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Original

Cobalt induces hypoxia-inducible factor-1α (HIF-1α) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism

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Pages 847-856 | Received 22 Nov 2005, Published online: 07 Jul 2009

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Freek A. Groenman, Martin Rutter, Jinxia Wang, Isabella Caniggia, Dick Tibboel & Martin Post. (2007) Effect of chemical stabilizers of hypoxia-inducible factors on early lung development. American Journal of Physiology-Lung Cellular and Molecular Physiology 293:3, pages L557-L567.
Crossref
Hyeseung Lee, Clara M. Bien, Adam L. Hughes, Peter J. Espenshade, Kyung J. Kwon-Chung & Yun C. Chang. (2007) Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans. Molecular Microbiology 65:4, pages 1018-1033.
Crossref
Marc U. Baumann, Stacy Zamudio & Nicholas P. Illsley. (2007) Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1. American Journal of Physiology-Cell Physiology 293:1, pages C477-C485.
Crossref
Aggeliki Lyberopoulou, Emmanouil Venieris, Ilias Mylonis, Georgia Chachami, Ioannis Pappas, George Simos, Sofia Bonanou & Eleni Georgatsou. (2007) MgcRacGAP Interacts with HIF-1α and Regulates its Transcriptional Activity. Cellular Physiology and Biochemistry 20:6, pages 995-1006.
Crossref

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