Advanced search
Publication Cover
Endothelium
Journal of Endothelial Cell Research
Volume 13, 2006 - Issue 4
Journal homepage
41
Views
38
CrossRef citations to date
0
Altmetric
Regular Articles

Inhibition of Endothelial Cell Proliferation, In Vitro Angiogenesis, and the Down-Regulation of Cell Adhesion–Related Genes by Genistein Combined with a cDNA Microarray Analysis

Meihua Piao Department of Pathology and Biodefense, Faculty of Medicine, Saga University, Japan
,
Daisuke Mori Department of Pathology and Biodefense, Faculty of Medicine, Saga University, Japan
,
Tosimi Satoh Department of Pathology and Biodefense, Faculty of Medicine, Saga University, Japan
,
Yasuo Sugita Department of Pathology and Biodefense, Faculty of Medicine, Saga University, Japan
&
Osamu Tokunaga Department of Pathology and Biodefense, Faculty of Medicine, Saga University, Japan
Pages 249-266 | Received 18 Aug 2005, Accepted 06 Jul 2006, Published online: 13 Jul 2009

Citations (38)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Peramaiyan Rajendran, Thamaraiselvan Rengarajan, Natarajan Nandakumar, H. Divya & Ikuo Nishigaki. (2015) Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets. Journal of Receptors and Signal Transduction 35:1, pages 76-84.
Read now
M Wasif Saif, Ewan Tytler, Frederick Lansigan, David M Brown & Alan J Husband. (2009) Flavonoids, phenoxodiol, and a novel agent, triphendiol, for the treatment of pancreaticobiliary cancers. Expert Opinion on Investigational Drugs 18:4, pages 469-479.
Read now
Evelyne Reiter, Evelyne Reiter, Verena Beck, Svjetlana Medjakovic & Alois Jungbauer. (2009) Isoflavones are safe compounds for therapeutical applications – Evaluation of in vitro data. Gynecological Endocrinology 25:9, pages 554-580.
Read now

Articles from other publishers (35)

