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Original Article

Lipofuscin-mediated photic stress inhibits phagocytic activity of ARPE-19 cells; effect of donors’ age and antioxidants

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Pages 799-811 | Received 14 Jul 2017, Accepted 12 Sep 2017, Published online: 03 Oct 2017

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Magdalena Olchawa, Olga Krzysztynska-Kuleta, Mariusz Duda, Anna Pawlak, Pawel Pabisz, Barbara Czuba-Pelech & Tadeusz Sarna. (2019) In vitro phototoxicity of rhodopsin photobleaching products in the retinal pigment epithelium (RPE). Free Radical Research 53:4, pages 456-471.
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Articles from other publishers (17)

Zhibo Si, Yajuan Zheng & Jing Zhao. (2023) The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy. Biomolecules 13:6, pages 901.
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Alexey N. Semenov, Eugene G. Maksimov, Anastasia M. Moysenovich, Marina A. Yakovleva, Georgy V. Tsoraev, Alla A. Ramonova, Evgeny A. Shirshin, Nikolai N. Sluchanko, Tatiana B. Feldman, Andrew B. Rubin, Mikhail P. Kirpichnikov & Mikhail A. Ostrovsky. (2023) Protein-Mediated Carotenoid Delivery Suppresses the Photoinducible Oxidation of Lipofuscin in Retinal Pigment Epithelial Cells. Antioxidants 12:2, pages 413.
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Josephine H. C. Wong, Jessica Y. W. Ma, Andrew I. Jobling, Alice Brandli, Ursula Greferath, Erica L. Fletcher & Kirstan A. Vessey. (2022) Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune system. Frontiers in Neuroscience 16.
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Tatiana Feldman, Dmitriy Ostrovskiy, Marina Yakovleva, Alexander Dontsov, Sergey Borzenok & Mikhail Ostrovsky. (2022) Lipofuscin-Mediated Photic Stress Induces a Dark Toxic Effect on ARPE-19 Cells. International Journal of Molecular Sciences 23:20, pages 12234.
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Magdalena M. Olchawa, Anja M. Herrnreiter, Christine M.B. Skumatz, Olga I. Krzysztynska‐Kuleta, Krystian T. Mokrzynski, Janice M. Burke & Tadeusz J. Sarna. (2022) The Inhibitory Effect of Blue Light on Phagocytic Activity by ARPE‐19 Cells. Photochemistry and Photobiology 98:5, pages 1110-1121.
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Małgorzata B. Różanowska, Barbara Czuba-Pełech & Bartosz Różanowski. (2022) Is There an Optimal Combination of AREDS2 Antioxidants Zeaxanthin, Vitamin E and Vitamin C on Light-Induced Toxicity of Vitamin A Aldehyde to the Retina?. Antioxidants 11:6, pages 1132.
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Małgorzata B. Różanowska & Bartosz Różanowski. (2022) Photodegradation of Lipofuscin in Suspension and in ARPE-19 Cells and the Similarity of Fluorescence of the Photodegradation Product with Oxidized Docosahexaenoate. International Journal of Molecular Sciences 23:2, pages 922.
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Magdalena M. Olchawa, Grzegorz M. Szewczyk, Andrzej C. Zadlo, Olga I. Krzysztynska‐Kuleta & Tadeusz J. Sarna. (2020) The effect of aging and antioxidants on photoreactivity and phototoxicity of human melanosomes: An in vitro study. Pigment Cell & Melanoma Research 34:4, pages 670-682.
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Małgorzata B. Różanowska, Barbara Czuba-Pelech, John T. Landrum & Bartosz Różanowski. (2021) Comparison of Antioxidant Properties of Dehydrolutein with Lutein and Zeaxanthin, and their Effects on Cultured Retinal Pigment Epithelial Cells. Antioxidants 10:5, pages 753.
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Sayena Jabbehdari & James T. Handa. (2021) Oxidative stress as a therapeutic target for the prevention and treatment of early age-related macular degeneration. Survey of Ophthalmology 66:3, pages 423-440.
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Justyna Furso, Andrzej Zadlo, Grzegorz Szewczyk & Tadeusz J. Sarna. (2020) Photoreactivity of Bis-retinoid A2E Complexed with a Model Protein in Selected Model Systems. Cell Biochemistry and Biophysics 78:4, pages 415-427.
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Magdalena M. Olchawa, Grzegorz M. Szewczyk, Andrzej C. Zadlo, Michal W. Sarna, Dawid Wnuk & Tadeusz J. Sarna. (2020) The Effect of Antioxidants on Photoreactivity and Phototoxic Potential of RPE Melanolipofuscin Granules from Human Donors of Different Age. Antioxidants 9:11, pages 1044.
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Camille Keisha Mahendra, Loh Teng Hern Tan, Priyia Pusparajah, Thet Thet Htar, Lay-Hong Chuah, Vannajan Sanghiran Lee, Liang Ee Low, Siah Ying Tang, Kok-Gan Chan & Bey Hing Goh. (2020) Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity 2020, pages 1-29.
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Magdalena M. Olchawa, Olga I. Krzysztynska-Kuleta, Krystian T. Mokrzynski, Piotr M. Sarna & Tadeusz J. Sarna. (2020) Quercetin protects ARPE-19 cells against photic stress mediated by the products of rhodopsin photobleaching. Photochemical & Photobiological Sciences 19:8, pages 1022-1034.
Crossref
Samuel Abokyi, Chi-Ho To, Tim T. Lam & Dennis Y. Tse. (2020) Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models. Oxidative Medicine and Cellular Longevity 2020, pages 1-19.
Crossref
Anna M. Pawlak, Magdalena Olchawa, Anna Koscielniak, Andrzej Zadlo, Agnieszka Broniec, Tomasz Oles & Tadeusz J. Sarna. (2019) Oxidized Lipids Decrease Phagocytic Activity of ARPE‐19 Cells In Vitro. European Journal of Lipid Science and Technology 121:9, pages 1800476.
Crossref
Anna Wiktor, Michal Sarna, Dawid Wnuk & Tadeusz Sarna. (2018) Lipofuscin-mediated photodynamic stress induces adverse changes in nanomechanical properties of retinal pigment epithelium cells. Scientific Reports 8:1.
Crossref

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