108
Views
61
CrossRef citations to date
0
Altmetric
Original Article

Increased oxidative damage to DNA in an animal model of amyotrophic lateral sclerosis

, , &
Pages 383-388 | Received 02 Sep 2004, Accepted 25 Nov 2004, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Nadine Bakkar, Arianna Kousari, Tina Kovalik, Yang Li & Robert Bowser. (2015) RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. Molecular and Cellular Biology 35:14, pages 2385-2399.
Read now
Daniel J. Amante, Jinho Kim, Samantha T. Carreiro, Andrew C. Cooper, Steven W. Jones, Ting Li, Jennifer P. Moody, Christina K. Edgerly, Olivia L. Bordiuk, Kerry Cormier, Karen Smith, Robert J. Ferrante & James Rusche. (2010) Uridine ameliorates the pathological phenotype in transgenic G93A-ALS mice. Amyotrophic Lateral Sclerosis 11:6, pages 520-530.
Read now

Articles from other publishers (59)

Daniela Gerovska, Julie B. Noer, Yating Qin, Quratul Ain, Donjetë Januzi, Matthias Schwab, Otto W. Witte, Marcos J. Araúzo-Bravo & Alexandra Kretz. (2023) A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1G93A model of ALS. Cell & Bioscience 13:1.
Crossref
Franziska T. Wunsch, Nils Metzler-Nolte, Carsten Theiss & Veronika Matschke. (2023) Defects in Glutathione System in an Animal Model of Amyotrophic Lateral Sclerosis. Antioxidants 12:5, pages 1014.
Crossref
John C. SchimentiRui HuangLiangdao LiRyan James. (2022) Genome Maintenance in Mammalian Stem Cells. Annual Review of Genetics 56:1, pages 145-164.
Crossref
Anna Konopka & Julie D. Atkin. (2022) The Role of DNA Damage in Neural Plasticity in Physiology and Neurodegeneration. Frontiers in Cellular Neuroscience 16.
Crossref
Takashi Hosaka, Hiroshi Tsuji & Akira Tamaoka. (2021) Biomolecular Modifications Linked to Oxidative Stress in Amyotrophic Lateral Sclerosis: Determining Promising Biomarkers Related to Oxidative Stress. Processes 9:9, pages 1667.
Crossref
Jannigje Rachel Kok, Nelma M. Palminha, Cleide Dos Santos Souza, Sherif F. El-Khamisy & Laura Ferraiuolo. (2021) DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity. Cellular and Molecular Life Sciences 78:15, pages 5707-5729.
Crossref
Brunno R. Levone, Silvia C. Lenzken, Marco Antonaci, Andreas Maiser, Alexander Rapp, Francesca Conte, Stefan Reber, Jonas Mechtersheimer, Antonella E. Ronchi, Oliver Mühlemann, Heinrich Leonhardt, M. Cristina Cardoso, Marc-David Ruepp & Silvia M.L. Barabino. (2021) FUS-dependent liquid–liquid phase separation is important for DNA repair initiation. Journal of Cell Biology 220:5.
Crossref
Yu. V. Andreychuk, S. P. Zadorsky, A. S. Zhuk, E. I. Stepchenkova & S. G. Inge-Vechtomov. (2020) Relationship between Type I and Type II Template Processes: Amyloids and Genome Stability. Molecular Biology 54:5, pages 661-683.
Crossref
Yue-Qing Yang, Yong-Hui Zheng, Chun-Ting Zhang, Wei-Wei Liang, Shu-Yu Wang, Xu-Dong Wang, Ying Wang, Tian-Hang Wang, Hong-Quan Jiang & Hong-Lin Feng. (2020) Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis. Neurobiology of Disease 134, pages 104648.
