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Original Articles

Physiologically based pharmacokinetic (PBPK) tool kit for environmental pollutants – metals

, , , &
Pages 603-618 | Received 16 Jun 2010, Accepted 25 Sep 2010, Published online: 29 Nov 2010

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P. Ruiz, L. L. Aylward & M. Mumtaz. (2014) Application of pharmacokinetic modelling for 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure assessment. SAR and QSAR in Environmental Research 25:11, pages 873-890.
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M. Moiz Mumtaz, Meredith Ray, Susan R. Crowell, Deborah Keys, Jeffrey Fisher & Patricia Ruiz. (2012) Translational Research to Develop a Human PBPK Models Tool Kit—Volatile Organic Compounds (VOCs). Journal of Toxicology and Environmental Health, Part A 75:1, pages 6-24.
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Andrea N Edginton & Ghanashyam Joshi. (2011) Have physiologically-based pharmacokinetic models delivered?. Expert Opinion on Drug Metabolism & Toxicology 7:8, pages 929-934.
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Articles from other publishers (30)

Amanda S Bernstein, Bidya Prasad, Paul M Schlosser & Dustin F Kapraun. (2023) A model template approach for rapid evaluation and application of physiologically based pharmacokinetic models: extension to volatile organic compounds. Toxicological Sciences 192:2, pages 194-208.
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Soisungwan Satarug, David A. Vesey, Glenda C. Gobe & Kenneth R. Phelps. (2023) Estimation of health risks associated with dietary cadmium exposure. Archives of Toxicology 97:2, pages 329-358.
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Yuan-Shen Zhu, Jia-Qi Yang, Na Wang, Ze-Qun Deng, Ying Qing, Min Wu, Hua Cai, Hong Liu & Geng-Sheng He. (2022) Estimation of the bio-accessibility of methylmercury from aquatic foods using a PBTK model with an approximate Bayesian computation method in Chinese pregnant women. Food and Chemical Toxicology 168, pages 113372.
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Katherine von Stackelberg, Pamela R. D. Williams & Ernesto Sánchez-TrianaKatherine von Stackelberg, Pamela R. D. Williams & Ernesto Sánchez-Triana. 2022. Artisanal Small-Scale Gold Mining: A Framework for Collecting Site-Specific Sampling and Survey Data to Support Health-Impact Analyses. Artisanal Small-Scale Gold Mining: A Framework for Collecting Site-Specific Sampling and Survey Data to Support Health-Impact Analyses 53 109 .
Craig A. Poland, Noömi Lombaert, Carol Mackie, Alain Renard, Parikhit Sinha, Violaine Verougstraete & Nicky J.J. Lourens. (2021) Bioaccessibility as a determining factor in the bioavailability and toxicokinetics of cadmium compounds. Toxicology 463, pages 152969.
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Amanda S Bernstein, Dustin F Kapraun & Paul M Schlosser. (2021) A Model Template Approach for Rapid Evaluation and Application of Physiologically Based Pharmacokinetic Models for Use in Human Health Risk Assessments: A Case Study on Per- and Polyfluoroalkyl Substances. Toxicological Sciences 182:2, pages 215-228.
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Szu-Chieh Chen, Hsing-Chieh Lin & Wei-Yu Chen. (2020) Risks of consuming cadmium-contaminated shellfish under seawater acidification scenario: Estimates of PBPK and benchmark dose. Ecotoxicology and Environmental Safety 201, pages 110763.
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Patricia Ruiz, Claude Emond, Eva D McLanahan, Shivanjali Joshi-Barr & Moiz Mumtaz. (2020) Exploring Mechanistic Toxicity of Mixtures Using PBPK Modeling and Computational Systems Biology. Toxicological Sciences 174:1, pages 38-50.
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Abraham Madariaga-Mazón, Ricardo Bruno Hernández-Alvarado, Karla Olivia Noriega-Colima, Adriana Osnaya-Hernández & Karina Martinez-Mayorga. (2019) Toxicity of secondary metabolites. Physical Sciences Reviews 4:12.
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Dimosthenis A. Sarigiannis, Spyros Karakitsios, Elena Dominguez-Romero, Krystalia Papadaki, Celine Brochot, Vikas Kumar, Marta Schuhmacher, Moustapha Sy, Hans Mielke, Mathias Greiner, Marcel Mengelers & Martin Scheringer. (2019) Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative. Environmental Research 172, pages 216-230.
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Soisungwan Satarug. (2018) Dietary Cadmium Intake and Its Effects on Kidneys. Toxics 6:1, pages 15.
