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Review Articles

Serpina3n: Potential drug and challenges, mini review

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Pages 368-378 | Received 14 Aug 2019, Accepted 11 Nov 2019, Published online: 02 Dec 2019

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Articles from other publishers (31)

Bo Cao, Jing‐Wang Gao, Qing‐Peng Zhang, Xing‐Ming Xu, Rui‐Yang Zhao, Hang‐Hang Li & Bo Wei. (2023) Melatonin supplementation protects against traumatic colon injury by regulating SERPINA3N protein expression. iMeta 2:4.
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Xueyao Cai, Ruijin Yang, Wenjun Shi, Yuchen Cai & Zhengzheng Ma. (2023) Exploration of the common pathogenic link between COVID‐19 and diabetic foot ulcers: An in silico approach. Health Science Reports 6:11.
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Chong Liu, Xue-Min Zhao, Qiao Wang, Ting-Ting Du, Mo-Xuan Zhang, Hui-Zhi Wang, Ren-Peng Li, Kun Liang, Yuan Gao, Si-Yu Zhou, Tao Xue, Jian-Guo Zhang, Chun-Lei Han, Lin Shi, Liang-Wen Zhang & Fan-Gang Meng. (2023) Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy. Journal of Neuroinflammation 20:1.
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Suzuro Hitomi, Tomotaka Nodai, Shoichiro Kokabu, Takemi Shikayama, Misa Sago-Ito, Chihiro Nakatomi, Kiyoshi Terawaki, Yuji Omiya, Masamichi Shinoda & Kentaro Ono. (2023) Hepcidin expression in the trigeminal ganglion and the oral mucosa in an oral ulcerative mucositis rat model. PLOS ONE 18:4, pages e0284617.
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Chary Lopez-Pedrera, Rafael Oteros, Alejandro Ibáñez-Costa, María Luque-Tévar, Laura Muñoz-Barrera, Nuria Barbarroja, Eduardo Chicano-Gálvez, Juan Marta-Enguita, Josune Orbe, Francisco Velasco & Carlos Perez-Sanchez. (2023) The thrombus proteome in stroke reveals a key role of the innate immune system and new insights associated with its etiology, severity, and prognosis. Journal of Thrombosis and Haemostasis.
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Fengshi Li, Yueman Zhang, Ruqi Li, Yan Li, Shenghao Ding, Jianpo Zhou, Tianchen Huang, Chen Chen, Bingwei Lu, Weifeng Yu, Johannes Boltze, Peiying Li & Jieqing Wan. (2022) Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke. Journal of Cerebral Blood Flow & Metabolism 43:2, pages 241-257.
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Pan Zhang, Quan Li, Yuni Zhang, Qianqian Wang, Junfang Yan, Aihua Shen & Burong Hu. (2023) Identification of a Novel Gene Signature with DDR and EMT Difunctionalities for Predicting Prognosis, Immune Activity, and Drug Response in Breast Cancer. International Journal of Environmental Research and Public Health 20:2, pages 1221.
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Mateusz de Mezer, Jan Rogaliński, Stanisław Przewoźny, Michał Chojnicki, Leszek Niepolski, Magdalena Sobieska & Agnieszka Przystańska. (2023) SERPINA3: Stimulator or Inhibitor of Pathological Changes. Biomedicines 11:1, pages 156.
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Jinyue Zhao, Chao Feng, Wenwen Wang, Libo Su & Jianwei Jiao. (2022) Human SERPINA3 induces neocortical folding and improves cognitive ability in mice. Cell Discovery 8:1.
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Katlyn C. Richardson, Karen Jung, Julian Pardo, Christopher T. Turner & David J. Granville. (2022) Noncytotoxic Roles of Granzymes in Health and Disease. Physiology 37:6, pages 323-348.
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Xudong Ma, Xiaorong Niu, Junjie Zhao, Zhong Deng, Jiaxi Li, Xiang Wu, Bo Wang, Ming Zhang, Yonglin Zhao, Xiaoye Guo, Peng Sun, Tingqin Huang, Jia Wang & Jinning Song. (2022) Downregulation of Sepina3n Aggravated Blood–Brain Barrier Disruption after Traumatic Brain Injury by Activating Neutrophil Elastase in Mice. Neuroscience 503, pages 45-57.
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Yarlagadda Anusha-Kiran, Praseeda Mol, Gourav Dey, Firdous Ahmad Bhat, Oishi Chatterjee, Sayali Chandrashekhar Deolankar, Mariamma Philip, T.S. Keshava Prasad, M.M. Srinivas Bharath & Anita Mahadevan. (2022) Regional heterogeneity in mitochondrial function underlies region specific vulnerability in human brain ageing: Implications for neurodegeneration. Free Radical Biology and Medicine 193, pages 34-57.
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Qian Zhang, Qian Wang & Li-Xia Zhang. (2022) Granzyme B: A novel therapeutic target for treatment of atopic dermatitis. Indian Journal of Dermatology, Venereology and Leprology 89, pages 166-169.
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Zhendong Liu, Ruizhou Liu, Rui Wang, Jihang Dai, Hui Chen, Jingcheng Wang & Xiaolei Li. (2022) Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3. Food & Function 13:19, pages 9973-9987.
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Eden Dubchak, Gideon Obasanmi, Matthew R. Zeglinski, David J. Granville, Sonia N. Yeung & Joanne A. Matsubara. (2022) Potential role of extracellular granzyme B in wet age-related macular degeneration and fuchs endothelial corneal dystrophy. Frontiers in Pharmacology 13.