Mohd Mursal, Arun Kumar, Syed Misbahul Hasan, Sahil Hussain, Kuldeep Singh, Shom Prakash Kushwaha, Muhammad Arif, Rajeev Kumar Singh, Deepshikha Singh, Ali Mohammad & Syed Kaynat Fatima. (2023) Role of natural bioactive compounds in the management of neurodegenerative disorders. Intelligent Pharmacy.
Crossref
Afshin Babazadeh, Fereshteh Mohammadi Vahed, Qi Liu, Shahida Anusha Siddiqui, Mohammad Saeed Kharazmi & Seid Mahdi Jafari. (2023) Natural Bioactive Molecules as Neuromedicines for the Treatment/Prevention of Neurodegenerative Diseases. ACS Omega 8:4, pages 3667-3683.
Crossref
Kajetan Kiełbowski, Estera Bakinowska & Andrzej Pawlik. (2023) The Potential Role of Connexins in the Pathogenesis of Atherosclerosis. International Journal of Molecular Sciences 24:3, pages 2600.
Crossref
Sergio Izcara, Rosa Perestrelo, Sonia Morante-Zarcero, José S. Câmara & Isabel Sierra. (2022) High throughput analytical approach based on μQuEChERS combined with UHPLC-PDA for analysis of bioactive secondary metabolites in edible flowers. Food Chemistry 393, pages 133371.
Crossref
Mona Luciana Gălăţanu, Mariana Panţuroiu & Roxana Colette Sandulovici. 2022. Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics. Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics 297 318 .
Matúš Čoma, Veronika Lachová, Petra Mitrengová & Peter Gál. (2021) Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review. Current Issues in Molecular Biology 43:1, pages 127-141.
Crossref
Vidya Mukund. (2020) Genistein: Its Role in Breast Cancer Growth and Metastasis. Current Drug Metabolism 21:1, pages 6-10.
Crossref
Joselin Aguiar, João L. Gonçalves, Vera L. Alves & José S. Câmara. (2020) Chemical Fingerprint of Free Polyphenols and Antioxidant Activity in Dietary Fruits and Vegetables Using a Non-Targeted Approach Based on QuEChERS Ultrasound-Assisted Extraction Combined with UHPLC-PDA. Antioxidants 9:4, pages 305.
Crossref
Saumya Srivastava & Anjana Pandey. 2019. Current Aspects of Flavonoids: Their Role in Cancer Treatment. Current Aspects of Flavonoids: Their Role in Cancer Treatment 149 158 .
Christiana Eleojo Aruwa, Stephen O. Amoo & Tukayi Kudanga. (2018) Opuntia (Cactaceae) plant compounds, biological activities and prospects – A comprehensive review. Food Research International 112, pages 328-344.
Crossref
Caterina Faggio, Antoni Sureda, Silvia Morabito, Ana Sanches-Silva, Andrei Mocan, Seyed Fazel Nabavi & Seyed Mohammad Nabavi. (2017) Flavonoids and platelet aggregation: A brief review. European Journal of Pharmacology 807, pages 91-101.
Crossref
Rakesh Pandeet Nankar, Maya Raman & Mukesh Doble. 2016. Emulsions. Emulsions 107 151 .
Ye-Seul Kim, Kyung-Chul Choi & Kyung-A Hwang. (2015) Genistein suppressed epithelial–mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by estrogenic chemicals via estrogen receptor pathway and downregulation of TGF-β signaling pathway. Phytomedicine 22:11, pages 993-999.
Crossref
Young Ran Ha, Yang-Jun Kang & Sang Joon Lee. (2015) In vivo study on splenomegaly inhibition by genistein in Plasmodium berghei -infected mice. Parasitology International 64:5, pages 369-376.
Crossref
Lenka Varinska, Peter Gal, Gabriela Mojzisova, Ladislav Mirossay & Jan Mojzis. (2015) Soy and Breast Cancer: Focus on Angiogenesis. International Journal of Molecular Sciences 16:12, pages 11728-11749.
Crossref
Zakia Benayad, Cristina Martinez-Villaluenga, Juana Frias, Carmen Gomez-Cordoves & Nour Eddine Es-Safi. (2014) Phenolic composition, antioxidant and anti-inflammatory activities of extracts from Moroccan Opuntia ficus-indica flowers obtained by different extraction methods. Industrial Crops and Products 62, pages 412-420.
Crossref
Ana C. Moreira, Ana M. Silva, Maria S. Santos & Vilma A. Sardão. (2014) Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown. The Journal of Steroid Biochemistry and Molecular Biology 143, pages 61-71.
Crossref
Miyuki Fukai, Toshihiro Suzuki, Ikuko Nagasawa, Kaoru Kinoshita, Kunio Takahashi & Kiyotaka Koyama. (2014) Antiangiogenic Activity of Hypoxylonol C. Journal of Natural Products 77:4, pages 1065-1068.
Crossref
