Advanced search
Publication Cover
Free Radical Research Volume 55, 2021 - Issue 4: Special issue on "Recent topics of redox chemistry and biology". Guest editors: Etsuo Niki and Koji Uchida
Submit an article Journal homepage
2,037
Views
55
CrossRef citations to date
0
Altmetric
Review Articles

Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation

Xin Chena CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaView further author information
,
Xuan Lib Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaView further author information
,
Xiaodong Xua CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaView further author information
,
Luxiao Lia CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaView further author information
,
Ningning Lianga CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaView further author information
,
Lili Zhanga CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaView further author information
,
Jingwen Lva CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, ChinaView further author information
,
Yun-Cheng Wuc School of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaView further author information
&
Huiyong Yina CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China;c School of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaCorrespondence[email protected]
View further author information
 show all
Pages 405-415 | Received 28 Nov 2020, Accepted 07 Jan 2021, Published online: 27 Jan 2021

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Salim Lounansa, Hacene Ameddah, Hammoudi Mazouz & Ebrahim Ahmed Ali Alkebsi. (2022) Computational analysis of designing an improved coronary stents of biodegradable Poly-lactic Acid (PLA). Australian Journal of Mechanical Engineering 0:0, pages 1-10.
Read now
Etsuo Niki & Koji Uchida. (2021) Special issue on “recent topics of redox chemistry and biology”. Free Radical Research 55:4, pages 305-306.
Read now

Articles from other publishers (53)

Xiong Piao, Lie Ma, Qinqi Xu, Xiaomin Zhang & Chengzhu Jin. (2023) Noncoding RNAs: Versatile regulators of endothelial dysfunction. Life Sciences 334, pages 122246.
Crossref
Yuqian Mo, Zhilin Zou & Erbao Chen. (2023) Targeting ferroptosis in hepatocellular carcinoma. Hepatology International.
Crossref
Yu Wang, Junjie Yang, Jieru Lu, Qingjie Wang, Jian Wang, Jianyuan Zhao, Yuqiang Huang & Kun Sun. (2023) Novel hub genes and regulatory network related to ferroptosis in tetralogy of Fallot. Frontiers in Pediatrics 11.
Crossref
Ruo-qi Feng, Ming-yue Xu, Rui-ying Feng, Lei Zhang, Xiao-fei Yin, Chuan Wang & Jin-bo Liu. (2023) Serum Isthmin-1 is negatively correlated with HDL-C in type 2 diabetes mellitus. Journal of Diabetes and its Complications 37:10, pages 108567.
Crossref
Ze-Fan Wu, Xi-Yan Liu, Nian-Hua Deng, Zhong Ren & Zhi-Sheng Jiang. (2023) Outlook of Ferroptosis-Targeted Lipid Peroxidation in Cardiovascular Disease. Current Medicinal Chemistry 30:31, pages 3550-3561.
Crossref
Almila Senat, Esra Kabadayi-Sahin, Ibrahim Sogut, Tomris Duymaz & Ozcan Erel. (2023) Evaluation of Atherosclerotic Risk by Oxidative Contributors in Alcohol Use Disorder. Clinical Psychopharmacology and Neuroscience 21:3, pages 526-533.
Crossref
Dhananjay Tandon & Ashwini Kumar Gupta. (2023) Bioautography, synergistic effect and HPTLC-MS and SEM analysis of antimicrobial and antioxidant compounds of inflorescence extract of Sphaeranthus indicus. Future Journal of Pharmaceutical Sciences 9:1.
Crossref
Agnieszka Czyżowska, Jacob Brown, Hongyang Xu, Kavitha Sataranatarajan, Michael Kinter, Victoria J. Tyrell, Valerie B. O'Donnell & Holly Van Remmen. (2023) Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness. Redox Biology 64, pages 102761.
Crossref
Ying Liu, Wei Ding, Jianxun Wang, Xiang Ao & Junqiang Xue. (2023) Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases. Biomedicine & Pharmacotherapy 164, pages 114993.
Crossref
Ling Xie, Bin Fang & Chun Zhang. (2023) The role of ferroptosis in metabolic diseases. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1870:6, pages 119480.
Crossref
Jian Zhang, Yunyun Guo, Xiangkai Zhao, Jiaojiao Pang, Chang Pan, Jiali Wang, Shujian Wei, Xiao Yu, Cheng Zhang, Yuguo Chen, Huiyong Yin & Feng Xu. (2023) The role of aldehyde dehydrogenase 2 in cardiovascular disease. Nature Reviews Cardiology 20:7, pages 495-509.
