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Free Radical Research Volume 54, 2020 - Issue 11-12: SFRR ASIA 2019. Guest Editors: Shinya Toyokuni, Yuji Naito, Koji Uchida
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Ferroptosis caused by cysteine insufficiency and oxidative insult

Junichi FujiiDepartment of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata City, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2267-7357View further author information
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Takujiro HommaDepartment of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata City, JapanORCID Iconhttps://orcid.org/0000-0003-3886-7411View further author information
ORCID Icon &
Sho KobayashiDepartment of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata City, JapanORCID Iconhttps://orcid.org/0000-0002-3697-3512View further author information
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Pages 969-980 | Received 15 Aug 2019, Accepted 05 Sep 2019, Published online: 23 Sep 2019

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Junichi Fujii & Ken-ichi Yamada. (2023) Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage. Free Radical Research 57:5, pages 353-372.
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Yuji Naito, Koji Uchida & Shinya Toyokuni. (2020) The new era for redox research. Free Radical Research 54:11-12, pages 787-789.
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Lei Yang, Yu Fan & Qian Zhang. (2023) Targeting ferroptosis in renal cell carcinoma: Potential mechanisms and novel therapeutics. Heliyon 9:8, pages e18504.
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JingRuo Zhang, Wa Cai, Xifang Wei, Yanbo Shi, Kun Zhang, Chen Hu, Jie Wan, Kaitao Luo & Weidong Shen. (2023) Moxibustion ameliorates cerebral ischemia–reperfusion injury by regulating ferroptosis in rats. Clinical and Experimental Pharmacology and Physiology.
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Yi Li, Zhongmin Fan, Qi Jia, Hongwei Ma, You Wu, Xiaofeng Guo, Lixia Du, Xi Wang, Wugang Hou, Zongping Fang & Xijing Zhang. (2023) Chaperone-mediated autophagy (CMA) alleviates cognitive impairment by reducing neuronal death in sepsis-associated encephalopathy (SAE). Experimental Neurology 365, pages 114417.
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Xuan Zou, Chang Liu, Zuotian Huang, Song Xiang, Kaili Li, Yuan Yuan, Yingting Hao & Fachun Zhou. (2023) Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells. Molecular Biology Reports 50:7, pages 5667-5674.
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Hang Wu, Dongmei Li, Te Zhang & Guoqing Zhao. (2023) Novel Mechanisms of Perioperative Neurocognitive Disorders: Ferroptosis and Pyroptosis. Neurochemical Research.
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Jun Guo, Qing‐zhang Tuo & Peng Lei. (2023) Iron, ferroptosis, and ischemic stroke. Journal of Neurochemistry 165:4, pages 487-520.
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Junichi Fujii, Tsukasa Osaki, Yuya Soma & Yumi Matsuda. (2023) Critical Roles of the Cysteine–Glutathione Axis in the Production of γ-Glutamyl Peptides in the Nervous System. International Journal of Molecular Sciences 24:9, pages 8044.
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Yurong Zhang, Dianlun Qian, Xiangfeng Bai & Shibo Sun. (2023) Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases. Cellular Microbiology 2023, pages 1-14.
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Sarah Barker, Bindu D. Paul & Andrew A. Pieper. (2023) Increased Risk of Aging-Related Neurodegenerative Disease after Traumatic Brain Injury. Biomedicines 11:4, pages 1154.
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Pavan S. Upadhyayula, Dominique M. Higgins, Angeliki Mela, Matei Banu, Athanassios Dovas, Fereshteh Zandkarimi, Purvi Patel, Aayushi Mahajan, Nelson Humala, Trang T. T. Nguyen, Kunal R. Chaudhary, Lillian Liao, Michael Argenziano, Tejaswi Sudhakar, Colin P. Sperring, Benjamin L. Shapiro, Eman R. Ahmed, Connor Kinslow, Ling F. Ye, Markus D. Siegelin, Simon Cheng, Rajesh Soni, Jeffrey N. Bruce, Brent R. Stockwell & Peter Canoll. (2023) Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism. Nature Communications 14:1.
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Yuan Cao, Wenbiao Xiao, Shuzhen Liu & Yi Zeng. (2023) Ferroptosis: Underlying mechanism and the crosstalk with other modes of neuronal death after intracerebral hemorrhage. Frontiers in Cellular Neuroscience 17.