Divyashree Ravishankar, Amit Kumar Rajora, Francesca Greco & Helen. M.I. Osborn. (2013) Flavonoids as prospective compounds for anti-cancer therapy. The International Journal of Biochemistry & Cell Biology 45:12, pages 2821-2831.
Crossref
Jerry T. Thornthwaite, Hare R. Shah, Pasupati Shah, William C. Peeples & Henry Respess. (2013) The formulation for cancer prevention & therapy. Advances in Biological Chemistry 03:03, pages 356-387.
Crossref
Umit A. Kayisli, Ozlem Guzeloglu-Kayisli, Elif Guzel & Aydin Arici. (2013) Genistein Inhibits Cell Proliferation and Stimulates Apoptosis in Human Coronary Artery Endothelial Cells. Gynecologic and Obstetric Investigation 75:4, pages 235-242.
Crossref
Fei Liu, Jian-Guo Cao, Cheng Li, Jin-Seng Tan & Xiao-Hua Fu. (2011) Protective effects of 7-difluoromethyl-5,4′-dimethoxygenistein against human aorta endothelial injury caused by lysophosphatidyl choline. Molecular and Cellular Biochemistry 363:1-2, pages 147-155.
Crossref
David Vauzour, Katerina Vafeiadou & Jeremy P. E. Spencer. 2012. Phytonutrients. Phytonutrients 110 145 .
Xudong DiDanica M.K. AndrewsCharles J. TuckerLinda YuAlicia B. MooreXiaolin ZhengLysandra CastroTonia HermonHang XiaoDarlene Dixon. (2012) A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. Experimental & Molecular Medicine 44:4, pages 281.
Crossref
Jie Yu, Juanjuan Wu, Indrani C. Bagchi, Milan K. Bagchi, Neil Sidell & Robert N. Taylor. (2011) Disruption of gap junctions reduces biomarkers of decidualization and angiogenesis and increases inflammatory mediators in human endometrial stromal cell cultures. Molecular and Cellular Endocrinology 344:1-2, pages 25-34.
Crossref
G. Basini, S. Bussolati, S. E. Santini & F. Grasselli. (2010) The impact of the phyto-oestrogen genistein on swine granulosa cell function. Journal of Animal Physiology and Animal Nutrition 94:6, pages e374-e382.
Crossref
David Vauzour, Ana Rodriguez-Mateos, Giulia Corona, Maria Jose Oruna-Concha & Jeremy P. E. Spencer. (2010) Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action. Nutrients 2:11, pages 1106-1131.
Crossref
Adriana Albini, Stefano Indraccolo, Douglas M. Noonan & Ulrich Pfeffer. (2010) Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs. Clinical & Experimental Metastasis 27:6, pages 419-439.
Crossref
Marisa J. Sandoval, Pablo H. Cutini, María Belén Rauschemberger & Virginia L. Massheimer. (2010) The soyabean isoflavone genistein modulates endothelial cell behaviour. British Journal of Nutrition 104:2, pages 171-179.
Crossref
Matthias W. Laschke, Christine Schwender, Brigitte Vollmar & Michael D. Menger. (2010) Genistein Does Not Affect Vascularization and Blood Perfusion of Endometriotic Lesions and Ovarian Follicles in Dorsal Skinfold Chambers of Syrian Golden Hamsters. Reproductive Sciences 17:6, pages 568-577.
Crossref
Priya Prahalad, Sivanesan Dakshanamurthy, Habtom Ressom & Stephen W. Byers. (2010) Retinoic Acid Mediates Regulation of Network Formation by COUP-TFII and VE-Cadherin Expression by TGF? Receptor Kinase in Breast Cancer Cells. PLoS ONE 5:4, pages e10023.
Crossref
Rihong Cong, Qingmin Sun, Li Yang, Haijuan Gu, Ying Zeng & Bin Wang. (2009) Effect of Genistein on vasculogenic mimicry formation by human uveal melanoma cells. Journal of Experimental & Clinical Cancer Research 28:1.
Crossref
Ivan P. Gorlov, Gary E. Gallick, Olga Y. Gorlova, Christopher Amos & Christopher J. Logothetis. (2009) GWAS Meets Microarray: Are the Results of Genome-Wide Association Studies and Gene-Expression Profiling Consistent? Prostate Cancer as an Example. PLoS ONE 4:8, pages e6511.
Crossref
Li Hou, Daisuke Mori, Yukari Takase, Piao Meihua, Keita Kai & Osamu Tokunaga. (2009) Fumagillin inhibits colorectal cancer growth and metastasis in mice: In vivo and in vitro study of anti-angiogenesis . Pathology International 59:7, pages 448-461.
Crossref
Li Wang, Xing Zheng, Hong-lin Xiang, Xiao-hua Fu & Jian-guo Cao. (2009) 7-Difluoromethyl-5,4′-dimethoxygenistein inhibits oxidative stress induced adhesion between endothelial cells and monocytes via NF-κB. European Journal of Pharmacology 605:1-3, pages 31-35.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.