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Journal of Drug Targeting Volume 11, 2003 - Issue 8-10: Strategies for Vaccine Delivery
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Research Article

Adjuvant Action of Melittin Following Intranasal Immunisation with Tetanus and Diphtheria Toxoids

V.W. Bramwell Centre for Drug Delivery Research, School of Pharmacy, University of London, Brunswick Square, WC1N 1AX, 29-39, London, UK
,
S. Somavarapu Immune Response Unit, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, 28220, Madrid, Spain
,
I. Outschoorn Immune Response Unit, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, 28220, Madrid, Spain
&
H.O. Alpar Centre for Drug Delivery Research, School of Pharmacy, University of London, Brunswick Square, WC1N 1AX, 29-39, London, UKCorrespondence[email protected]
Pages 525-530 | Published online: 03 Oct 2008

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Sreenivas Pandit, Erdal Cevher, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu & H. Oya Alpar. (2007) Enhancement of immune response of HBsAg loaded poly (L-lactic acid) microspheres against Hepatitis B through incorporation of alum and chitosan. Journal of Microencapsulation 24:6, pages 539-552.
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Sherif A. Gaballa, Taro Shimizu, Hidenori Ando, Haruka Takata, Sherif E. Emam, Eslam Ramadan, Youssef W. Naguib, Fatma M. Mady, Khaled A. Khaled & Tatsuhiro Ishida. (2023) Treatment-induced and Pre-existing Anti-peg Antibodies: Prevalence, Clinical Implications, and Future Perspectives. Journal of Pharmaceutical Sciences.
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Gholamreza Karimi, Sina Fatemi, Bahram Memar, Mohammad-Bagher Khorrami, Arian Amali, Mahmood Sadeghi, Seyed-Alireza Esmaeili & Bamdad Riahi-Zanjani. (2023) Melittin as a safe compound to BALB/c mice immune system; a tiered approach immunotoxicity screening. BMC Complementary Medicine and Therapies 23:1.
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Nur Aqlili Riana Alias, Winfrey Pui Yee Hoo, Pui Yan Siak, Siti Sarah Othman, Noorjahan Banu Mohammed Alitheen, Lionel Lian Aun In, Raha Abdul Rahim & Adelene Ai-Lian Song. (2023) Effect of Secretion Efficiency of Mutant KRAS Neoantigen by Lactococcus lactis on the Immune Response of a Mucosal Vaccine Delivery Vehicle Targeting Colorectal Cancer. International Journal of Molecular Sciences 24:10, pages 8928.
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Amjad Islam Aqib, Khazeena Atta, Afshan Muneer, Muhammad Luqman Sohail, Kashif Rahim & Firasat Hussain. 2023. Application of Natural Products in SARS-CoV-2. Application of Natural Products in SARS-CoV-2 491 507 .
Anqi Wang, Yuan Zheng, Wanxin Zhu, Liuxin Yang, Yang Yang & Jinliang Peng. (2022) Melittin-Based Nano-Delivery Systems for Cancer Therapy. Biomolecules 12:1, pages 118.
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Hamed Memariani & Mojtaba Memariani. (2021) Melittin as a promising anti-protozoan peptide: current knowledge and future prospects. AMB Express 11:1.
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Shantanu Guha, Ryan P. Ferrie, Jenisha Ghimire, Cristina R. Ventura, Eric Wu, Leisheng Sun, Sarah Y. Kim, Gregory R. Wiedman, Kalina Hristova & Wimley C. Wimley. (2021) Applications and evolution of melittin, the quintessential membrane active peptide. Biochemical Pharmacology 193, pages 114769.
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Elham Jafari & Shirin Mahmoodi. (2021) Design, expression, and purification of a multi-epitope vaccine against Helicobacter Pylori based on Melittin as an adjuvant. Microbial Pathogenesis 157, pages 104970.
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Meilyn Sylvestre, Shixian Lv, Lucy F. Yang, Nicholas Luera, David J. Peeler, Bing-Mae Chen, Steve R. Roffler & Suzie H. Pun. (2021) Replacement of L-amino acid peptides with D-amino acid peptides mitigates anti-PEG antibody generation against polymer-peptide conjugates in mice. Journal of Controlled Release 331, pages 142-153.
