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Research Article

Polyplex gene delivery modulated by redox potential gradients

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Pages 519-526 | Received 07 Mar 2006, Accepted 31 May 2006, Published online: 20 Oct 2008

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Zhi-Qiang Yu, Jun-Jie Yan, Ye-Zi You & Qing-Hui Zhou. (2012) Bioreducible and acid-labile poly(amido amine)s for efficient gene delivery. International Journal of Nanomedicine 7, pages 5819-5832.
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Kenneth A Howard & Jørgen Kjems. (2007) Polycation-based nanoparticle delivery for improved RNA interference therapeutics. Expert Opinion on Biological Therapy 7:12, pages 1811-1822.
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Adriano P. Pontes, Steffen van der Wal, Saketh R. Ranamalla, Karin Roelofs, Ioan Tomuta, Laura B. Creemers & Jaap Rip. (2023) Cell uptake and intracellular trafficking of bioreducible poly(amidoamine) nanoparticles for efficient mRNA translation in chondrocytes. Frontiers in Bioengineering and Biotechnology 11.
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Adriano P. Pontes, Tim J. M. Welting, Jaap Rip & Laura B. Creemers. (2022) Polymeric Nanoparticles for Drug Delivery in Osteoarthritis. Pharmaceutics 14:12, pages 2639.
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Anisha D'Souza, Amelia Burch, Kandarp M. Dave, Aravind Sreeram, Michael J. Reynolds, Duncan X. Dobbins, Yashika S. Kamte, Wanzhu Zhao, Courtney Sabatelle, Gina M. Joy, Vishal Soman, Uma R. Chandran, Sruti S. Shiva, Nidia Quillinan, Paco S. Herson & Devika S Manickam. (2021) Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells. Journal of Controlled Release 338, pages 505-526.
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M. Rachèl Elzes, Guoying Si, Johan F. J. Engbersen & Jos M. J. Paulusse. 2019. Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity. Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity 93 117 .
M. Caroline Diana Sherly, S. S. Priya & M. R. Rekha. 2017. Particulate Technology for Delivery of Therapeutics. Particulate Technology for Delivery of Therapeutics 395 417 .
M. Rachèl Elzes, Niels Akeroyd, Johan F.J. Engbersen & Jos M.J. Paulusse. (2016) Disulfide-functional poly(amido amine)s with tunable degradability for gene delivery. Journal of Controlled Release 244, pages 357-365.
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Hanmei Li, Hao Jiang, Mengnan Zhao, Yao Fu & Xun Sun. (2015) Intracellular redox potential-responsive micelles based on polyethylenimine-cystamine-poly(ε-caprolactone) block copolymer for enhanced miR-34a delivery. Polymer Chemistry 6:11, pages 1952-1960.
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Yongzheng Ma, Baizhu Chen, Ning He, Gaojian Chen, Lianwei Li & Chi Wu. (2014) Revisiting Complexation between DNA and Polyethylenimine: Does the Disulfide Linkage Play a Critical Role in Promoting Gene Delivery?. Macromolecular Bioscience 14:12, pages 1807-1815.
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Chan Woo Kim, Riki Toita, Jeong-Hun Kang, Kai Li, Eun Kyung Lee, Guo Xi Zhao, Daiki Funamoto, Takanobu Nobori, Yuta Nakamura, Takeshi Mori, Takuro Niidome & Yoshiki Katayama. (2013) Stabilization of cancer-specific gene carrier via hydrophobic interaction for a clear-cut response to cancer signaling. Journal of Controlled Release 170:3, pages 469-476.
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Agnieszka Stryjewska, Katarzyna Kiepura, Tadeusz Librowski & Stanisław Lochyński. (2013) Biotechnology and genetic engineering in the new drug development. Part II. Monoclonal antibodies, modern vaccines and gene therapy. Pharmacological Reports 65:5, pages 1086-1101.
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Kenneth Howard. 2013. Nanotechnology for the Delivery of Therapeutic Nucleic Acids. Nanotechnology for the Delivery of Therapeutic Nucleic Acids 129 151 .
Wenjing Wang, Chenjie Fang, Xiaozhu Wang, Yuxi Chen, Yaonan Wang, Wei Feng, Chunhua Yan, Ming Zhao & Shiqi Peng. (2013) Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy. Nanoscale 5:14, pages 6249.
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Yu Zhu, Jing Li & David Oupický. 2013. RNA Interference from Biology to Therapeutics. RNA Interference from Biology to Therapeutics 79 95 .
Jing Li, Yu Zhu, Stuart T. Hazeldine, Steven M. Firestine & David Oupický. (2012) Cyclam-Based Polymeric Copper Chelators for Gene Delivery and Potential PET Imaging. Biomacromolecules 13:10, pages 3220-3227.
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Benjamin M. Wohl & Johan F.J. Engbersen. (2012) Responsive layer-by-layer materials for drug delivery. Journal of Controlled Release 158:1, pages 2-14.