Crossref
Yang Zhang, Yihui Liu, Gaoyang Ni, Jiahao Xu, Yuping Tian, Xingyu Liu, Jia Gao, Qi Gao, Yingchao Shen & Zhaowei Yan. (2023) Sulfated modification, basic characterization, antioxidant and anticoagulant potentials of polysaccharide from Sagittaria trifolia. Arabian Journal of Chemistry 16:7, pages 104812.
Crossref
Taiwo Scholes Adewole, Boluwatife Bolanle Dudu, Johnson Olaleye Oladele, Oyedotun Moses Oyeleke & Adenike Kuku. (2023) Functional Bioactivities of Soluble Seed Proteins from Two Leguminous Seeds. Preventive Nutrition and Food Science 28:2, pages 160-169.
Crossref
Mohammad Reza Hajinezhad, Amir Mokhtarpour & Aazam Mirheidari. (2023) Hypolipidemic and antioxidant effects of aqueous ethanolic extract from Moringa peregrina leaves on high-fat diet-induced fatty liver disease in rabbits. Comparative Clinical Pathology 32:4, pages 617-628.
Crossref
Cuihua Liu, Zunjiang Li, Botao Li, Wei Liu, Shizhong Zhang, Kuncheng Qiu & Wei Zhu. (2023) Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review. PeerJ 11, pages e14952.
Crossref
Muhamad Adib Abdul Ghani, Azizah Ugusman, Jalifah Latip & Satirah Zainalabidin. (2023) Role of Terpenophenolics in Modulating Inflammation and Apoptosis in Cardiovascular Diseases: A Review. International Journal of Molecular Sciences 24:6, pages 5339.
Crossref
Xialian Cui, Yangyan Su, Xiaotong Huang, Jiaping Chen, Jiang Ma, Peiran Liao & Xin He. (2023) Combined analysis of plasma metabolome and intestinal microbiome sequencing to explore jiashen prescription and its potential role in changing intestine–heart axis and effect on chronic heart failure. Frontiers in Cardiovascular Medicine 10.
Crossref
Zi He, Yijun Guo, Jinzhu Chen, Huiling Luo, Xinxin Liu, Xiuming Zhang, Yanan Sun, Dongtao Ge, Shefang Ye & Wei Shi. (2023) Unsaturated phospholipid modified FeOCl nanosheets for enhancing tumor ferroptosis. Journal of Materials Chemistry B 11:9, pages 1891-1903.
Crossref
Yunqi Jiang, Yuhui Qiao, Dan He, Aiju Tian & Zijian Li. (2023) Adaptor protein HIP-55-mediated signalosome protects against ferroptosis in myocardial infarction. Cell Death & Differentiation 30:3, pages 825-838.
Crossref
Xiaoyan Niu, Yupei Yao, Yaping Li, Cuiping Li, Xiao Pan & Lirong Han. (2023) The role of the ferroptosis pathway in the regulation of polysaccharides for human health: A review. International Journal of Biological Macromolecules 231, pages 123349.
Crossref
Meng-hui Shang, Jian-fei Sun, Ying Bi, Xiao-ting Xu & Xiao-nan Zang. (2023) Fluorescence and antioxidant activity of heterologous expression of phycocyanin and allophycocyanin from Arthrospira platensis. Frontiers in Nutrition 10.
Crossref
Alvaro Hermida-Ameijeiras, Nestor Vazquez-Agra, Anton Cruces-Sande, Estefania Mendez-Alvarez, Ramon Soto-Otero, Jose-Enrique Lopez-Paz, Antonio Pose-Reino & Arturo Gonzalez-Quintela. (2023) Implications of Inflammatory and Oxidative Stress Markers in the Attenuation of Nocturnal Blood Pressure Dipping. Journal of Clinical Medicine 12:4, pages 1643.
Crossref
Ming-Shan Chen, Jia-Xin Wang, Hao Zhang, Jia-Gen Cui, Yi Zhao & Jin-Long Li. (2023) Novel Role of Hemeoxygenase-1 in Phthalate-Induced Renal Proximal Tubule Cell Ferroptosis. Journal of Agricultural and Food Chemistry 71:5, pages 2579-2589.
Crossref
Yu Zhang, Xu Zhang & Bing Zhou. (2023) Zinc Protoporphyrin-9 Potentiates the Anticancer Activity of Dihydroartemisinin. Antioxidants 12:2, pages 250.
