & Pradip Paik. (2016) Designing idiosyncratic hmPCL -siRNA nanoformulated capsules for silencing and cancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine 12:3, pages 579-588.
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Jay S. Petrick, William M. Moore, William F. Heydens, Michael S. Koch, James H. Sherman & Shawna L. Lemke. (2015) A 28-day oral toxicity evaluation of small interfering RNAs and a long double-stranded RNA targeting vacuolar ATPase in mice. Regulatory Toxicology and Pharmacology 71:1, pages 8-23.
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Young-Wook Won, David A. Bull & Sung Wan Kim. (2014) Functional polymers of gene delivery for treatment of myocardial infarct. Journal of Controlled Release 195, pages 110-119.
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Hsiao-yin Yang, Lucienne A. Vonk, Ruud Licht, Antonetta M.G. van Boxtel, Joris E.J. Bekkers, Angela H.M. Kragten, San Hein, Oommen P. Varghese, Kenneth A. Howard, F. Cumhur Öner, Wouter J.A. Dhert & Laura B. Creemers. (2014) Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells. European Journal of Pharmaceutical Sciences 53, pages 35-44.
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Rita B. Restani, Jo?o Conde, Pedro V. Baptista, Maria Teresa Cidade, Ana M. Bragan?a, Jorge Morgado, Il?dio J. Correia, Ana Aguiar-Ricardo & Vasco D. B. Bonif?cio. (2014) Polyurea dendrimer for efficient cytosolic siRNA delivery. RSC Adv. 4:97, pages 54872-54878.
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Cinzia Stigliano, Santosh Aryal, Marco Donato de Tullio, Grazia Paola Nicchia, Giuseppe Pascazio, Maria Svelto & Paolo Decuzzi. (2013) siRNA-Chitosan Complexes in Poly(lactic- co -glycolic acid) Nanoparticles for the Silencing of Aquaporin-1 in Cancer Cells . Molecular Pharmaceutics 10:8, pages 3186-3194.
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Jay S. Petrick, Brent Brower-Toland, Aimee L. Jackson & Larry D. Kier. (2013) Safety assessment of food and feed from biotechnology-derived crops employing RNA-mediated gene regulation to achieve desired traits: A scientific review. Regulatory Toxicology and Pharmacology 66:2, pages 167-176.
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Pallavi Ananda Kadengodlu, Toshiro Aigaki, Hiroshi Abe & Yoshihiro Ito. (2013) Cationic cholesterol-modified gelatin as an in vitro siRNA delivery vehicle. Molecular BioSystems 9:5, pages 965.
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Junfeng Ji, Bonan Zhong & Mickie Bhatia. 2013. Handbook of Stem Cells. Handbook of Stem Cells 311 325 .
K. V. Glebova, A. V. Marakhonov, A. V. Baranova & M. Yu. Skoblov. (2012) Nonviral delivery systems for small interfering RNAs. Molecular Biology 46:3, pages 349-361.
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Sang-Mi Ryou, Mira Park, Jong-Myung Kim, Che Ok Jeon, Cheol-Hui Yun, Seung Hyun Han, Si Wouk Kim, Younghoon Lee, Sudeok Kim, Min Su Han, Jeehyeon Bae & Kangseok Lee. (2011) Inhibition of xenograft tumor growth in mice by gold nanoparticle-assisted delivery of short hairpin RNAs against Mcl-1L. Journal of Biotechnology 156:2, pages 89-94.
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Hong Y. Cho, Abiraman Srinivasan, Joanna Hong, Eric Hsu, Shiguang Liu, Arun Shrivats, Dan Kwak, Andrew K. Bohaty, Hyun-jong Paik, Jeffrey O. Hollinger & Krzysztof Matyjaszewski. (2011) Synthesis of Biocompatible PEG-Based Star Polymers with Cationic and Degradable Core for siRNA Delivery. Biomacromolecules 12:10, pages 3478-3486.
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Amir Khashayar Varkouhi, Stéphanie Foillard, Twan Lammers, Raymond M. Schiffelers, Eric Doris, Wim E. Hennink & Gert Storm. (2011) SiRNA delivery with functionalized carbon nanotubes. International Journal of Pharmaceutics 416:2, pages 419-425.
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Amir K. Varkouhi, Twan Lammers, Raymond M. Schiffelers, Mies J. van Steenbergen, Wim E. Hennink & Gert Storm. (2011) Gene silencing activity of siRNA polyplexes based on biodegradable polymers. European Journal of Pharmaceutics and Biopharmaceutics 77:3, pages 450-457.
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Junfeng Ji, Bonan Zhong & Mickie Bhatia. 2011. Principles of Regenerative Medicine. Principles of Regenerative Medicine 179 198 .
Amir K. Varkouhi, Rolf J. Verheul, Raymond M. Schiffelers, Twan Lammers, Gert Storm & Wim. E. Hennink. (2010) Gene Silencing Activity of siRNA Polyplexes Based on Thiolated N , N , N -Trimethylated Chitosan . Bioconjugate Chemistry 21:12, pages 2339-2346.
