Advanced search
Publication Cover
Journal of Drug Targeting Volume 16, 2008 - Issue 5
Submit an article Journal homepage
421
Views
66
CrossRef citations to date
0
Altmetric
Research Article

The role of macromolecular architecture in passively targeted polymeric carriers for drug and gene delivery

Scott M. Grayson Department of Chemistry, Tulane University, New Orleans, LA70118, USA
&
W T. Godbey Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA70118, USA
Pages 329-356 | Received 16 Nov 2007, Accepted 31 Jan 2008, Published online: 08 Oct 2008

Citations (66)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Saghir Akhtar. (2010) Cationic nanosystems for the delivery of small interfering ribonucleic acid therapeutics: a focus on toxicogenomics. Expert Opinion on Drug Metabolism & Toxicology 6:11, pages 1347-1362.
Read now

Articles from other publishers (65)

Ashkan Nasery, Gholamhassan Imanzadeh, Mohammadreza Zamanlu, Zahra Soltanzadeh & Turan Öztürk. (2023) Highly enantioselective Biginelli reaction using sulfonic-functionalized chiral hyperbranched polylysine in absence of solvent: A new catalyst for asymmetric synthesis of dihydropyrimidinones. Tetrahedron, pages 133656.
Crossref
Nadia Shafaei, Sajedeh Khorshidi & Akbar Karkhaneh. (2023) The immune-stealth polymeric coating on drug delivery nanocarriers: In vitro engineering and in vivo fate. Journal of Biomaterials Applications 38:2, pages 159-178.
Crossref
Dagan Hadar, Daniela S. Strugach & Miriam Amiram. (2022) Conjugates of Recombinant Protein‐Based Polymers: Combining Precision with Chemical Diversity. Advanced NanoBiomed Research 2:6, pages 2100142.
Crossref
Ki Hyun Kim, Jiyun Nam, Jinwoong Choi, Myungeun Seo & Joona Bang. (2022) From macromonomers to bottlebrush copolymers with sequence control: synthesis, properties, and applications. Polymer Chemistry 13:16, pages 2224-2261.
Crossref
Yonca Kittel, Alexander J. C. Kuehne & Laura De Laporte. (2021) Translating Therapeutic Microgels into Clinical Applications. Advanced Healthcare Materials 11:6, pages 2101989.
Crossref
W T. Godbey. 2022. Biotechnology and its Applications. Biotechnology and its Applications 287 325 .
Margarida Ferreira-Silva, Catarina Faria-Silva, Pedro Viana Baptista, Eduarda Fernandes, Alexandra Ramos Fernandes & Maria Luísa Corvo. (2021) Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury. Drug Delivery and Translational Research 11:2, pages 397-410.
Crossref
Bianka Golba, Edmondo M. Benetti & Bruno G. De Geest. (2021) Biomaterials applications of cyclic polymers. Biomaterials 267, pages 120468.
Crossref
Tong Wu, Xuefei Leng, Yanshai Wang, Zhiyong Wei & Yang Li. (2020) Linear- and star-brush poly(ethylene glycol)s: Synthesis and architecture-dependent crystallization behavior. Polymer 202, pages 122661.
Crossref
George Zapsas, Yogesh Patil, Yves Gnanou, Bruno Ameduri & Nikos Hadjichristidis. (2020) Poly(vinylidene fluoride)-based complex macromolecular architectures: From synthesis to properties and applications. Progress in Polymer Science 104, pages 101231.
Crossref
Alireza Kavand, Nicolas Anton, Thierry Vandamme, Christophe A. Serra & Delphine Chan-Seng. (2020) Synthesis and functionalization of hyperbranched polymers for targeted drug delivery. Journal of Controlled Release 321, pages 285-311.
Crossref
Alexander B. Cook & Sébastien Perrier. (2019) Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery. Advanced Functional Materials 30:2, pages 1901001.
