Advanced search
Publication Cover
Journal of Drug Targeting Volume 26, 2018 - Issue 10
Submit an article Journal homepage
279
Views
17
CrossRef citations to date
0
Altmetric
Original Article

Cyclopamine treatment disrupts extracellular matrix and alleviates solid stress to improve nanomedicine delivery for pancreatic cancer

Bo ZhangInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China; View further author information
,
Honglan WangInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China; View further author information
,
Ting JiangInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China; View further author information
,
Kai JinSchool of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai, ChinaView further author information
,
Zimiao LuoSchool of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai, ChinaView further author information
,
Wei ShiInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China; View further author information
,
Heng MeiInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China; View further author information
,
Huafang WangInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China; View further author information
,
Yu HuInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China; Correspondence[email protected]
View further author information
,
Zhiqing PangSchool of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai, ChinaCorrespondence[email protected]
View further author information
&
Xinguo JiangSchool of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai, ChinaView further author information
 show all
Pages 913-919 | Received 17 Nov 2017, Accepted 11 Mar 2018, Published online: 20 Mar 2018

Citations (17)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Kai Huang, Junqiang Liu, Qiwei Chen, Dan Feng, Haotian Wu, Abdullah Aldanakh, Yuli Jian, Zhongyang Xu, Shujing Wang & Deyong Yang. (2022) The effect of mechanical force in genitourinary malignancies. Expert Review of Anticancer Therapy 22:1, pages 53-64.
Read now

Articles from other publishers (16)

Linlin Tao, Gang Cheng, Fangnan Lv, Ruiqi Wang, Nan Yang, Zuhang Xing, Boyu Gu, Siyuan Meng, Wei Xu & Meirong Huo. (2023) Synergistic strategy based on mild phototherapy and deep tumor hypoxia reversal comprehensively remodels the tumor microenvironment for improved immunotherapy. Chemical Engineering Journal 472, pages 145092.
Crossref
Xiaohui Wang, Hong Zhang, Xiaohui Chen, Chunrong Wu, Ke Ding, Guiyin Sun, Yang Luo & Debing Xiang. (2023) Overcoming tumor microenvironment obstacles: Current approaches for boosting nanodrug delivery. Acta Biomaterialia 166, pages 42-68.
Crossref
Honglan Wang, Huiwen Liu, Jia Li, Chunying Liu, Hui Chen, Junying Li, Chunyan Sun, Tao Guo, Zhiqing Pang, Bo Zhang & Yu Hu. (2023) Cytokine nanosponges suppressing overactive macrophages and dampening systematic cytokine storm for the treatment of hemophagocytic lymphohistiocytosis. Bioactive Materials 21, pages 531-546.
Crossref
Bo Liu, Chengxi Kou, Yafei Ren, Qi Li, Tong Wang, Rui Ma, Wei Sun, Zheyong Xue & Pengda Ma. (2023) Advances of Veratrum nigrum L. Steroid Alkaloids. Industrial Crops and Products 191, pages 115946.
Crossref
Alireza Najafi, Maryam Keykhaee, Hossein Khorramdelazad, Mohammad Yahya Karimi, Leila Nejatbakhsh Samimi, Nazanin Aghamohamadi, Milad Karimi, Reza Falak & Mehdi Khoobi. (2022) Catalase application in cancer therapy: Simultaneous focusing on hypoxia attenuation and macrophage reprogramming. Biomedicine & Pharmacotherapy 153, pages 113483.
Crossref
Dan Wang, Yuqiang Li, Heming Ge, Tarik Ghadban, Matthias Reeh & Cenap Güngör. (2022) The Extracellular Matrix: A Key Accomplice of Cancer Stem Cell Migration, Metastasis Formation, and Drug Resistance in PDAC. Cancers 14:16, pages 3998.
Crossref
Delphine Quatannens, Yannick Verhoeven, Peter Van Dam, Filip Lardon, Hans Prenen, Geert Roeyen, Marc Peeters, Evelien L.J. Smits & Jonas Van Audenaerde. (2022) Targeting hedgehog signaling in pancreatic ductal adenocarcinoma. Pharmacology & Therapeutics 236, pages 108107.
Crossref
Vahideh Mohammadzadeh, Niloufar Rahiman, Seyedeh Maryam Hosseinikhah, Mahmood Barani, Abbas Rahdar, Mahmoud Reza Jaafari, Saman Sargazi, Mohammad Reza Zirak, Sadanand Pandey, Rahul Bhattacharjee, Ashish Kumar Gupta, Vijay Kumar Thakur, Belay Zeleke Sibuh & Piyush Kumar Gupta. (2022) Novel EPR-enhanced strategies for targeted drug delivery in pancreatic cancer: An update. Journal of Drug Delivery Science and Technology 73, pages 103459.
Crossref
Yanan Li, Wenting Song, Yumin Hu, Yun Xia, Zhen Li, Yang Lu & Yan Shen. (2021) “Petal-like” size-tunable gold wrapped immunoliposome to enhance tumor deep penetration for multimodal guided two-step strategy. Journal of Nanobiotechnology 19:1.
Crossref
Gabriela S. Kronemberger, Guilherme A. S. C. Miranda, Renata S. N. Tavares, Bianca Montenegro, Úrsula de A. Kopke & Leandra S. Baptista. (2021) Recapitulating Tumorigenesis in vitro: Opportunities and Challenges of 3D Bioprinting. Frontiers in Bioengineering and Biotechnology 9.
Crossref
Menghong Xu, Ping Wang, Suhui Sun, Liquan Gao, Lihong Sun, Lulu Zhang, Jinxia Zhang, Shumin Wang & Xiaolong Liang. (2020) Smart strategies to overcome tumor hypoxia toward the enhancement of cancer therapy. Nanoscale 12:42, pages 21519-21533.
Crossref
Rujing Chen, Leaf Huang & Kaili Hu. (2020) Natural products remodel cancer-associated fibroblasts in desmoplastic tumors. Acta Pharmaceutica Sinica B 10:11, pages 2140-2155.
Crossref
Jingxing Yang & Chunfu Zhang. (2020) Regulation of cancer‐immunity cycle and tumor microenvironment by nanobiomaterials to enhance tumor immunotherapy. WIREs Nanomedicine and Nanobiotechnology 12:4.
Crossref
Chan Feng, Lv Chen, Yonglin Lu, Jie Liu, Shujing Liang, Yun Lin, Yongyong Li & Chunyan Dong. (2019) Programmable Ce6 Delivery via Cyclopamine Based Tumor Microenvironment Modulating Nano-System for Enhanced Photodynamic Therapy in Breast Cancer. Frontiers in Chemistry 7.
Crossref
Alain Vella, Enanga M. EkoArmando del Río Hernández. (2018) The emergence of solid stress as a potent biomechanical marker of tumour progression. Emerging Topics in Life Sciences 2:5, pages 739-749.
Crossref
Gulcen Yeldag, Alistair Rice & Armando Del Río Hernández. (2018) Chemoresistance and the Self-Maintaining Tumor Microenvironment. Cancers 10:12, pages 471.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.