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Free Radical Research Volume 51, 2017 - Issue 4
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Original Article

Intracellular methylglyoxal induces oxidative damage to pancreatic beta cell line INS-1 cell through Ire1α-JNK and mitochondrial apoptotic pathway

Chongxiao LiuDepartment of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; View further author information
,
Yanhong HuangDepartment of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; View further author information
,
Yifan ZhangDepartment of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; View further author information
,
Xueru ChenDepartment of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; View further author information
,
Xiang KongDepartment of Endocrinology, Yijishan Hospital Affiliated Wannan Medical College, Anhui, ChinaView further author information
&
Yan DongDepartment of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence[email protected]
View further author information
Pages 337-350 | Received 12 Oct 2016, Accepted 28 Jan 2017, Published online: 10 May 2017

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Mustafa Kırça & Akın Yeşilkaya. (2022) Methylglyoxal stimulates endoplasmic reticulum stress in vascular smooth muscle cells. Journal of Receptors and Signal Transduction 42:3, pages 279-284.
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Nikoletta Papaevgeniou, Annika Hoehn, Josep A. Tur, Lars-Oliver Klotz, Tilman Grune & Niki Chondrogianni. (2019) Sugar-derived AGEs accelerate pharyngeal pumping rate and increase the lifespan of Caenorhabditis elegans. Free Radical Research 53:sup1, pages 1056-1067.
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Articles from other publishers (14)

Baiyi Yan, Yanchun Gong, Wei Meng, Huizhen Sun, Wenxi Li, Kaizhi Ding, Caixia Dang, Xiaofei Gao, Wei Sun, Chunhua Yuan, Songhua Wang & Li-Hua Yao. (2023) Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway. Biomedicine & Pharmacotherapy 163, pages 114776.
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Shunxiao Zhang, Sheng Zhang, Yuan‐Yuan Li, Yan Zhang, Hua Wang, Yue Chen & Mingyu Sun. (2022) Umbelliferone protects against methylglyoxal‐induced HUVECs dysfunction through suppression of apoptosis and oxidative stress. Journal of Applied Toxicology 43:4, pages 490-499.
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Yi Cheng, Xin-Ming Yao, Si-Min Zhou, Yue Sun, Xiang-Jian Meng, Yong Wang, Yu-Jie Xing, Shu-Jun Wan & Qiang Hua. (2022) The m6A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic β Cells by Regulating MafA Expression. Frontiers in Endocrinology 13.
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Alessandro de Souza Prestes, Matheus Mülling dos Santos, Jean Paul Kamdem, Gianni Mancini, Luana Caroline Schüler da Silva, Andreza Fabro de Bem & Nilda Vargas Barbosa. (2022) Methylglyoxal disrupts the functionality of rat liver mitochondria. Chemico-Biological Interactions 351, pages 109677.
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Su-Ping Ng, Wataru Nomura, Haruya Takahashi, Kazuo Inoue, Teruo Kawada & Tsuyoshi Goto. (2021) Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes. Biochemistry and Biophysics Reports 28, pages 101127.
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Vanesa Cepas, Friederike Manig, Juan C. Mayo, Michael Hellwig, Debora Collotta, Valentina Sanmartino, Rebeca Carrocera-Pumarino, Massimo Collino, Thomas Henle & Rosa M. Sainz. (2021) In Vitro Evaluation of the Toxicological Profile and Oxidative Stress of Relevant Diet-Related Advanced Glycation End Products and Related 1,2-Dicarbonyls. Oxidative Medicine and Cellular Longevity 2021, pages 1-20.
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Ayse Basak Engin & Atilla Engin. 2021. Protein Kinase-mediated Decisions Between Life and Death. Protein Kinase-mediated Decisions Between Life and Death 195 227 .
Hyun-jung Yoo, Chung-Oui Hong, Sang Keun Ha & Kwang-Won Lee. (2020) Chebulic Acid Prevents Methylglyoxal-Induced Mitochondrial Dysfunction in INS-1 Pancreatic β-Cells. Antioxidants 9:9, pages 771.
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Tanyawan Suantawee, Thavaree Thilavech, Henrique Cheng & Sirichai Adisakwattana. (2020) Cyanidin Attenuates Methylglyoxal-Induced Oxidative Stress and Apoptosis in INS-1 Pancreatic β-Cells by Increasing Glyoxalase-1 Activity. Nutrients 12:5, pages 1319.
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Chongxiao Liu, Baige Cao, Qianren Zhang, Yifan Zhang, Xueru Chen, Xiang Kong & Yan Dong. (2020) Inhibition of thioredoxin 2 by intracellular methylglyoxal accumulation leads to mitochondrial dysfunction and apoptosis in INS-1 cells. Endocrine 68:1, pages 103-115.
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C. G. Schalkwijk & C. D. A. Stehouwer. (2020) Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases. Physiological Reviews 100:1, pages 407-461.
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Xiang Kong, Chong-xiao Liu, Guo-dong Wang, Hui Yang, Xin-ming Yao, Qiang Hua, Xiao-yong Li, Hong-mei Zhang, Ming-zhe Ma, Qing Su & Kun Lv. (2019) LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis. Oxidative Medicine and Cellular Longevity 2019, pages 1-16.
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Petr JežekMartin JabůrekLydie Plecitá-Hlavatá. (2019) Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes. Antioxidants & Redox Signaling 31:10, pages 722-751.
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Meenakshi Ravichandran, Steffen Priebe, Giovanna Grigolon, Leonid Rozanov, Marco Groth, Beate Laube, Reinhard Guthke, Matthias Platzer, Kim Zarse & Michael Ristow. (2018) Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis. Cell Metabolism 27:4, pages 914-925.e5.
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