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Research Article

Non-invasive Analysis of Reactive Oxygen Species Generated in NH4OH-induced Gastric Lesions of Rats using a 300 MHz In Vivo ESR Technique

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Pages 757-766 | Received 24 Sep 2002, Published online: 07 Jul 2009

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Takuro Niidome, Risa Gokuden, Kazuto Watanabe, Takeshi Mori, Tatsuya Naganuma, Hideo Utsumi, Kazuhiro Ichikawa & Yoshiki Katayama. (2014) Nitroxyl radicals-modified dendritic poly(l-lysine) as a contrast agent for Overhauser-enhanced MRI. Journal of Biomaterials Science, Polymer Edition 25:13, pages 1425-1439.
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Kazuhiro Ichikawa, Yasuko Sato, Hiroshi Kondo & Hideo Utsumi. (2006) An ESR contrast agent is transported to rat liver through organic anion transporter. Free Radical Research 40:4, pages 403-408.
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Rupam Ghosh, Rania Dumarieh, Yiling Xiao & Kendra K Frederick. (2022) Stability of the nitroxide biradical AMUPol in intact and lysed mammalian cells. Journal of Magnetic Resonance 336, pages 107150.
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Keiji Yasukawa. (2022) Redox-Based Theranostics of Gastric Ulcers Using Nitroxyl Radicals. Antioxidants & Redox Signaling 36:1-3, pages 160-171.
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Kota KimuraNami IguchiHitomi NakanoHironobu YasuiShingo MatsumotoOsamu InanamiHiroshi Hirata. (2022) Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance. Antioxidants & Redox Signaling 36:1-3, pages 57-69.
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A. S. Sementsov, N. V. Naryzhnaya, M. A. Sirotina & L. N. Maslov. (2021) The role of reactive oxygen species in the infarct-limiting effect of hypoxic preconditioning. Regional blood circulation and microcirculation 20:2, pages 87-91.
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Keiji Yasukawa. (2020) Free Radical Production and Production Mechanism in the Early and Advanced Stages of Gastrointestinal Lesions消化管炎症の発症・進展におけるフリーラジカル産生とその産生機序の解析. YAKUGAKU ZASSHI 140:11, pages 1343-1350.
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Kelsey M. McCoy, Rivkah Rogawski, Olivia Stovicek & Ann E. McDermott. (2019) Stability of nitroxide biradical TOTAPOL in biological samples. Journal of Magnetic Resonance 303, pages 115-120.
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Keiji Yasukawa, Akinobu Hirago, Kazunori Yamada, Xin Tun, Kenji Ohkuma & Hideo Utsumi. (2019) In vivo redox imaging of dextran sodium sulfate-induced colitis in mice using Overhauser-enhanced magnetic resonance imaging. Free Radical Biology and Medicine 136, pages 1-11.
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Hideo Utsumi. (2013) Novel Redox Molecular Imaging “ReMI” with Dual Magnetic Resonance磁気共鳴を用いた生体レドックスイメージング(ReMI). YAKUGAKU ZASSHI 133:7, pages 803-814.
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Martyna Elas, Kazuhiro Ichikawa & Howard J. Halpern. (2012) Oxidative Stress Imaging in Live Animals with Techniques Based on Electron Paramagnetic Resonance. Radiation Research 177:4, pages 514-523.
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Hisato Deguchi, Keiji Yasukawa, Toshihide Yamasaki, Fumiya Mito, Yuichi Kinoshita, Tatsuya Naganuma, Suguru Sato, Mayumi Yamato, Kazuhiro Ichikawa, Kiyoshi Sakai, Hideo Utsumi & Ken-ichi Yamada. (2011) Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats. Free Radical Biology and Medicine 51:9, pages 1799-1805.
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Atsuko Matsumoto, Ken-ichiro Matsumoto, Shingo MatsumotoFuminori Hyodo, Anastasia L. SowersJanusz W. KoscielniakNallathamby DevasahayamSankaran SubramanianJames B. MitchellMurali C. Krishna. (2011) Intracellular Hypoxia of Tumor Tissue Estimated by Noninvasive Electron Paramagnetic Resonance Oximetry Technique Using Paramagnetic Probes. Biological and Pharmaceutical Bulletin 34:1, pages 142-145.
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Mark Merchant, Stetson Williams & Ross Hardy. (2009) Production of superoxide ions by leukocytes of the American alligator (Alligator mississippiensis). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 152:1, pages 67-71.
