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Review Articles

Biological characteristics of exosomes and genetically engineered exosomes for the targeted delivery of therapeutic agents

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Pages 129-141 | Received 25 Mar 2019, Accepted 05 Jul 2019, Published online: 12 Aug 2019

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Xin Zhao, Pingyuan Ge, Shaohua Lei, Siqi Guo, Peng Zhou, Li Zhao, Yiyu Qi, Xiaotong Wei, Weizhen Wu, Ningjing Wang, Rui Guo, Nianyun Yang, Qingqing Xiao, Qichun Zhang & Huaxu Zhu. (2023) An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer’s Disease with Berberine and Palmatine. Drug Design, Development and Therapy 17, pages 2401-2420.
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Rimsha Bhatta, Joonsu Han, Yusheng Liu, Yang Bo, David Lee, Jiadiao Zhou, Yueji Wang, Erik Russell Nelson, Qian Chen, Xiaojia Shelly Zhang, Wael Hassaneen & Hua Wang. (2023) Metabolic tagging of extracellular vesicles and development of enhanced extracellular vesicle based cancer vaccines. Nature Communications 14:1.
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Xiaorong Yin, Lizhi Lin, Fang Fang, Bin Zhang & Cheng Shen. (2023) Mechanisms and Optimization Strategies of Paracrine Exosomes from Mesenchymal Stem Cells in Ischemic Heart Disease. Stem Cells International 2023, pages 1-20.
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Mu Zhang, Lei Wan, Ruiqi Li, Xiaoling Li, Taifu Zhu & Haibin Lu. (2023) Engineered exosomes for tissue regeneration: from biouptake, functionalization and biosafety to applications. Biomaterials Science 11:22, pages 7247-7267.
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Chunman Huang, Liwei Li, Yongbin Huang, Jingqun Pang & Guanghua Chen. (2023) Advances in targeted modification of extracellular vesicles. Chinese Science Bulletin 68:33, pages 4532-4543.
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Qingpeng Xie, Yujia Hao, Na Li, Haoyue Song, Xiaohang Chen, Zilan Zhou, Jia Wang, Yuan Zhang, Huifei Li, Pengcheng Han & Xing Wang. (2023) Cellular Uptake of Engineered Extracellular Vesicles: Biomechanisms, Engineered Strategies, and Disease Treatment. Advanced Healthcare Materials.
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Siqi Xia, Chaoran Xu, Fuyi Liu & Gao Chen. (2023) Development of microRNA-based therapeutics for central nervous system diseases. European Journal of Pharmacology 956, pages 175956.
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Xianghui Zou, Qian Lei, Xinghong Luo, Jingyao Yin, Shuoling chen, Chunbo Hao, Liu Shiyu & Dandan Ma. (2023) Advances in biological functions and applications of apoptotic vesicles. Cell Communication and Signaling 21:1.
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Xingru Peng, Tingting Zhang, Rui Liu & Xin Jin. (2023) Potential in exosome-based targeted nano-drugs and delivery vehicles for posterior ocular disease treatment: from barriers to therapeutic application. Molecular and Cellular Biochemistry.
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Qingying Si, Linlin Wu, Deshui Pang & Pei Jiang. (2023) Exosomes in brain diseases: Pathogenesis and therapeutic targets. MedComm 4:3.
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Madhu Rani, Rashmi Kumari, Shashi Prakash Singh, Annu Devi, Preeti Bansal, Aisha Siddiqi, Mohammed A. Alsahli, Saleh A. Almatroodi, Arshad Husain Rahmani & M. Moshahid Alam Rizvi. (2023) MicroRNAs as master regulators of FOXO transcription factors in cancer management. Life Sciences 321, pages 121535.
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Snigdha Samarpita & Xiaogang Li. (2023) Leveraging Exosomes as the Next-Generation Bio-Shuttles: The Next Biggest Approach against Th17 Cell Catastrophe. International Journal of Molecular Sciences 24:8, pages 7647.
