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Free Radical Research Volume 34, 2001 - Issue 1
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Original Article

Protective effects of fluvastatin against reactive oxygen species induced DNA damage and mutagenesis

Atsumune Imaeda Safety Research Laboratory, Tanabe Seiyaku Co., Ltd., 3-16-89, Kashima, Yodogawa-ku, Osaka, 532-8505, Japan
,
Tomonori Aoki Advanced Medical Research Department, Tanabe Seiyaku Co., Ltd., 3-16-89, Kashima, Yodogawa-ku, Osaka, 532-8505, Japan
,
Yasushi Kondo Department of Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, 602-0841, Japan
,
Masaki Hori 1st Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, 602-0841, Japan
,
Masakazu Ogata Safety Research Laboratory, Tanabe Seiyaku Co., Ltd., 3-16-89, Kashima, Yodogawa-ku, Osaka, 532-8505, Japan
,
Hiroshi Obayashi Advanced Medical Research Department, Tanabe Seiyaku Co., Ltd., 3-16-89, Kashima, Yodogawa-ku, Osaka, 532-8505, Japan
,
Goji Hasegawa Department of Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, 602-0841, Japan
,
Naoto Nakamura 1st Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, 602-0841, Japan
,
Kuniharu Tokuda Safety Research Laboratory, Tanabe Seiyaku Co., Ltd., 3-16-89, Kashima, Yodogawa-ku, Osaka, 532-8505, Japan
,
Hoyoku Nishino Advanced Medical Research Department, Tanabe Seiyaku Co., Ltd., 3-16-89, Kashima, Yodogawa-ku, Osaka, 532-8505, Japan
,
Toshikazu Yoshikawa Department of Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, 602-0841, Japan
&
Motoharu Kondo 1st Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, 602-0841, Japan
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Pages 33-44 | Received 07 Feb 2000, Published online: 07 Jul 2009

Citations (16)

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Jerzy Beltowski. (2005) Statins and Modulation of Oxidative Stress. Toxicology Mechanisms and Methods 15:2, pages 61-92.
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Atsumune Imaeda, Toru Tanigawa, Tomonori Aoki, Yasushi Kondo, Naoto Nakamura & Toshikazu Yoshikawa. (2001) Antioxidative effects of fluvastatin and its metabolites against oxidative DNA damage in mammalian cultured cells. Free Radical Research 35:6, pages 789-801.
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Articles from other publishers (14)

Saleem Ali Banihani. (2020) Effect of statin on semen quality characteristics. Andrologia 52:6.
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Anna UrygaKelly GrayMartin Bennett. (2016) DNA Damage and Repair in Vascular Disease. Annual Review of Physiology 78:1, pages 45-66.
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Fang Xie, Chao Sun, Li-hua Sun, Jing-yuan Li, Xin Chen, Hui Che, Guan-yi Lu, Bao-feng Yang & Jing Ai. (2011) Influence of fluvastatin on cardiac function and baroreflex sensitivity in diabetic rats. Acta Pharmacologica Sinica 32:3, pages 321-328.
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Carlos Alberto Yasin Wayhs, Vanusa Manfredini, Angela Sitta, Marion Deon, Graziela S. Ribas, Camila S. Vanzin, Giovana B. Biancini, Maurício S. Nin, Helena M.T. Barros & Carmen Regla Vargas. (2010) Effects of insulin and clonazepam on DNA damage in diabetic rats submitted to the forced swimming test. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 703:2, pages 187-190.
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Luciane B. Ceretta, Gislaine Z. Réus, Gislaine T. Rezin, Giselli Scaini, Emílio L. Streck & João Quevedo. (2010) Brain energy metabolism parameters in an animal model of diabetes. Metabolic Brain Disease 25:4, pages 391-396.
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Carlos Alberto Yasin Wayhs, Vanusa Manfredini, Angela Sitta, Marion Deon, Graziela Ribas, Camila Vanzin, Giovana Biancini, Marcelo Ferri, Maurício Nin, Helena Maria Tannhauser Barros & Carmen Regla Vargas. (2010) Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect. Metabolic Brain Disease 25:3, pages 297-304.
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Melli MahmoudiIsabelle GorenneJohn MercerNicola FiggTrevor LittlewoodMartin Bennett. (2008) Statins Use a Novel Nijmegen Breakage Syndrome-1–Dependent Pathway to Accelerate DNA Repair in Vascular Smooth Muscle Cells. Circulation Research 103:7, pages 717-725.
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Nicole Schupp, Ursula Schmid, August Heidland & Helga Stopper. (2008) Rosuvastatin protects against oxidative stress and DNA damage in vitro via upregulation of glutathione synthesis. Atherosclerosis 199:2, pages 278-287.
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Alexsandro da Silva Haeser, Angela Sitta, Alethéa Gatto Barschak, Marion Deon, Amanda Thomas Barden, Graziela Oliveira Schmitt, Sharon Landgraff, Rosane Gomez, Helena M.T. Barros & Carmen Regla Vargas. (2007) Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect. Brain Research 1154, pages 137-143.
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Shoko NagotaniTakeshi HayashiKeiko SatoWenri ZhangKentaro DeguchiIsao NaganoMikio ShojiKoji Abe. (2005) Reduction of Cerebral Infarction in Stroke-Prone Spontaneously Hypertensive Rats by Statins Associated With Amelioration of Oxidative Stress. Stroke 36:3, pages 670-672.
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Takao Kaneko, Shoichi Tahara & Fumiyo Takabayashi. (2003) Protective Effect of Fluvastatin, an HMG-CoA Reductase Inhibitor, on the Formation of 8-Oxo-2'-deoxyguanosine in the Nuclear DNA of Hamster Pancreas after a Single Administration of N-Nitrosobis(2-oxopropyl)amine. Biological and Pharmaceutical Bulletin 26:9, pages 1245-1248.
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A. Imaeda, T. Kaneko, T. Aoki, Y. Kondo, N. Nakamura, H. Nagase & T. Yoshikawa. (2002) Antioxidative effects of fluvastatin and its metabolites against DNA damage in streptozotocin-treated mice. Food and Chemical Toxicology 40:10, pages 1415-1422.
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A Imaeda, T Kaneko, T Aoki, Y Kondo & H Nagase. (2002) DNA damage and the effect of antioxidants in streptozotocin-treated mice. Food and Chemical Toxicology 40:7, pages 979-987.
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K Korlipara. (2002) STATIN THERAPY: RATIONALE FOR A NEW AGENT, ROSUVASTATIN. International Journal of Clinical Practice 56:5, pages 379-387.
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