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Jin-Young Min, Kyung-Soo Chun & Do-Hee Kim. (2023) The versatile utility of cysteine as a target for cancer treatment. Frontiers in Oncology 12.
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Gang Wang, Jun-Jie Wang, Zhu Zhi-Min, Xiao-Na Xu, Feng Shi & Xing-Li Fu. (2023) Targeting critical pathways in ferroptosis and enhancing antitumor therapy of Platinum drugs for colorectal cancer. Science Progress 106:1, pages 003685042211471.
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Junichi Fujii. 2023. Ferroptosis in Health and Disease. Ferroptosis in Health and Disease 195 212 .
Huan Yang, Xuemei Zhang, Yubin Ding, Hui Xiong, Shaojian Xiang, Yang Wang, Huanhuan Li, Zheng Liu, Jie He, Yuelan Tao, Hongbing Yang & Hongbo Qi. (2022) Elabela: Negative Regulation of Ferroptosis in Trophoblasts via the Ferritinophagy Pathway Implicated in the Pathogenesis of Preeclampsia. Cells 12:1, pages 99.
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Fei Wang, Lianxia Guo, Zhengping Wu, Tianpeng Zhang, Dong Dong & Baojian Wu. (2022) The Clock gene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice . Journal of Pharmacy and Pharmacology 74:11, pages 1640-1650.
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Takujiro Homma, Yuki Nishino, Junichi Fujii & Chikako Yokoyama. (2022) Flow cytometric determination of ferroptosis using a rat monoclonal antibody raised against ferroptotic cells. Journal of Immunological Methods 510, pages 113358.
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Xiaoming Wang, Yilan Wang, Demei Huang, Shihua Shi, Caixia Pei, Yongcan Wu, Zherui Shen, Fei Wang & Zhenxing Wang. (2022) Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2/SLC7A11/GPX4 axis to inhibit PM2.5-mediated lung injury in mice. International Immunopharmacology 112, pages 109186.
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Komal Thapa, Thakur Gurjeet Singh & Amarjot Kaur. (2022) Targeting ferroptosis in ischemia/reperfusion renal injury. Naunyn-Schmiedeberg's Archives of Pharmacology 395:11, pages 1331-1341.
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Lena Johannes, Chun-Yu Fu & Günter Schwarz. (2022) Molybdenum Cofactor Deficiency in Humans. Molecules 27:20, pages 6896.
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Yanhong Song, Ziyi Wu, Hang Xue & Ping Zhao. (2022) Ferroptosis is involved in regulating perioperative neurocognitive disorders: emerging perspectives. Journal of Neuroinflammation 19:1.
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Yunhan Wang, Zongying Zhang, Weichen Sun, Jie Zhang, Qiuyun Xu, Xiaorong Zhou & Liming Mao. (2022) Ferroptosis in colorectal cancer: Potential mechanisms and effective therapeutic targets. Biomedicine & Pharmacotherapy 153, pages 113524.
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Jacinta Serpa. (2022) The putative role of gut microbiota in cancer: Cysteine is a pivotal coin. Frontiers in Gastroenterology 1.
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Takujiro Homma, Sho Kobayashi & Junichi Fujii. (2022) Methionine Deprivation Reveals the Pivotal Roles of Cell Cycle Progression in Ferroptosis That Is Induced by Cysteine Starvation. Cells 11:10, pages 1603.
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Junichi Fujii, Takujiro Homma & Tsukasa Osaki. (2022) Superoxide Radicals in the Execution of Cell Death. Antioxidants 11:3, pages 501.
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Deng Guan, Wei Zhou, Huiping Wei, Ting Wang, Kangwei Zheng, Chunjie Yang, Rui Feng, Ruifang Xu, Yun Fu, Cuiping Li, Yongli Li & Changzheng Li. (2022) Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2 -Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester . Oxidative Medicine and Cellular Longevity 2022, pages 1-15.
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Takujiro Homma, Tsukasa Osaki, Sho Kobayashi, Hideyo Sato & Junichi Fujii. (2022) D-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione. Journal of Clinical Biochemistry and Nutrition 71:1, pages 48-54.
