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Original Article

Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin

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Pages 123-136 | Received 13 Apr 2000, Published online: 07 Jul 2009

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Nooshin Ghodsian, Anthony Yeandle, Barry D. Hock & Steven P. Gieseg. (2022) CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin through modulation of PPAR-γ activity. Free Radical Research 56:5-6, pages 366-377.
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Tejraj V. Janmale, Angus Lindsay & Steven P. Gieseg. (2020) Nucleoside transporters are critical to the uptake and antioxidant activity of 7,8-dihydroneopterin in monocytic cells. Free Radical Research 54:5, pages 341-350.
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Carole A. Firth, Ya-Ting Yang & Steven P. Gieseg. (2007) Lipid oxidation predominates over protein hydroperoxide formation in human monocyte-derived macrophages exposed to aqueous peroxyl radicals. Free Radical Research 41:7, pages 839-848.
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Steven P. Gieseg, Joseph Pearson & Carole A. Firth. (2003) Protein Hydroperoxides are a Major Product of Low Density Lipoprotein Oxidation During Copper, Peroxyl Radical and Macrophage-mediated Oxidation. Free Radical Research 37:9, pages 983-991.
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S. Duggan, C. Rait, J.M. Gebicki & S.P. Gieseg. (2001) Inhibition of protein oxidation by the macrophage-synthesised antioxidant 7,8-dihydroneopterin. Redox Report 6:3, pages 188-190.
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Articles from other publishers (22)

