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Original Article

Trypanosoma Cruzi trypanothione reductase is inactivated by peroxidase-generated phenothiazine cationic radicals

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Pages 363-378 | Received 28 Jun 2000, Published online: 07 Jul 2009

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Fernando Villalta & Girish Rachakonda. (2019) Advances in preclinical approaches to Chagas disease drug discovery. Expert Opinion on Drug Discovery 14:11, pages 1161-1174.
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Mei-Kuan Lai, Ching-Yu Chang, Yi-Wen Lien & Raymond Chien-Chao Tsiang. (2006) Application of gold nanoparticles to microencapsulation of thioridazine. Journal of Controlled Release 111:3, pages 352-361.
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W.A. Daniel, A. Haduch & J. Wójcikowski. (2005) Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo–possible involvement of different mechanisms. European Neuropsychopharmacology 15:1, pages 103-110.
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M.S Lo Presti, H.W Rivarola, J.M Bustamante, A.R Fernández, J.E Enders, R Fretes, S Gea & P.A Paglini-Oliva. (2004) Thioridazine treatment prevents cardiopathy in Trypanosoma cruzi infected mice. International Journal of Antimicrobial Agents 23:6, pages 634-636.
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R. Luise Krauth-Siegel & Oliver Inhoff. (2003) Parasite-specific trypanothione reductase as a drug target molecule. Parasitology Research 90:S2, pages S77-S85.
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José Rodrigues Coura & Solange L de Castro. (2002) A Critical Review on Chagas Disease Chemotherapy. Memórias do Instituto Oswaldo Cruz 97:1, pages 3-24.
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