226
Views
43
CrossRef citations to date
0
Altmetric
Research Article

Oral gene delivery: Strategies to improve stability of pDNA towards intestinal digestion

, , &
Pages 311-319 | Published online: 08 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Jinghan Xin, Mengdi Qin, Genyang Ye, Haonan Gong, Mo Li, Xiaofan Sui, Bingyang Liu, Qiang Fu & Zhonggui He. (2023) Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs. Expert Opinion on Drug Delivery 20:1, pages 1-11.
Read now
Bo Xiao & Didier Merlin. (2012) Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease. Expert Opinion on Drug Delivery 9:11, pages 1393-1407.
Read now
Crispin R. Dass & Peter F. M. Choong. (2008) Chitosan-mediated orally delivered nucleic acids: A gutful of gene therapy. Journal of Drug Targeting 16:4, pages 257-261.
Read now
Mayank D Bhavsar & Mansoor M Amiji. (2007) Polymeric nano- and microparticle technologies for oral gene delivery. Expert Opinion on Drug Delivery 4:3, pages 197-213.
Read now

Articles from other publishers (39)

Yuansong Wei, Xudong Li, Juanhui Lin, Yang Zhou, Jiandong Yang, Mengying Hou, Fan Wu, Jing Yan, Chenglong Ge, Duanmin Hu & Lichen Yin. (2023) Oral Delivery of siRNA Using Fluorinated, Small‐Sized Nanocapsules toward Anti‐Inflammation Treatment. Advanced Materials 35:11, pages 2206821.
Crossref
Neha Kumari, Kasturi Siddhanta, Sudipta Panja, Vineet Joshi, Chinmay Jogdeo, Ekta Kapoor, Rubayat Khan, Sai Sundeep Kollala, Balawant Kumar, Diptesh Sil, Amar B. Singh, Daryl J. Murry & David Oupický. (2022) Oral Delivery of Nucleic Acid Therapies for Local and Systemic Action. Pharmaceutical Research 40:1, pages 107-122.
Crossref
Jongyoon Shinn, Juyeon Lee, Seon Ah Lee, Seon Ju Lee, Ah Hyun Choi, Jung Seo Kim, Su Jin Kim, Hyo Jin Kim, Cherin Lee, Yejin Kim, Joohyeon Kim, Jonghee Choi, Byungchae Jung, Taeho Kim, HyeonTaek Nam, Hyungjun Kim & Yonghyun Lee. (2022) Oral Nanomedicines for siRNA Delivery to Treat Inflammatory Bowel Disease. Pharmaceutics 14:9, pages 1969.
Crossref
Deepak A. Subramanian, Robert Langer & Giovanni Traverso. (2022) Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems. Journal of Nanobiotechnology 20:1.
Crossref
Iyyakkannu Sivanesan, Shadma Tasneem, Nazim Hasan, Juhyun Shin, Manikandan Muthu, Judy Gopal & Jae-Wook Oh. (2022) Surveying the Oral Drug Delivery Avenues of Novel Chitosan Derivatives. Polymers 14:11, pages 2131.
Crossref
Ruiqi Xing, Hui Liu, Xia Qi & Lingzi Pan. (2022) Measuring the process and rate of exogenous DNA degradation during digestion in mice. Scientific Reports 12:1.
Crossref
Nazma N. Inamdar & Vishnukant Mourya. 2021. Applications of Polymers in Drug Delivery. Applications of Polymers in Drug Delivery 449 534 .
Devasena T.Devasena T.. 2021. Nanotechnology-COVID-19 Interface. Nanotechnology-COVID-19 Interface 71 114 .
A K M Nawshad Hossian, Gerardo G Mackenzie & George Mattheolabakis. (2019) miRNAs in gastrointestinal diseases: can we effectively deliver RNA-based therapeutics orally?. Nanomedicine 14:21, pages 2873-2889.
Crossref
Caitriona M. O'Driscoll, Andreas Bernkop-Schnürch, Julian D. Friedl, Véronique Préat & Vincent Jannin. (2019) Oral delivery of non-viral nucleic acid-based therapeutics - do we have the guts for this?. European Journal of Pharmaceutical Sciences 133, pages 190-204.
Crossref
Arshad Mahmood & Andreas Bernkop-Schnürch. (2019) SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs. Advanced Drug Delivery Reviews 142, pages 91-101.
Crossref
K.R. Slinger, A.H. Stewart, Z.C.T.R. Daniel, H. Hall, H.V. Masey O’Neill, M.R. Bedford, T. Parr & J.M. Brameld. (2019) The association between faecal host DNA or faecal calprotectin and feed efficiency in pigs fed yeast-enriched protein concentrate. Animal 13:11, pages 2483-2491.
Crossref
Seungbin Cha, Sun Hwa Lee, Sung Hun Kang, Mohammad Nazmul Hasan, Young Jun Kim, Sungpil Cho & Yong-Kyu Lee. (2018) Antibody-mediated oral delivery of therapeutic DNA for type 2 diabetes mellitus. Biomaterials Research 22:1.
Crossref
Khalid M. El-Say & Hossam S. El-Sawy. (2017) Polymeric nanoparticles: Promising platform for drug delivery. International Journal of Pharmaceutics 528:1-2, pages 675-691.
Crossref
Bo Xiao & Didier Merlin. 2017. Nanomedicine for Inflammatory Diseases. Nanomedicine for Inflammatory Diseases 125 144 .
Wongsakorn Suchaoin & Andreas Bernkop-Schnürch. (2017) Nanocarriers protecting toward an intestinal pre-uptake metabolism. Nanomedicine 12:3, pages 255-269.