Crossref
Pascual Torres, Daniel Cacabelos, Jèssica Pairada, Kylynda C Bauer, Jordi Boada, Laia Fontdevila, Chiara Rossi, Monica Povedano, Isidre Ferrer, Reinald Pamplona, B. Brett Finlay, Manuel Portero-Otín & Victòria Ayala. (2019) Gender-Specific Beneficial Effects of Docosahexaenoic Acid Dietary Supplementation in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice. Neurotherapeutics 17:1, pages 269-281.
Crossref
Li, Song, Moh, Kim & Kim. (2019) Cytoplasmic Restriction of Mutated SOD1 Impairs the DNA Repair Process in Spinal Cord Neurons. Cells 8:12, pages 1502.
Crossref
Xu-Dong Wang, Min-Wei Zhu, Dan Shan, Shu-Yu Wang, Xiang Yin, Yue-Qing Yang, Tian-Hang Wang, Chun-Ting Zhang, Ying Wang, Wei-Wei Liang, Jun Zhang, Hai-Zhi Jiang, Guang-Tao Dong, Hong-Quan Jiang, Yan Qi & Hong-Lin Feng. (2019) Spy1, a unique cell cycle regulator, alters viability in ALS motor neurons and cell lines in response to mutant SOD1-induced DNA damage. DNA Repair 74, pages 51-62.
Crossref
Sonia Kartha, Christine L. Weisshaar, Blythe H. Philips & Beth A. Winkelstein. (2018) Pre-treatment with Meloxicam Prevents the Spinal Inflammation and Oxidative Stress in DRG Neurons that Accompany Painful Cervical Radiculopathy. Neuroscience 388, pages 393-404.
Crossref
Diane Penndorf, OttoW Witte & Alexandra Kretz. (2018) DNA plasticity and damage in amyotrophic lateral sclerosis. Neural Regeneration Research 13:2, pages 173.
Crossref
Ping Han, Ruiyou Guo, Yefei Wang, Lishan Yao & Chengbu Liu. (2017) Bidirectional Electron-Transfer in Polypeptides with Various Secondary Structures. Scientific Reports 7:1.
Crossref
Diane Penndorf, Vedrana Tadić, Otto W. Witte, Julian Grosskreutz & Alexandra Kretz. (2017) DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1G93A model of amyotrophic lateral sclerosis in vivo and in vitro. PLOS ONE 12:8, pages e0183684.
Crossref
Stefan Stamenković, Aleksandra Pavićević, Miloš Mojović, Ana Popović-Bijelić, Vesna Selaković, Pavle Andjus & Goran Bačić. (2017) In vivo EPR pharmacokinetic evaluation of the redox status and the blood brain barrier permeability in the SOD1 G93A ALS rat model. Free Radical Biology and Medicine 108, pages 258-269.
Crossref
Shane Wald-Altman, Edward Pichinuk, Or Kakhlon & Miguel Weil. (2017) A differential autophagy dependent response to DNA-double strand brakes in bone marrow mesenchymal stem cells from sporadic ALS patients. Disease Models & Mechanisms.
Crossref
Charles Schutt, Howard E. Gendelman & R. Lee Mosley. 2017. Neuroimmune Pharmacology. Neuroimmune Pharmacology 767 797 .
Anna V. Kudryavtseva, George S. Krasnov, Alexey A. Dmitriev, Boris Y. Alekseev, Olga L. Kardymon, Asiya F. Sadritdinova, Maria S. Fedorova, Anatoly V. Pokrovsky, Nataliya V. Melnikova, Andrey D. Kaprin, Alexey A. Moskalev & Anastasiya V. Snezhkina. (2016) Mitochondrial dysfunction and oxidative stress in aging and cancer. Oncotarget 7:29, pages 44879-44905.
Crossref
Changsong Wang, Mingjuan Li, Hongquan Jiang, Hongshuang Tong, Yue Feng, Yue Wang, Xin Pi, Lei Guo, Maomao Nie, Honglin Feng & Enyou Li. (2016) Comparative Analysis of VOCs in Exhaled Breath of Amyotrophic Lateral Sclerosis and Cervical Spondylotic Myelopathy Patients. Scientific Reports 6:1.
