Advanced search
Publication Cover
Drug Delivery Volume 15, 2008 - Issue 4
Submit an article Journal homepage
1,148
Views
33
CrossRef citations to date
0
Altmetric
Research Article

Chitosan-N-Acetyl Cysteine Conjugates: In Vitro Evaluation of Permeation Enhancing and P-Glycoprotein Inhibiting Properties

Thierry Schmitz Institute of Pharmacy, Department of Pharmaceutical Technology, University of Innsbruck, Innsbruck, Austria
,
Juliane Hombach Institute of Pharmacy, Department of Pharmaceutical Technology, University of Innsbruck, Innsbruck, Austria
&
Andreas Bernkop-Schnürch Institute of Pharmacy, Department of Pharmaceutical Technology, University of Innsbruck, Innsbruck, Austria
Pages 245-252 | Received 22 Oct 2007, Accepted 29 Nov 2007, Published online: 10 Oct 2008

Citations (33)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Vimratjeet Kaur, Tarun Garg, Goutam Rath & Amit K. Goyal. (2014) Therapeutic potential of nanocarrier for overcoming to P-glycoprotein. Journal of Drug Targeting 22:10, pages 859-870.
Read now

Articles from other publishers (32)

Pranab Kumar Bandyopadhyay, Md Saquib Hasnain & Amit Kumar Nayak. 2023. Tailor-Made Polysaccharides in Drug Delivery. Tailor-Made Polysaccharides in Drug Delivery 83 106 .
Atiđa Selmani, Elisabeth Seibert, Carolin Tetyczka, Doris Kuehnelt, Ivan Vidakovic, Karin Kornmueller, Markus Absenger-Novak, Borna Radatović, Ivana Vinković Vrček, Gerd Leitinger, Eleonore Fröhlich, Andreas Bernkop-Schnürch, Eva Roblegg & Ruth Prassl. (2022) Thiolated Chitosan Conjugated Liposomes for Oral Delivery of Selenium Nanoparticles. Pharmaceutics 14:4, pages 803.
Crossref
Shailja Jain, Kshitij Nuwal, Arisha Mahmood, Mona Piplani, Subhash Chander, Sunil Kumar Dubey & Gautam Singhvi. 2022. Chitosan in Drug Delivery. Chitosan in Drug Delivery 247 276 .
Md Saquib Hasnain & Amit Kumar Nayak. 2022. Chitosan in Drug Delivery. Chitosan in Drug Delivery 225 246 .
Marta Guerini, Pietro Grisoli, Cristina Pane & Paola Perugini. (2021) Microstructured Lipid Carriers (MLC) Based on N-Acetylcysteine and Chitosan Preventing Pseudomonas aeruginosa Biofilm. International Journal of Molecular Sciences 22:2, pages 891.
Crossref
Christoph Federer, Markus Kurpiers & Andreas Bernkop-Schnürch. (2020) Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications. Biomacromolecules 22:1, pages 24-56.
Crossref
Shanshan Zhang, Sajid Asghar, Feng Yu, Ziyi Hu, Qineng Ping, Zhipeng Chen, Feng Shao & Yanyu Xiao. (2020) The enhancement of N-acetylcysteine on intestinal absorption and oral bioavailability of hydrophobic curcumin. European Journal of Pharmaceutical Sciences 154, pages 105506.
Crossref
Hang Chen, Jian-hua Wang, Chun-dong Liu, Yan Wang, Yu-na Fu, Dong Wang, Heng Sun, Yue Peng, Meng Jiang & Dao-jun Pu. (2019) The effect of amphiphilic N,N,N-trimethyl-O-octadecyl chitosan on the oral bioavailability of acyclovir. Journal of Drug Delivery Science and Technology 51, pages 244-254.
Crossref
María J. Limeres, Marcela A. Moretton, Ezequiel Bernabeu, Diego A. Chiappetta & María L. Cuestas. (2019) Thinking small, doing big: Current success and future trends in drug delivery systems for improving cancer therapy with special focus on liver cancer. Materials Science and Engineering: C 95, pages 328-341.
Crossref
Hans Merzendorfer. 2019. Extracellular Sugar-Based Biopolymers Matrices. Extracellular Sugar-Based Biopolymers Matrices 95 151 .
M. Hasanifard, B. Ebrahimi-Hosseinzadeh, A. Hatamian-Zarmi, A. H. Rezayan & M. A. Esmaeili. (2018) Development of Thiolated Chitosan Nanoparticles Based Mucoadhesive Vaginal Drug Delivery Systems. Polymer Science, Series A 59:6, pages 858-865.
Crossref
Claudio Palazzo, Giuseppe Trapani, Gilles Ponchel, Adriana Trapani & Christine Vauthier. (2017) Mucoadhesive properties of low molecular weight chitosan- or glycol chitosan- and corresponding thiomer-coated poly(isobutylcyanoacrylate) core-shell nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics 117, pages 315-323.
Crossref
