101
Views
40
CrossRef citations to date
0
Altmetric
NUTRITIONAL ANTIOXIDANTS

Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: Implications for an anticancer mechanism

, , , , &
Pages 764-772 | Received 10 Mar 2008, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Gholamreza Kavoosi & Zahra Amirghofran. (2017) Chemical composition, radical scavenging and anti-oxidant capacity of Ocimum Basilicum essential oil . Journal of Essential Oil Research 29:2, pages 189-199.
Read now
M. Shahid, Armeen Siddique, Istikhar A. Ansari, Farasha Sama, Sandesh Chibber, Mohd Khalid, Zafar A. Siddiqi & Serajul Haque Faizi. (2015) Syntheses, crystal structures, and genotoxic studies of cis-µ-1,2-peroxo dicobalt(III) complexes. Journal of Coordination Chemistry 68:5, pages 848-862.
Read now
Karuppiah Nagaraj, Subramanian Ambika & Sankaralingam Arunachalam. (2015) Synthesis, CMC determination, and intercalative binding interaction with nucleic acid of a surfactant–copper(II) complex with modified phenanthroline ligand (dpq). Journal of Biomolecular Structure and Dynamics 33:2, pages 274-288.
Read now
Amanda N. Carey, Derek R. Fisher, James A. Joseph & Barbara Shukitt-Hale. (2013) The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. Nutritional Neuroscience 16:1, pages 13-20.
Read now

Articles from other publishers (36)

Khaled M. A. Ramadan, Hossam S. El-Beltagi, Eslam S. A. Bendary & Hussein M. Ali. (2022) Experimental evaluation of the antioxidant and antitumor activities of thyme and basil essential oils and their phenolic constituents: theoretical antioxidant evaluation. Chemical and Biological Technologies in Agriculture 9:1.
Crossref
Mohd Farhan & Asim Rizvi. (2022) Understanding the Prooxidant Action of Plant Polyphenols in the Cellular Microenvironment of Malignant Cells: Role of Copper and Therapeutic Implications. Frontiers in Pharmacology 13.
Crossref
Mohammad Rafiq Wani & G.G. Hammad Ahmad Shadab. (2021) Low doses of thymoquinone protect isolated human blood cells from TiO2 nanoparticles induced oxidative stress, hemolysis, cytotoxicity, DNA damage and collapse of mitochondrial activity. Phytomedicine Plus 1:4, pages 100056.
Crossref
Tahereh Jamali, Gholamreza Kavoosi, Yousef Jamali, Saeed Mortezazadeh & Susan K. Ardestani. (2021) In-vitro, in-vivo, and in-silico assessment of radical scavenging and cytotoxic activities of Oliveria decumbens essential oil and its main components. Scientific Reports 11:1.
Crossref
Husain Y. Khan, Sheikh Mumtaz Hadi, Ramzi M. Mohammad & Asfar S. Azmi. 2020. Functional Foods in Cancer Prevention and Therapy. Functional Foods in Cancer Prevention and Therapy 221 236 .
Hussain Arif, Aamir Sohail, Mohd Farhan, Ahmed Abdur Rehman, Aamir Ahmad & S.M. Hadi. (2018) Flavonoids-induced redox cycling of copper ions leads to generation of reactive oxygen species: A potential role in cancer chemoprevention. International Journal of Biological Macromolecules 106, pages 569-578.
Crossref
Atif Zafar, Swarnendra Singh & Imrana Naseem. (2017) Cytotoxic activity of soy phytoestrogen coumestrol against human breast cancer MCF-7 cells: Insights into the molecular mechanism. Food and Chemical Toxicology 99, pages 149-161.
Crossref
Mohd Farhan, Mohammad Oves, Sandesh Chibber, Sheikh Hadi & Aamir Ahmad. (2016) Mobilization of Nuclear Copper by Green Tea Polyphenol Epicatechin-3-Gallate and Subsequent Prooxidant Breakage of Cellular DNA: Implications for Cancer Chemotherapy. International Journal of Molecular Sciences 18:1, pages 34.