Crossref
Guangquan Ji, Renqiong Chen, Shan Feng, Wenhao Cheng & Hong Ren. (2023) Suppressing Ferroptosis Decreases the Multiplication of Mycobacterium Marinum in Human Macrophages. SSRN Electronic Journal.
Crossref
Liu Yang, Yong Liu, Sijie Zhou, Qi Feng, Yanfang Lu, Dongwei Liu & Zhangsuo Liu. (2023) Novel Insight into Ferroptosis in Kidney Diseases. American Journal of Nephrology 54:5-6, pages 184-199.
Crossref
Ying Liu, Lin Zhou, Caihong Lv, Lingyun Liu, Shuying Miao, Yunfei Xu, Kexin Li, Yao Zhao & Jie Zhao. (2022) PGE2 pathway mediates oxidative stress‐induced ferroptosis in renal tubular epithelial cells . The FEBS Journal 290:2, pages 533-549.
Crossref
Jia-Xin Wang, Yi Zhao, Ming-Shan Chen, Hao Zhang, Jia-Gen Cui & Jin-Long Li. (2023) Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis. Environmental Pollution 317, pages 120717.
Crossref
Reinaldo Marín, Cilia Abad, Deliana Rojas, Delia I. Chiarello & Teppa-Garrán Alejandro. 2023. 157 233 .
Sidhartha D. Ray, Ningning Yang, Aniqa Niha & Diane Genis. 2023. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Yuwu Chen, Xing Luo, Biyi Xu, Xiaoyi Bao, Haibo Jia & Bo Yu. (2022) Oxidative Stress-Mediated Programmed Cell Death: a Potential Therapy Target for Atherosclerosis. Cardiovascular Drugs and Therapy.
Crossref
Qian Chen, Qingqi Zhang, Pan Cao, Chunxia Shi, Luyi Zhang, Luwen Wang & Zuojiong Gong. (2022) NOD2 ‐mediated HDAC6 / NF ‐κb signalling pathway regulates ferroptosis induced by extracellular histone H3 in acute liver failure . Journal of Cellular and Molecular Medicine 26:21, pages 5528-5538.
Crossref
Yuehong Shen, Xinyu Shen, Shulin Wang, Yunyun Zhang, Yue Wang, Ye Ding, Jiayun Shen, Jianqiao Zhao, Huahan Qin, Yijiao Xu, Qian Zhou, Xindong Wang & Jianping Shen. (2022) Protective effects of Salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathway. International Immunopharmacology 112, pages 109257.
Crossref
Tingting Mo, Pinpin Long, Yufei Wang, Rong Peng, Rundong Niu, Qiuhong Wang, Jing Jiang, Limei Shi, Handong Yang, Chengwei Xu, Xiaomin Zhang, Meian He, Huan Guo & Tangchun Wu. (2022) Genetic susceptibility, homocysteine levels, and risk of all-cause and cause-specific mortality: a prospective cohort study. Clinica Chimica Acta.
Crossref
Zhen Wang, Hongbo Li, Wei Zhou, Jintae Lee, Zhenbin Liu, Zhixing An, Dan Xu, Haizhen Mo, Liangbin Hu & Xiaohui Zhou. (2022) Ferrous sulfate-loaded hydrogel cures Staphylococcus aureus infection via facilitating a ferroptosis-like bacterial cell death in a mouse keratitis model. Biomaterials 290, pages 121842.
Crossref
Namani Satyanarayana, Suresh V. Chinni, Ramachawolran Gobinath, Paripelli Sunitha, Akula Uma Sankar & Bala Sundaram Muthuvenkatachalam. (2022) Antidiabetic activity of Solanum torvum fruit extract in streptozotocin-induced diabetic rats. Frontiers in Nutrition 9.
Crossref
Tianyin Du, Jicheng Xu, Shengnan Zhu, Xinjun Yao, Jun Guo & Weiqiao Lv. (2022) Effects of spray drying, freeze drying, and vacuum drying on physicochemical and nutritional properties of protein peptide powder from salted duck egg white. Frontiers in Nutrition 9.
Crossref
Ben Li, Chufan Wang, Peng Lu, Yumeng Ji, Xufeng Wang, Chaoyang Liu, Xiaohu Lu, Xiaohan Xu & Xiaowei Wang. (2022) IDH1 Promotes Foam Cell Formation by Aggravating Macrophage Ferroptosis. Biology 11:10, pages 1392.
Crossref
Jia Li, Ling Xu, Yi Zuo, Xue Chang & Hai Chi. (2022) Potential intervention target of atherosclerosis: Ferroptosis (Review). Molecular Medicine Reports 26:5.
