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Original

Cilnidipine Inhibits the Sympathetic Nerve Activity and Improves Baroreflex Sensitivity in Patients with Hypertension

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Pages 241-249 | Received 03 Sep 2007, Accepted 24 Apr 2008, Published online: 03 Jul 2009

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Takayasu Ito, Naoki Fujimoto, Eiji Ishikawa, Kaoru Dohi, Mika Fujimoto, Tomohiro Murata, Michiyo Kiyohara, Hideyuki Takeuchi, Sukenari Koyabu, Hiroyuki Nishimura, Toshiaki Takeuchi & Masaaki Ito. (2019) The effect of an L/N-type calcium channel blocker on intradialytic blood pressure in intradialytic hypertensive patients. Clinical and Experimental Hypertension 41:1, pages 92-99.
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Dan Huang, Jie Zhou, Diansan Su, Weifeng Yu & Jie Chen. (2017) Variations of perioperative baroreflex sensitivity in hypertensive and normotensive patients. Clinical and Experimental Hypertension 39:1, pages 74-79.
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Shunsuke Kiuchi, Shinji Hisatake, Muneyasu Kawasaki, Osamu Hirashima, Takayuki Kabuki, Junichi Yamazaki & Takanori Ikeda. (2015) Addition of a renin-angiotensin-aldosterone system inhibitor to a calcium channel blocker ameliorates arterial stiffness. Clinical Pharmacology: Advances and Applications 7, pages 97-102.
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Yumi Koike, Tetsuya Kawabe, Kanami Nishihara, Naomi Iwane & Takuzo Hano. (2015) Cilnidipine but not amlodipine suppresses sympathetic activation elicited by isometric exercise in hypertensive patients. Clinical and Experimental Hypertension 37:7, pages 531-535.
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Articles from other publishers (16)

Fotini Iatridi, Marieta P. Theodorakopoulou, Aikaterini Papagianni & Pantelis Sarafidis. (2022) Management of intradialytic hypertension: current evidence and future perspectives. Journal of Hypertension 40:11, pages 2120-2129.
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Rabindra Nath Chakraborty, Deepak Langade, Shyam More, Vaibhav Revandlkar & Ashish Birla. (2021) Efficacy of Cilnidipine (L/N-type Calcium Channel Blocker) in Treatment of Hypertension: A Meta-Analysis of Randomized and Non-randomized Controlled Trials. Cureus.
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Masaya Sakamoto, Daisuke Matsutani & Yosuke Kayama. (2019) Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes. International Heart Journal 60:2, pages 241-246.
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James Schultz, Elizabeth M. Annoni & Elena G. Tolkacheva. (2018) Modified Sequence Method to Assess Baroreflex Sensitivity in Rats. Modified Sequence Method to Assess Baroreflex Sensitivity in Rats.
Satoko Nozato, Koichi Yamamoto, Yoichi Nozato, Masao Takeda, Kazuhiro Hongyo, Miyuki Takeya, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Norihisa Ito & Hiromi Rakugi. (2018) Comparison between L-type and N/L-type calcium channel blockers in the regulation of home blood-pressure variability in elderly hypertensive patients. Hypertension Research 41:4, pages 290-298.
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Guido Grassi. (2016) Sympathomodulatory Effects of Antihypertensive Drug Treatment. American Journal of Hypertension 29:6, pages 665-675.
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Yuko Yamada, Hideyuki Kinoshita, Koichiro Kuwahara, Yasuaki Nakagawa, Yoshihiro Kuwabara, Takeya Minami, Chinatsu Yamada, Junko Shibata, Kazuhiro Nakao, Kosai Cho, Yuji Arai, Shinji Yasuno, Toshio Nishikimi, Kenji Ueshima, Shiro Kamakura, Motohiro Nishida, Shigeki Kiyonaka, Yasuo Mori, Takeshi Kimura, Kenji Kangawa & Kazuwa Nakao. (2014) Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure. Cardiovascular Research 104:1, pages 183-193.
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Guido Grassi. (2014) Discovering the sympathomodulatory properties of new calcium channel blockers. Journal of Hypertension 32:9, pages 1780-1781.
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Juan J. Bolívar. (2013) Essential Hypertension: An Approach to Its Etiology and Neurogenic Pathophysiology. International Journal of Hypertension 2013, pages 1-11.
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M. V. Grigor’eva, M. M. Fateev & F. A. Kouzmin. (2012) Peculiarities of Heart Rhythm Variability in Narcotized and Immobilized Wakeful Rats during Blockade of Calcium Channels. Bulletin of Experimental Biology and Medicine 153:5, pages 634-637.
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Shinya Fukumoto, Eiji Ishimura, Koka Motoyama, Tomoaki Morioka, Eiji Kimoto, Ken Wakikawa, Shigeichi Shoji, Hidenori Koyama, Tetsuo Shoji, Masanori Emoto, Yoshiki Nishizawa & Masaaki Inaba. (2012) Antialbuminuric advantage of cilnidipine compared with L-type calcium channel blockers in type 2 diabetic patients with normoalbuminuria and microalbuminuria. Diabetes Research and Clinical Practice 97:1, pages 91-98.
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Hajime Nagasu, Minoru Satoh, Sohachi Fujimoto, Naruya Tomita, Tamaki Sasaki & Naoki Kashihara. (2011) Azelnidipine attenuates glomerular damage in Dahl salt-sensitive rats by suppressing sympathetic nerve activity. Hypertension Research 35:3, pages 348-355.
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Kiyohiro Ogawa, Yoshitaka Hirooka, Keisuke Shinohara, Takuya Kishi & Kenji Sunagawa. (2012) Inhibition of Oxidative Stress in Rostral Ventrolateral Medulla Improves Impaired Baroreflex Sensitivity in Stroke-Prone Spontaneously Hypertensive Rats. International Heart Journal 53:3, pages 193-198.
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Katsuyuki Ando, Masakazu Haneda, Sadayoshi Ito, Naoki Kashihara, Koichi Node, Masaomi Nangaku, Tatsuo Shimosawa, Junji Kishimoto & Toshiro Fujita. (2011) Design and Rationale of Japanese Evaluation Between Formula of Azelnidipine and Amlodipine Add on Olmesartan to Get Antialbuminuric Effect Study (J-FLAG). Cardiovascular Drugs and Therapy 25:4, pages 341-347.
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Kenneth M Madden, Chris K Lockhart, Tiffany F Potter, Darcye J Cuff & Graydon S Meneilly. (2011) Short-term Aerobic Exercise Reduces Nitroglycerin-induced Orthostatic Intolerance in Older Adults With Type 2 Diabetes. Journal of Cardiovascular Pharmacology 57:6, pages 666-671.
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Tadashi Konoshita, Yasukazu Makino, Tomoko Kimura, Miki Fujii, Shigeyuki Wakahara, Kenichiro Arakawa, Isao Inoki, Hiroyuki Nakamura & Isamu Miyamori. (2010) A new-generation N/L-type calcium channel blocker leads to less activation of the renin–angiotensin system compared with conventional L type calcium channel blocker. Journal of Hypertension 28:10, pages 2156-2160.
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