Crossref
Yannick von Grabowiecki, Paula Abreu, Orphee Blanchard, Lavinia Palamiuc, Samir Benosman, Sophie Mériaux, Véronique Devignot, Isabelle Gross, Georg Mellitzer, José L Gonzalez de Aguilar & Christian Gaiddon. (2016) Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63. eLife 5.
Crossref
In Seok Hong & Marc M. Greenberg. (2015) Sequence selective tagging of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) using PNAs. Bioorganic & Medicinal Chemistry Letters 25:21, pages 4918-4921.
Crossref
Fabio Coppedè & Lucia Migliore. (2015) DNA damage in neurodegenerative diseases. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 776, pages 84-97.
Crossref
Hongquan Jiang, Changsong Wang, Ming Ren, Xiang Yin, Chunjie Chi, Lei Guo, Chaofu Ke, Honglin Feng & Enyou Li. (2014) Blood Volatile Organic Compounds as Potential Biomarkers for Amyotrophic Lateral Sclerosis: an Animal Study in the SOD1 G93A Mouse. Journal of Molecular Neuroscience 55:1, pages 167-173.
Crossref
John Ernest Vallarta Bajacan, In Seok Hong, Trevor W. Penning & Marc M. Greenberg. (2014) Quantitative Detection of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Using Chemical Tagging and qPCR. Chemical Research in Toxicology 27:7, pages 1227-1235.
Crossref
L. Sarga, N. Hart, L.G. Koch, S.L. Britton, G. Hajas, I. Boldogh, X. Ba & Z. Radak. (2013) Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair. Neuroscience 252, pages 326-336.
Crossref
Rheal A. Towner, Nataliya Smith, Debra Saunders, Florea Lupu, Robert Silasi-Mansat, Melinda West, Dario C. Ramirez, Sandra E. Gomez-Mejiba, Marcelo G. Bonini, Ronald P. Mason, Marilyn Ehrenshaft & Kenneth Hensley. (2013) In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis. Free Radical Biology and Medicine 63, pages 351-360.
Crossref
Peter Sykora, Jenq-Lin Yang, Leslie K. Ferrarelli, Jingyan Tian, Takashi Tadokoro, Avanti Kulkarni, Lior Weissman, Guido Keijzers, David M. WilsonIIIIII, Mark P. Mattson & Vilhelm A. Bohr. (2013) Modulation of DNA base excision repair during neuronal differentiation. Neurobiology of Aging 34:7, pages 1717-1727.
Crossref
Mauro CozzolinoMaria Grazia PesaresiValeria GerbinoJulian GrosskreutzMaria Teresa Carrì. (2012) Amyotrophic Lateral Sclerosis: New Insights into Underlying Molecular Mechanisms and Opportunities for Therapeutic Intervention. Antioxidants & Redox Signaling 17:9, pages 1277-1330.
Crossref
Aaron M. Fleming, James G. Muller, Adrienne C. Dlouhy & Cynthia J. Burrows. (2012) Structural Context Effects in the Oxidation of 8-Oxo-7,8-dihydro-2′-deoxyguanosine to Hydantoin Products: Electrostatics, Base Stacking, and Base Pairing. Journal of the American Chemical Society 134:36, pages 15091-15102.
Crossref
Sandy Pacheco‐Ortín, Ricardo Gaitán Lozano & Esther Agacino Valdés. (2012) Possible DNA damage by oxidation products of guanine: A density functional and electron propagator theoretical study. International Journal of Quantum Chemistry 112:16, pages 2840-2847.
Crossref
Xiaoxing Ma, Mazen J. Hamadeh, Brain R. Christie, Jane A. Foster & Mark A. Tarnopolsky. (2012) Impact of Treadmill Running and Sex on Hippocampal Neurogenesis in the Mouse Model of Amyotrophic Lateral Sclerosis. PLoS ONE 7:4, pages e36048.
