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Journal of Drug Targeting Volume 15, 2007 - Issue 2
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Research Article

Enhanced transport of P-glycoprotein substrate saquinavir in presence of thiolated chitosan

Florian Föger Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens University Innsbruck, Innrain 52, Josef Möller Haus, A-6020, Innsbruck, Austria
,
Krum Kafedjiiski Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens University Innsbruck, Innrain 52, Josef Möller Haus, A-6020, Innsbruck, Austria
,
Herbert Hoyer Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens University Innsbruck, Innrain 52, Josef Möller Haus, A-6020, Innsbruck, Austria
,
Brigitta Loretz Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens University Innsbruck, Innrain 52, Josef Möller Haus, A-6020, Innsbruck, Austria
&
Andreas Bernkop-Schnürch Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens University Innsbruck, Innrain 52, Josef Möller Haus, A-6020, Innsbruck, Austria
Pages 132-139 | Received 26 Sep 2006, Accepted 27 Nov 2006, Published online: 08 Oct 2008

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Kesinee Netsomboon, Flavia Laffleur & A. Bernkop-Schnürch. (2016) P-glycoprotein inhibitors: synthesis and in vitro evaluation of a preactivated thiomer. Drug Development and Industrial Pharmacy 42:4, pages 668-675.
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Kun Hu, Xinyan Xie, Yi-Ni Zhao, Yi Li, Jiming Ruan, Hao-Ran Li, Tianyi Jin & Xian-Le Yang. (2015) Chitosan Influences the Expression of P-gp and Metabolism of Norfloxacin in Grass Carp. Journal of Aquatic Animal Health 27:2, pages 104-111.
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Vimratjeet Kaur, Tarun Garg, Goutam Rath & Amit K. Goyal. (2014) Therapeutic potential of nanocarrier for overcoming to P-glycoprotein. Journal of Drug Targeting 22:10, pages 859-870.
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Duangkamon Sakloetsakun, Javed Iqbal, Gioconda Millotti, Anja Vetter & Andreas Bernkop-Schnürch. (2011) Thiolated chitosans: influence of various sulfhydryl ligands on permeation-enhancing and P-gp inhibitory properties. Drug Development and Industrial Pharmacy 37:6, pages 648-655.
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Herbert Hoyer, Juliane Hombach, Glen Perera, Michael Thaurer & Andreas Bernkop-Schnürch. (2011) Synthesis and in vitro characterization of a novel PAA–ATP conjugate. Drug Development and Industrial Pharmacy 37:3, pages 300-309.
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Martin Werle, Hirofumi Takeuchi & Andreas Bernkop-Schnürch. (2008) New-generation efflux pump inhibitors. Expert Review of Clinical Pharmacology 1:3, pages 429-440.
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Florian Föger, Suchinda Malaivijitnond, Thanakul Wannaprasert, Christian Huck, Andreas Bernkop-Schnürch & Martin Werle. (2008) Effect of a thiolated polymer on oral paclitaxel absorption and tumor growth in rats. Journal of Drug Targeting 16:2, pages 149-155.
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Articles from other publishers (17)

Mohamed S. Attia, Mohamed T. Elsebaey, Galal Yahya, Hitesh Chopra, Mohammed A. Marzouk, Ahmed Yahya & Ahmed S. Abdelkhalek. (2023) Pharmaceutical polymers and P-glycoprotein: Current trends and possible outcomes in drug delivery. Materials Today Communications 34, pages 105318.
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Athar Husain, Vishal Makadia, Guru R. Valicherla, Mohammed Riyazuddin & Jiaur R. Gayen. (2022) Approaches to minimize the effects of P‐glycoprotein in drug transport: A review. Drug Development Research 83:4, pages 825-841.
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Iyyakkannu Sivanesan, Shadma Tasneem, Nazim Hasan, Juhyun Shin, Manikandan Muthu, Judy Gopal & Jae-Wook Oh. (2022) Surveying the Oral Drug Delivery Avenues of Novel Chitosan Derivatives. Polymers 14:11, pages 2131.
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Supriya D. Mahajan, Ravikumar Aalinkeel, Jessica L. Reynolds, Bindukumar B. Nair, Manoj J. Mammen, Lili Dai, Paras N. Prasad & Stanley A. Schwartz. 2015. Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases. Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases 251 268 .
Nazma Inamdar & Vishnukant Mourya. 2013. Chitin and Chitosan Derivatives. Chitin and Chitosan Derivatives 121 150 .
K. Gradauer, J. Barthelmes, C. Vonach, G. Almer, H. Mangge, B. Teubl, E. Roblegg, S. Dünnhaupt, E. Fröhlich, A. Bernkop-Schnürch & R. Prassl. (2013) Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats. Journal of Controlled Release 172:3, pages 872-878.
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Alejandro Sosnik. (2013) Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing “Generally Recognized As Safe” (GRAS) nanopharmaceuticals: A review. Advanced Drug Delivery Reviews 65:13-14, pages 1828-1851.
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Vinod L. Gaikwad & Manish S. Bhatia. (2013) Polymers influencing transportability profile of drug. Saudi Pharmaceutical Journal 21:4, pages 327-335.
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Ana Beloqui, Mara ngeles Solins, Alicia R. Gascn, Ana del Pozo-Rodrguez, Anne des Rieux & Vronique Prat. (2013) Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier. Journal of Controlled Release 166:2, pages 115-123.
Crossref
Javed Iqbal, Federica Sarti, Glen Perera & Andreas Bernkop-Schnürch. (2011) Development and in vivo evaluation of an oral drug delivery system for paclitaxel. Biomaterials 32:1, pages 170-175.
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Jiasheng Tu, Yan Shen, Ravichandran Mahalingam, Bhaskara Jasti & Xiaoling Li. 2010. Oral Controlled Release Formulation Design and Drug Delivery. Oral Controlled Release Formulation Design and Drug Delivery 71 87 .
Jianghong Fan, Han‐Joo Maeng & K. Sandy Pang. (2010) Interplay of transporters and enzymes in the Caco‐2 cell monolayer: I. effect of altered apical secretion. Biopharmaceutics & Drug Disposition 31:4, pages 215-227.
Crossref
Martin Werle & Andreas Bernkop-Schnürch. (2008) Thiolated chitosans: useful excipients for oral drug delivery. Journal of Pharmacy and Pharmacology 60:3, pages 273-281.
Crossref
K. Sandy Pang, Han-Joo Maeng & Jianghong Fan. (2009) Interplay of Transporters and Enzymes in Drug and Metabolite Processing. Molecular Pharmaceutics 6:6, pages 1734-1755.
Crossref
Martin Werle, Hirofumi Takeuchi & Andreas Bernkop-Schnürch. (2009) Modified Chitosans for Oral Drug Delivery. Journal of Pharmaceutical Sciences 98:5, pages 1643-1656.
Crossref
Florian Föger. 2009. Oral Delivery of Macromolecular Drugs. Oral Delivery of Macromolecular Drugs 123 136 .
Martin Werle. (2007) Natural and Synthetic Polymers as Inhibitors of Drug Efflux Pumps. Pharmaceutical Research 25:3, pages 500-511.
Crossref

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