Crossref
Mohd Farhan, Husain Khan, Mohammad Oves, Ahmed Al-Harrasi, Nida Rehmani, Hussain Arif, Sheikh Hadi & Aamir Ahmad. (2016) Cancer Therapy by Catechins Involves Redox Cycling of Copper Ions and Generation of Reactive Oxygen Species. Toxins 8:2, pages 37.
Crossref
Junjie Li, Beibei Fu, Changjun Hou, Danqun Huo, Mei Yang, Caihong Shen & Huibo Luo. (2016) A colorimetric multilayer sensor for discriminating red wine and green tea by measurement of antioxidant activity. Analytical Methods 8:16, pages 3345-3352.
Crossref
SM Hadi & Mohd Farhan. 2016. Critical Dietary Factors in Cancer Chemoprevention. Critical Dietary Factors in Cancer Chemoprevention 31 35 .
Hussain Arif, Nida Rehmani, Mohd Farhan, Aamir Ahmad & Sheikh Hadi. (2015) Mobilization of Copper ions by Flavonoids in Human Peripheral Lymphocytes Leads to Oxidative DNA Breakage: A Structure Activity Study. International Journal of Molecular Sciences 16:11, pages 26754-26769.
Crossref
Mohd Farhan, Asim Rizvi, Imrana Naseem, S. M. Hadi & Aamir Ahmad. (2015) Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate. Tumor Biology 36:11, pages 8861-8867.
Crossref
Mohd Farhan, Atif Zafar, Sandesh Chibber, Husain Yar Khan, Hussain Arif & S.M. Hadi. (2015) Mobilization of copper ions in human peripheral lymphocytes by catechins leading to oxidative DNA breakage: A structure activity study. Archives of Biochemistry and Biophysics 580, pages 31-40.
Crossref
Harald Kühnel, Abulimiti Adilijiang, Agnes Dadak, Matthias Wieser, Halmurat Upur, Klaus Stolze, Johannes Grillari & Alois Strasser. (2015) Investigations into cytotoxic effects of the herbal preparation Abnormal Savda Munziq. Chinese Journal of Integrative Medicine.
Crossref
Asma Perveen, Husain Yar Khan, S. M. Hadi, Ghazi A. Damanhouri, Ahmed Alharrasi, Shams Tabrez & Ghulam Md Ashraf. 2015. GeNeDis 2014. GeNeDis 2014 37 51 .
B. N. Singh, Harikesh Bahadur Singh, A. Singh, Alim H. Naqvi & Braj Raj Singh. (2014) Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade. Cancer and Metastasis Reviews 33:1, pages 41-85.
Crossref
Mohsen Taheri Shirazi, Hamid Gholami, Gholamreza Kavoosi, Vahid Rowshan & Asad Tafsiry. (2014) Chemical composition, antioxidant, antimicrobial and cytotoxic activities of T agetes minuta and O cimum basilicum essential oils . Food Science & Nutrition 2:2, pages 146-155.
Crossref
Gabriel Silva, Ana Fachin, Renê Beleboni, Suzelei França & Mozart Marins. (2013) In Vitro Action of Flavonoids in the Canine Malignant Histiocytic Cell Line DH82. Molecules 18:12, pages 15448-15463.
Crossref
H Zubair, H Y Khan, A Sohail, S Azim, M F Ullah, A Ahmad, F H Sarkar & S M Hadi. (2013) Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants. Cell Death & Disease 4:6, pages e660-e660.
Crossref
Sandesh Chibber, Iftekhar Hassan, Mohd Farhan, Maria Salman & Imrana Naseem. (2012) White light augments chemotherapeutic potential of cyclophosphamide: an in vitro study. BioMetals 26:1, pages 23-31.
Crossref
Haseeb Zubair, Husain Y. Khan, M.F. Ullah, Aamir Ahmad, Daocheng Wu & S.M. Hadi. (2012) Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage. European Journal of Pharmaceutical Sciences 47:1, pages 280-286.
Crossref
Magdalini A. Papandreou, Maria Tsachaki, Spiros Efthimiopoulos, Dorothy Klimis-Zacas, Marigoula Margarity & Fotini N. Lamari. (2012) Cell-Line Specific Protection by Berry Polyphenols Against Hydrogen Peroxide Challenge and Lack of Effect on Metabolism of Amyloid Precursor Protein. Phytotherapy Research 26:7, pages 956-963.
