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Free Radical Research Volume 34, 2001 - Issue 4
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Original Article

Trypanosoma Cruzi trypanothione reductase is inactivated by peroxidase-generated phenothiazine cationic radicals

Jose Gutierrez-Correa Bioenergetics Research Centre, School of Medicine, University of Buenos Aires, Paraguay 2155, 1121, Buenos Aires, Argentina
,
Alan H. Fairlamb Division of Molecular Parasitology and Biological Chemistry, Department of Biochemistry, University of Dundee, Dundee, DD1, 5EH, United Kingdom
&
Andres O.M. Stoppani Bioenergetics Research Centre, School of Medicine, University of Buenos Aires, Paraguay 2155, 1121, Buenos Aires, ArgentinaCorrespondence[email protected]
Pages 363-378 | Received 28 Jun 2000, Published online: 07 Jul 2009

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Fernando Villalta & Girish Rachakonda. (2019) Advances in preclinical approaches to Chagas disease drug discovery. Expert Opinion on Drug Discovery 14:11, pages 1161-1174.
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José Gutiérrez-Correa. (2010) Trypanosoma cruzi dihydrolipoamide dehydrogenase as target of reactive metabolites generated by cytochrome c/hydrogen peroxide (or linoleic acid hydroperoxide)/phenol systems. Free Radical Research 44:11, pages 1345-1358.
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Articles from other publishers (29)