Ondrej Heneberk, Eliska Wurfelova & Vladimira Radochova. (2023) Neopterin, the Cell-Mediated Immune Response Biomarker, in Inflammatory Periodontal Diseases: A Narrative Review of a More than Fifty Years Old Biomarker. Biomedicines 11:5, pages 1294.
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Nooshin Ghodsian, Anthony Yeandle & Steven P. Gieseg. (2021) Foam cell formation but not oxLDL cytotoxicity is inhibited by CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin. The International Journal of Biochemistry & Cell Biology 133, pages 105918.
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Gregory Baxter-Parker, Hannah M. Prebble, Sean Cross, Nina Steyn, Anastasia Shchepetkina, Barry D. Hock, Andrew Cousins & Steven P. Gieseg. (2020) Neopterin formation through radical scavenging of superoxide by the macrophage synthesised antioxidant 7,8-dihydroneopterin. Free Radical Biology and Medicine 152, pages 142-151.
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Gregory Baxter-Parker, Ravinder Reddy Gaddam, Elena Moltchanova, Anitra Carr, Geoff Shaw, Stephen Chambers & Steven P. Gieseg. (2020) Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis. Pteridines 31:1, pages 68-82.
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Angus Lindsay & Steven P. Gieseg. (2020) Pterins as diagnostic markers of exercise-induced stress: a systematic review. Journal of Science and Medicine in Sport 23:1, pages 53-62.
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Steven Gieseg, Gregory Baxter-Parker & Angus Lindsay. (2018) Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?. Antioxidants 7:7, pages 80.
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A. Lindsay, J. Healy, W. Mills, J. Lewis, N. Gill, N. Draper & S. P. Gieseg. (2016) Impact-induced muscle damage and urinary pterins in professional rugby: 7,8-dihydroneopterin oxidation by myoglobin. Scandinavian Journal of Medicine & Science in Sports 26:3, pages 329-337.
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Hanadi Katouah, Alpha Chen, Izani Othman & Steven P. Gieseg. (2015) Oxidised low density lipoprotein causes human macrophage cell death through oxidant generation and inhibition of key catabolic enzymes. The International Journal of Biochemistry & Cell Biology 67, pages 34-42.
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Steven P. GiesegZunika AmitYa-Ting YangAnastasia ShchepetkinaHanadi Katouah. (2010) Oxidant Production, oxLDL Uptake, and CD36 Levels in Human Monocyte–Derived Macrophages Are Downregulated by the Macrophage-Generated Antioxidant 7,8-Dihydroneopterin. Antioxidants & Redox Signaling 13:10, pages 1525-1534.
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Zai-Qun Liu, Xu-Yang Luo, Yun-Xiu Sun, Wei Wu, Chun-Ming Liu, Zhi-Qiang Liu & Shu-Ying Liu. (2004) The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis. Journal of Pharmacy and Pharmacology 56:12, pages 1557-1562.
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Robert Sucher, Katharina Schroecksnadel, Guenter Weiss, Raimund Margreiter, Dietmar Fuchs & Gerald Brandacher. (2010) Neopterin, a prognostic marker in human malignancies. Cancer Letters 287:1, pages 13-22.
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Nicholas P.L. Tuckey, Malcolm E. Forster & Steven P. Gieseg. (2009) Lipid Oxidation Is Inhibited by Isoeugenol Exposure in Chinook Salmon ( Oncorhynchus Tshawytscha ) Fillets during Storage at 15 °C . Journal of Food Science 74:4, pages C333-C338.
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M. Laura Dántola, Tobias M. Schuler, M. Paula Denofrio, Mariana Vignoni, Alberto L. Capparelli, Carolina Lorente & Andrés H. Thomas. (2008) Reaction between 7,8-dihydropterins and hydrogen peroxide under physiological conditions. Tetrahedron 64:37, pages 8692-8699.
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Carole A. Firth, Andrew D. Laing, Sarah K. Baird, Joseph Pearson & Steven P. Gieseg. (2008) Inflammatory sites as a source of plasma neopterin: Measurement of high levels of neopterin and markers of oxidative stress in pus drained from human abscesses. Clinical Biochemistry 41:13, pages 1078-1083.
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Carole A. Firth, Elizabeth M. Crone, Elizabeth A. Flavall, Justin A. Roake & Steven P. Gieseg. (2008) Macrophage mediated protein hydroperoxide formation and lipid oxidation in low density lipoprotein are inhibited by the inflammation marker 7,8-dihydroneopterin. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:6, pages 1095-1101.
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S P Gieseg, E M Crone, E A Flavall & Z Amit. (2008) Potential to inhibit growth of atherosclerotic plaque development through modulation of macrophage neopterin/7,8-dihydroneopterin synthesis. British Journal of Pharmacology 153:4, pages 627-635.
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Elizabeth A. Flavall, Elizabeth M. Crone, Grant A. Moore & Steven P. Gieseg. (2008) Dissociation of neopterin and 7,8-dihydroneopterin from plasma components before HPLC analysis. Journal of Chromatography B 863:1, pages 167-171.
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Sarah K. Baird, Linzi Reid, Mark B. Hampton & Steven P. Gieseg. (2005) OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1745:3, pages 361-369.
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Karl Oettl, Joachim Greilberger, Sergey Dikalov & Gilbert Reibnegger. (2004) Interference of 7,8-dihydroneopterin with peroxynitrite-mediated reactions. Biochemical and Biophysical Research Communications 321:2, pages 379-385.
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J. Parrado, E.H. Absi, A. Machado & A. Ayala. (2003) “In vitro” effect of cumene hydroperoxide on hepatic elongation factor-2 and its protection by melatonin. Biochimica et Biophysica Acta (BBA) - General Subjects 1624:1-3, pages 139-144.
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Sean Duggan, Christopher Rait, Aaron Platt & Steven P Gieseg. (2002) Protein and thiol oxidation in cells exposed to peroxyl radicals is inhibited by the macrophage synthesised pterin 7,8-dihydroneopterin. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1591:1-3, pages 139-145.
Crossref
Renate Horejsi, Christiane Jung, Reinhard Möller, Erwin Tafeit & Gilbert Reibnegger. (2002) Generation of carbon monoxide and iron from hemeproteins in the presence of 7,8-dihydroneopterin. Biochimica et Biophysica Acta (BBA) - General Subjects 1571:2, pages 124-130.
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