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Free Radical Research Volume 54, 2020 - Issue 11-12: SFRR ASIA 2019. Guest Editors: Shinya Toyokuni, Yuji Naito, Koji Uchida
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Original Articles

Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line

Daisuke Yasudaa Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, JapanView further author information
,
Tomoyuki Ohea Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0002-0931-1708View further author information
ORCID Icon,
Kyoko Takahashia Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, JapanView further author information
,
Riyo Imamurab Drug Discovery Initiative, University of Tokyo, Tokyo, JapanView further author information
,
Hirotatsu Kojimab Drug Discovery Initiative, University of Tokyo, Tokyo, JapanView further author information
,
Takayoshi Okabeb Drug Discovery Initiative, University of Tokyo, Tokyo, JapanView further author information
,
Yoshinobu Ichimurac Department of Physiology, Juntendo University School of Medicine, Tokyo, JapanView further author information
,
Masaaki Komatsuc Department of Physiology, Juntendo University School of Medicine, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0001-7672-7722View further author information
ORCID Icon,
Masayuki Yamamotod Department of Medical Biochemistry, Tohoku University School of Medicine, Sendai-shi, JapanView further author information
,
Tetsuo Naganob Drug Discovery Initiative, University of Tokyo, Tokyo, JapanView further author information
&
Tadahiko Mashinoa Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, JapanCorrespondence[email protected]
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Pages 859-871 | Received 23 Aug 2019, Accepted 27 Jan 2020, Published online: 30 Mar 2020

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Yuji Naito, Koji Uchida & Shinya Toyokuni. (2020) The new era for redox research. Free Radical Research 54:11-12, pages 787-789.
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Jinqiu Li, Xueshibojie Liu, Shanji Nan & Chengbi Xu. (2020) Silencing of long non-coding RNA LINC00520 promotes radiosensitivity of head and neck squamous cell carcinoma cells. Free Radical Research 54:4, pages 254-270.
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Articles from other publishers (20)

Yawen Li, Halahati Tuerxun, Xingyu Liu, Yixin Zhao, Shuhui Wen, Yaping Li, Jingjing Cao & Yuguang Zhao. (2023) Nrf2--a hidden bridge linking cancer stem cells to ferroptosis. Critical Reviews in Oncology/Hematology 190, pages 104105.
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An-bo Fu, Sen-feng Xiang, Qiao-jun He & Mei-dan Ying. (2022) Kelch-like proteins in the gastrointestinal tumors. Acta Pharmacologica Sinica 44:5, pages 931-939.
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Cai-Yu Lian, Bing-Xin Chu, Wei-Hao Xia, Zhen-Yong Wang, Rui-Feng Fan & Lin Wang. (2023) Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy. Journal of Advanced Research 46, pages 87-100.
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Chong Teik Tan, Natalie Jun Hui Soh, Hao‐Chun Chang & Victor C. Yu. (2021) p62/SQSTM1 in liver diseases: the usual suspect with multifarious identities. The FEBS Journal 290:4, pages 892-912.
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Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López & Rafael León. (2022) KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential. Medicinal Research Reviews 43:1, pages 237-287.
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Qing Wu, Wei Qian, Xiaoli Sun & Shaojie Jiang. (2022) Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021. Journal of Hematology & Oncology 15:1.
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Mario Angelo Pagano, Federica Frezzato, Andrea Visentin, Livio Trentin & Anna Maria Brunati. (2022) Protein Phosphorylation and Redox Status: An as Yet Elusive Dyad in Chronic Lymphocytic Leukemia. Cancers 14:19, pages 4881.
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Daisuke Yasuda, Ippei Yoshida, Riyo Imamura, Daiki Katagishi, Kyoko Takahashi, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Tadahiko Mashino & Tomoyuki Ohe. (2022) Development of p62-Keap1 protein–protein interaction inhibitors as doxorubicin-sensitizers against non-small cell lung cancer. Results in Chemistry 4, pages 100609.
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Sandra Mattu, Patrizia Zavattari, Marta Anna Kowalik, Marina Serra, Pia Sulas, Rajesh Pal, Elisabetta Puliga, Salvatore Sutti, Beatrice Foglia, Maurizio Parola, Emanuele Albano, Silvia Giordano, Andrea Perra & Amedeo Columbano. (2022) Nrf2 Mutation/Activation Is Dispensable for the Development of Chemically Induced Mouse HCC. Cellular and Molecular Gastroenterology and Hepatology 13:1, pages 113-127.
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Rui-Feng Fan, Kou-Kou Tang, Zhen-Yong Wang & Lin Wang. (2021) Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury. Toxicology 464, pages 152999.
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Chorlada Paiboonrungruang, Emily Simpson, Zhaohui Xiong, Caizhi Huang, Jianying Li, Yahui Li & Xiaoxin Chen. (2021) Development of targeted therapy of NRF2high esophageal squamous cell carcinoma. Cellular Signalling 86, pages 110105.
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Lei Zhou, Ken HO Yu, Tin Lok Wong, Zhao Zhang, Chun Ho Chan, Jane HC Loong, Noelia Che, Hua Jian Yu, Kel Vin Tan, Man Tong, Elly S Ngan, Joshua WK Ho & Stephanie Ma. (2021) Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression. Gut, pages gutjnl-2021-324321.
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Emiliano PanieriLuciano Saso. (2021) Inhibition of the NRF2/KEAP1 Axis: A Promising Therapeutic Strategy to Alter Redox Balance of Cancer Cells. Antioxidants & Redox Signaling 34:18, pages 1428-1483.
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Bo-Hyun Choi, Jin Myung Kim & Mi-Kyoung Kwak. (2021) The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance. Archives of Pharmacal Research 44:3, pages 263-280.
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Keiko Taguchi & Masayuki Yamamoto. (2020) The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment. Cancers 13:1, pages 46.
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Adriana Celesia, Ornella Morana, Tiziana Fiore, Claudia Pellerito, Antonella D’Anneo, Marianna Lauricella, Daniela Carlisi, Anna De Blasio, Giuseppe Calvaruso, Michela Giuliano & Sonia Emanuele. (2020) ROS-Dependent ER Stress and Autophagy Mediate the Anti-Tumor Effects of Tributyltin (IV) Ferulate in Colon Cancer Cells. International Journal of Molecular Sciences 21:21, pages 8135.
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Claudia Orrù, Silvia Giordano & Amedeo Columbano. (2020) Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases. Cancers 12:10, pages 2932.
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Ying Chen, Qi Li, Qihang Li, Shuaishuai Xing, Yang Liu, Yijun Liu, Yao Chen, Wenyuan Liu, Feng Feng & Haopeng Sun. (2020) p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. Journal of Medicinal Chemistry 63:18, pages 10135-10157.
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Zhao-Shan Niu, Wen-Hong Wang, Xian-Ning Dong & Li-Mei-Li Tian. (2020) Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma. World Journal of Gastroenterology 26:29, pages 4240-4260.
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Sonia Emanuele, Marianna Lauricella, Antonella D’Anneo, Daniela Carlisi, Anna De Blasio, Diana Di Liberto & Michela Giuliano. (2020) p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus Roles. International Journal of Molecular Sciences 21:14, pages 5029.
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