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Andrey A. Bobko, Igor A. Kirilyuk, Igor A. Grigor’ev, Jay L. Zweier & Valery V. Khramtsov. (2007) Reversible reduction of nitroxides to hydroxylamines: Roles for ascorbate and glutathione. Free Radical Biology and Medicine 42:3, pages 404-412.
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Sushma Manda, Ikuo Nakanishi, Kei Ohkubo, Haruko Yakumaru, Ken-ichiro Matsumoto, Toshihiko Ozawa, Nobuo Ikota, Shunichi Fukuzumi & Kazunori Anzai. (2007) Nitroxyl radicals: electrochemical redox behaviour and structure–activity relationships. Organic & Biomolecular Chemistry 5:24, pages 3951.
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A. Milton Franklin Benial, Kazuhiro Ichikawa, Ramachandran Murugesan, Ken-ichi Yamada & Hideo Utsumi. (2006) Dynamic nuclear polarization properties of nitroxyl radicals used in Overhauser-enhanced MRI for simultaneous molecular imaging. Journal of Magnetic Resonance 182:2, pages 273-282.
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Hideo Utsumi, Keiji Yasukawa, Tetsuhiro Soeda, Ken-ichi Yamada, Ryota Shigemi, Takashi Yao & Masazumi Tsuneyoshi. (2006) Noninvasive Mapping of Reactive Oxygen Species by in Vivo Electron Spin Resonance Spectroscopy in Indomethacin-Induced Gastric Ulcers in Rats. Journal of Pharmacology and Experimental Therapeutics 317:1, pages 228-235.
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Keizo Takeshita, Cuiping Chi, Hiroshi Hirata, Mitsuhiro Ono & Toshihiko Ozawa. (2006) In vivo generation of free radicals in the skin of live mice under ultraviolet light, measured by L-band EPR spectroscopy. Free Radical Biology and Medicine 40:5, pages 876-885.
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Martin Kopáni, Peter Celec, Luboš Danišovič, Peter Michalka & Csaba Biró. (2006) Oxidative stress and electron spin resonance. Clinica Chimica Acta 364:1-2, pages 61-66.
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Hideo Utsumi, Ken-ichi Yamada, Kazuhiro Ichikawa, Kiyoshi Sakai, Yuichi Kinoshita, Shingo Matsumoto & Mika Nagai. (2006) Simultaneous molecular imaging of redox reactions monitored by Overhauser-enhanced MRI with 14 N- and 15 N-labeled nitroxyl radicals . Proceedings of the National Academy of Sciences 103:5, pages 1463-1468.
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Iori Ui, Aya Okajo, Kazutoyo Endo, Hideo Utsumi & Ken-Ichiro Matsumoto. (2004) Effect of hydrogen peroxide in redox status estimation using nitroxyl spin probe. Free Radical Biology and Medicine 37:12, pages 2012-2017.
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Ken-ichiro Matsumoto, Murali C. Krishna & James B. Mitchell. (2004) Novel Pharmacokinetic Measurement Using Electron Paramagnetic Resonance Spectroscopy and Simulation of in Vivo Decay of Various Nitroxyl Spin Probes in Mouse Blood. Journal of Pharmacology and Experimental Therapeutics 310:3, pages 1076-1083.
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Hideo Utsumi, Youn-Hee Han & Kazuhiro Ichikawa. (2003) A kinetic study of 3-chlorophenol enhanced hydroxyl radical generation during ozonation. Water Research 37:20, pages 4924-4928.
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Mayumi Yamato, Toru Egashira & Hideo Utsumi. (2003) Application of in vivo ESR spectroscopy to measurement of cerebrovascular ROS generation in stroke. Free Radical Biology and Medicine 35:12, pages 1619-1631.
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Hideo Utsumi & Ken-ichi Yamada. (2003) In vivo electron spin resonance-computed tomography/nitroxyl probe technique for non-invasive analysis of oxidative injuries. Archives of Biochemistry and Biophysics 416:1, pages 1-8.
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. (2003) Current Awareness in NMR in Biomedicine. NMR in Biomedicine 16:5, pages 289-300.
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Youn-Hee Han & Hideo Utsumi. (2003) ANALYSIS OF HYDROXYL RADICAL GENERATION IN ADVANCED OXIDATION PROCESS. Journal of Water and Environment Technology 1:2, pages 209-216.
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