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Original Articles

Fluoride and human health: Systematic appraisal of sources, exposures, metabolism, and toxicity

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Pages 1116-1193 | Published online: 18 Aug 2019

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Satheeswaran Balasubramanian & Ekambaram Perumal. (2022) A systematic review on fluoride-induced epigenetic toxicity in mammals. Critical Reviews in Toxicology 52:6, pages 449-468.
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Charu Upadhyay, Monika Chaudhary, Ronaldo N. De Oliveira, Aniko Borbas, Prakasha Kempaiah, Poonam S & Brijesh Rathi. (2020) Fluorinated scaffolds for antimalarial drug discovery. Expert Opinion on Drug Discovery 15:6, pages 705-718.
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Articles from other publishers (74)

Bhaswati Devi, Ankur Kanti Guha & Arundhuti Devi. (2024) Fluoride ion detection in aqueous medium: Colorimetric and turn-off fluorescent Schiff base chemosensor. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 305, pages 123448.
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Vinay Kumar, Munish Sharma, Sonica Sondhi, Komalpreet Kaur, Deepak Sharma, Shivali Sharma & Divya Utreja. (2023) Removal of Inorganic Pollutants from Wastewater: Innovative Technologies and Toxicity Assessment. Sustainability 15:23, pages 16376.
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Anuj Saraswat, Shri Ram, Saber Kouadri, Md Basit Raza, H.C. Hombegowda, Randhir Kumar, Debasis Golui, Pragati K. Maurya, Predrag Ilić, Mohammad Mahmudur Rahman & Roomesh K. Jena. (2023) Groundwater quality, fluoride health risk and geochemical modelling for drinking and irrigation water suitability assessment in Tundla block, Uttar Pradesh, India. Groundwater for Sustainable Development 23, pages 100991.
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Niharika Singh, Ankita Dhillon & Dinesh Kumar. (2023) Metal-organic frameworks for adsorption of fluoride for groundwater treatment. Groundwater for Sustainable Development 23, pages 100967.
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Zhen Zeng, Qian Li, Jia Yan, Lei Huang, Samuel Raj Babu Arulmani, Hongguo Zhang, Shaojian Xie & Wenghong Sio. (2023) The model and mechanism of adsorptive technologies for wastewater containing fluoride: A review. Chemosphere 340, pages 139808.
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David Clases, Raquel Gonzalez de Vega, John Parnell & Jörg Feldmann. (2023) Fluorine mapping via LA-ICP-MS/MS: a proof of concept for biological and geological specimens . Journal of Analytical Atomic Spectrometry 38:8, pages 1661-1667.
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Panhong Wu, Kaidong Yang, Zilong Sun, Yangfei Zhao, Ram Kumar Manthari, Jundong Wang & Jinling Cao. (2023) Interleukin-17A knockout or self-recovery alleviated autoimmune reaction induced by fluoride in mouse testis. Science of The Total Environment 884, pages 163616.
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Yunpeng Li, Naiyi Yin, Xiaolin Cai, Pengfei Wang, Chuanfang Fan, Xuhui Chang, Xiaotong Liu, Ziqi Geng, Liwei Cui, Xin Du & Yanshan Cui. (2023) Effects of calcium supplements on oral bioavailability of fluoride in soil based on In Vivo and In Vitro methods. Journal of Hazardous Materials 456, pages 131663.
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Guijie Chen, Yujia Peng, Yujie Huang, Minhao Xie, Zhuqing Dai, Huimei Cai, Wei Dong, Weiqi Xu, Zhiyong Xie, Dan Chen, Xia Fan, Wangting Zhou, Xuhui Kan, Tingting Yang, Chunxu Chen, Yi Sun, Xiaoxiong Zeng & Zhonghua Liu. (2023) Fluoride induced leaky gut and bloom of Erysipelatoclostridium ramosum mediate the exacerbation of obesity in high-fat-diet fed mice. Journal of Advanced Research 50, pages 35-54.
