Advanced search
Publication Cover
Drug Delivery Volume 24, 2017 - Issue 1
Submit an article Journal homepage
1,865
Views
30
CrossRef citations to date
0
Altmetric
Research Article

Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol–polyethylene glycol–ginsenoside Rh2

Peng Li1 Department of Oncology, Changzhou Cancer Hospital of Soochow University, Changzhou, P.R. China, ;2 Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, P.R. China,
,
XiaoYue Zhou1 Department of Oncology, Changzhou Cancer Hospital of Soochow University, Changzhou, P.R. China,
,
Ding Qu2 Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, P.R. China, ;3 Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, P.R. China, and Correspondence[email protected]
,
Mengfei Guo2 Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, P.R. China, ;3 Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, P.R. China, and
,
Chenyi Fan2 Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, P.R. China, ;3 Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, P.R. China, and
,
Tong Zhou1 Department of Oncology, Changzhou Cancer Hospital of Soochow University, Changzhou, P.R. China,
&
Yang Ling1 Department of Oncology, Changzhou Cancer Hospital of Soochow University, Changzhou, P.R. China, ;4 Clinical Oncology Laboratory, Changzhou Cancer Hospital of Soochow University, Changzhou, P.R. ChinaCorrespondence[email protected]
 show all
Pages 834-845 | Received 03 Apr 2017, Accepted 02 May 2017, Published online: 22 May 2017

Citations (30)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Minfang Feng, Xingxing Dai, Cuiting Yang, Yingying Zhang, Yuting Tian, Qingsong Qu, Mengke Sheng, Zhixun Li, Xinhui Peng, Shuai Cen & Xinyuan Shi. (2023) Unification of medicines and excipients: The roles of natural excipients for promoting drug delivery. Expert Opinion on Drug Delivery 20:5, pages 597-620.
Read now
Xiaojing Xia, Jin Tao, Zhuwa Ji, Chencheng Long, Ying Hu & Zhiying Zhao. (2020) Increased antitumor efficacy of ginsenoside Rh2 via mixed micelles: in vivo and in vitro evaluation. Drug Delivery 27:1, pages 1369-1377.
Read now
Yeon-Ju Kim, Haribalan Perumalsamy, Josua Markus, Sri Renukadevi Balusamy, Chao Wang, Seong Ho Kang, Seungah Lee, Sang Yong Park, Sung Kim, Verónica Castro-Aceituno, Seung Hyun Kim & Deok Chun Yang. (2019) Development of Lactobacillus kimchicus DCY51T-mediated gold nanoparticles for delivery of ginsenoside compound K: in vitro photothermal effects and apoptosis detection in cancer cells. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 30-44.
Read now
Yunyan Chen, Ding Qu, Rongping Fu, Mengfei Guo, Yue Qin, Jian Guo & Yan Chen. (2018) A Tf-modified tripterine-loaded coix seed oil microemulsion enhances anti-cervical cancer treatment. International Journal of Nanomedicine 13, pages 7275-7287.
Read now
Ding Qu, Mengfei Guo, Yue Qin, Lixiang Wang, Bing Zong, Yunyan Chen & Yan Chen. (2017) A multicomponent microemulsion using rational combination strategy improves lung cancer treatment through synergistic effects and deep tumor penetration. Drug Delivery 24:1, pages 1179-1190.
Read now

Articles from other publishers (25)

