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Research Article

Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats

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Pages 40-50 | Received 03 Jun 2016, Accepted 22 Aug 2016, Published online: 03 Feb 2017

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Xiaoming Zhong, Jianqiong Yang, Hongyan Liu, Zhiwen Yang & Ping Luo. (2023) Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application. Drug Delivery 30:1.
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Janet Sui Ling Tan, Clive J. Roberts & Nashiru Billa. (2019) Mucoadhesive chitosan-coated nanostructured lipid carriers for oral delivery of amphotericin B. Pharmaceutical Development and Technology 24:4, pages 504-512.
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Hafiz Shoaib Sarwar, Muhammad Farhan Sohail, Noushin Saljoughian, Anees Ur Rehman, Sohail Akhtar, Akhtar Nadhman, Masoom Yasinzai, Howard E. Gendelman, Abhay R. Satoskar & Gul Shahnaz. (2018) Design of mannosylated oral amphotericin B nanoformulation: efficacy and safety in visceral leishmaniasis. Artificial Cells, Nanomedicine, and Biotechnology 46:sup1, pages 521-531.
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Crossref
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Sandra Jesus, Mélanie Schmutz, Claudia Som, Gerrit Borchard, Peter Wick & Olga Borges. (2019) Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We Learn From Literature So Far. Frontiers in Bioengineering and Biotechnology 7.
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Crossref
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Crossref
Kajal Pawar, Rutuja Gadhave, Swati Waydande & Pravin Pawar. (2019) Recent Trends in Antifungal Agents: A Reference to Formulation, Characterization and Applications. Drug Delivery Letters 9:3, pages 199-210.
Crossref
R. Lu, C. Hollingsworth, J. Qiu, A. Wang, E. Hughes, X. Xin, K. M. Konrath, W. Elsegeiny, Yoon-Dong Park, L. Atakulu, J. C. Craft, E. C. Tramont, R. Mannino & P. R. Williamson. (2019) Efficacy of Oral Encochleated Amphotericin B in a Mouse Model of Cryptococcal Meningoencephalitis. mBio 10:3.
Crossref
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Crossref
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Aun Raza, Fekade Bruck Sime, Peter J. Cabot, Faheem Maqbool, Jason A. Roberts & James Robert Falconer. (2019) Solid nanoparticles for oral antimicrobial drug delivery: a review. Drug Discovery Today 24:3, pages 858-866.
Crossref
Grace Cuddihy, Ellen Wasan, Yunyun Di & Kishor Wasan. (2019) The Development of Oral Amphotericin B to Treat Systemic Fungal and Parasitic Infections: Has the Myth Been Finally Realized?. Pharmaceutics 11:3, pages 99.
Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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