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Husheng Zhang, Zhongfang Yang, Tao Yu, Xueqi Xia, Qiong Yang, Duoxun Xu & Shengfei Yang. (2023) A preliminary discussion on a framework for health geological survey and evaluation. Applied Geochemistry 155, pages 105738.
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Haoyang Wang, Teng Hu, Minghan Wang, Yunshan Liang, Chengwen Shen, Huaqin Xu, Yaoyu Zhou & Zhonghua Liu. (2023) Biochar addition to tea garden soils: effects on tea fluoride uptake and accumulation. Biochar 5:1.
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Chandra Bhan, Jiwan Singh, Naincy Sahu & Janardhan Reddy Koduru. (2023) Reutilization of carbon of waste filter cartridge after its surface modification for the fluoride removal from water by continuous flow process. Environmental Science and Pollution Research 30:37, pages 87483-87499.
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Emmanuel Anuoluwapo Oke, Olutayo Abiodun Oluyinka, Stephen Damilare Afolabi, Kelechukwu Kelvin Ibe & Saheed Abiola Raheem. (2023) Latest insights on technologies for halides and halogenated compounds extraction/abatement from water and wastewater: Challenges and future perspectives. Journal of Water Process Engineering 53, pages 103724.
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Linyang Li, Junlian Chen, Chuanbao Xiao, Yihao Luo, Nianbing Zhong, Quanhua Xie, Haixing Chang, Dengjie Zhong, Yunlan Xu, Mingfu Zhao & Qiang Liao. (2023) Recent advances in photoelectrochemical sensors for detection of ions in water. Chinese Chemical Letters 34:6, pages 107904.
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Nazar M. Smereczański & Małgorzata M. Brzóska. (2023) Current Levels of Environmental Exposure to Cadmium in Industrialized Countries as a Risk Factor for Kidney Damage in the General Population: A Comprehensive Review of Available Data. International Journal of Molecular Sciences 24:9, pages 8413.
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Mei Wang, Lei Liu, Dan Chen, Yasir Hamid, Anqi Shan, Zhiqin Chen, Song Yu, Ying Feng & Xiaoe Yang. (2022) Fluorine in 20 vegetable species and 25 lettuce cultivars grown on a contaminated field adjacent to a brick kiln. Environmental Geochemistry and Health 45:5, pages 1655-1667.
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Siyuan Dong, Yanni Yang, Biqi He, Zhao Xu, Zhaoqiang Zhou, Jinhai Wang, Chen Chen & Qun Chen. (2022) Effect of Sodium Fluoride on Reproductive Function Through Regulating Reproductive Hormone Level and Circulating SIRT1 in Female Rats. Biological Trace Element Research 201:4, pages 1825-1836.
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V. V. Belyaev, O. A. Gavrilova, I. V. Belyaev, O. A. Myalo & M. A. El-Aydi. (2023) Prevalence of malocclusions under conditions of prolonged introduction of systemic fluorides in variable concentrations: Literature review. Acta Biomedica Scientifica 8:1, pages 158-169.
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Mauro Martinez, G. Jean Harry, Erin N. Haynes, Pi-I. D. Lin, Emily Oken, Megan K. Horton, Robert O. Wright, Manish Arora & Christine Austin. (2023) Quantitative fluoride imaging of teeth using CaF emission by laser induced breakdown spectroscopy. Journal of Analytical Atomic Spectrometry 38:2, pages 303-314.
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Krishna Neeti & Reena Singh. (2023) Groundwater Quality Assessment and Health Risks from Fluoride in Jamui, Bihar. Engineering, Technology & Applied Science Research 13:1, pages 10204-10208.
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Noor A. S. Al-Gadi, Abdulaziz Y. T. Al-Saffawi, Mustapha Béjaoui & Ezzeddine Mahmoudi. (2023) Investigation of the potential risks to the human health risk of fluoride and nitrate via water consumption for some areas in Nineveh Governorate, Iraq. Acta Geophysica.
