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Review

The NAD(P)H Oxidase Inhibitor Apocynin Improves Endothelial NO/Superoxide Balance and Lowers Effectively Blood Pressure in Spontaneously Hypertensive Rats: Comparison to Calcium Channel Blockade

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Pages 287-299 | Accepted 13 Oct 2006, Published online: 03 Jul 2009

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Yaru Ju, Yan Feng, Xiaolin Hou, Lixia Wu, Huixia Yang, Hongjuan Zhang & Yan’Na Ma. (2022) Combined apocyanin and aspirin treatment activates the PI3K/Nrf2/HO-1 signaling pathway and ameliorates preeclampsia symptoms in rats. Hypertension in Pregnancy 41:1, pages 39-50.
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You-Lin Tain, Chien-Ning Hsu, Li-Tung Huang & Ying-Tung Lau. (2012) Apocynin attenuates oxidative stress and hypertension in young spontaneously hypertensive rats independent of ADMA/NO pathway. Free Radical Research 46:1, pages 68-76.
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L. C. Oostwoud, P. Gunasinghe, H. J. Seow, J. M. Ye, S. Selemidis, S. Bozinovski & R. Vlahos. (2016) Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice. Scientific Reports 6:1.
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Sven WindKnut BeuerleinMelanie E. ArmitageAshraf TayeArun H.S. KumarDaniel JanowitzChristina NeffAjay M. ShahKirstin WinglerHarald H.H.W. Schmidt. (2010) Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition. Hypertension 56:3, pages 490-497.
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Stavros Selemidis, Christopher G. Sobey, Kirstin Wingler, Harald H.H.W. Schmidt & Grant R. Drummond. (2008) NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition. Pharmacology & Therapeutics 120:3, pages 254-291.
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Melissa Li, Xiaoling Dai, Stephanie Watts, David Kreulen & Gregory Fink. (2008) Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertension. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295:5, pages R1546-R1554.
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Shane R. ThomasPaul K. WittingGrant R. Drummond. (2008) Redox Control of Endothelial Function and Dysfunction: Molecular Mechanisms and Therapeutic Opportunities. Antioxidants & Redox Signaling 10:10, pages 1713-1766.
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T. Schluter, A. C. Steinbach, A. Steffen, R. Rettig & O. Grisk. (2008) Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition. Cardiovascular Research 80:2, pages 271-279.
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