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Bozhang Yu. (2012) Reducible Poly (2-Dimethylaminoethyl) Methacrylate-Block-Polyvinylimidazole: Synthesis, Transfection Activity <i>in Vitro</i>. Journal of Biomaterials and Nanobiotechnology 03:01, pages 118-124.
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Rui Guo, Le-Le Li, Wen-Hua Zhao, Yu-Xi Chen, Xiao-Zhu Wang, Chen-Jie Fang, Wei Feng, Tian-Lan Zhang, Xiang Ma, Meng Lu, Shi-Qi Peng & Chun-Hua Yan. (2012) The intracellular controlled release from bioresponsive mesoporous silica with folate as both targeting and capping agent. Nanoscale 4:11, pages 3577.
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Rahau S. Shirazi, Kai K. Ewert, Cecilia Leal, Ramsey N. Majzoub, Nathan F. Bouxsein & Cyrus R. Safinya. (2011) Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery. Biochimica et Biophysica Acta (BBA) - Biomembranes 1808:9, pages 2156-2166.
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Pieter Vader, Leonardus J. van der Aa, Johan F. J. Engbersen, Gert Storm & Raymond M. Schiffelers. (2010) Disulfide-Based Poly(amido amine)s for siRNA Delivery: Effects of Structure on siRNA Complexation, Cellular Uptake, Gene Silencing and Toxicity. Pharmaceutical Research 28:5, pages 1013-1022.
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Tae-il Kim & Sung Wan Kim. (2011) Bioreducible polymers for gene delivery. Reactive and Functional Polymers 71:3, pages 344-349.
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Han Chang Kang, Ho-Jung Kang & You Han Bae. (2011) A reducible polycationic gene vector derived from thiolated low molecular weight branched polyethyleneimine linked by 2-iminothiolane. Biomaterials 32:4, pages 1193-1203.
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Yelena Vachutinsky & Kazunori Kataoka. (2010) PEG-based Polyplex Design for Gene and Nucleotide Delivery. Israel Journal of Chemistry 50:2, pages 175-184.
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Kyeng Min Park, Don-Wook Lee, Bijay Sarkar, Hyuntae Jung, Jeeyeon Kim, Young Ho Ko, Kyung Eun Lee, Hyesung Jeon & Kimoon Kim. (2010) Reduction-Sensitive, Robust Vesicles with a Non-covalently Modifiable Surface as a Multifunctional Drug-Delivery Platform. Small 6:13, pages 1430-1441.
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Xuan Jiang, Yiran Zheng, Hunter H. Chen, Kam W. Leong, Tza‐Huei Wang & Hai‐Quan Mao. (2010) Dual‐Sensitive Micellar Nanoparticles Regulate DNA Unpacking and Enhance Gene‐Delivery Efficiency. Advanced Materials 22:23, pages 2556-2560.
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Siow-Feng Chong, Rona Chandrawati, Brigitte Städler, Jeongju Park, Jinhan Cho, Yajun Wang, Zhongfan Jia, Volga Bulmus, Thomas P. Davis, Alexander N. Zelikin & Frank Caruso. (2009) Stabilization of Polymer-Hydrogel Capsules via ThiolâDisulfide Exchange. Small 5:22, pages 2601-2610.
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Jun Chen, Chao Wu & David Oupický. (2009) Bioreducible Hyperbranched Poly(amido amine)s for Gene Delivery. Biomacromolecules 10:10, pages 2921-2927.
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Sonja Bauhuber, Constantin Hozsa, Miriam Breunig & Achim Göpferich. (2009) Delivery of Nucleic Acids via Disulfide-Based Carrier Systems. Advanced Materials 21:32-33, pages 3286-3306.
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Jenifer Blacklock, Ye-Zi You, Qing-Hui Zhou, Guangzhao Mao & David Oupický. (2009) Gene delivery in vitro and in vivo from bioreducible multilayered polyelectrolyte films of plasmid DNA. Biomaterials 30:5, pages 939-950.
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Devika S. Manickam, Aiko Hirata, David A. Putt, Lawrence H. Lash, Fusao Hirata & David Oupický. (2008) Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of non-viral redox-responsive delivery vectors. Biomaterials 29:17, pages 2680-2688.
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Alexander N. Zelikin, Qi Li & Frank Caruso. (2008) Disulfide-Stabilized Poly(methacrylic acid) Capsules: Formation, Cross-Linking, and Degradation Behavior. Chemistry of Materials 20:8, pages 2655-2661.
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Ulrik L. Rahbek, Kenneth A. Howard, David Oupicky, Devika S. Manickam, Mingdong Dong, Anne F. Nielsen, Thomas B. Hansen, Flemming Besenbacher & Jørgen Kjems. (2007) Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides. The Journal of Gene Medicine 10:1, pages 81-93.
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Ye-Zi You, Devika Soundara Manickam, Qing-Hui Zhou & David Oupický. (2007) Reducible poly(2-dimethylaminoethyl methacrylate): Synthesis, cytotoxicity, and gene delivery activity. Journal of Controlled Release 122:3, pages 217-225.
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