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Vivek P. Chavda, Anjali Pandya, Lalit Kumar, Nidhi Raval, Lalitkumar K. Vora, Sreeranjini Pulakkat, Vandana Patravale, Salwa, Yanhong Duo & Ben Zhong Tang. (2023) Exosome nanovesicles: A potential carrier for therapeutic delivery. Nano Today 49, pages 101771.
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Alireza Joorabloo & Tianqing Liu. (2023) Engineering exosome-based biomimetic nanovehicles for wound healing. Journal of Controlled Release 356, pages 463-480.
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Xin-Xin Li, Lu-Xuan Yang, Chuang Wang, Hui Li, De-Shun Shi & Jian Wang. (2023) The Roles of Exosomal Proteins: Classification, Function, and Applications. International Journal of Molecular Sciences 24:4, pages 3061.
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Fatemeh Khazaei, Leila Rezakhani, Morteza Alizadeh, Elahe Mahdavian & Mozafar Khazaei. (2023) Exosomes and exosome-loaded scaffolds: Characterization and application in modern regenerative medicine. Tissue and Cell 80, pages 102007.
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Hasti Tashak Golroudbari, Seyedeh Parnian Banikarimi, Aryan Ayati, Alireza Hadizadeh, Zahra Khorasani Zavareh, Kiana Hajikhani, Asieh Heirani-Tabasi, Mohsen Ahmadi Tafti, Saeed Davoodi & Hossein Ahmadi Tafti. (2023) Advanced micro-/nanotechnologies for exosome encapsulation and targeting in regenerative medicine. Clinical and Experimental Medicine.
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Man Yao, Shufang Liang & Binbin Cheng. (2023) Role of exosomes in hepatocellular carcinoma and the regulation of traditional Chinese medicine. Frontiers in Pharmacology 14.
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Christopher R. Pitzer, Hector G. Paez & Stephen E. Alway. (2023) The Contribution of Tumor Derived Exosomes to Cancer Cachexia. Cells 12:2, pages 292.
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Yan Lin, Mengchao Yan, Zhongtian Bai, Ye Xie, Longfei Ren, Jiayun Wei, Dan Zhu, Haiping Wang, Yonggang Liu, Junqian Luo & Xun Li. (2022) Huc-MSC-derived exosomes modified with the targeting peptide of aHSCs for liver fibrosis therapy. Journal of Nanobiotechnology 20:1.
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Ziang Yang, Bei Xu, Sheng Wu, Weige Yang, Rongkui Luo, Shengkai Geng, Zhaochen Xin, Wen Jin, Xiong Shen, Xixi Gu, Hongwei Zhang & Hong Wang. (2022) Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling. Human Cell 35:6, pages 1797-1812.
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Chase Cornelison & Sherly Fadel. (2022) Clickable Biomaterials for Modulating Neuroinflammation. International Journal of Molecular Sciences 23:15, pages 8496.
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Chen‐Chen Zhao, Hui‐Zhong Lv, Su‐Wan Tao, Tong‐Cun Zhang, Na Xu & Lian Zhu. (2021) Exosomes: Promising nanocarrier for cancer therapy. Nano Select 3:5, pages 919-929.
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Gecioni Loch-Neckel, Ana Teresa Matos, Ana Rita Vaz & Dora Brites. (2022) Challenges in the Development of Drug Delivery Systems Based on Small Extracellular Vesicles for Therapy of Brain Diseases. Frontiers in Pharmacology 13.
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Dimitrios Goutas, Alexandros Pergaris, Nikolaos Goutas & Stamatios Theocharis. (2022) Utilizing Exosomal-EPHs/Ephrins as Biomarkers and as a Potential Platform for Targeted Delivery of Therapeutic Exosomes. International Journal of Molecular Sciences 23:7, pages 3551.
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Yiling Guo, Yujia Zhai, Longyuan Wu, Yazhuo Wang, Puzhen Wu & Lixia Xiong. (2022) Mesenchymal Stem Cell-Derived Extracellular Vesicles: Pleiotropic Impacts on Breast Cancer Occurrence, Development, and Therapy. International Journal of Molecular Sciences 23:6, pages 2927.
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Tao Feng, Johannes Karges, Xinxing Liao, Liangnian Ji & Hui Chao. (2022) Engineered exosomes as a natural nanoplatform for cancer targeted delivery of metal-based drugs. Coordination Chemistry Reviews 454, pages 214325.