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Min Suk Shim & Young Jik Kwon. (2010) Efficient and targeted delivery of siRNA in vivo . The FEBS Journal 277:23, pages 4814-4827.
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Olivia M. MerkelMeredith A. MintzerDamiano LibrizziOlga SamsonovaTanja DickeBrian SproatHolger GarnPeter J. BarthEric E. SimanekThomas Kissel. (2010) Triazine Dendrimers as Nonviral Vectors for in Vitro and in Vivo RNAi: The Effects of Peripheral Groups and Core Structure on Biological Activity. Molecular Pharmaceutics 7:4, pages 969-983.
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Tathagata Dutta, Melinda Burgess, Nigel A.J. McMillan & Harendra S. Parekh. (2010) Dendrosome-based delivery of siRNA against E6 and E7 oncogenes in cervical cancer. Nanomedicine: Nanotechnology, Biology and Medicine 6:3, pages 463-470.
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Aimee L. Jackson & Peter S. Linsley. (2010) Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nature Reviews Drug Discovery 9:1, pages 57-67.
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Jeffrey Hughes, Preeti Yadava & Ryan Mesaros. 2010. Liposomes. Liposomes 445 459 .
Gro F. Flatekval & Mouldy Sioud. (2009) Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase. Immunology 128:1pt2, pages e837-e848.
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Kun Gao & Leaf Huang. (2008) Nonviral Methods for siRNA Delivery. Molecular Pharmaceutics 6:3, pages 651-658.
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Won Jong Kim & Sung Wan Kim. (2008) Efficient siRNA Delivery with Non-viral Polymeric Vehicles. Pharmaceutical Research 26:3, pages 657-666.
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K. Forbes, M. Desforges, R. Garside, J.D. Aplin & M. Westwood. (2009) Methods for siRNA-mediated Reduction of mRNA and Protein Expression in Human Placental Explants, Isolated Primary Cells and Cell Lines. Placenta 30:2, pages 124-129.
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Renata Servan de Almeida, Djénéba Keita, Geneviève Libeau & Emmanuel Albina. (2008) Structure and sequence motifs of siRNA linked with in vitro down-regulation of morbillivirus gene expression. Antiviral Research 79:1, pages 37-48.
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Junfeng Ji, Bonan Zhong & Mickie Bhatia. 2008. Principles of Regenerative Medicine. Principles of Regenerative Medicine 190 209 .
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Toshihito Tsutsumi, Fumitoshi Hirayama, Kaneto Uekama & Hidetoshi Arima. (2007) Evaluation of polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA). Journal of Controlled Release 119:3, pages 349-359.
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Sabrina Oliveira, Marjan M. Fretz, Anders Høgset, Gert Storm & Raymond M. Schiffelers. (2007) Photochemical internalization enhances silencing of epidermal growth factor receptor through improved endosomal escape of siRNA. Biochimica et Biophysica Acta (BBA) - Biomembranes 1768:5, pages 1211-1217.
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Saghir Akhtar & Ibrahim Benter. (2007) Toxicogenomics of non-viral drug delivery systems for RNAi: Potential impact on siRNA-mediated gene silencing activity and specificity. Advanced Drug Delivery Reviews 59:2-3, pages 164-182.
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Marine Guillot-Nieckowski, Sara Eisler & François Diederich. (2007) Dendritic vectors for gene transfection. New J. Chem. 31:7, pages 1111-1127.
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John J. Turner, Simon W. Jones, Sterghios A. Moschos, Mark A. Lindsay & Michael J. Gait. (2007) MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity. Mol. BioSyst. 3:1, pages 43-50.
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Masato Yamagata, Takahito Kawano, Kouhei Shiba, Takeshi Mori, Yoshiki Katayama & Takuro Niidome. (2007) Structural advantage of dendritic poly(l-lysine) for gene delivery into cells. Bioorganic & Medicinal Chemistry 15:1, pages 526-532.
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Bart Spee, Martijn DB Jonkers, Brigitte Arends, Gerard R Rutteman, Jan Rothuizen & Louis C Penning. (2006) Specific down-regulation of XIAP with RNA interference enhances the sensitivity of canine tumor cell-lines to TRAIL and doxorubicin. Molecular Cancer 5:1.
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Yann Fichou & Claude Férec. (2006) The potential of oligonucleotides for therapeutic applications. Trends in Biotechnology 24:12, pages 563-570.
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Toshihito Tsutsumi, Hidetoshi Arima, Fumitoshi Hirayama & Kaneto Uekama. (2006) Potential Use of Dendrimer/α-Cyclodextrin Conjugate as a Novel Carrier for Small Interfering RNA (siRNA). Journal of Inclusion Phenomena and Macrocyclic Chemistry 56:1-2, pages 81-84.
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Ashwini Dhume, Shajia Lu & Robert Horowits. (2006) Targeted disruption of N-RAP gene function by RNA interference: A role for N-RAP in myofibril organization. Cell Motility and the Cytoskeleton 63:8, pages 493-511.
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Xavier Coumoul & Chu-Xia Deng. (2006) RNAi in mice: a promising approach to decipher gene functions in vivo. Biochimie 88:6, pages 637-643.
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