Crossref
Muralidhar L. Hegde, Anil K. Mantha, Tapas K. Hazra, Kishor K. Bhakat, Sankar Mitra & Bartosz Szczesny. (2012) Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases. Mechanisms of Ageing and Development 133:4, pages 157-168.
Crossref
Barry Gertz, Margaret Wong & Lee J. Martin. (2012) Nuclear Localization of Human SOD1 and Mutant SOD1-Specific Disruption of Survival Motor Neuron Protein Complex in Transgenic Amyotrophic Lateral Sclerosis Mice. Journal of Neuropathology & Experimental Neurology 71:2, pages 162-177.
Crossref
Susanne Petri, Sonja Körner & Mahmoud Kiaei. (2012) Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS. Neurology Research International 2012, pages 1-7.
Crossref
Jenq-Lin Yang, Peter Sykora, David M. WilsonIIIIII, Mark P. Mattson & Vilhelm A. Bohr. (2011) The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency. Mechanisms of Ageing and Development 132:8-9, pages 405-411.
Crossref
Francisco Javier Miana-Mena, Cristina González-Mingot, Pilar Larrodé, María Jesús Muñoz, Sara Oliván, Lorena Fuentes-Broto, Enrique Martínez-Ballarín, Russel J. Reiter, Rosario Osta & Joaquín José García. (2010) Monitoring systemic oxidative stress in an animal model of amyotrophic lateral sclerosis. Journal of Neurology 258:5, pages 762-769.
Crossref
Francisco Javier Miana-Mena, Eduardo Piedrafita, Cristina González-Mingot, Pilar Larrodé, María Jesús Muñoz, Enrique Martínez-Ballarín, Russel J. Reiter, Rosario Osta & Joaquín J. García. (2011) Levels of membrane fluidity in the spinal cord and the brain in an animal model of amyotrophic lateral sclerosis. Journal of Bioenergetics and Biomembranes 43:2, pages 181-186.
Crossref
Fabio Coppedè. (2011) An Overview of DNA Repair in Amyotrophic Lateral Sclerosis. The Scientific World JOURNAL 11, pages 1679-1691.
Crossref
Ilenia Ventura, Maria Teresa Russo, Gabriele De Luca & Margherita Bignami. (2010) Oxidized purine nucleotides, genome instability and neurodegeneration. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 703:1, pages 59-65.
Crossref
Lubin Fang, Marko Teuchert, Friederike Huber-Abel, Dagmar Schattauer, Corinna Hendrich, Johannes Dorst, Heinz Zettlmeissel, Meinhard Wlaschek, Karin Scharffetter-Kochanek, Tamara Kapfer, Hayrettin Tumani, Albert C. Ludolph & Johannes Brettschneider. (2010) MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS. Journal of the Neurological Sciences 294:1-2, pages 51-56.
Crossref
Jinho Kim, Daniel J. Amante, Jennifer P. Moody, Christina K. Edgerly, Olivia L. Bordiuk, Karen Smith, Samantha A. Matson, Wayne R. Matson, Clemens R. Scherzer, H. Diana Rosas, Steven M. Hersch & Robert J. Ferrante. (2010) Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1802:7-8, pages 673-681.
Crossref
Livea F. Barbosa, Fernanda M. Cerqueira, Antero F.A. Macedo, Camila C.M. Garcia, José Pedro F. Angeli, Robert I. Schumacher, Mari Cleide Sogayar, Ohara Augusto, Maria Teresa Carrì, Paolo Di Mascio & Marisa H.G. Medeiros. (2010) Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1802:5, pages 462-471.
Crossref
Akhlaq A. FarooquiAkhlaq A. Farooqui. 2010. Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases. Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases 249 324 .
Samantha L. Crowe & Alexei D. Kondratyev. 2010. Acute Neuronal Injury. Acute Neuronal Injury 243 275 .