Crossref
Vijayalaxmi Gupta, Sneha Bhavanasi, Mohiuddin Quadir, Kevin Singh, Gaurav Ghosh, Kritin Vasamreddy, Arnab Ghosh, Teruna J. Siahaan, Snigdha Banerjee & Sushanta K. Banerjee. (2018) Protein PEGylation for cancer therapy: bench to bedside. Journal of Cell Communication and Signaling 13:3, pages 319-330.
Crossref
Jinhua Chi, Zhiwen Jiang, Jing Qiao, Yanfei Peng, Wanshun Liu & Baoqin Han. (2019) Synthesis and anti-metastasis activities of norcantharidin-conjugated carboxymethyl chitosan as a novel drug delivery system. Carbohydrate Polymers 214, pages 80-89.
Crossref
Petr Chytil, Milada Šírová, Júlia Kudláčová, Blanka Říhová, Karel Ulbrich & Tomáš Etrych. (2018) Bloodstream Stability Predetermines the Antitumor Efficacy of Micellar Polymer–Doxorubicin Drug Conjugates with pH-Triggered Drug Release. Molecular Pharmaceutics 15:9, pages 3654-3663.
Crossref
Raghu Ganugula, Meenakshi Arora, Prabhjot Saini, Melissa Guada & Majeti N. V. Ravi Kumar. (2017) Next Generation Precision-Polyesters Enabling Optimization of Ligand–Receptor Stoichiometry for Modular Drug Delivery. Journal of the American Chemical Society 139:21, pages 7203-7216.
Crossref
Li-Zhong Hu, Ning Wan, Xi-Xi Ma, Zi-Wei Jing, Ya-Xuan Zhang, Chen Li, Si-Yuan Zhou & Bang-Le Zhang. (2017) Enhanced gene transfection performance and biocompatibility of polyethylenimine through pseudopolyrotaxane formation with ? -cyclodextrin . Nanotechnology 28:12, pages 125102.
Crossref
Bernhard V. K. J. Schmidt & Christopher Barner&xKowollik. 2016. Macromolecular Self&;#x02010;assembly. Macromolecular Self&;#x02010;assembly 1 32 .
Wenhao Qian, Xuemei Song, Chun Feng, Peicheng Xu, Xue Jiang, Yongjun Li & Xiaoyu Huang. (2016) Construction of PEG-based amphiphilic brush polymers bearing hydrophobic poly(lactic acid) side chains via successive RAFT polymerization and ROP. Polymer Chemistry 7:19, pages 3300-3310.
Crossref
Hanxiang Zeng, Cathleen Schlesener, Olivia Cromwell, Markus Hellmund, Rainer Haag & Zhibin Guan. (2015) Amino Acid-Functionalized Dendritic Polyglycerol for Safe and Effective siRNA Delivery. Biomacromolecules 16:12, pages 3869-3877.
Crossref
Esteban F. Durán-Lara, Jennifer L. Marple, Joseph A. Giesen, Yunlan Fang, Jacobs H. Jordan, W Terrence Godbey, Adolfo Marican, Leonardo S. Santos & Scott M. Grayson. (2015) Investigation of Lysine-Functionalized Dendrimers as Dichlorvos Detoxification Agents. Biomacromolecules 16:11, pages 3434-3444.
Crossref
Mallory A. Cortez, W T. Godbey, Yunlan Fang, Molly E. Payne, Brian J. Cafferty, Karolina A. Kosakowska & Scott M. Grayson. (2015) The Synthesis of Cyclic Poly(ethylene imine) and Exact Linear Analogues: An Evaluation of Gene Delivery Comparing Polymer Architectures. Journal of the American Chemical Society 137:20, pages 6541-6549.
Crossref
Shinya Masukawa, Takahiro Kikkawa, Atsuhiro Fujimori, Yoshiyuki Oishi & Yuji Shibasaki. (2015) Synthesis of a A 2 B 3 -type Hyperbranched Copolymers Based on a 3-Armed Unimolecular 4- N -Methylbenzamide Pentamer and Poly(propylene oxide) . Chemistry Letters 44:4, pages 536-538.