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Rui Miguel Marques Bernardino, Ricardo Leão, Rui Henrique, Luis Campos Pinheiro, Prashant Kumar, Prashanth Suravajhala, Hans Christian Beck, Ana Sofia Carvalho & Rune Matthiesen. (2021) Extracellular Vesicle Proteome in Prostate Cancer: A Comparative Analysis of Mass Spectrometry Studies. International Journal of Molecular Sciences 22:24, pages 13605.
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Anastasiya Oshchepkova, Oleg Markov, Evgeniy Evtushenko, Alexander Chernonosov, Elena Kiseleva, Ksenia Morozova, Vera Matveeva, Lyudmila Artemyeva, Valentin Vlassov & Marina Zenkova. (2021) Tropism of Extracellular Vesicles and Cell-Derived Nanovesicles to Normal and Cancer Cells: New Perspectives in Tumor-Targeted Nucleic Acid Delivery. Pharmaceutics 13:11, pages 1911.
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Ekene Anakor, Laura Le Gall, Julie Dumonceaux, William John Duddy & Stephanie Duguez. (2021) Exosomes in Ageing and Motor Neurone Disease: Biogenesis, Uptake Mechanisms, Modifications in Disease and Uses in the Development of Biomarkers and Therapeutics. Cells 10:11, pages 2930.
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Shilpa Lekhraj Peswani Sajnani, Yunyue Zhang & Driton Vllasaliu. (2021) Exosome-based therapies for mucosal delivery. International Journal of Pharmaceutics 608, pages 121087.
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Nimeet Desai, Anuradha Gadeval, Umesh Kathar, Pinaki Sengupta, Kiran Kalia & Rakesh Kumar Tekade. (2021) Emerging roles and biopharmaceutical applications of milk derived exosomes. Journal of Drug Delivery Science and Technology 64, pages 102577.
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Zixuan Sun, Jiaxin Zhang, Jiali Li, Mi Li, Jing Ge, Peipei Wu, Benshuai You & Hui Qian. (2021) Roles of Mesenchymal Stem Cell-Derived Exosomes in Cancer Development and Targeted Therapy. Stem Cells International 2021, pages 1-10.
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Jing Miao, Xiqin Yang, Xuwei Shang, Zhe Gao, Qian Li, Yun Hong, Jiaying Wu, Tingting Meng, Hong Yuan & Fuqiang Hu. (2021) Hepatocyte-targeting and microenvironmentally responsive glycolipid-like polymer micelles for gene therapy of hepatitis B. Molecular Therapy - Nucleic Acids 24, pages 127-139.
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Lefki‐Pavlina N. Giassafaki, Scheyla Siqueira, Emmanuel Panteris, Konstantina Psatha, Fani Chatzopoulou, Michalis Aivaliotis, Georgios Tzimagiorgis, Anette Müllertz, Dimitrios G. Fatouros & Ioannis S. Vizirianakis. (2020) Towards analyzing the potential of exosomes to deliver microRNA therapeutics. Journal of Cellular Physiology 236:2, pages 1529-1544.
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Vincent Q. Sier, Margreet R. de Vries, Joost R. van der Vorst, Alexander L. Vahrmeijer, Cornelis van Kooten, Luis J. Cruz, Lioe-Fee de Geus-Oei, Valerie Ferreira, Cornelis F. M. Sier, Frauke Alves & Munitta Muthana. (2021) Cell-Based Tracers as Trojan Horses for Image-Guided Surgery. International Journal of Molecular Sciences 22:2, pages 755.
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Mohammed Moulay & Saleh Al-Kareem. 2021. Role of Exosomes in Biological Communication Systems. Role of Exosomes in Biological Communication Systems 311 319 .
Tomasz Lorenc, Katarzyna Klimczyk, Izabela Michalczewska, Monika Słomka, Grażyna Kubiak-Tomaszewska & Wioletta Olejarz. (2020) Exosomes in Prostate Cancer Diagnosis, Prognosis and Therapy. International Journal of Molecular Sciences 21:6, pages 2118.
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