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Original Article

Oral self-emulsifying delivery systems for systemic administration of therapeutic proteins: science fiction?

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Pages 1017-1024 | Received 15 Oct 2018, Accepted 11 Feb 2019, Published online: 17 Jul 2019

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Read on this site (2)

Jinghan Xin, Mengdi Qin, Genyang Ye, Haonan Gong, Mo Li, Xiaofan Sui, Bingyang Liu, Qiang Fu & Zhonggui He. (2023) Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs. Expert Opinion on Drug Delivery 20:1, pages 1-11.
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Swapna Poudwal & Pravin Shende. (2022) Multi-strategic approaches for enhancing active transportation using self-emulsifying drug delivery system. Journal of Drug Targeting 30:7, pages 726-736.
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Articles from other publishers (20)

Matthew N. O’Brien Laramy, Suman Luthra, Matthew F. Brown & Derek W. Bartlett. (2023) Delivering on the promise of protein degraders. Nature Reviews Drug Discovery 22:5, pages 410-427.
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Weeranuch Lang, Debashish Mondol, Aphichat Trakooncharoenvit, Takayoshi Tagami, Masayuki Okuyama, Tohru Hira, Nobuo Sakairi & Atsuo Kimura. (2023) Formulation and evaluation of a novel megalomeric microemulsion from tamarind seed xyloglucan-megalosaccharides for improved high-dose quercetin delivery. Food Hydrocolloids 137, pages 108430.
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Merima Šahinović, Alharith Hassan, Katalin Kristó, Géza RegdonJr.Jr., Edina Vranić & Tamás Sovány. (2023) Quality by Design-Based Development of Solid Self-Emulsifying Drug Delivery System (SEDDS) as a Potential Carrier for Oral Delivery of Lysozyme. Pharmaceutics 15:3, pages 995.
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Gyubin Noh, Taekwang Keum, Vinit Raj, Jeonghwan Kim, Chhitij Thapa, Kanchan Shakhakarmi, Myung Joo Kang, Yoon Tae Goo, Young Wook Choi & Sangkil Lee. (2023) Assessment of hydrophobic-ion paired insulin incorporated SMEDDS for the treatment of diabetes mellitus. International Journal of Biological Macromolecules 225, pages 911-922.
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Richard Wibel, Patrick Knoll, Bao Le-Vinh, Gergely Kali & Andreas Bernkop-Schnürch. (2022) Synthesis and evaluation of sulfosuccinate-based surfactants as counterions for hydrophobic ion pairing. Acta Biomaterialia 144, pages 54-66.
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Soheil Haddadzadegan, Farid Dorkoosh & Andreas Bernkop-Schnürch. (2022) Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers. Advanced Drug Delivery Reviews 182, pages 114097.
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Gyubin Noh, Taekwang Keum, Santosh Bashyal, Jo-Eun Seo, Lamichhane Shrawani, Jeong Hwan Kim & Sangkil Lee. (2021) Recent progress in hydrophobic ion-pairing and lipid-based drug delivery systems for enhanced oral delivery of biopharmaceuticals. Journal of Pharmaceutical Investigation 52:1, pages 75-93.
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Julian David Friedl, Arne Matteo Jörgensen, Bao Le‐Vinh, Doris Elfriede Braun, Martina Tribus & Andreas Bernkop-Schnürch. (2021) Solidification of self-emulsifying drug delivery systems (SEDDS): Impact on storage stability of a therapeutic protein. Journal of Colloid and Interface Science 584, pages 684-697.
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Marwa Hasanein Asfour. (2020) Advanced trends in protein and peptide drug delivery: a special emphasis on aquasomes and microneedles techniques. Drug Delivery and Translational Research 11:1, pages 1-23.
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Alexander Gamboa, Nina Schüßler, Eduardo Soto-Bustamante, Patricio Romero-Hasler, Lorenz Meinel & Javier O. Morales. (2020) Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids. European Journal of Pharmaceutics and Biopharmaceutics 156, pages 203-218.
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Imran Nazir, Martina Ghezzi, Mulazim Hussain Asim, Thi Nhu Quynh Phan & Andreas Bernkop-Schnürch. (2020) Self-emulsifying drug delivery systems: About the fate of hydrophobic ion pairs on a phospholipid bilayer. Journal of Molecular Liquids 312, pages 113382.
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Marwa Hasanein Asfour, Ahmed Alaa Kassem, Abeer Salama & Sameh Hosam Abd El-Alim. (2020) Hydrophobic ion pair loaded self-emulsifying drug delivery system (SEDDS): A novel oral drug delivery approach of cromolyn sodium for management of bronchial asthma. International Journal of Pharmaceutics 585, pages 119494.
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Ruba Ismail, Thi Nhu Quynh Phan, Flavia Laffleur, Ildikó Csóka & Andreas Bernkop-Schnürch. (2020) Hydrophobic ion pairing of a GLP-1 analogue for incorporating into lipid nanocarriers designed for oral delivery. European Journal of Pharmaceutics and Biopharmaceutics 152, pages 10-17.
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Nermin E. Eleraky, Nitin K. Swarnakar, Dina F. Mohamed, Mohamed A. Attia & Giovanni M. Pauletti. (2020) Permeation-Enhancing Nanoparticle Formulation to Enable Oral Absorption of Enoxaparin. AAPS PharmSciTech 21:3.
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Mansi Shah & Anuj G. Agrawal. 2020. Colloid Science in Pharmaceutical Nanotechnology. Colloid Science in Pharmaceutical Nanotechnology.
Abu Hajleh Maha & Al-Dujaili Emad A.S. (2020) HYDROPHOBIC ION-PAIRED DRUG DELIVERY SYSTEM: A REVIEW. INDIAN DRUGS 57:01, pages 7-18.
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Imran Nazir, Iram Shahzadi, Aamir Jalil & Andreas Bernkop-Schnürch. (2020) Hydrophobic H-bond pairing: A novel approach to improve membrane permeability. International Journal of Pharmaceutics 573, pages 118863.
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D.J. Brayden, T.A. Hill, D.P. Fairlie, S. Maher & R.J. Mrsny. (2020) Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches. Advanced Drug Delivery Reviews 157, pages 2-36.
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Thi Nhu Quynh Phan, Iram Shahzadi & Andreas Bernkop-Schnürch. (2019) Hydrophobic ion-pairs and lipid-based nanocarrier systems: The perfect match for delivery of BCS class 3 drugs. Journal of Controlled Release 304, pages 146-155.
Crossref
Imran Nazir, Mulazim Hussain Asim, Aida Dizdarević & Andreas Bernkop-Schnürch. (2019) Self-emulsifying drug delivery systems: Impact of stability of hydrophobic ion pairs on drug release. International Journal of Pharmaceutics 561, pages 197-205.
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