Crossref
Victoria Fernández-García, Silvia González-Ramos, Paloma Martín-Sanz, Antonio Castrillo & Lisardo Boscá. (2022) Unraveling the interplay between iron homeostasis, ferroptosis and extramedullary hematopoiesis. Pharmacological Research 183, pages 106386.
Crossref
Michael Aschner, Anatoly V. Skalny, Airton C. Martins, Anton I. Sinitskii, Marcelo Farina, Rongzhu Lu, Fernando BarbosaJr.Jr., Yordanka G. Gluhcheva, Abel Santamaria & Alexey A. Tinkov. (2022) Ferroptosis as a mechanism of non-ferrous metal toxicity. Archives of Toxicology 96:9, pages 2391-2417.
Crossref
Jinrui Ren, Yanze Lv, Lianglin Wu, Siliang Chen, Chuxiang Lei, Dan Yang, Fangda Li, Changzheng Liu & Yuehong Zheng. (2022) Key ferroptosis-related genes in abdominal aortic aneurysm formation and rupture as determined by combining bioinformatics techniques. Frontiers in Cardiovascular Medicine 9.
Crossref
Wei Yu, Weidong Liu, De Xie, Qiang Wang, Chenxi Xu, Hairong Zhao, Jiaming Lv, Furong He, Bingyang Chen, Tetsuya Yamamoto, Hidenori Koyama & Jidong Cheng. (2022) High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2-Mediated Autophagy Dysfunction and Ferroptosis. Oxidative Medicine and Cellular Longevity 2022, pages 1-21.
Crossref
Yi Guo, Chanjun Lu, Ke Hu, Chuanqi Cai & Weici Wang. (2022) Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives. Biomolecules 12:3, pages 390.
Crossref
Lina JIAN, Jiangtao GUO, Yongping ZHANG, Jie LIU, Yao LIU & Jian XU. (2022) Using integrated GC-MS analysis, in vitro experiments, network pharmacology: exploring migao fatty oil active components/mechanisms against coronary heart disease. Food Science and Technology 42.
Crossref
Chunye Zhang, Shuai Liu & Ming Yang. (2021) Hepatocellular Carcinoma and Obesity, Type 2 Diabetes Mellitus, Cardiovascular Disease: Causing Factors, Molecular Links, and Treatment Options. Frontiers in Endocrinology 12.
Crossref
Daniel Pitz Jacobsen, Heidi Elisabeth Fjeldstad, Guro Mørk Johnsen, Ingrid Knutsdotter Fosheim, Kjartan Moe, Patji Alnæs-Katjavivi, Ralf Dechend, Meryam Sugulle & Anne Cathrine Staff. (2021) Acute Atherosis Lesions at the Fetal-Maternal Border: Current Knowledge and Implications for Maternal Cardiovascular Health. Frontiers in Immunology 12.
Crossref
Lexing Li, Xueyan Sun, Dai Zhao & Hanchuan Dai. (2021) Pharmacological Applications and Action Mechanisms of Phytochemicals as Alternatives to Antibiotics in Pig Production. Frontiers in Immunology 12.
Crossref
Yanhong Shou, Lu Yang, Yongsheng Yang & Jinhua Xu. (2021) Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation. Cell Death & Disease 12:11.
Crossref
Lina He, Ying-Yi Liu, Kun Wang, Chengxi Li, Weibin Zhang, Zhen-Zhen Li, Xian-Zhang Huang & Yujuan Xiong. (2021) Tanshinone IIA protects human coronary artery endothelial cells from ferroptosis by activating the NRF2 pathway. Biochemical and Biophysical Research Communications 575, pages 1-7.
Crossref
Lin Li, Haining Wang, Jing Zhang, Xiao Chen, Zhongwang Zhang & Qiang Li. (2021) Effect of endothelial progenitor cell-derived extracellular vesicles on endothelial cell ferroptosis and atherosclerotic vascular endothelial injury. Cell Death Discovery 7:1.
Crossref
Arti Devi, Vagish Dwibedi & Zaved Ahmed Khan. (2021) Natural Antioxidants in New Age-Related Diseases. Revista Brasileira de Farmacognosia 31:4, pages 387-407.
Crossref
Shanshan Zhong, Luxiao Li, Ningning Liang, Lili Zhang, Xiaodong Xu, Shiting Chen & Huiyong Yin. (2021) Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver. Redox Biology 41, pages 101919.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.