Mangesh R. Bhalekar, Rajesh V. Bargaje, Prashant G. Upadhaya, Ashwini R. Madgulkar & Sanjay J. Kshirsagar. (2016) Formulation of mucoadhesive gastric retentive drug delivery using thiolated xyloglucan. Carbohydrate Polymers 136, pages 537-542.
Crossref
Flavia Laffleur, Julia Psenner & Wongsakorn Suchaoin. (2015) Permeation Enhancement via Thiolation: In Vitro and Ex Vivo Evaluation of Hyaluronic Acid-Cysteine Ethyl Ester. Journal of Pharmaceutical Sciences 104:7, pages 2153-2160.
Crossref
Flavia Laffleur, Julian Wagner & Arshad Mahmood. (2015) In vitro and ex vivo evaluation of biomaterials' distinctive properties as a result of thiolation . Future Medicinal Chemistry 7:4, pages 449-457.
Crossref
Xianhui Chen, Yang Zhang, Lan Yuan, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang & Qiang Zhang. (2015) The P-glycoprotein inhibitory effect and related mechanisms of thiolated chitosan and its S-protected derivative. RSC Advances 5:126, pages 104228-104238.
Crossref
Sonja Bonengel & Andreas Bernkop-Schn?rch. (2014) Thiomers ? From bench to market. Journal of Controlled Release 195, pages 120-129.
Crossref
Flavia Laffleur, Julia Röggla, Muneeb Ahmad Idrees & Julia Griessinger. (2014) Chemical Modification of Hyaluronic Acid for Intraoral Application. Journal of Pharmaceutical Sciences 103:8, pages 2414-2423.
Crossref
Christiane Müller & Andreas Bernkop-Schnürch. 2014. Mucoadhesive Materials and Drug Delivery Systems. Mucoadhesive Materials and Drug Delivery Systems 255 278 .
Adriana Trapani, Claudio Palazzo, Marialessandra Contino, Maria Grazia Perrone, Nicola Cioffi, Nicoletta Ditaranto, Nicola Antonio Colabufo, Massimo Conese, Giuseppe Trapani & Giovanni Puglisi. (2014) Mucoadhesive Properties and Interaction with P-Glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent Polymers: A Comparative Study. Biomacromolecules 15:3, pages 882-893.
Crossref
Yuanjie Liu & Gigi N. C. Chiu. (2013) Dual-Functionalized PAMAM Dendrimers with Improved P-Glycoprotein Inhibition and Tight Junction Modulating Effect. Biomacromolecules 14:12, pages 4226-4235.
Crossref
Nazma Inamdar & Vishnukant Mourya. 2013. Chitin and Chitosan Derivatives. Chitin and Chitosan Derivatives 121 150 .
Kaushik Thanki, Rahul P. Gangwal, Abhay T. Sangamwar & Sanyog Jain. (2013) Oral delivery of anticancer drugs: Challenges and opportunities. Journal of Controlled Release 170:1, pages 15-40.
Crossref
Luca Casettari, Driton Vllasaliu, Jenny K.W. Lam, Mahmoud Soliman & Lisbeth Illum. (2012) Biomedical applications of amino acid-modified chitosans: A review. Biomaterials 33:30, pages 7565-7583.
Crossref
Christiane Mueller, Andrea Verroken, Javed Iqbal & Andreas Bernkop‐Schnuerch. (2011) Thiolated chitosans: In vitro comparison of mucoadhesive properties . Journal of Applied Polymer Science 124:6, pages 5046-5055.
Crossref
Shadabul Haque, Shadab Md, Mohammad Fazil, Manish Kumar, Jasjeet Kaur Sahni, Javed Ali & Sanjula Baboota. (2012) Venlafaxine loaded chitosan NPs for brain targeting: Pharmacokinetic and pharmacodynamic evaluation. Carbohydrate Polymers 89:1, pages 72-79.
Crossref
Katharina Leithner & Andreas Bernkop‐Schnürch. 2012. Chitosan‐Based Systems for Biopharmaceuticals. Chitosan‐Based Systems for Biopharmaceuticals 159 180 .
Payam Zahedi, Raquel De Souza, Loan Huynh, Micheline Piquette-Miller & Christine Allen. (2010) Combination Drug Delivery Strategy for the Treatment of Multidrug Resistant Ovarian Cancer. Molecular Pharmaceutics 8:1, pages 260-269.
Crossref
Federica Sarti & Andreas Bernkop-Schnürch. 2011. Chitosan for Biomaterials I. Chitosan for Biomaterials I 93 110 .
Johannes Parmentier, Felix J. Hartmann & Gert Fricker. (2010) In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules. European Journal of Pharmaceutics and Biopharmaceutics 76:3, pages 394-403.
Crossref
Mikio Tomita, Nobuyuki Doi & Masahiro Hayashi. (2010) Effects of acylcarnitines on efflux transporting system in Caco-2 cell monolayers. European Journal of Drug Metabolism and Pharmacokinetics 35:1-2, pages 1-7.
Crossref
D. Sakloetsakun & A. Bernkop-Schnürch. (2010) Thiolated chitosans. Journal of Drug Delivery Science and Technology 20:1, pages 63-69.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.