Crossref
Markus Müllner, Sarah J. Dodds, Tri-Hung Nguyen, Danielle Senyschyn, Christopher J. H. Porter, Ben J. Boyd & Frank Caruso. (2015) Size and Rigidity of Cylindrical Polymer Brushes Dictate Long Circulating Properties In Vivo . ACS Nano 9:2, pages 1294-1304.
Crossref
Meina Liu, Robert P. Burford & Andrew B. Lowe. (2014) Thiol-Michael coupling and ring-opening metathesis polymerization: facile access to functional exo -7-oxanorbornene dendron macromonomers . Polymer International 63:7, pages 1174-1183.
Crossref
Florian Szillat, Bernhard V. K. J. Schmidt, Artur Hubert, Christopher Barner-Kowollik & Helmut Ritter. (2014) Redox-Switchable Supramolecular Graft Polymer Formation via Ferrocene-Cyclodextrin Assembly. Macromolecular Rapid Communications 35:14, pages 1293-1300.
Crossref
Olivier Coulembier, Julien De Winter, Thomas Josse, Laetitia Mespouille, Pascal Gerbaux & Philippe Dubois. (2014) One-step synthesis of polylactide macrocycles from sparteine-initiated ROP. Polymer Chemistry 5:6, pages 2103.
Crossref
Bernhard V.K.J. Schmidt, Martin Hetzer, Helmut Ritter & Christopher Barner-Kowollik. (2014) Complex macromolecular architecture design via cyclodextrin host/guest complexes. Progress in Polymer Science 39:1, pages 235-249.
Crossref
W.T. Godbey. 2014. An Introduction to Biotechnology. An Introduction to Biotechnology 275 312 .
Bernhard V. K. J. SchmidtBernhard Volkmar Konrad Jakob Schmidt. 2014. Novel Macromolecular Architectures via a Combination of Cyclodextrin Host/Guest Complexation and RAFT Polymerization. Novel Macromolecular Architectures via a Combination of Cyclodextrin Host/Guest Complexation and RAFT Polymerization 1 5 .
Olivier Coulembier, Sébastien Moins & Philippe Dubois. (2013) Preparation and copolymerization of a functionalized lactone with (DHQD) 2 AQN . Green Materials 1:4, pages 203-208.
Crossref
Abebe E. Mengesha, Robert J. Wydra, J. Zach Hilt & Paul M. Bummer. (2013) Binary Blend of Glyceryl Monooleate and Glyceryl Monostearate for Magnetically Induced Thermo-Responsive Local Drug Delivery System. Pharmaceutical Research 30:12, pages 3214-3224.
Crossref
Xiaofen Xu, Yanggong Li, Feihu Wang, Li Lv, Jieying Liu, Mingna Li, Aijie Guo, Jinjun Jiang, Yuanyuan Shen & Shengrong Guo. (2013) Synthesis, in vitro and in vivo evaluation of new norcantharidin-conjugated hydroxypropyltrimethyl ammonium chloride chitosan derivatives as polymer therapeutics. International Journal of Pharmaceutics 453:2, pages 610-619.
Crossref
Martin Hetzer, Carolin Fleischmann, Bernhard V.K.J. Schmidt, Christopher Barner-Kowollik & Helmut Ritter. (2013) Visual recognition of supramolecular graft polymer formation via phenolphthalein–cyclodextrin association. Polymer 54:19, pages 5141-5147.
Crossref
Hanxiang Zeng, Hannah C. Little, Timothy N. Tiambeng, Gregory A. Williams & Zhibin Guan. (2013) Multifunctional Dendronized Peptide Polymer Platform for Safe and Effective siRNA Delivery. Journal of the American Chemical Society 135:13, pages 4962-4965.
Crossref
Nowsheen Goonoo, Archana Bhaw‐Luximon, Gary L Bowlin & Dhanjay Jhurry. (2013) An assessment of biopolymer‐ and synthetic polymer‐based scaffolds for bone and vascular tissue engineering. Polymer International 62:4, pages 523-533.
Crossref
Aristides D. TagalakisLuisa SaraivaDavid McCarthyKenth T. GustafssonStephen L. Hart. (2013) Comparison of Nanocomplexes with Branched and Linear Peptides for SiRNA Delivery. Biomacromolecules 14:3, pages 761-770.