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Eric Dede, Marcus J. Tindall, John W. Cherrie, Steve Hankin & Chris Collins. (2018) Physiologically-based pharmacokinetic and toxicokinetic models for estimating human exposure to five toxic elements through oral ingestion. Environmental Toxicology and Pharmacology 57, pages 104-114.
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B.A. Fowler. 2018. Comprehensive Toxicology. Comprehensive Toxicology 127 135 .
Soisungwan Satarug, David A. Vesey & Glenda C. Gobe. (2017) Current health risk assessment practice for dietary cadmium: Data from different countries. Food and Chemical Toxicology 106, pages 430-445.
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Zhoumeng Lin, Majid Jaberi-Douraki, Chunla He, Shiqiang Jin, Raymond S. H. Yang, Jeffrey W. Fisher & Jim E. Riviere. (2017) Performance Assessment and Translation of Physiologically Based Pharmacokinetic Models From acslX to Berkeley Madonna, MATLAB, and R Language: Oxytetracycline and Gold Nanoparticles As Case Examples. Toxicological Sciences 158:1, pages 23-35.
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M. Mumtaz, P. Ruiz & Q. Zhang. 2017. Computational Systems Pharmacology and Toxicology. Computational Systems Pharmacology and Toxicology 191 208 .
Claude Emond, Patricia Ruiz & Moiz Mumtaz. (2017) Physiologically based pharmacokinetic toolkit to evaluate environmental exposures: Applications of the dioxin model to study real life exposures. Toxicology and Applied Pharmacology 315, pages 70-79.
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Bruce A. Fowler. 2016. Molecular Biological Markers for Toxicology and Risk Assessment. Molecular Biological Markers for Toxicology and Risk Assessment 101 108 .
Bruce A. Fowler. 2016. Molecular Biological Markers for Toxicology and Risk Assessment. Molecular Biological Markers for Toxicology and Risk Assessment 39 62 .
Bruce A. Fowler. 2016. Molecular Biological Markers for Toxicology and Risk Assessment. Molecular Biological Markers for Toxicology and Risk Assessment 1 16 .
Elaina M. Kenyon & Harvey J. ClewellIIIIII. 2015. Arsenic. Arsenic 495 509 .
Katherine von Stackelberg, Elizabeth Guzy, Tian Chu & Birgit Claus Henn. (2015) Exposure to Mixtures of Metals and Neurodevelopmental Outcomes: A Multidisciplinary Review Using an Adverse Outcome Pathway Framework. Risk Analysis 35:6, pages 971-1016.
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Bradley E Sample, Chris Schlekat, David J Spurgeon, Charlie Menzie, Jon Rauscher & Bill Adams. (2013) Recommendations to improve wildlife exposure estimation for development of soil screening and cleanup values. Integrated Environmental Assessment and Management 10:3, pages 372-387.
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Soisungwan Satarug, Witaya Swaddiwudhipong, Werawan Ruangyuttikarn, Muneko Nishijo & Patricia Ruiz. (2013) Modeling Cadmium Exposures in Low- and High-Exposure Areas in Thailand. Environmental Health Perspectives 121:5, pages 531-536.
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Pamela F. Heckel, Tim C. Keener & Grace K. LeMasters. (2013) Background Soil Mercury: An Unrecognized Source of Blood Mercury in Infants?. Open Journal of Soil Science 03:01, pages 23-29.
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Patricia Ruiz, Xiaoxia Yang, Annie Lumen & Jeff Fisher. 2013. Computational Toxicology. Computational Toxicology 5 21 .
Andrey I. Egorov, Dafina Dalbokova & Michal Krzyzanowski. 2013. Computational Toxicology. Computational Toxicology 275 293 .
Moiz Mumtaz, Jeffrey Fisher, Benjamin Blount & Patricia Ruiz. (2012) Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment. Journal of Toxicology 2012, pages 1-11.
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David J. Spurgeon, Alan Lawlor, Helen L. Hooper, Richard Wadsworth, Claus Svendsen, Laura D.K. Thomas, James K. Ellis, Jacob G. Bundy, Hector C. Keun & Lars Jarup. (2011) Outdoor and indoor cadmium distributions near an abandoned smelting works and their relations to human exposure. Environmental Pollution 159:12, pages 3425-3432.
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Patricia Ruiz, Meredith Ray, Jeffrey Fisher & Moiz Mumtaz. (2011) Development of a Human Physiologically Based Pharmacokinetic (PBPK) Toolkit for Environmental Pollutants. International Journal of Molecular Sciences 12:11, pages 7469-7480.
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