Crossref
Husain Attarwala & Mansoor Amiji. 2016. Handbook of Polyester Drug Delivery Systems. Handbook of Polyester Drug Delivery Systems 417 443 .
Xiao-Ying Si, Didier Merlin & Bo Xiao. (2016) Recent advances in orally administered cell-specific nanotherapeutics for inflammatory bowel disease. World Journal of Gastroenterology 22:34, pages 7718.
Crossref
Irene Pereira de Sousa & Andreas Bernkop-Schnürch. (2014) Pre-systemic metabolism of orally administered drugs and strategies to overcome it. Journal of Controlled Release 192, pages 301-309.
Crossref
James A. Baum & James K. Roberts. 2014. Insect Midgut and Insecticidal Proteins. Insect Midgut and Insecticidal Proteins 249 295 .
Martin J. O’Neill, Aoife M. O’Mahony, Colin Byrne, Raphael Darcy & Caitriona M. O’Driscoll. (2013) Gastrointestinal gene delivery by cyclodextrins – In vitro quantification of extracellular barriers. International Journal of Pharmaceutics 456:2, pages 390-399.
Crossref
Jay S. Petrick, Brent Brower-Toland, Aimee L. Jackson & Larry D. Kier. (2013) Safety assessment of food and feed from biotechnology-derived crops employing RNA-mediated gene regulation to achieve desired traits: A scientific review. Regulatory Toxicology and Pharmacology 66:2, pages 167-176.
Crossref
Christina Kriegel, Husain Attarwala & Mansoor Amiji. (2013) Multi-compartmental oral delivery systems for nucleic acid therapy in the gastrointestinal tract. Advanced Drug Delivery Reviews 65:6, pages 891-901.
Crossref
Jianfeng Guo, Aoife M. O’Mahony, Woei Ping Cheng & Caitriona M. O’Driscoll. (2013) Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: In vitro investigations. International Journal of Pharmaceutics 447:1-2, pages 150-157.
Crossref
Mary C Regier, Jessica D Taylor, Tyler Borcyk, Yiqi Yang & Angela K Pannier. (2012) Fabrication and characterization of DNA-loaded zein nanospheres. Journal of Nanobiotechnology 10:1.
Crossref
Flavia Laffleur & Andreas Bernkop-Schnürch. (2012) Thiomers: promising platform for macromolecular drug delivery. Future Medicinal Chemistry 4:17, pages 2205-2216.
Crossref
Filipa Antunes, Fernanda Andrade & Bruno Sarmento. 2012. Chitosan‐Based Systems for Biopharmaceuticals. Chitosan‐Based Systems for Biopharmaceuticals 225 241 .
Katharina Leithner & Andreas Bernkop‐Schnürch. 2012. Chitosan‐Based Systems for Biopharmaceuticals. Chitosan‐Based Systems for Biopharmaceuticals 159 180 .
Martin J. O’Neill, Ludovic Bourre, Silvia Melgar & Caitriona M. O’Driscoll. (2011) Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models. Drug Discovery Today 16:5-6, pages 203-218.
Crossref
SHARDOOL JAIN, HUSAIN ATTARWALA & MANSOOR AMIJI. (2012) NON-CONDENSING POLYMERIC GENE DELIVERY SYSTEMS: PRINCIPLES AND APPLICATIONS. Nano LIFE 01:03n04, pages 219-237.
Crossref
A. Vetter, R. Martien & A. Bernkop‐Schnürch. (2010) Thiolated Polycarbophil as an Adjuvant for Permeation Enhancement in Nasal Delivery of Antisense Oligonucleotides. Journal of Pharmaceutical Sciences 99:3, pages 1427-1439.
Crossref
Martin Werle, Hirofumi Takeuchi & Andreas Bernkop-Schnürch. (2009) Modified Chitosans for Oral Drug Delivery. Journal of Pharmaceutical Sciences 98:5, pages 1643-1656.
Crossref
Claudia Vigl. 2009. Oral Delivery of Macromolecular Drugs. Oral Delivery of Macromolecular Drugs 137 152 .
Martin Werle & Hirofumi Takeuchi. 2009. Oral Delivery of Macromolecular Drugs. Oral Delivery of Macromolecular Drugs 65 83 .
Ronny Martien. 2009. Oral Delivery of Macromolecular Drugs. Oral Delivery of Macromolecular Drugs 223 236 .
M. Werle, H. Kolmar, R. Albrecht & A. Bernkop-Schnürch. (2007) Characterisation of the barrier caused by luminally secreted gastro-intestinal proteolytic enzymes for two novel cystine-knot microproteins. Amino Acids 35:1, pages 195-200.
Crossref
Mayank D. Bhavsar & Mansoor M. Amiji. (2008) Development of Novel Biodegradable Polymeric Nanoparticles-in-Microsphere Formulation for Local Plasmid DNA Delivery in the Gastrointestinal Tract. AAPS PharmSciTech 9:1, pages 288-294.
Crossref
Mayank D. Bhavsar & Mansoor M. Amiji. (2007) Gastrointestinal distribution and in vivo gene transfection studies with nanoparticles-in-microsphere oral system (NiMOS). Journal of Controlled Release 119:3, pages 339-348.
Crossref
Hirokazu Okamoto. (2007) Gene delivery with chitosan. Drug Delivery System 22:2, pages 131-139.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.