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Free Radical Research Volume 51, 2017 - Issue 1
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Original Article

xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway

Eun Sil KangDepartment of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan; ;Department of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea; View further author information
,
Jaeyong LeeDepartment of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan; View further author information
,
Takujiro HommaDepartment of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan; View further author information
,
Toshihiro KurahashiDepartment of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan; View further author information
,
Sho KobayashiDepartment of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan; View further author information
,
Atsunori NabeshimaDepartment of Pathology and Cell Biology, University of Occupational and Environmental Health, Kitakyushu, Japan; View further author information
,
Sohsuke YamadaDepartment of Pathology and Cell Biology, University of Occupational and Environmental Health, Kitakyushu, Japan; View further author information
,
Han Geuk SeoDepartment of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea; View further author information
,
Satoshi MiyataDepartment of Internal Medicine, Osaka Hospital, Japan Community Healthcare Organization, Osaka, Japan; View further author information
,
Hideyo SatoLaboratory of Biochemistry and Molecular Biology, Department of Medical Technology, Faculty of Medicine, Niigata University, Niigata, JapanView further author information
&
Junichi FujiiDepartment of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan; Correspondence[email protected]
View further author information
 show all
Pages 80-90 | Received 23 Sep 2016, Accepted 10 Jan 2017, Published online: 06 Feb 2017

Citations (21)

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Junichi Fujii, Takujiro Homma & Sho Kobayashi. (2020) Ferroptosis caused by cysteine insufficiency and oxidative insult. Free Radical Research 54:11-12, pages 969-980.
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Gyul Moon, Sho Kobayashi, Ye Aung Naing, Ken-ichi Yamada, Mitsunori Yamakawa & Junichi Fujii. (2020) Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice. Free Radical Research 54:8-9, pages 606-619.
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Articles from other publishers (19)

Shumin Sun, Jie Shen, Jianwei Jiang, Fudi Wang & Junxia Min. (2023) Targeting ferroptosis opens new avenues for the development of novel therapeutics. Signal Transduction and Targeted Therapy 8:1.
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Siyu Yuan, Can Wei, Guofang Liu, Lijun Zhang, Jiahao Li, Lingling Li, Shiyi Cai & Ling Fang. (2021) Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF‐1α/SLC7A11 pathway. Cell Proliferation 55:1.
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Sho Kobayashi, Takujiro Homma, Nobuaki Okumura, Jia Han, Keita Nagaoka, Hideyo Sato, Hiroyuki Konno, Sohsuke Yamada, Toshifumi Takao & Junichi Fujii. (2021) Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides. Free Radical Biology and Medicine 174, pages 12-27.
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Kuo Du, Seh Hoon Oh, Rajesh K. Dutta, Tianai Sun, Wen‐Hsuan Yang, Jen‐Tsan Chi & Anna Mae Diehl. (2021) Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury. Liver International 41:9, pages 2214-2227.
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Junichi Fujii, Takujiro Homma, Satoshi Miyata & Motoko Takahashi. (2021) Pleiotropic Actions of Aldehyde Reductase (AKR1A). Metabolites 11:6, pages 343.
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Vasco D. B. Bonifácio, Sofia A. Pereira, Jacinta Serpa & João B. Vicente. (2020) Cysteine metabolic circuitries: druggable targets in cancer. British Journal of Cancer 124:5, pages 862-879.
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Junichi Fujii. (2021) Ascorbate is a multifunctional micronutrient whose synthesis is lacking in primates. Journal of Clinical Biochemistry and Nutrition 69:1, pages 1-15.
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Chrismis Novalinda Ginting, I Nyoman Ehrich Lister, Ermi Girsang, Wahyu Widowati, Dewani Tediana Yusepany, Alya Mardhotillah Azizah & Hanna Sari Widya Kusuma. (2021) Hepatotoxicity prevention in Acetaminophen-induced HepG2 cells by red betel (Piper crocatum Ruiz and Pav) extract from Indonesia via antioxidant, anti-inflammatory, and anti-necrotic. Heliyon 7:1, pages e05620.
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Jacinta Serpa. (2020) Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival. Frontiers in Oncology 10.
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Sho Kobayashi, Yoshitaka Ikeda, Yuhei Shigeno, Hiroyuki Konno & Junichi Fujii. (2020) γ-Glutamylcysteine synthetase and γ-glutamyl transferase as differential enzymatic sources of γ-glutamylpeptides in mice. Amino Acids 52:4, pages 555-566.
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Jacinta Serpa. 2020. Tumor Microenvironment. Tumor Microenvironment 1 34 .
Sho Kobayashi, Yoshinori Tokairin, Takeru Miyakoshi, Takuya Saito, Keita Nagaoka, Yoshitaka Ikeda, Junichi Fujii & Hiroyuki Konno. (2019) Quantitative analysis of γ-glutamylpeptides by liquid chromatography-mass spectrometry and application for γ-glutamyltransferase assays. Analytical Biochemistry 578, pages 13-22.
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Roberto Ruiu, Valeria Rolih, Elisabetta Bolli, Giuseppina Barutello, Federica Riccardo, Elena Quaglino, Irene Fiore Merighi, Federica Pericle, Gaetano Donofrio, Federica Cavallo & Laura Conti. (2018) Fighting breast cancer stem cells through the immune-targeting of the xCT cystine–glutamate antiporter. Cancer Immunology, Immunotherapy 68:1, pages 131-141.
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Xing-Yue Xu, Zi Wang, Shen Ren, Jing Leng, Jun-nan Hu, Zhi Liu, Chen Chen & Wei Li. (2018) Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-α-mediated caspase-3/-8/-9 signaling pathways. Phytomedicine 51, pages 128-138.
Crossref
Sho Kobayashi, Shinji Hamashima, Takujiro Homma, Mami Sato, Ryosuke Kusumi, Shiro Bannai, Junichi Fujii & Hideyo Sato. (2018) Cystine/glutamate transporter, system x c − , is involved in nitric oxide production in mouse peritoneal macrophages. Nitric Oxide 78, pages 32-40.
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Amber W. Wang, Kirk J. Wangensteen, Yue J. Wang, Adam M. Zahm, Nicholas G. Moss, Noam Erez & Klaus H. Kaestner. (2018) TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury. Journal of Clinical Investigation 128:6, pages 2297-2309.
Crossref
Jaeyong Lee, Eun Sil Kang, Sho Kobayashi, Takujiro Homma, Hideyo Sato, Han Geuk Seo & Junichi Fujii. (2017) The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production. Experimental Cell Research 361:1, pages 178-191.
Crossref
Sho Kobayashi, Jaeyong Lee, Toshifumi Takao & Junichi Fujii. (2017) Increased ophthalmic acid production is supported by amino acid catabolism under fasting conditions in mice. Biochemical and Biophysical Research Communications 491:3, pages 649-655.
Crossref
Gethin McBean. (2017) Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes. Antioxidants 6:3, pages 62.
Crossref

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