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Qing‐zhang Tuo, Shu‐ting Zhang & Peng Lei. (2021) Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications. Medicinal Research Reviews 42:1, pages 259-305.
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Jing-yan Li, Shuang-qing Liu, Ren-qi Yao, Ying-ping Tian & Yong-ming Yao. (2021) A Novel Insight Into the Fate of Cardiomyocytes in Ischemia-Reperfusion Injury: From Iron Metabolism to Ferroptosis. Frontiers in Cell and Developmental Biology 9.
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Li Liu, Liqi Li, Menghuan Li & Zhong Luo. (2021) Autophagy‐Dependent Ferroptosis as a Therapeutic Target in Cancer. ChemMedChem 16:19, pages 2942-2950.
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Li Meihe, Gao Shan, Kang Minchao, Wu Xiaoling, An Peng, Wu Xili, Zheng Jin & Dang Huimin. (2021) The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy. Frontiers in Cell and Developmental Biology 9.
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Takujiro Homma, Sho Kobayashi, Hideyo Sato & Junichi Fujii. (2021) Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation. Archives of Biochemistry and Biophysics 700, pages 108775.
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Lin Liu, Rui Liu, Yi Liu, Guanghui Li, Qing Chen, Xiaodong Liu & Shumei Ma. (2020) Cystine‐glutamate antiporter xCT as a therapeutic target for cancer . Cell Biochemistry and Function 39:2, pages 174-179.
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Sho Kobayashi, Yumi Harada, Takujiro Homma, Chikako Yokoyama & Junichi Fujii. (2021) Characterization of a rat monoclonal antibody raised against ferroptotic cells. Journal of Immunological Methods 489, pages 112912.
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Shreyas Gaikwad & Sanjay K. Srivastava. (2021) Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer. Antioxidants 10:1, pages 83.
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Jian-Shu Lou, Li-Ping Zhao, Zhi-Hui Huang, Xia-Yin Chen, Jing-Ting Xu, William Chi-Shing TAI, Karl W.K. Tsim, Yi-Tao Chen & Tian Xie. (2021) Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer. Phytomedicine 80, pages 153370.
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Jun Yu & Jian-qing Wang. (2021) Research mechanisms of and pharmaceutical treatments for ferroptosis in liver diseases. Biochimie 180, pages 149-157.
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Junhong Zhang, Ni Wang, Yuanyuan Zhou, Kaili Wang, Yaxin Sun, Hao Yan, Wenchao Han, Xinying Wang, Bo Wei, Yu Ke & Xia Xu. (2020) Oridonin induces ferroptosis by inhibiting gamma‐glutamyl cycle in TE1 cells . Phytotherapy Research 35:1, pages 494-503.
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Sheng-Yu Zhou, Guo-Zhen Cui, Xiu-Li Yan, Xu Wang, Yang Qu, Zhen-Ni Guo & Hang Jin. (2020) Mechanism of Ferroptosis and Its Relationships With Other Types of Programmed Cell Death: Insights for Potential Interventions After Intracerebral Hemorrhage. Frontiers in Neuroscience 14.
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Yuehong Wang, Ruihuan Yu, Lingyun Wu & Guangdong Yang. (2020) Hydrogen sulfide signaling in regulation of cell behaviors. Nitric Oxide 103, pages 9-19.
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Jacinta Serpa. (2020) Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival. Frontiers in Oncology 10.
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Liang Chen, Linlin Qiao, Yue Bian & Xiuju Sun. (2020) GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression. Biochemical and Biophysical Research Communications 526:2, pages 293-299.
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Sho Kobayashi, Yoshitaka Ikeda, Yuhei Shigeno, Hiroyuki Konno & Junichi Fujii. (2020) γ-Glutamylcysteine synthetase and γ-glutamyl transferase as differential enzymatic sources of γ-glutamylpeptides in mice. Amino Acids 52:4, pages 555-566.
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Xiaomim Wang, Yilan Wang, Demei Huang, Shihua Shi, Caixia Pei, Yoncgan Wu, Zherui Shen, Fei Wang & Zhenxing Wang. (2021) Astragaloside IV Regulates the Ferroptosis Signaling Pathway via the Nrf2/SLC7A11/GPX4 Axis to Inhibit PM2.5-Mediated Acute Lung Injury in Mice. SSRN Electronic Journal.
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