Crossref
Jiangtao Xu, Qiang Fu, Jing M. Ren, Gary Bryant & Greg G. Qiao. (2013) Novel drug carriers: from grafted polymers to cross-linked vesicles. Chem. Commun. 49:1, pages 33-35.
Crossref
Chau Hon Ho, Matthias Thiel, Seref Celik, Erich K. Odermatt, Ingo Berndt, Ralf Thomann & Joerg C. Tiller. (2012) Conventional and microwave-assisted synthesis of hyperbranched and highly branched polylysine towards amphiphilic core–shell nanocontainers for metal nanoparticles. Polymer 53:21, pages 4623-4630.
Crossref
Bart J. Crielaard, Twan Lammers, Raymond M. Schiffelers & Gert Storm. (2012) Drug targeting systems for inflammatory disease: One for all, all for one. Journal of Controlled Release 161:2, pages 225-234.
Crossref
Douglas G. Mullen, Ankur Desai, Mallory A. van Dongen, Mark Barash, James R. BakerJr.Jr. & Mark M. Banaszak Holl. (2012) Best Practices for Purification and Characterization of PAMAM Dendrimer. Macromolecules 45:12, pages 5316-5320.
Crossref
Petr Chytil, Tomáš Etrych, Libor Kostka & Karel Ulbrich. (2012) Hydrolytically Degradable Polymer Micelles for Anticancer Drug Delivery to Solid Tumors. Macromolecular Chemistry and Physics 213:8, pages 858-867.
Crossref
Vanessa Giménez, Craig James, Ana Armiñán, Ralf Schweins, Alison Paul & María J. Vicent. (2012) Demonstrating the importance of polymer-conjugate conformation in solution on its therapeutic output: Diethylstilbestrol (DES)-polyacetals as prostate cancer treatment. Journal of Controlled Release 159:2, pages 290-301.
Crossref
Cédric‐Olivier Turrin & Anne‐Marie Caminade. 2011. Dendrimers. Dendrimers 437 461 .
Cédric‐Olivier Turrin & Anne‐Marie Caminade. 2011. Dendrimers. Dendrimers 413 435 .
Tom?? Etrych, Lubom?r Kov??Ji?? Strohalm, Petr Chytil, Blanka ??hov?Karel Ulbrich. (2011) Biodegradable star HPMA polymer?drug conjugates: Biodegradability, distribution and anti-tumor efficacy. Journal of Controlled Release 154:3, pages 241-248.
Crossref
Aristides D. Tagalakis, Lin He, Luisa Saraiva, Kenth T. Gustafsson & Stephen L. Hart. (2011) Receptor-targeted liposome-peptide nanocomplexes for siRNA delivery. Biomaterials 32:26, pages 6302-6315.
Crossref
Meta M. Bloksma, Christine Weber, Igor Y. Perevyazko, Anette Kuse, Anja Baumgärtel, Antje Vollrath, Richard Hoogenboom & Ulrich S. Schubert. (2011) Poly(2-cyclopropyl-2-oxazoline): From Rate Acceleration by Cyclopropyl to Thermoresponsive Properties. Macromolecules 44:11, pages 4057-4064.
Crossref
Haskell W. Beckham. 2011. Complex Macromolecular Architectures. Complex Macromolecular Architectures 791 821 .
Bo Chen, Derek G. van der Poll, Katherine Jerger, William C. Floyd, Jean M. J. Fréchet & Francis C. Szoka. (2011) Synthesis and Properties of Star-Comb Polymers and Their Doxorubicin Conjugates. Bioconjugate Chemistry 22:4, pages 617-624.
Crossref
Christian Porsch, Susanne Hansson, Niklas Nordgren & Eva Malmström. (2011) Thermo-responsive cellulose-based architectures: tailoring LCST using poly(ethylene glycol) methacrylates. Polymer Chemistry 2:5, pages 1114-1123.