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Xunrong Huang, Hao Li, Xuzhe Ma, Wei Ji, Kun Chen, Bingnian Zhai & Pengcheng Gao. (2023) Fluoride accumulation characteristics in a northern China apple orchard that has had long-term phosphate fertilization. Science of The Total Environment 860, pages 160481.
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Benyapa Sawangjang & Satoshi Takizawa. (2023) Re-evaluating fluoride intake from food and drinking water: Effect of boiling and fluoride adsorption on food. Journal of Hazardous Materials 443, pages 130162.
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Elias Dritsas & Maria Trigka. (2023) Efficient Data-Driven Machine Learning Models for Water Quality Prediction. Computation 11:2, pages 16.
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Mu-Yuan Lu, Yuan Liu, Gui-Jian Liu, Yong-Li Li, Jin-Zhao Xu & Guan-Yu Wang. (2023) Spatial distribution characteristics and prediction of fluorine concentration in groundwater based on driving factors analysis. Science of The Total Environment 857, pages 159415.
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Shurong Wang, Haohao Wang, Shuqin Liu, Hongyuan Guo, Junlong Meng, Mingchang Chang & Suozhu Wu. (2023) Highly sensitive detection of fluoride based on poly(3-aminophenylboronic acid)-reduced graphene oxide multilayer modified electrode. Food Chemistry 400, pages 134042.
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Melike Karaman, Emine Toraman, Ekrem Sulukan, Alper Baran, İsmail Bolat, Serkan Yıldırım, Meryem Kankaynar, Atena Ghosigharehagaji, Harun Budak & Saltuk Buğrahan Ceyhun. (2023) Fluoride exposure causes behavioral, molecular and physiological changes in adult zebrafish (Danio rerio) and their offspring. Environmental Toxicology and Pharmacology 97, pages 104044.
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Chencheng Li, Lihua Xu, Jian'an Li, Xiaojie Chen, Zhenguo Chi, Bingjia Xu & Jiang Zhao. (2023) Light-up, colorimetric anion sensing and fingerprint visualization using the salicylaldehyde-based aggregation-induced emission-active phosphorescent Pt(II) complexes formed by restricting the molecular configuration transformations. Dyes and Pigments 209, pages 110912.
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Fazli Aziz, Islamud Din, Fawad Khan, Pervez Manan, Aroosa Sher & Said Hakim. (2023) Treatment of fluoride contaminated water using mango (Mangifera indica) leaves powder as an adsorbent. Current Research in Green and Sustainable Chemistry 6, pages 100359.
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Arthur Almeida Rodrigues, Douglas Almeida Rodrigues, Juliana de Fátima Sales, Sebastião Carvalho Vasconcelos Filho, Alan Carlos Costa, Cássia Lino Rodrigues, Adinan Alves da Silva, Marisa Domingos & Caroline Müller. (2022) Morphoanatomical, Physiological, and Biochemical Indicators in Lactuca sativa L. Germination and Growth in Response to Fluoride. Plants 11:23, pages 3406.
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Yijie Wu, Xiuling Zhang, Jianjie Chen, Jinling Cao, Cuiping Feng, Yongju Luo & Yong Lin. (2022) Self-recovery study of fluoride-induced ferroptosis in the liver of zebrafish (Danio rerio). Aquatic Toxicology 251, pages 106275.
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Akshay Kumar Chaudhry & Payal Sachdeva. (2022) Assessment of groundwater quality and human health risks from fluoride in Lower Satluj Basin, Punjab, India. Arabian Journal of Geosciences 15:19.
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Yan Liu, Yaping Zhou, Hongyu Li, Jie Gao, Mingyan Yang, Zeli Yuan & Xinmin Li. (2022) Near-Infrared Turn-On Fluorescent Probe for Aqueous Fluoride Ion Detection and Cell Imaging. ACS Omega 7:38, pages 34317-34325.
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Kaihong Xu, Zichen Feng, Francis Kojo Afrim, Jun Ma, Shuo Yang, Xuanyin Zhang, Zeyuan Niu, Ning An, Yuhui Du, Fangfang Yu, Guoyu Zhou & Yue Ba. (2022) Interaction of fluoride exposure and CREB1 gene polymorphisms on thyroid function in school-age children. Chemosphere 303, pages 135156.
