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Research Article

A novel method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system

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Pages 280-288 | Received 23 Apr 2009, Accepted 20 May 2009, Published online: 01 Jul 2009

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Nagaraja SreeHarsha, Katharigatta N Venugopala, Anroop B Nair, Teeka S Roopashree, Mahesh Attimarad, Jagadeesh G Hiremath, Bandar E Al-Dhubiab, Chandramouli Ramnarayanan, Pottathil Shinu, Mukund Handral, Micheline Haroun & Christophe Tratrat. (2019) An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles. Drug Design, Development and Therapy 13, pages 4389-4403.
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Sree Harsha, Bandar E. Al-Dhubiab, Anroop B. Nair, Mohammed Al-Khars, Mohammed Al-Hassan, Raja Rajan, Mahesh Attimarad, Katharigatta N. Venugopala & Afzal Haq Asif. (2015) Novel Drying Technology of Microsphere and Its Evaluation for Targeted Drug Delivery for Lungs. Drying Technology 33:4, pages 502-512.
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Fatemeh Farjadian, Zahra Faghih, Maryam Fakhimi, Pooya Iranpour, Soliman Mohammadi-Samani & Mohammad Doroudian. (2023) Glucosamine-Modified Mesoporous Silica-Coated Magnetic Nanoparticles: A “Raisin-Cake”-like Structure as an Efficient Theranostic Platform for Targeted Methotrexate Delivery. Pharmaceutics 15:10, pages 2491.
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Shraddha Borse, Z.V.P. Murthy & Suresh Kumar Kailasa. (2023) Fabrication of water-soluble blue emitting molybdenum nanoclusters for sensitive detection of cancer drug methotrexate. Journal of Photochemistry and Photobiology A: Chemistry 435, pages 114323.
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Navid Mousazadeh, Mahmoud Gharbavi, Hamid Rashidzadeh, Hamed Nosrati, Hossein Danafar & Behrooz Johari. (2022) Anticancer evaluation of methotrexate and curcumin-coencapsulated niosomes against colorectal cancer cell lines. Nanomedicine 17:4, pages 201-217.
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Mudasir Ahmad, Jianquan Ren, Yunfei Zhang, Hao Kou, Mehraj-ud-din Naik, Qiuyu Zhang & Baoliang Zhang. (2022) Simple and facile preparation of tunable chitosan tubular nanocomposite microspheres for fast uranium(VI) removal from seawater. Chemical Engineering Journal 427, pages 130934.
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Elham Rostami. (2020) Progresses in targeted drug delivery systems using chitosan nanoparticles in cancer therapy: A mini-review. Journal of Drug Delivery Science and Technology 58, pages 101813.
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Jingwei Wang, Yong Kong, Feng Liu, Dan Shou, Yongxin Tao & Yong Qin. (2018) Construction of pH-responsive drug delivery platform with calcium carbonate microspheres induced by chitosan gels. Ceramics International 44:7, pages 7902-7907.
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Javid Jalvandi, Max White, Yuan Gao, Yen Bach Truong, Rajiv Padhye & Ilias Louis Kyratzis. (2017) Polyvinyl alcohol composite nanofibres containing conjugated levofloxacin-chitosan for controlled drug release. Materials Science and Engineering: C 73, pages 440-446.
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Lester C Barnsley, Dario Carugo & Eleanor Stride. (2016) Optimized shapes of magnetic arrays for drug targeting applications. Journal of Physics D: Applied Physics 49:22, pages 225501.
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Jianjun Cheng, Guanghui Tan, Wenting Li, Hongyue Zhang, Xiaodan Wu, Zhiqiang Wang & Yingxue Jin. (2016) Facile synthesis of chitosan assisted multifunctional magnetic Fe 3 O 4 @SiO 2 @CS@pyropheophorbide-a fluorescent nanoparticles for photodynamic therapy . New Journal of Chemistry 40:10, pages 8522-8534.
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Vadim Volkov, Marisa P. Sárria, Andreia C. Gomes & Artur Cavaco-Paulo. (2014) Phosphorylated Silk Fibroin Matrix for Methotrexate Release. Molecular Pharmaceutics 12:1, pages 75-86.
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Liling Dong, Hailong Peng, Shenqi Wang, Zhong Zhang, Jinhua Li, Fanrong Ai, Qiang Zhao, Mei Luo, Hua Xiong & Lingxin Chen. (2014) Thermally and magnetically dual-responsive mesoporous silica nanospheres: preparation, characterization, and properties for the controlled release of sophoridine. Journal of Applied Polymer Science 131:13, pages n/a-n/a.
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Priyanka Murawala, Amruta Tirmale, Anjali Shiras & B.L.V. Prasad. (2014) In situ synthesized BSA capped gold nanoparticles: Effective carrier of anticancer drug Methotrexate to MCF-7 breast cancer cells. Materials Science and Engineering: C 34, pages 158-167.
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Alexandru Mihai Grumezescu, Ecaterina Andronescu, Alina Maria Holban, Anton Ficai, Denisa Ficai, Georgeta Voicu, Valentina Grumezescu, Paul Cătălin Balaure & Carmen Mariana Chifiriuc. (2013) Water dispersible cross-linked magnetic chitosan beads for increasing the antimicrobial efficiency of aminoglycoside antibiotics. International Journal of Pharmaceutics 454:1, pages 233-240.
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Samira Sadat Abolmaali, Ali Mohammad Tamaddon & Rassoul Dinarvand. (2013) A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis. Cancer Chemotherapy and Pharmacology 71:5, pages 1115-1130.
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Amit Chandna, Deepa Batra, Satinder Kakar & Ramandeep Singh. (2013) A review on target drug delivery: magnetic microspheres. Journal of Acute Disease 2:3, pages 189-195.
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A. S. Berezin, E. A. Lomkova & Yu. A. Skorik. (2013) Chitosan conjugates with biologically active compounds: design strategies, properties, and targeted drug delivery. Russian Chemical Bulletin 61:4, pages 781-795.
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Yulei Tai, Li Wang, Guangqing Yan, Jin-min Gao, Haojie Yu & Lei Zhang. (2011) Recent research progress on the preparation and application of magnetic nanospheres. Polymer International 60:7, pages 976-994.
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Carlo Morasso, Miriam Colombo, Silvia Ronchi, Laura Polito, Serena Mazzucchelli, Diego Monti, Marco Buscaglia, Tommaso Bellini & Davide Prosperi. (2010) Towards a Universal Method for the Stable and Clean Functionalization of Inert Perfluoropolymer Nanoparticles: Exploiting Photopolymerizable Amphiphilic Diacetylenes. Advanced Functional Materials 20:22, pages 3932-3940.
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Hakan Eroglu, Emirhan Nemutlu, Omer Faruk Turkoglu, Osman Nacar, Ebru Bodur, Mustafa Fevzi Sargon, Etem Beskonakli & Levent Oner. (2010) A Quadruped Study on Chitosan Microspheres Containing Atorvastatin Calcium: Preparation, Characterization, Quantification and <i>in-Vivo</i> Application. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 58:9, pages 1161-1167.
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