Giorgio Lenaz & Paola Strocchi. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Yuri Katayama, Kengo Maeda, Takahiro Iizuka, Masaharu Hayashi, Yoshio Hashizume, Mitsuru Sanada, Hiromichi Kawai & Atsunori Kashiwagi. (2009) Accumulation of oxidative stress around the stroke-like lesions of MELAS patients. Mitochondrion 9:5, pages 306-313.
Crossref
Nirit Lev, Debby Ickowicz, Yael Barhum, Eldad Melamed & Daniel Offen. (2008) DJ-1 Changes in G93A-SOD1 Transgenic Mice: Implications for Oxidative Stress in ALS. Journal of Molecular Neuroscience 38:2, pages 94-102.
Crossref
Lívea Fujita Barbosa, Camila Carrião Machado Garcia, Paolo Di Mascio & Marisa Helena Gennari de Medeiros. (2009) DNA oxidation, strand-breaks and etheno-adducts formation promoted by Cu, Zn-superoxide dismutase–H2O2 in the presence and absence of bicarbonate. Dalton Transactions:8, pages 1450.
Crossref
Alexander Sarlette, Klaus Krampfl, Claudia Grothe, Nils von Neuhoff, Reinhard Dengler & Susanne Petri. (2008) Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis. Journal of Neuropathology & Experimental Neurology 67:11, pages 1055-1062.
Crossref
Jenq-Lin Yang, Lior Weissman, Vilhelm A. Bohr & Mark P. Mattson. (2008) Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair 7:7, pages 1110-1120.
Crossref
Qing-Shan Xue, D Larry Sparks & Wolfgang J Streit. (2007) Microglial activation in the hippocampus of hypercholesterolemic rabbits occurs independent of increased amyloid production. Journal of Neuroinflammation 4:1.
Crossref
M. Glas, B. Popp, B. Angele, U. Koedel, C. Chahli, W.A. Schmalix, J.M. Anneser, H.W. Pfister & S. Lorenzl. (2007) A role for the urokinase-type plasminogen activator system in amyotrophic lateral sclerosis. Experimental Neurology 207:2, pages 350-356.
Crossref
Hirokazu Ohtaki, Takaaki Takeda, Kenji Dohi, Sachiko Yofu, Tomoya Nakamachi, Kazue Satoh, Yutaka Hiraizumi, Hideyo Miyaoka, Masaji Matsunaga & Seiji Shioda. (2007) Increased mitochondrial DNA oxidative damage after transient middle cerebral artery occlusion in mice. Neuroscience Research 58:4, pages 349-355.
Crossref
Daniela Sau, Silvia De Biasi, Laura Vitellaro-Zuccarello, Patrizia Riso, Serena Guarnieri, Marisa Porrini, Silvia Simeoni, Valeria Crippa, Elisa Onesto, Isabella Palazzolo, Paola Rusmini, Elena Bolzoni, Caterina Bendotti & Angelo Poletti. (2007) Mutation of SOD1 in ALS: a gain of a loss of function. Human Molecular Genetics 16:13, pages 1604-1618.
Crossref
L. Weissman, N.C. de Souza-Pinto, T. Stevnsner & V.A. Bohr. (2007) DNA repair, mitochondria, and neurodegeneration. Neuroscience 145:4, pages 1318-1329.
Crossref
Susanne Petri, Mahmoud Kiaei, Maria Damiano, Andrew Hiller, Elizabeth Wille, Giovanni Manfredi, Noel Y. Calingasan, Hazel H. Szeto & M. Flint Beal. (2006) Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry 98:4, pages 1141-1148.
Crossref
Tatyana D. Sotnikova & Raul R. Gainetdinov. 2006. Handbook of Microdialysis - Methods, Applications and Perspectives. Handbook of Microdialysis - Methods, Applications and Perspectives 399 417 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.