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Mengxin Mu, Xin Ke, Wenyu Cheng, Jie Li, Chendong Ji & Meizhen Yin. (2022) Perylenemonoimide-Based Colorimetric Probe with High Contrast for Naked-Eye Detection of Fluoride Ions. Analytical Chemistry 94:33, pages 11470-11475.
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Wangkhem P. Singh, Laishram Robindro Singh & Rajkumar S. Singh. (2022) Gelation–based visual detection of fluoride ion: Strategic use of silyl protection–deprotection chemistry. Journal of Molecular Liquids 360, pages 119536.
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Ankita Dhillon, Surbhi Sharma, Niharika Singh & Dinesh Kumar. (2022) Use of core-shell nanomaterials as potential adsorbents for fluoride remediation: Toward a sustainable ecosystem. Groundwater for Sustainable Development 18, pages 100785.
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Jianglan Wu, Chencheng Li, Qiaobin Chen, Lihua Xu, Maoyang Jian & Jiang Zhao. (2022) Detection of volatile organic compounds, water in organic solvents, and anions using all-in-one type fluorescent emitters, and their data protection applications. Journal of Materials Chemistry C 10:29, pages 10595-10608.
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Wittaya Tewarangsri, Tippawan Chaiwong, Kongkea Phan, Chaipat Lapinee & Sanhawat Chaiwong. (2022) Knowledge Level and Consumption Behavior of Native Plants, Meats, and Drinking Waters with High Fluoride Concentrations about the Relation to the Potential Health Risk of Fluoride in Lamphun Province Thailand: A Case Study. Sustainability 14:14, pages 8701.
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Jinat Aktar & Manabendra Ray. (2022) Iron-polyphenol nanomaterial removes fluoride and methylene blue dye from water and promotes plant growth. Journal of Environmental Chemical Engineering 10:3, pages 107707.
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Shenglun Xiong, M.V. Nanda Kishore, Wei Zhou & Qing He. (2022) Recent advances in selective recognition of fluoride with macrocyclic receptors. Coordination Chemistry Reviews 461, pages 214480.
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Lin Wang, Yanyan Ma, Junling Yin, Linlin Zhu, Shifei Li & Weiying Lin. (2022) A deep-red emission fluorescent probe for visualization of fluoride anion accumulation in a murine model of acute fluoride toxicity and the roots of Arabidopsis thaliana. Sensors and Actuators B: Chemical 358, pages 131508.
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Chengyan Wang, Yangsai Lyu, Jia Li, Li Li, Tingting Li, Jie Yang, Ningning Xing & Xiaolei Zhang. (2022) Bioinspired 3D Hierarchical UiO-66-NH 2 Nanoparticle/γ-AlO(OH) Nanowire for Simultaneous Detection and Removal of Fluoride Ions . ACS Applied Nano Materials 5:3, pages 3201-3212.
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Catherine Fallon Grasham, Katrina Jane Charles & Tilahun Geneti Abdi. (2022) (Re-)orienting the Concept of Water Risk to Better Understand Inequities in Water Security. Frontiers in Water 3.
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Abdellatif Rahim, Abdelkhalid Essamadi & Bouchra El Amiri. (2022) A comprehensive review on endemic and experimental fluorosis in sheep: Its diverse effects and prevention. Toxicology 465, pages 153025.
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Xuan Zhao, Yaran Song, Ziyi Zhao, Wenyan Gao, Qiuming Peng & Qingrui Zhang. (2022) Efficient fluoride removal from water by amino Acid-enriched Artemia Cyst motivated Sub-10 nm La(OH)3 confined inside superporous skeleton. Separation and Purification Technology 283, pages 120205.