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Pilar González-García, María Elena Díaz-Casado, Agustín Hidalgo-Gutiérrez, Laura Jiménez-Sánchez, Mohammed Bakkali, Eliana Barriocanal-Casado, Germaine Escames, Riccardo Zenezini Chiozzi, Franziska Völlmy, Esther A. Zaal, Celia R. Berkers, Albert J.R. Heck & Luis C. López. (2022) The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency. Redox Biology 55, pages 102403.
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Anjana Soman & S. Asha Nair. (2022) Unfolding the cascade of SERPINA3: Inflammation to cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1877:5, pages 188760.
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Karen Jung, Megan A. Pawluk, Michael Lane, Layla Nabai & David J. Granville. (2022) Granzyme B in epithelial barrier dysfunction and related skin diseases. American Journal of Physiology-Cell Physiology 323:1, pages C170-C189.
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Marco Zattoni, Marika Mearelli, Silvia Vanni, Arianna Colini Baldeschi, Thanh Hoa Tran, Chiara Ferracin, Marcella Catania, Fabio Moda, Giuseppe Di Fede, Giorgio Giaccone, Fabrizio Tagliavini, Gianluigi Zanusso, James W. Ironside, Isidre Ferrer & Giuseppe Legname. (2022) Serpin Signatures in Prion and Alzheimer’s Diseases. Molecular Neurobiology 59:6, pages 3778-3799.
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Mehwish Saba Aslam, Mobeena Saba Aslam, Komal Saba Aslam, Asia Iqbal & Liudi Yuan. (2022) Therapeutical Significance of Serpina3n Subsequent Cerebral Ischemia via Cytotoxic Granzyme B Inactivation. BioMed Research International 2022, pages 1-13.
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Yuna Choi & Taekyun Shin. (2022) Alendronate Enhances Functional Recovery after Spinal Cord Injury. Experimental Neurobiology 31:1, pages 54-64.
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Priyanka Thakur, Ryne DeBo, Gregory O. Dugan, J. Daniel Bourland, Kris T. Michalson, John D. Olson, Thomas C. Register, Nancy D. Kock & J. Mark Cline. (2021) Clinicopathologic and Transcriptomic Analysis of Radiation-Induced Lung Injury in Nonhuman Primates. International Journal of Radiation Oncology*Biology*Physics 111:1, pages 249-259.
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Yuna Choi, Kyungsook Jung, Hyo Jin Kim, Jiyoon Chun, Meejung Ahn, Youngheun Jee, Hyun Ju Ko, Changjong Moon, Hiroshi Matsuda, Akane Tanaka, Jeongtae Kim & Taekyun Shin. (2021) Attenuation of Experimental Autoimmune Uveitis in Lewis Rats by Betaine. Experimental Neurobiology 30:4, pages 308-317.
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Margarida Ferreira, Stephany Francisco, Ana R. Soares, Ana Nobre, Miguel Pinheiro, Andreia Reis, Sonya Neto, Ana João Rodrigues, Nuno Sousa, Gabriela Moura & Manuel A. S. Santos. (2021) Integration of segmented regression analysis with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues. Aging 13:14, pages 18150-18190.
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Hai-Tao Zhang, Ping Wang, Yuan Li & Yong-Bo Bao. (2021) SerpinA3n affects ovalbumin (OVA)-induced asthma in neonatal mice via the regulation of collagen deposition and inflammatory response. Respiratory Physiology & Neurobiology 288, pages 103642.
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Melanie Tran, Jianguo Wu, Li Wang & Dong-Ju Shin. (2021) A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity. Molecular Pharmacology 99:4, pages 277-285.
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Nicolás Fissolo, Clara Matute-Blanch, Mohamoud OsmanCarme Costa, Rucsanda PinteacBerta Miró, Alex SanchezVerónica Brito, Irena Dujmovic, Margarete Voortman, Michael Khalil, Eva BorràsEduard Sabidó, Shohreh Issazadeh-Navikas, Xavier Montalban & Manuel Comabella Lopez. (2021) CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS. Neurology Neuroimmunology & Neuroinflammation 8:2.
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Ling-lin Qian, Jing-jing Ji, Jia-qi Guo, Yan-ping Wu, Gen-shan Ma & Yu-yu Yao. (2021) Protective role of serpina3c as a novel thrombin inhibitor against atherosclerosis in mice. Clinical Science 135:3, pages 447-463.
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Tahsin F. Kellici, Ewa S. Pilka & Michael J. Bodkin. (2021) Small-molecule modulators of serine protease inhibitor proteins (serpins). Drug Discovery Today 26:2, pages 442-454.
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Francesca Velotti, Ilaria Barchetta, Flavia Agata Cimini & Maria Gisella Cavallo. (2020) Granzyme B in Inflammatory Diseases: Apoptosis, Inflammation, Extracellular Matrix Remodeling, Epithelial-to-Mesenchymal Transition and Fibrosis. Frontiers in Immunology 11.
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Andrea Sanchez-Navarro, Isaac González-Soria, Rebecca Caldiño-Bohn & Norma A. Bobadilla. (2020) Integrative view of serpins in health and disease: the contribution of serpinA3. American Journal of Physiology-Cell Physiology.
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