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Drug Delivery Volume 24, 2017 - Issue 1

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Research Article

Anhydrous reverse micelle nanoparticles: new strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers

Zhengwei Huang1 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China and

Han Wu1 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China and

Beibei Yang2 School of Pharmaceutical Sciences, School Southern Medical University, Guangzhou, Guangdong, P.R. China

Longkai Chen1 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China and

Ying Huang1 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China and

Guilan Quan1 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China and

Chune Zhu1 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China and

Xing Li1 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China and

Xin Pan1 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China and Correspondence[email protected]

Chuanbin Wu1 School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China and

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Pages 527-538 | Received 26 Oct 2016, Accepted 05 Dec 2016, Published online: 09 Feb 2017

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https://doi.org/10.1080/10717544.2016.1269850
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Ziyao Chang, Wenhao Wang, Zhengwei Huang, Ying Huang, Chuanbin Wu & Xin Pan. (2023) Lecithin Reverse Micelle System is Promising in Constructing Carrier Particles for Protein Drugs Encapsulated Pressurized Metered‐Dose Inhalers. Advanced Therapeutics 6:10.
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Manali Harshal Barve, Priti Kiran ShardulSatish Sundarrao Munne, Atul R BendaleVaishali Naphade, Vasim T. Pathan & Laxmikant B. Borse. (2023) Metered Dose Inhalers (MDI’S) for High-Performance Pulmonary Drug Delivery in Assistance to Nanotechnology. Biosciences Biotechnology Research Asia 20:2, pages 433-447.
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Raj Kumar, Piyush Mehta, Konathala Ravi Shankar, Manju A. K. Rajora, Yogendra Kumar Mishra, Ebrahim Mostafavi & Ajeet Kaushik. (2022) Nanotechnology-Assisted Metered-Dose Inhalers (MDIs) for High-Performance Pulmonary Drug Delivery Applications. Pharmaceutical Research 39:11, pages 2831-2855.
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Zhengwei Huang, Lei Shu, Ying Huang, Chuanbin Wu & Xin Pan. (2022) Low Drug Loading Hampers the Clinical Translation of Peptide Drugs-Containing Metered-Dose Inhalers. Pharmaceuticals 15:4, pages 389.
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Xiuhua Wang, Wei Wan, Jing Lu, Guilan Quan, Xin Pan & Peiqing Liu. (2021) Effects of L-leucine on the properties of spray-dried swellable microparticles with wrinkled surfaces for inhalation therapy of pulmonary fibrosis. International Journal of Pharmaceutics 610, pages 121223.
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Sheersha Pramanik, Sourav Mohanto, Ravi Manne, Rahul R. Rajendran, A. Deepak, Sijo Joy Edapully, Triveni Patil & Oly Katari. (2021) Nanoparticle-Based Drug Delivery System: The Magic Bullet for the Treatment of Chronic Pulmonary Diseases. Molecular Pharmaceutics 18:10, pages 3671-3718.
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Meisam Omidi, Vahid Mansouri, Leila Mohammadi Amirabad & Lobat Tayebi. (2021) Impact of Lipid/Magnesium Hydroxide Hybrid Nanoparticles on the Stability of Vascular Endothelial Growth Factor-Loaded PLGA Microspheres. ACS Applied Materials & Interfaces 13:21, pages 24370-24384.
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Meisam Omidi, Luis Almeida & Lobat Tayebi. (2020) Microfluidic‐assisted fabrication of reverse micelle/PLGA hybrid microspheres for sustained vascular endothelial growth factor delivery. Biotechnology and Applied Biochemistry 68:3, pages 616-625.
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Anne Haaije de Boer & Kyrre Thalberg. 2021. Inhaled Medicines. Inhaled Medicines 65 97 .

Zhengwei Huang, Mingjun Wu, Cheng Ma, Xuequn Bai, Xuejuan Zhang, Ziyu Zhao, Ying Huang, Xin Pan & Chuanbin Wu. (2019) Spectroscopic Quantification of Surfactants in Solid Lipid Nanoparticles. Journal of Pharmaceutical Innovation 15:1, pages 155-162.
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Yao Yang, Zhengwei Huang, Jinyuan Li, Ziran Mo, Ying Huang, Cheng Ma, Wenhao Wang, Xin Pan & Chuanbin Wu. (2019) PLGA Porous Microspheres Dry Powders for Codelivery of Afatinib‐Loaded Solid Lipid Nanoparticles and Paclitaxel: Novel Therapy for EGFR Tyrosine Kinase Inhibitors Resistant Nonsmall Cell Lung Cancer. Advanced Healthcare Materials 8:23, pages 1900965.
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Xiaohong Sun & Nandika Bandara. (2019) Applications of reverse micelles technique in food science: A comprehensive review. Trends in Food Science & Technology 91, pages 106-115.
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Kai Ding, Rong Li, Yao Ma, Nan Li, Ting Zhang, Xing Cheng-Mei, Hai-Tao Jiang & Yong-Kuan Gong. (2018) Folate Ligand Orientation Optimized during Cell Membrane Mimetic Micelle Formation for Enhanced Tumor Cell Targeting. Langmuir 35:5, pages 1257-1265.
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Zhengwei Huang, Ying Huang, Cheng Ma, Xiangyu Ma, Xuejuan Zhang, Ling Lin, Ziyu Zhao, Xin Pan & Chuanbin Wu. (2018) Endotracheal Aerosolization Device for Laboratory Investigation of Pulmonary Delivery of Nanoparticle Suspensions: In Vitro and in Vivo Validation. Molecular Pharmaceutics 15:12, pages 5521-5533.
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Yingtong Cui, Xuejuan Zhang, Wen Wang, Zhengwei Huang, Ziyu Zhao, Guanlin Wang, Shihao Cai, Hui Jing, Ying Huang, Xin Pan & Chuanbin Wu. (2018) Moisture-Resistant Co-Spray-Dried Netilmicin with l-Leucine as Dry Powder Inhalation for the Treatment of Respiratory Infections. Pharmaceutics 10:4, pages 252.
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Xing Li, Ying Huang, Zhengwei Huang, Xiangyu Ma, Ni Dong, Wanxin Chen, Xin Pan & Chuanbin Wu. (2018) Enhancing Stability of Exenatide-Containing Pressurized Metered-Dose Inhaler Via Reverse Microemulsion System. AAPS PharmSciTech 19:6, pages 2499-2508.
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Longkai Chen, Liling Mei, Disang Feng, Di Huang, Xin Tong, Xin Pan, Chune Zhu & Chuanbin Wu. (2018) Anhydrous reverse micelle lecithin nanoparticles/PLGA composite microspheres for long-term protein delivery with reduced initial burst. Colloids and Surfaces B: Biointerfaces 163, pages 146-154.
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Anhydrous reverse micelle nanoparticles: new strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers

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Anhydrous reverse micelle nanoparticles: new strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers

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