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Shi-quan Zhu, Jing Liu, Bo Han, Wen-peng Zhao, Bian-hua Zhou, Jing Zhao & Hong-wei Wang. (2022) Fluoride exposure cause colon microbiota dysbiosis by destroyed microenvironment and disturbed antimicrobial peptides expression in colon. Environmental Pollution 292, pages 118381.
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Edward Raja Chellaiah, Pandeeswari Ravi & Ramesh Uthandakalaipandian. (2021) Isolation and identification of high fluoride resistant bacteria from water samples of Dindigul district, Tamil Nadu, South India. Current Research in Microbial Sciences 2, pages 100038.
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Rakesh Kumar, Rama Sinha, Pushpa Kumari Sharma, Nishita Ivy, Pawan Kumar, Nishi Kant, Aprajita Jha, Prakash Kumar Jha, Pankaj Kumar Gupta, Prabhakar Sharma, Rakesh Kumar Singh, Rajeev Pratap Singh, Ashok Ghosh & P. V. Vara Prasad. (2021) Bioaccumulation of Fluoride in Plants and Its Microbially Assisted Remediation: A Review of Biological Processes and Technological Performance. Processes 9:12, pages 2154.
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Carla Candeias, Paula Freire Ávila, Célia Alves, Carla Gama, Cristina Sequeira, Eduardo Ferreira da Silva & Fernando Rocha. (2021) Dust Characterization and Its Potential Impact during the 2014–2015 Fogo Volcano Eruption (Cape Verde). Minerals 11:11, pages 1275.
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Shreyas J. Kashyap, Ravi Sankannavar & G.M. Madhu. (2021) Fluoride sources, toxicity and fluorosis management techniques – A brief review. Journal of Hazardous Materials Letters 2, pages 100033.
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Rajveer S. Dhingra & Manan Shah. (2021) A holistic study on fluoride-contaminated groundwater models and its widespread effects in healthcare and irrigation. Environmental Science and Pollution Research 28:43, pages 60329-60345.
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Ahmad Moloodi, Haniyeh Toraby, Saeed Kahrobaee, Morteza Kafaie Razavi & Akram Salehi. (2021) Evaluation of fluorohydroxyapatite/strontium coating on titanium implants fabricated by hydrothermal treatment. Progress in Biomaterials 10:3, pages 185-194.
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B. Sathish Kumar, Brijesh Chandra, K. V. Jovan Jose & Pradeepta K. Panda. (2021) 1,2-Phenylene-Incorporated Smallest Expanded Calix[4]pyrrole via One-Step Synthesis of Tetrapyrrane: A Fluorescent Host for Fluoride Ion. The Journal of Organic Chemistry 86:15, pages 10536-10543.
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Naiyi Yin, Yunpeng Li, Yuting Yang, Chuanfang Fan, Yan Li, Xin Du, Guoxin Sun & Yanshan Cui. (2021) Human health risk assessment in aluminium smelting site: Soil fluoride bioaccessibility and relevant mechanism in simulated gastrointestinal tract. Journal of Hazardous Materials 416, pages 125899.
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Zixuan Li, Deyi Zhan, Abdul Saeed, Nanjing Zhao, Junfeng Wang, Weihong Xu & Jinhuai Liu. (2021) Fluoride sensing performance of fluorescent NH 2 -MIL-53(Al): 2D nanosheets vs. 3D bulk . Dalton Transactions 50:24, pages 8540-8548.
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Leszek Borkowski, Agata Przekora, Anna Belcarz, Krzysztof Palka, Grzegorz Jozefaciuk, Tomasz Lübek, Mariusz Jojczuk, Adam Nogalski & Grazyna Ginalska. (2020) Fluorapatite ceramics for bone tissue regeneration: Synthesis, characterization and assessment of biomedical potential. Materials Science and Engineering: C 116, pages 111211.
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Maria Cristina Collivignarelli, Alessandro Abbà, Marco Carnevale Miino, Vincenzo Torretta, Elena Cristina Rada, Francesca Maria Caccamo & Sabrina Sorlini. (2020) Adsorption of Fluorides in Drinking Water by Palm Residues. Sustainability 12:9, pages 3786.
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