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Free Radical Research Volume 55, 2021 - Issue 4: Special issue on "Recent topics of redox chemistry and biology". Guest editors: Etsuo Niki and Koji Uchida
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Review Articles

Understanding the antioxidant and carbonyl sequestering activity of carnosine: direct and indirect mechanisms

Giancarlo Aldinia Department of Pharmaceutical Sciences, University of Milan, Milan, ItalyCorrespondence[email protected]
,
Barbora de Courtenb Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia
,
Luca Regazzonia Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
,
Ettore Gilardonia Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
,
Giulio Ferrarioa Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
,
Giovanna Barona Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
,
Alessandra Altomarea Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
,
Alfonsina D’Amatoa Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
,
Giulio Vistolia Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
&
Marina Carinia Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
 show all
Pages 321-330 | Received 21 Sep 2020, Accepted 23 Nov 2020, Published online: 11 Dec 2020

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Kaiyan Yue, Bingyong Mao, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Shumao Cui & Wei Chen. (2023) Recent updates in anti-glycation strategies: selection of natural products and lactic acid bacteria as potential inhibitors based on the multi-pathway anti-glycation targets. Critical Reviews in Food Science and Nutrition 0:0, pages 1-18.
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Etsuo Niki & Koji Uchida. (2021) Special issue on “recent topics of redox chemistry and biology”. Free Radical Research 55:4, pages 305-306.
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Articles from other publishers (22)