Crossref
Albert Kwok & Stephen L. Hart. (2011) Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery. Nanomedicine: Nanotechnology, Biology and Medicine 7:2, pages 210-219.
Crossref
Jeremiah A. Johnson, Ying Y. Lu, Alan O. Burts, Yeon-Hee Lim, M. G. Finn, Jeffrey T. Koberstein, Nicholas J. Turro, David A. Tirrell & Robert H. Grubbs. (2010) Core-Clickable PEG- Branch -Azide Bivalent-Bottle-Brush Polymers by ROMP: Grafting-Through and Clicking-To . Journal of the American Chemical Society 133:3, pages 559-566.
Crossref
Yejia Li, Marco D. Giles, Simin Liu, Boyd A. Laurent, Jessica N. Hoskins, Mallory A. Cortez, Subramanya G. Sreerama, Bruce C. Gibb & Scott M. Grayson. (2011) A versatile and modular approach to functionalisation of deep-cavity cavitands via“click” chemistry. Chemical Communications 47:32, pages 9036.
Crossref
Uwe Hahn, Francesca Setaro, Xavier Rag?s, Angus Gray-Weale, Santi Nonell & Tomas Torres. (2011) Microenvironment-switchable singlet oxygen generation by axially-coordinated hydrophilic ruthenium phthalocyanine dendrimers. Phys. Chem. Chem. Phys. 13:8, pages 3385-3393.
Crossref
Jeremiah A. Johnson, Ying Y. Lu, Alan O. Burts, Yan Xia, Alec C. Durrell, David A. Tirrell & Robert H. Grubbs. (2010) Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP. Macromolecules 43:24, pages 10326-10335.
Crossref
Katrin Knop, Richard Hoogenboom, Dagmar Fischer & Ulrich S. Schubert. (2010) Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives. Angewandte Chemie International Edition 49:36, pages 6288-6308.
Crossref
Katrin Knop, Richard Hoogenboom, Dagmar Fischer & Ulrich S. Schubert. (2010) Anwendung von Poly(ethylenglycol) beim Wirkstoff‐Transport: Vorteile, Nachteile und Alternativen. Angewandte Chemie 122:36, pages 6430-6452.
Crossref
A. Paul, C. James, R. K. Heenan & R. Schweins. (2010) Drug Mimic Induced Conformational Changes in Model Polymer−Drug Conjugates Characterized by Small-Angle Neutron Scattering. Biomacromolecules 11:8, pages 1978-1982.
Crossref
Scott M. Grayson & Bruce C. Gibb. (2010) Dendronized cavitands: A step towards a synthetic viral capsid?. Soft Matter 6:7, pages 1377.
Crossref
Maisie J. Joralemon, Samantha McRae & Todd Emrick. (2010) PEGylated polymers for medicine: from conjugation to self-assembled systems. Chemical Communications 46:9, pages 1377.
Crossref
Bo Chen, Katherine Jerger, Jean M.J. Fr?chet & Francis C. SzokaJr.Jr.. (2009) The influence of polymer topology on pharmacokinetics: Differences between cyclic and linear PEGylated poly(acrylic acid) comb polymers. Journal of Controlled Release 140:3, pages 203-209.
Crossref
Athuluri Divakar Sai Krishna, Raj Kumar Mandraju, Golla Kishore & Anand Kumar Kondapi. (2009) An Efficient Targeted Drug Delivery through Apotransferrin Loaded Nanoparticles. PLoS ONE 4:10, pages e7240.
Crossref
Megan E. Fox, Francis C. Szoka & Jean M. J. Fréchet. (2009) Soluble Polymer Carriers for the Treatment of Cancer: The Importance of Molecular Architecture. Accounts of Chemical Research 42:8, pages 1141-1151.
Crossref
Norased Nasongkla, Bo Chen, Nichole Macaraeg, Megan E. Fox, Jean M. J. Fréchet & Francis C. Szoka. (2009) Dependence of Pharmacokinetics and Biodistribution on Polymer Architecture: Effect of Cyclic versus Linear Polymers. Journal of the American Chemical Society 131:11, pages 3842-3843.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.