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Original

Lipid oxidation predominates over protein hydroperoxide formation in human monocyte-derived macrophages exposed to aqueous peroxyl radicals

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Pages 839-848 | Received 11 Dec 2006, Published online: 07 Jul 2009

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Oluwatosin O. Ojo & David S. Leake. (2022) Effects of lysosomal low-density lipoprotein oxidation by ferritin on macrophage function. Free Radical Research 56:5-6, pages 436-446.
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Yichuan Wen, Feroz Ahmad, Zahra Mohri, Peter D. Weinberg & David S. Leake. (2019) Cysteamine inhibits lysosomal oxidation of low density lipoprotein in human macrophages and reduces atherosclerosis in mice. Atherosclerosis 291, pages 9-18.
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Feroz Ahmad & David S. Leake. (2019) Lysosomal oxidation of LDL alters lysosomal pH, induces senescence, and increases secretion of pro-inflammatory cytokines in human macrophages. Journal of Lipid Research 60:1, pages 98-110.
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Anastasia A. Shchepetkina, Barry D. Hock, Allison Miller, Martin A. Kennedy & Steven P. Gieseg. (2017) Effect of 7,8-dihydroneopterin mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages. The International Journal of Biochemistry & Cell Biology 87, pages 27-33.
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Angus Lindsay, Mohd Izani Othman, Hannah Prebble, Sian Davies & Steven P. Gieseg. (2016) Repetitive cryotherapy attenuates the in vitro and in vivo mononuclear cell activation response . Experimental Physiology 101:7, pages 851-865.
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Michael J. Davies. (2016) Protein oxidation and peroxidation. Biochemical Journal 473:7, pages 805-825.
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Janusz M. Gebicki. (2016) Oxidative stress, free radicals and protein peroxides. Archives of Biochemistry and Biophysics 595, pages 33-39.
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A.B. Gerry & D.S. Leake. (2014) Effect of low extracellular pH on NF-κB activation in macrophages. Atherosclerosis 233:2, pages 537-544.
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Nely SanJuan-Reyes, Leobardo Manuel Gómez-Oliván, Marcela Galar-Martínez, Patricia Vieyra-Reyes, Sandra García-Medina, Hariz Islas-Flores & Nadia Neri-Cruz. (2013) Effluent from an NSAID-Manufacturing Plant in Mexico Induces Oxidative Stress on Cyprinus carpio. Water, Air, & Soil Pollution 224:9.
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Puja Kumari, Ravindra Pal Singh, A. J. Bijo, C. R. K. Reddy & Bhavanath Jha. (2012) Estimation of Lipid Hydroperoxide Levels in Tropical Marine Macroalgae. Journal of Phycology 48:6, pages 1362-1373.
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Sang Eun Kim, Eun Ok Lee, Ji Hye Yang, Ji Hee Lee Kang, Yoo‐Hun Suh & Young Hae Chong. (2012) 15‐deoxy‐Δ 12,14 ‐prostaglandin J 2 inhibits human immunodeficiency virus‐1 tat‐induced monocyte chemoattractant protein‐1/CCL2 production by blocking the extracellular signal‐regulated kinase‐1/2 signaling pathway independently of peroxisome proliferator‐activated receptor‐γ and heme oxygenase‐1 in rat hippocampal slices . Journal of Neuroscience Research 90:9, pages 1732-1742.
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Ya-ting Tina Yang, Matthew Whiteman & Steven P. Gieseg. (2012) Intracellular glutathione protects human monocyte-derived macrophages from hypochlorite damage. Life Sciences 90:17-18, pages 682-688.
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Ya-ting Tina Yang, Matthew Whiteman & Steven P. Gieseg. (2012) HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1823:2, pages 420-429.
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Roberto Scarpato, Carolina Gambacciani, Benedetta Svezia, Daniele Chimenti & Gino Turchi. (2011) Cytotoxicity and genotoxicity studies of two free-radical generators (AAPH and SIN-1) in human microvascular endothelial cells (HMEC-1) and human peripheral lymphocytes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 722:1, pages 69-77.
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Steven P. GiesegZunika AmitYa-Ting YangAnastasia ShchepetkinaHanadi Katouah. (2010) Oxidant Production, oxLDL Uptake, and CD36 Levels in Human Monocyte–Derived Macrophages Are Downregulated by the Macrophage-Generated Antioxidant 7,8-Dihydroneopterin. Antioxidants & Redox Signaling 13:10, pages 1525-1534.
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Steven P. Gieseg, Elizabeth Crone & Zunika Amit. 2009. Endogenous Toxins. Endogenous Toxins 619 645 .
Rachel Williams, Honghong Yao, Fuwang Peng, Yanjing Yang, Crystal Bethel-Brown & Shilpa Buch. (2009) Cooperative induction of CXCL10 involves NADPH oxidase: Implications for HIV dementia. Glia, pages NA-NA.
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Carole A. Firth, Andrew D. Laing, Sarah K. Baird, Joseph Pearson & Steven P. Gieseg. (2008) Inflammatory sites as a source of plasma neopterin: Measurement of high levels of neopterin and markers of oxidative stress in pus drained from human abscesses. Clinical Biochemistry 41:13, pages 1078-1083.
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. (2008) Current World Literature. Current Opinion in Lipidology 19:3, pages 314-321.
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Carole A. Firth, Elizabeth M. Crone, Elizabeth A. Flavall, Justin A. Roake & Steven P. Gieseg. (2008) Macrophage mediated protein hydroperoxide formation and lipid oxidation in low density lipoprotein are inhibited by the inflammation marker 7,8-dihydroneopterin. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:6, pages 1095-1101.
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S P Gieseg, E M Crone, E A Flavall & Z Amit. (2008) Potential to inhibit growth of atherosclerotic plaque development through modulation of macrophage neopterin/7,8-dihydroneopterin synthesis. British Journal of Pharmacology 153:4, pages 627-635.
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