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Steven Willows & Marianna Kulka. (2020) Harnessing the Power of Mast Cells in unconventional Immunotherapy Strategies and Vaccine Adjuvants. Cells 9:12, pages 2713.
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Keneth Iceland Kasozi, Gniewko Niedbała, Mohammed Alqarni, Gerald Zirintunda, Fred Ssempijja, Simon Peter Musinguzi, Ibe Michael Usman, Kevin Matama, Helal F. Hetta, Ngala Elvis Mbiydzenyuy, Gaber El-Saber Batiha, Amany Magdy Beshbishy & Susan Christina Welburn. (2020) Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections. Frontiers in Public Health 8.
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Konstantinos Katsoulis-Dimitriou, Johanna Kotrba, Martin Voss, Jan Dudeck & Anne Dudeck. (2020) Mast Cell Functions Linking Innate Sensing to Adaptive Immunity. Cells 9:12, pages 2538.
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Jinxia Qi, Yonghui Chen, Tiantian Xue, Yue Lin, Shiyuan Huang, Shuyan Cao, Xiaona Wang, Yu Su & Zhenkun Lin. (2020) Graphene oxide-based magnetic nanocomposites for the delivery of melittin to cervical cancer HeLa cells. Nanotechnology 31:6, pages 065102.
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Brandi T. Johnson-Weaver, Soman N. Abraham & Herman F. Staats. 2020. Mucosal Vaccines. Mucosal Vaccines 167 183 .
Hamed Memariani, Mojtaba Memariani, Hamideh Moravvej & Mohammad Shahidi-Dadras. (2019) Melittin: a venom-derived peptide with promising anti-viral properties. European Journal of Clinical Microbiology & Infectious Diseases 39:1, pages 5-17.
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Hannaneh Zarrinnahad, Amir Mahmoodzadeh, Monireh Parviz Hamidi, Mehdi Mahdavi, Ali Moradi, Kamran Pooshang Bagheri & Delavar Shahbazzadeh. (2017) Apoptotic Effect of Melittin Purified from Iranian Honey Bee Venom on Human Cervical Cancer HeLa Cell Line. International Journal of Peptide Research and Therapeutics 24:4, pages 563-570.
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Abdulmalik Alqarni, Valerie Ferro, John Parkinson, Mark Dufton & David Watson. (2018) Effect of Melittin on Metabolomic Profile and Cytokine Production in PMA-Differentiated THP-1 Cells. Vaccines 6:4, pages 72.
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Brandi Johnson-Weaver, Hae Woong Choi, Soman N Abraham & Herman F Staats. (2018) Mast cell activators as novel immune regulators. Current Opinion in Pharmacology 41, pages 89-95.
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Evelyn Sun, Corrie R. Belanger, Evan F. Haney & Robert E.W. Hancock. 2018. Peptide Applications in Biomedicine, Biotechnology and Bioengineering. Peptide Applications in Biomedicine, Biotechnology and Bioengineering 253 285 .
N. Woods, K. Niwasabutra, R. Acevedo, J. Igoli, N.A. Altwaijry, J. Tusiimire, A.I. Gray, D.G. Watson & V.A. Ferro. 2017. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 211 229 .
Jonans Tusiimire, Jennifer Wallace, Nicola Woods, Mark Dufton, John Parkinson, Grainne Abbott, Carol Clements, Louise Young, Jin Park, Jong Jeon, Valerie Ferro & David Watson. (2016) Effect of Bee Venom and Its Fractions on the Release of Pro-Inflammatory Cytokines in PMA-Differentiated U937 Cells Co-Stimulated with LPS. Vaccines 4:2, pages 11.
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Kim Alan Brogden, Amber M. Bates & Carol L. Fischer. 2016. Antimicrobial Peptides. Antimicrobial Peptides 129 146 .
Karl G KohlgrafLindsey C PingelDeborah E DietrichKim A Brogden. (2010) Defensins as anti-inflammatory compounds and mucosal adjuvants. Future Microbiology 5:1, pages 99-113.
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Maryam Amidi, Hubert C. Pellikaan, Hoang Hirschberg, Anne H. de Boer, Daan J.A. Crommelin, Wim E. Hennink, Gideon Kersten & Wim Jiskoot. (2007) Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: Preparation, characterization and evaluation in guinea pigs. Vaccine 25:37-38, pages 6818-6829.
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Lindsey C. Pingel, Xiaoying Lu & Kim A. Brogden. 2007. Virulence Mechanisms of Bacterial Pathogens. Virulence Mechanisms of Bacterial Pathogens 281 295 .

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