64
Views
29
CrossRef citations to date
0
Altmetric
Original Article

Time course of dopaminergic cell death and changes in iron, ferritin and transferrin levels in the rat substantia nigra after 6-hydroxydopamine (6-OHDA) lesioning

, &
Pages 103-112 | Received 22 Dec 1998, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Hatasu Kobayashi, Shinji Oikawa, So Umemura, Iwao Hirosawa & Shosuke Kawanishi. (2008) Mechanism of metal-mediated DNA damage and apoptosis induced by 6-hydroxydopamine in neuroblastoma SH-SY5Y cells. Free Radical Research 42:7, pages 651-660.
Read now
Krishna P. Datla, Virginia Zbarsky, Deepal Rai, Shabnam Parkar, Naomi Osakabe, Okezie I. Aruoma & David T. Dexter. (2007) Short-Term Supplementation with Plant Extracts Rich in Flavonoids Protect Nigrostriatal Dopaminergic Neurons in a Rat Model of Parkinson's Disease. Journal of the American College of Nutrition 26:4, pages 341-349.
Read now

Articles from other publishers (27)

Guofen Gao, Linhao You, Jianhua Zhang, Yan-Zhong Chang & Peng Yu. (2023) Brain Iron Metabolism, Redox Balance and Neurological Diseases. Antioxidants 12:6, pages 1289.
Crossref
Adamantios Mamais, Jillian H. Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G. Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C. Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R. Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J. LaVoie, David C. Gershlick & Mark R. Cookson. (2021) Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia. PLOS Biology 19:12, pages e3001480.
Crossref
Santosh R D’Mello & Mark C Kindy. (2020) Overdosing on iron: Elevated iron and degenerative brain disorders. Experimental Biology and Medicine 245:16, pages 1444-1473.
Crossref
Rong Cai, Yu Zhang, Jacob E. Simmering, Jordan L. Schultz, Yuhong Li, Irene Fernandez-Carasa, Antonella Consiglio, Angel Raya, Philip M. Polgreen, Nandakumar S. Narayanan, Yanpeng Yuan, Zhiguo Chen, Wenting Su, Yanping Han, Chunyue Zhao, Lifang Gao, Xunming Ji, Michael J. Welsh & Lei Liu. (2019) Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases. Journal of Clinical Investigation 129:10, pages 4539-4549.
Crossref
Camila Mouhape, Gustavo Costa, Margot Ferreira, Juan Andrés Abin-Carriquiry, Federico Dajas & Giselle Prunell. (2018) Nicotine-Induced Neuroprotection in Rotenone In Vivo and In Vitro Models of Parkinson’s Disease: Evidences for the Involvement of the Labile Iron Pool Level as the Underlying Mechanism. Neurotoxicity Research 35:1, pages 71-82.
Crossref
Hong Jiang, Ning Song, Qian Jiao, Limin Shi & Xixun Du. 2019. Brain Iron Metabolism and CNS Diseases. Brain Iron Metabolism and CNS Diseases 45 66 .
Sonia Olmedo-Díaz, Héctor Estévez-Silva, Greger Orädd, Sara af Bjerkén, Daniel Marcellino & Ana Virel. (2017) An altered blood–brain barrier contributes to brain iron accumulation and neuroinflammation in the 6-OHDA rat model of Parkinson’s disease. Neuroscience 362, pages 141-151.
Crossref
Guofen Gao, Lin-Hao You & Yan-Zhong Chang. 2017. Oxidative Stress and Redox Signalling in Parkinson’s Disease. Oxidative Stress and Redox Signalling in Parkinson’s Disease 255 276 .
John Loike, Vernice Jackson-Lewis & Serge Przedborski. 2017. Neuroimmune Pharmacology. Neuroimmune Pharmacology 477 492 .
Ana Virel, Anna Rehnmark, Greger Orädd, Sonia Olmedo-Díaz, Erik Faergemann & Ingrid Strömberg. (2015) Magnetic resonance imaging as a tool to image neuroinflammation in a rat model of Parkinson's disease - phagocyte influx to the brain is promoted by bilberry-enriched diet. European Journal of Neuroscience 42:10, pages 2761-2771.
Crossref