Yang Liu, Lu Lu, Shaofeng Yuan, Yahui Guo, Weirong Yao, Weibiao Zhou & Hang Yu. (2023) Formation of advanced glycation end-products and α-dicarbonyl compounds through Maillard reaction: Solutions from natural polyphenols. Journal of Food Composition and Analysis 120, pages 105350.
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Ondrej Cesak, Jitka Vostalova, Ales Vidlar, Petra Bastlova & Vladimir StudentJr.Jr.. (2023) Carnosine and Beta-Alanine Supplementation in Human Medicine: Narrative Review and Critical Assessment. Nutrients 15:7, pages 1770.
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Chiara Abate, Anna Piperno, Alex Fragoso, Ottavia Giuffrè, Antonino Mazzaglia, Angela Scala & Claudia Foti. (2023) Thermodynamic and voltammetric study on carnosine and ferrocenyl-carnosine. Dalton Transactions 52:12, pages 3699-3708.
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Giuseppe Caruso, Lucia Di Pietro & Filippo Caraci. (2023) Gap Junctions and Connexins in Microglia-Related Oxidative Stress and Neuroinflammation: Perspectives for Drug Discovery. Biomolecules 13:3, pages 505.
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Wei Jia, Aiai Guo, Rong Zhang & Lin Shi. (2023) Mechanism of natural antioxidants regulating advanced glycosylation end products of Maillard reaction. Food Chemistry 404, pages 134541.
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Joseph J. Matthews, Mark D. Turner, Livia Santos, Kirsty J. Elliott-Sale & Craig Sale. (2023) Carnosine increases insulin-stimulated glucose uptake and reduces methylglyoxal-modified proteins in type-2 diabetic human skeletal muscle cells. Amino Acids 55:3, pages 413-420.
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Pengfei Yang, Fenfen Deng, Mengdi Yuan, Meng Chen, Li Zeng, Yanan Ouyang, Xiangbo Chen, Bin Zhao, Zhe Yang & Zhongmin Tian. (2023) Metabolomics reveals the defense mechanism of histidine supplementation on high-salt exposure-induced hepatic oxidative stress. Life Sciences 314, pages 121355.
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Giuseppe Caruso, Lucia Di Pietro, Vincenzo Cardaci, Salvatore Maugeri & Filippo Caraci. (2023) The therapeutic potential of carnosine: Focus on cellular and molecular mechanisms. Current Research in Pharmacology and Drug Discovery 4, pages 100153.
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Charlotte Wetzel, Tilman Pfeffer, Ruben Bulkescher, Johanna Zemva, Sergio Modafferi, Alessandra Polimeni, Angela Trovato Salinaro, Vittorio Calabrese, Claus Peter Schmitt & Verena Peters. (2022) Anserine and Carnosine Induce HSP70-Dependent H2S Formation in Endothelial Cells and Murine Kidney. Antioxidants 12:1, pages 66.
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Qiang Wang, Xiaofeng Xiang, Yuejie Xie, Kai Wang, Cao Wang, Xuyuan Nie & Puzhi Wang. (2022) Maillard reaction between oligopeptides and reducing sugar at body temperature: The putative anti-glycation agents. Frontiers in Nutrition 9.
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Solène Bardin, Michele Lecis, Davide Boido, Céline Boutin, Giovanna Baron, Giancarlo Aldini, Patrick Berthault, Fawzi Boumezbeur & Luisa Ciobanu. (2022) In vivo detection of carnosine and its derivatives using chemical exchange saturation transfer. Magnetic Resonance in Medicine 88:3, pages 1314-1323.
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Giuseppe Caruso, Anna Privitera, Barbara Moura Antunes, Giuseppe Lazzarino, Susan Marie Lunte, Giancarlo Aldini & Filippo Caraci. (2022) The Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway. Molecules 27:14, pages 4452.
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Angelica Rodriguez-Niño, Diego O. Pastene, Steffen A. Hettler, Jiedong Qiu, Thomas Albrecht, Srishti Vajpayee, Rossana Perciaccante, Norbert Gretz, Stephan J. L. Bakker, Bernhard K. Krämer, Benito A. Yard & Jacob van den Born. (2022) Influence of carnosine and carnosinase-1 on diabetes-induced afferent arteriole vasodilation: implications for glomerular hemodynamics. American Journal of Physiology-Renal Physiology 323:1, pages F69-F80.
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Giuseppe Caruso. (2022) Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper. Molecules 27:10, pages 3303.
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Cristina Solana-Manrique, Francisco José Sanz, Guillermo Martínez-Carrión & Nuria Paricio. (2022) Antioxidant and Neuroprotective Effects of Carnosine: Therapeutic Implications in Neurodegenerative Diseases. Antioxidants 11:5, pages 848.
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Luca Regazzoni, Laura Fumagalli, Angelica Artasensi, Silvia Gervasoni, Ettore Gilardoni, Angelica Mazzolari, Giancarlo Aldini & Giulio Vistoli. (2022) Cyclo(His-Pro) Exerts Protective Carbonyl Quenching Effects through Its Open Histidine Containing Dipeptides. Nutrients 14:9, pages 1775.
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Hélène Zucchi, Hervé Pageon, Daniel Asselineau, Marion Ghibaudo, Inês Sequeira & Sarah Girardeau-Hubert. (2022) Assessing the Role of Carbonyl Adducts, Particularly Malondialdehyde Adducts, in the Development of Dermis Yellowing Occurring during Skin Photoaging. Life 12:3, pages 403.
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Tapan Behl, Amit Gupta, Sridevi Chigurupati, Sukhbir Singh, Aayush Sehgal, Vishnu Nayak Badavath, Ahmad Alhowail, Vasudevan Mani, Saurabh Bhatia, Ahmed Al-Harrasi & Simona Bungau. (2022) Natural and Synthetic Agents Targeting Reactive Carbonyl Species against Metabolic Syndrome. Molecules 27:5, pages 1583.
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Gilda Aiello, Francesca Rescigno, Marisa Meloni, Giovanna Baron, Giancarlo Aldini, Marina Carini & Alfonsina D’Amato. (2022) Oxidative Stress Modulation by Carnosine in Scaffold Free Human Dermis Spheroids Model: A Proteomic Study. International Journal of Molecular Sciences 23:3, pages 1468.
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Rachel A. Crawford, Ettore Gilardoni, T. Blake Monroe, Luca Regazzoni, Ethan J. Anderson & Jonathan A. Doorn. (2021) Characterization of Catecholaldehyde Adducts with Carnosine and l -Cysteine Reveals Their Potential as Biomarkers of Catecholaminergic Stress . Chemical Research in Toxicology 34:10, pages 2184-2193.
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Qinghe Song, Junjun Liu, Liyuan Dong, Xiaolei Wang & Xiandang Zhang. (2021) Novel advances in inhibiting advanced glycation end product formation using natural compounds. Biomedicine & Pharmacotherapy 140, pages 111750.
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Jack Feehan, Maximilian de Courten, Vasso Apostolopoulos & Barbora de Courten. (2021) Nutritional Interventions for COVID-19: A Role for Carnosine?. Nutrients 13:5, pages 1463.
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