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Journal of Drug Targeting Volume 26, 2018 - Issue 10
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Original Article

Tf ligand-receptor-mediated exenatide-Zn2+ complex oral-delivery system for penetration enhancement of exenatide

Liping ZhangSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, PR China; View further author information
,
Yanan ShiSchool of Pharmacy, Binzhou Medical University, Yantai, PR China; Correspondence[email protected]
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Yina SongSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, PR China; View further author information
,
Dongyu DuanSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, PR China; View further author information
,
Xuemei ZhangState Key Laboratory of Long-acting and Targeting Drug Delivery System, Luye Pharmaceutical Co., Ltd, Yantai, PR ChinaView further author information
,
Kaoxiang SunSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, PR China; ;State Key Laboratory of Long-acting and Targeting Drug Delivery System, Luye Pharmaceutical Co., Ltd, Yantai, PR ChinaView further author information
&
Youxin LiSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, PR China; ;State Key Laboratory of Long-acting and Targeting Drug Delivery System, Luye Pharmaceutical Co., Ltd, Yantai, PR ChinaCorrespondence[email protected]
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Pages 931-940 | Received 01 Nov 2017, Accepted 19 Mar 2018, Published online: 16 Apr 2018

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Shiyun Liu, Xiangce Wen, Xin Zhang & Shirui Mao. (2023) Oral delivery of biomacromolecules by overcoming biological barriers in the gastrointestinal tract: an update. Expert Opinion on Drug Delivery 20:10, pages 1333-1347.
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Shiming He, Wenliang Fu, Minji Zou, Weiwei Xing, Zhongcheng Liu & Donggang Xu. (2019) Construction and evaluation of SAK-HV protein oral dosage form based on chitosan quaternary ammonium salt-PLGA microsphere. Journal of Drug Targeting 27:10, pages 1108-1117.
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Articles from other publishers (16)

Wenjing Jiang, Xiangjun Gao, Qiuli Wang, Yang Chen, Dan Li, Xiaoyan Zhang & Xinggang Yang. (2023) The Modified Exenatide Microspheres: PLGA-PEG-PLGA Gel and Zinc-Exenatide Complex Synergistically Reduce Burst Release and Shorten Platform Stage. AAPS PharmSciTech 24:8.
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Ping Wang, Yue Wang, Ping Li, Chen Chen, Siman Ma, Linxuan Zhao, Haibing He, Tian Yin, Yu Zhang, Xing Tang & Jingxin Gou. (2023) Oral delivery of polyester nanoparticles for brain-targeting: Challenges and opportunities. Chinese Chemical Letters 34:4, pages 107691.
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Mengran Guo, Zhongshan He, Zhaohui Jin, Lingjing Huang, Jingmei Yuan, Shugang Qin, Xinchun Wang, Lili Cao & Xiangrong Song. (2022) Oral nanoparticles containing naringenin suppress atherosclerotic progression by targeting delivery to plaque macrophages. Nano Research 16:1, pages 925-937.
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Carlynne Choy, Lee Yong Lim, Lai Wah Chan, Zhixiang Cui, Shirui Mao & Tin Wui Wong. (2022) Exploring Intestinal Surface Receptors in Oral Nanoinsulin Delivery. Pharmacological Reviews 74:4, pages 962-983.
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Nabilah Ibnat, Rahela Zaman, Mohammad Borhan Uddin, Ezharul Chowdhury & Chooi Yeng Lee. (2022) Improved systemic half-life of glucagon-like peptide-1-loaded carbonate apatite nanoparticles in rats. World Journal of Diabetes 13:8, pages 613-621.
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Ji-Yuan Zhang, Xiao-Xia Liu, Jia-Yi Lin, Xiao-Yan Bao, Jian-Qing Peng, Zi-Peng Gong, Xin Luan & Yi Chen. (2022) Biomimetic engineered nanocarriers inspired by viruses for oral-drug delivery. International Journal of Pharmaceutics 624, pages 121979.
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Meenakshi Arora, Dianxiong Zou & M.N.V. Ravi Kumar. 2022. Oral Delivery of Therapeutic Peptides and Proteins. Oral Delivery of Therapeutic Peptides and Proteins 131 166 .
Noura G. Eissa, Mahmoud Elsabahy & Ayat Allam. (2021) Engineering of smart nanoconstructs for delivery of glucagon-like peptide-1 analogs. International Journal of Pharmaceutics 597, pages 120317.
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José das Neves, Roni Sverdlov Arzi & Alejandro Sosnik. (2020) Molecular and cellular cues governing nanomaterial–mucosae interactions: from nanomedicine to nanotoxicology. Chemical Society Reviews 49:14, pages 5058-5100.
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Ruba Ismail, Thi Nhu Quynh Phan, Flavia Laffleur, Ildikó Csóka & Andreas Bernkop-Schnürch. (2020) Hydrophobic ion pairing of a GLP-1 analogue for incorporating into lipid nanocarriers designed for oral delivery. European Journal of Pharmaceutics and Biopharmaceutics 152, pages 10-17.
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Miaomiao Yin, Yina Song, Shiqi Guo, Xuemei Zhang, Kaoxiang Sun, Youxin Li & Yanan Shi. (2020) Intelligent Escape System for the Oral Delivery of Liraglutide: A Perfect Match for Gastrointestinal Barriers. Molecular Pharmaceutics 17:6, pages 1899-1909.
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D.J. Brayden, T.A. Hill, D.P. Fairlie, S. Maher & R.J. Mrsny. (2020) Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches. Advanced Drug Delivery Reviews 157, pages 2-36.
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A.R. Pinho, A. Fortuna, A. Falcão, A.C. Santos, R. Seiça, C. Estevens, F. Veiga & A.J. Ribeiro. (2019) Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices. Journal of Pharmaceutical Analysis 9:3, pages 143-155.
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Yina Song, Yanan Shi, Liping Zhang, Haiyan Hu, Chunyan Zhang, Miaomiao Yin, Xuemei Zhang & Kaoxiang Sun. (2019) Oral delivery system for low molecular weight protamine-dextran-poly(lactic-co-glycolic acid) carrying exenatide to overcome the mucus barrier and improve intestinal targeting efficiency. Nanomedicine 14:8, pages 989-1009.
Crossref
Yina Song, Yanan Shi, Liping Zhang, Haiyan Hu, Chunyan Zhang, Miaomiao Yin, Liuxiang Chu, Xiuju Yan, Mingyu Zhao, Xuemei Zhang, Hongjie Mu & Kaoxiang Sun. (2019) Synthesis of CSK-DEX-PLGA Nanoparticles for the Oral Delivery of Exenatide to Improve Its Mucus Penetration and Intestinal Absorption. Molecular Pharmaceutics 16:2, pages 518-532.
Crossref
A. B. Shreya, Sushil Yadaorao Raut, Renuka Suresh Managuli, Nayanabhirama Udupa & Srinivas Mutalik. (2018) Active Targeting of Drugs and Bioactive Molecules via Oral Administration by Ligand-Conjugated Lipidic Nanocarriers: Recent Advances. AAPS PharmSciTech 20:1.
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