Sergio Sifontes-Rodríguez, Niurka Mollineda-Diogo, Lianet Monzote-Fidalgo, Alma Reyna Escalona-Montaño, José Antonio Escario García-Trevijano, María Magdalena Aguirre-García & Alfredo Meneses-Marcel. (2023) In Vitro and In Vivo Antileishmanial Activity of Thioridazine. Acta Parasitologica.
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Roberto Docampo & Aníbal Eugénio Vercesi. (2022) Mitochondrial Ca 2+ and Reactive Oxygen Species in Trypanosomatids . Antioxidants & Redox Signaling 36:13-15, pages 969-983.
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Soraya Silva Santos, Renan Vinicius de Araújo, Jeanine Giarolla, Omar El Seoud & Elizabeth Igne Ferreira. (2020) Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review. International Journal of Antimicrobial Agents 55:4, pages 105906.
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Andréa Aparecida Santos Mendonça, Camila Morais Coelho, Marcia Paranho Veloso, Ivo Santana Caldas, Reggiani Vilela Gonçalves, Antônio Lucio Teixeira, Aline Silva de Miranda & Rômulo Dias Novaes. (2018) Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta-Analysis, and In Silico Integrated Approach . Oxidative Medicine and Cellular Longevity 2018, pages 1-20.
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Wilton H. Kawaguchi, Leticia Bonancio Cerqueira, Mariana Millan Fachi, Michel L. Campos, Iara J. Messias Reason & Roberto Pontarolo. 2018. Chagas Disease - Basic Investigations and Challenges. Chagas Disease - Basic Investigations and Challenges.
Policarpo Ademar Sales JuniorIsrael MolinaSilvane Maria Fonseca MurtaAdrián Sánchez-MontalváFernando SalvadorRodrigo Corrêa-OliveiraCláudia Martins Carneiro. (2017) Experimental and Clinical Treatment of Chagas Disease: A Review. The American Journal of Tropical Medicine and Hygiene 97:5, pages 1289-1303.
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R. Docampo & S.N.J. Moreno. 2017. American Trypanosomiasis Chagas Disease. American Trypanosomiasis Chagas Disease 371 400 .
Paola Carolina Bazán, María Silvina Lo Presti, Mariana Strauss, Alejandra Lidia Báez, Noemí Miler, Patricia Adriana Paglini & Héctor Walter Rivarola. (2016) Quantitative PCR and unconventional serological methods to evaluate clomipramine treatment effectiveness in experimental Trypanosoma cruzi infection. Experimental and Molecular Pathology 101:2, pages 274-280.
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M. Silvina Lo Presti, P. Carolina Bazán, Mariana Strauss, Alejandra L. Báez, H. Walter Rivarola & Patricia A. Paglini-Oliva. (2015) Trypanothione reductase inhibitors: Overview of the action of thioridazine in different stages of Chagas disease. Acta Tropica 145, pages 79-87.
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Benjamín Aguilera-VenegasClaudio Olea-Azar, Vicente J Arán & Hernán Speisky. (2013) Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi . Future Medicinal Chemistry 5:15, pages 1843-1859.
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ROMINA FAURO, SILVINA LO PRESTI, CAROLINA BAZAN, ALEJANDRA BAEZ, MARIANA STRAUSS, FERNANDA TRIQUELL, DAVID CREMONEZZI, OLGA SANCHEZ NEGRETE, GASTON CAMINO WILLHUBER, PATRICIA PAGLINI-OLIVA & HECTOR WALTER RIVAROLA. (2013) Use of clomipramine as chemotherapy of the chronic phase of Chagas disease. Parasitology 140:7, pages 917-927.
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Melisa Gualdrón‐López, Paul A. M. Michels, Wilfredo Quiñones, Ana J. Cáceres, Luisana Avilán & Juan‐Luis Concepción. 2013. Trypanosomatid Diseases. Trypanosomatid Diseases 121 151 .
Natália de Farias Silva, Jerônimo Lameira, Cláudio Nahum Alves & Sergio Martí. (2013) Computational study of the mechanism of half-reactions in class 1A dihydroorotate dehydrogenase from Trypanosoma cruzi. Physical Chemistry Chemical Physics 15:43, pages 18863.
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Artur F. Barbosa, Bruno B. Sangiorgi, Suely L. Galdino, Manoel Barral-Netto, Ivan R. Pitta & Antônio L. Pinheiro. (2012) Photodynamic antimicrobial chemotherapy (PACT) using phenothiazine derivatives as photosensitizers against Leishmania braziliensis . Lasers in Surgery and Medicine 44:10, pages 850-855.
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Juan C. Engel, Kenny K. H. Ang, Steven Chen, Michelle R. Arkin, James H. McKerrow & Patricia S. Doyle. (2010) Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi , the Agent of Chagas' Disease . Antimicrobial Agents and Chemotherapy 54:8, pages 3326-3334.
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Julio A. Urbina. (2010) Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches. Acta Tropica 115:1-2, pages 55-68.
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Roberto Docampo & Silvia N.J. Moreno. 2010. American Trypanosomiasis. American Trypanosomiasis 365 392 .
R. H. YOLKEN, F. B DICKERSON & E. FULLER TORREY. (2009) Toxoplasma and schizophrenia. Parasite Immunology 31:11, pages 706-715.
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F. Iribarne, M. Paulino, S. Aguilera & O. Tapia. (2009) Assaying phenothiazine derivatives as trypanothione reductase and glutathione reductase inhibitors by theoretical docking and Molecular Dynamics studies. Journal of Molecular Graphics and Modelling 28:4, pages 371-381.
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Paola Carolina Bazán, María Silvina Lo Presti, Héctor Walter Rivarola, María Fernanda Triquell, Ricardo Fretes, Alicia Ruth Fernández, Julio Enders & Patricia Paglini-Oliva. (2008) Chemotherapy of chronic indeterminate Chagas disease: a novel approach to treatment. Parasitology Research 103:3, pages 663-669.
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H. K. R. Thanacoody. (2007) Thioridazine: resurrection as an antimicrobial agent?. British Journal of Clinical Pharmacology 64:5, pages 566-574.
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Juan M. Bustamante, María S. Lo Presti, Héctor W. Rivarola, Alicia R. Fernández, Julio E. Enders, Ricardo E. Fretes & Patricia Paglini-Oliva. (2007) Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy. International Journal of Antimicrobial Agents 29:6, pages 733-737.
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Mei-Kuan Lai, Ching-Yu Chang, Yi-Wen Lien & Raymond Chien-Chao Tsiang. (2006) Application of gold nanoparticles to microencapsulation of thioridazine. Journal of Controlled Release 111:3, pages 352-361.
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H.W. Rivarola, J.M. Bustamante, S. Lo Presti, A.R. Fernández, J.E. Enders, S. Gea, R. Fretes & P. Paglini-Oliva. (2005) Trypanosoma cruzi: Chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area. Experimental Parasitology 111:2, pages 80-86.
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W.A. Daniel, A. Haduch & J. Wójcikowski. (2005) Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo–possible involvement of different mechanisms. European Neuropsychopharmacology 15:1, pages 103-110.
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M.S Lo Presti, H.W Rivarola, J.M Bustamante, A.R Fernández, J.E Enders, R Fretes, S Gea & P.A Paglini-Oliva. (2004) Thioridazine treatment prevents cardiopathy in Trypanosoma cruzi infected mice. International Journal of Antimicrobial Agents 23:6, pages 634-636.
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R. Luise Krauth-Siegel & Oliver Inhoff. (2003) Parasite-specific trypanothione reductase as a drug target molecule. Parasitology Research 90:S2, pages S77-S85.
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Takahiro Yano, Joseph Sklar, Eiko Nakamaru-Ogiso, Yasuhiro Takahashi, Takao Yagi & Tomoko Ohnishi. (2003) Characterization of Cluster N5 as a Fast-relaxing [4Fe-4S] Cluster in the Nqo3 Subunit of the Proton-translocating NADH-ubiquinone Oxidoreductase from Paracoccus denitrificans. Journal of Biological Chemistry 278:18, pages 15514-15522.
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José Rodrigues Coura & Solange L de Castro. (2002) A Critical Review on Chagas Disease Chemotherapy. Memórias do Instituto Oswaldo Cruz 97:1, pages 3-24.
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