Crossref
Maria C. Linder. (2012) The relationship of copper to DNA damage and damage prevention in humans. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 733:1-2, pages 83-91.
Crossref
Uzma Shamim, Sarmad Hanif, Abdulmajeed Albanyan, Frances W.J. Beck, Bin Bao, Zhiwei Wang, Sanjeev Banerjee, Fazlul H. Sarkar, Ramzi M. Mohammad, Sheikh M. Hadi & Asfar S. Azmi. (2012) Resveratrol-induced apoptosis is enhanced in low pH environments associated with cancer. Journal of Cellular Physiology 227:4, pages 1493-1500.
Crossref
Surawat Jariyawat, Thanapol Thammapratip, Kanoknetr Suksen, Podchanart Wanitchakool, Jintapat Nateewattana, Arthit Chairoungdua, Apichart Suksamrarn & Pawinee Piyachaturawat. (2011) Induction of apoptosis in murine leukemia by diarylheptanoids from Curcuma comosa Roxb.. Cell Biology and Toxicology 27:6, pages 413-423.
Crossref
Husain Y. Khan, Haseeb Zubair, Mohd F. Ullah, Aamir Ahmad & Sheikh M. Hadi. (2011) Oral administration of copper to rats leads to increased lymphocyte cellular DNA degradation by dietary polyphenols: implications for a cancer preventive mechanism. BioMetals 24:6, pages 1169-1178.
Crossref
Sandesh Chibber, Mohd Farhan, Iftekhar Hassan & Imrana Naseem. (2011) White light-mediated Cu (II)–5FU interaction augments the chemotherapeutic potential of 5-FU: an in vitro study. Tumor Biology 32:5, pages 881-892.
Crossref
Mohammad F. Ullah, Aamir Ahmad, Haseeb Zubair, Husain Y. Khan, Zhiwei Wang, Fazlul H. Sarkar & Sheikh M. Hadi. (2011) Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species. Molecular Nutrition & Food Research 55:4, pages 553-559.
Crossref
Isabel M. Quesada, Mario Bustos, Mayte Blay, Gerard Pujadas, Anna Ardèvol, M. Josepa Salvadó, Cinta Bladé, Lluís Arola & Juan Fernández-Larrea. (2011) Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells. The Journal of Nutritional Biochemistry 22:2, pages 153-163.
Crossref
M. F. Ullah, H. Y. Khan, H. Zubair, U. Shamim & S. M. Hadi. (2010) The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer. Cancer Chemotherapy and Pharmacology 67:1, pages 103-110.
Crossref
James A. Joseph, Barbara Shukitt-Hale, Gregory J. Brewer, Karen A. Weikel, Wilhelmina Kalt & Derek R. Fisher. (2010) Differential Protection among Fractionated Blueberry Polyphenolic Families against DA-, Aβ 42 - and LPS-Induced Decrements in Ca 2+ Buffering in Primary Hippocampal Cells . Journal of Agricultural and Food Chemistry 58:14, pages 8196-8204.
Crossref
S. M. Hadi, M. F. Ullah, A. S. Azmi, A. Ahmad, U. Shamim, H. Zubair & H. Y. Khan. (2010) Resveratrol Mobilizes Endogenous Copper in Human Peripheral Lymphocytes Leading to Oxidative DNA Breakage: A Putative Mechanism for Chemoprevention of Cancer. Pharmaceutical Research 27:6, pages 979-988.
Crossref
Lucia Biasutto, Nicola Sassi, Andrea Mattarei, Ester Marotta, Paola Cattelan, Antonio Toninello, Spiridione Garbisa, Mario Zoratti & Cristina Paradisi. (2010) Impact of mitochondriotropic quercetin derivatives on mitochondria. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797:2, pages 189-196.
Crossref
Mohd Fahad Ullah, Uzma Shamim, Sarmad Hanif, Asfar S. Azmi & Sheikh M. Hadi. (2009) Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A. Molecular Nutrition & Food Research 53:11, pages 1376-1385.
Crossref
Barry Halliwell. (2009) The wanderings of a free radical. Free Radical Biology and Medicine 46:5, pages 531-542.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.