Hany E.S. Marei, Samah Lashen, Amany Farag, Asmaa Althani, Nahla Afifi, Abd-Elmaksoud A, Shaymaa Rezk, Roberto Pallini, Patrizia Casalbore & Carlo Cenciarelli. (2015) Human olfactory bulb neural stem cells mitigate movement disorders in a rat model of Parkinson's disease. Journal of Cellular Physiology 230:7, pages 1614-1629.
Crossref
Ana Virel, Erik Faergemann, Greger Orädd & Ingrid Strömberg. (2014) Magnetic Resonance Imaging (MRI) to Study Striatal Iron Accumulation in a Rat Model of Parkinson’s Disease. PLoS ONE 9:11, pages e112941.
Crossref
Scott Ayton & Peng Lei. (2014) Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration. BioMed Research International 2014, pages 1-9.
Crossref
Sebastián Rodríguez, Kazuyuki Uchida & Hiroyuki Nakayama. (2013) Striatal TH-immunopositive fibers recover after an intrastriatal injection of 6-hydroxydopamine in golden hamsters treated with prednisolone: Roles of tumor necrosis factor-α and inducible nitric oxide synthase in neurodegeneration. Neuroscience Research 76:1-2, pages 83-92.
Crossref
Zhanyun Lv, Hong Jiang, Huamin Xu, Ning Song & Junxia Xie. (2010) Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson’s disease. Journal of Neural Transmission 118:3, pages 361-369.
Crossref
Wen-Jing Li, Hong Jiang, Ning Song & Jun-Xia Xie. (2010) Dose- and time-dependent α-synuclein aggregation induced by ferric iron in SK-N-SH cells铁离子对 α- 突触核蛋白聚集的诱发作用具有剂量和时间依赖性. Neuroscience Bulletin 26:3, pages 205-210.
Crossref
Serge Przedborski. 2007. Parkinson's Disease and Related Disorders, Part I. Parkinson's Disease and Related Disorders, Part I 535 551 .
Elias Matthew Quintero, Lauren Willis, Rachel Singleton, Naida Harris, Peng Huang, Narayan Bhat & Ann-Charlotte Granholm. (2006) Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease. Brain Research 1093:1, pages 198-207.
Crossref
En Huang & Wei-Yi Ong. (2004) Distribution of ferritin in the rat hippocampus after kainate-induced neuronal injury. Experimental Brain Research 161:4, pages 502-511.
Crossref
James Connor, Poonlarp Cheepsunthorn & Xuesheng Zhang. 2004. The Role of Glia in Neurotoxicity, Second Edition. The Role of Glia in Neurotoxicity, Second Edition 367 377 .
Yi He, Patricia S Thong, Timothy Lee, S.K Leong, Bo Y Mao, Fang Dong & Frank Watt. (2003) Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys. Free Radical Biology and Medicine 35:5, pages 540-547.
Crossref
Peter Teismann, Kim Tieu, Oren Cohen, Dong-Kug Choi, Du Chu Wu, Daniel Marks, Miquel Vila, Vernice Jackson-Lewis & Serge Przedborski. (2003) Pathogenic role of glial cells in Parkinson's disease. Movement Disorders 18:2, pages 121-129.
Crossref
S. Przedborski & James E. Goldman. 2003. Non-Neuronal Cells of the Nervous System: Function and Dysfunction. Non-Neuronal Cells of the Nervous System: Function and Dysfunction 967 982 .
Manfred Gerlach, Kay L. Double, Dorit Ben-Shachar, Luigi Zecca, Moussa B. H. Youdim & Peter Riederer. (2003) Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease. Neurotoxicity Research 5:1-2, pages 35-43.
Crossref
K.L Double, D Ben-Shachar, M.B.H Youdim, L Zecca, P Riederer & M Gerlach. (2002) Influence of neuromelanin on oxidative pathways within the human substantia nigra. Neurotoxicology and Teratology 24:5, pages 621-628.
Crossref
Yi He, Stanley Appel & Weidong Le. (2001) Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain Research 909:1-2, pages 187-193.
Crossref
K. L. Double, M. Gerlach, M.B.H. Youdim & P. Riederer. 2000. Advances in Research on Neurodegeneration. Advances in Research on Neurodegeneration 37 58 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.