Lina Wang, Yanxin Zhang, Zhimin Song, Qingchao Liu, Daidi Fan & Xiaoping Song. (2023) Ginsenosides: a potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease. Food & Function 14:20, pages 9137-9166.
Crossref
Jian Huang, Zhengji Wang, Zihe Chen, Chunxin Huang, Ying Wang, Xing Li, Weiyang Lv, Guiqiang Qi & Huilin Liu. (2023) Ultrasound-mediated multifunctional magnetic microbubbles for drug delivery of celastrol in VX2 liver transplant tumors. Drug Delivery and Translational Research.
Crossref
Xuechun Wang, Gautam Chauhan, Alison R. L. Tacderas, Aaron Muth & Vivek Gupta. (2023) Surface-Modified Inhaled Microparticle-Encapsulated Celastrol for Enhanced Efficacy in Malignant Pleural Mesothelioma. International Journal of Molecular Sciences 24:6, pages 5204.
Crossref
Lu Ding, Hongyu Qi, Yisa Wang, Zepeng Zhang, Qing Liu, Chen Guo, Jiaqi Liu, Zhaoqiang Chen, Jing Li, JinJin Chen, Qingxia Huang, Daqing Zhao, Zeyu Wang & Xiangyan Li. (2023) Recent advances in ginsenosides against respiratory diseases: Therapeutic targets and potential mechanisms. Biomedicine & Pharmacotherapy 158, pages 114096.
Crossref
Keke LI, Zhongyu LI, Lei Men, Wei LI & Xiaojie GONG. (2022) Potential of ginsenoside Rh2and its derivatives as anti-cancer agents. Chinese Journal of Natural Medicines 20:12, pages 881-901.
Crossref
Liwen Fu, Weiying Zhang, Xiaojun Zhou, Jingzhong Fu & Chuanglong He. (2022) Tumor cell membrane-camouflaged responsive nanoparticles enable MRI-guided immuno-chemodynamic therapy of orthotopic osteosarcoma. Bioactive Materials 17, pages 221-233.
Crossref
Na Wang, Yifan Li, Fei He, Susu Liu, Yuan Liu, Jinting Peng, Jiahui Liu, Changyuan Yu & Shihui Wang. (2022) Assembly of Celastrol to Zeolitic Imidazolate Framework-8 by Coordination as a Novel Drug Delivery Strategy for Cancer Therapy. Pharmaceuticals 15:9, pages 1076.
Crossref
Yue Ke, Lei Huang, Yu Song, Zhenxin Liu, Linshuang Liang, Linmao Wang & Taoyun Wang. (2022) Preparation and pharmacological effects of minor ginsenoside nanoparticles: a review. Frontiers in Pharmacology 13.
Crossref
Seyede Nazanin Zarneshan, Sajad Fakhri & Haroon Khan. (2022) Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach. Pharmacological Research 177, pages 106099.
Crossref
Li Liu, Huiyun Wang, Xiaoyun Chai, Qingguo Meng, Sheng Jiang & Fenglan Zhao. (2022) Advances in Biocatalytic Synthesis, Pharmacological Activities, Pharmaceutical Preparation and Metabolism of Ginsenoside Rh2. Mini-Reviews in Medicinal Chemistry 22:3, pages 437-448.
Crossref
Rama Rao Malla, Vasudevaraju Padmaraju, Rakshmitha Marni & Mohammad Amjad Kamal. (2021) Natural products: Potential targets of TME related long non-coding RNAs in lung cancer. Phytomedicine 93, pages 153782.
Crossref
Hong Wang, Yu Zheng, Qiang Sun, Zhen Zhang, Mengnan Zhao, Cheng Peng & Sanjun Shi. (2021) Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies. Journal of Nanobiotechnology 19:1.
Crossref
Ling Guo, Yongping Zhang & Khuloud T. Al-Jamal. (2021) Recent progress in nanotechnology-based drug carriers for celastrol delivery. Biomaterials Science 9:19, pages 6355-6380.
Crossref
Pushkaraj Rajendra Wagh, Preshita Desai, Sunil Prabhu & Jeffrey Wang. (2021) Nanotechnology-Based Celastrol Formulations and Their Therapeutic Applications. Frontiers in Pharmacology 12.
Crossref
Yuyao Liao, Zhixun Li, Qing Zhou, Mengke Sheng, Qingsong Qu, Yanshuang Shi, Jiaqi Yang, Lijing Lv, Xingxing Dai & Xinyuan Shi. (2021) Saponin surfactants used in drug delivery systems: A new application for natural medicine components. International Journal of Pharmaceutics 603, pages 120709.
Crossref
Zhenlei Wang, Rui Liu, Li Chen, Huanhuan Wang, Mi Zhou, Yongsheng Wang & Yongping Qin. (2020) Pharmacokinetics of Ginsenoside Rh2, the Major Anticancer Ingredient of Ginsenoside H Dripping Pills, in Healthy Subjects. Clinical Pharmacology in Drug Development 10:6, pages 669-674.
Crossref
Heeok Hong, Delgerzul Baatar & Seong Gu Hwang. (2021) Anticancer Activities of Ginsenosides, the Main Active Components of Ginseng. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-10.
Crossref
Jing Zhao, Zhiguang Duan, Xiaoxuan Ma, Yannan Liu & Daidi Fan. (2021) Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers. Chinese Journal of Chemical Engineering 30, pages 291-300.
Crossref
Jinfeng Shi, Jiaxin Li, Ziyi Xu, Liang Chen, Ruifeng Luo, Chen Zhang, Fei Gao, Jinming Zhang & Chaomei Fu. (2020) Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application. Frontiers in Pharmacology 11.
Crossref
Xun Li, Shifeng Chu, Meiyu Lin, Yan Gao, Yingjiao Liu, Songwei Yang, Xin Zhou, Yani Zhang, Yaomei Hu, Huiqin Wang & Naihong Chen. (2020) Anticancer property of ginsenoside Rh2 from ginseng. European Journal of Medicinal Chemistry 203, pages 112627.
Crossref
Shuyu Zhan, Amy Paik, Felicia Onyeabor, Baoyue Ding, Sunil Prabhu & Jeffrey Wang. (2020) Oral Bioavailability Evaluation of Celastrol-Encapsulated Silk Fibroin Nanoparticles Using an Optimized LC-MS/MS Method. Molecules 25:15, pages 3422.
Crossref
Wei Hou, Bo Liu & Hongtao Xu. (2020) Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology. European Journal of Medicinal Chemistry 189, pages 112081.
Crossref
Ding Qu, Mengying Jiao, Haijiao Lin, Chunli Tian, Guowei Qu, Jingwei Xue, Lingjing Xue, Caoyun Ju & Can Zhang. (2020) Anisamide-functionalized pH-responsive amphiphilic chitosan-based paclitaxel micelles for sigma-1 receptor targeted prostate cancer treatment. Carbohydrate Polymers 229, pages 115498.
Crossref
Qiushuang Li, Yang Xiong, Conghua Ji & Zhiqiang Yan. (2019) The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment. BioMed Research International 2019, pages 1-16.
Crossref
Josua Markus, Ramya Mathiyalagan, Yeon-Ju Kim, Yaxi Han, Zuly Elizabeth Jiménez-Pérez, Soshnikova Veronika & Deok-Chun Yang. (2019) Synthesis of hyaluronic acid or O -carboxymethyl chitosan-stabilized ZnO–ginsenoside Rh2 nanocomposites incorporated with aqueous leaf extract of Dendropanax morbifera Léveille: in vitro studies as potential sunscreen agents . New Journal of Chemistry 43:23, pages 9188-9200.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.