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Drug Delivery Volume 24, 2017 - Issue 1
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Research Article

Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique

Weiwei Wua Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field (SAVER), Ministry of Education, Alkali Soil Natural Environmental Science Center (ASNESC), Northeast Forestry University, Harbin, China;
,
Yuangang Zub Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, China
,
Li Wangb Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, China
,
Lingling Wangb Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, China
,
Huimei Wangb Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, China
,
Yuanyuan Lib Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, China
,
Mingfang Wub Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, China
,
Xiuhua Zhaob Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, ChinaCorrespondence[email protected]
&
Yujie Fub Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, ChinaCorrespondence[email protected]
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Pages 1713-1720 | Received 14 Sep 2017, Accepted 28 Oct 2017, Published online: 08 Nov 2017

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Chunkang Liu, Kunzhe Wu, Huan Gao, Jianyang Li & Xiaohua Xu. (2022) Current Strategies and Potential Prospects for Nanoparticle-Mediated Treatment of Diabetic Nephropathy. Diabetes, Metabolic Syndrome and Obesity 15, pages 2653-2673.
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Li Wang, Wenqiang Jia, Qilei Yang, Hongda Cai & Xiuhua Zhao. (2024) Casein nanoparticles as oral delivery carriers for improved bioavailability and hypoglycemic activity of apigenin.. Food Hydrocolloids 146, pages 109194.
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Yang Liu, Zhenfeng Wu, Yingchong Chen, Yongmei Guan, Huiwen Guo, Ming Yang & Pengfei Yue. (2023) Rubusoside as a multifunctional stabilizer for novel nanocrystal-based solid dispersions with a high drug loading: A case study. Journal of Pharmaceutical Sciences.
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Shengfeng Peng, David Julian McClements & Long Chen. 2023. Bioactive Delivery Systems for Lipophilic Nutraceuticals. Bioactive Delivery Systems for Lipophilic Nutraceuticals 301 321 .
Guendalina Zuccari & Silvana Alfei. (2023) Development of Phytochemical Delivery Systems by Nano-Suspension and Nano-Emulsion Techniques. International Journal of Molecular Sciences 24:12, pages 9824.
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Priya Shetti, Sunil S. Jalalpure, Archana S. Patil & Kirtanjot Kaur. (2023) Apigenin-Loaded Stealth Liposomes: Development and Pharmacokinetic Studies for Enhanced Plasma Retention of Drug in Cancer Therapy. Topics in Catalysis.
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Dan Yuan, Ziling Wang, Bin Li, Xiaoxuan Li, Yingyun Wang, Xinyu Wang, Jin Cao, Yujie Guo, Hongzhi Du & Shan Lu. (2023) Complexation of Apigenin and Oxymatrine Leading to Enhanced Anti-inflammatory Activity. Journal of Natural Products 86:5, pages 1179-1188.
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Rahul Kumar, Amit K. Thakur, Nilanjana Banerjee, Ashutosh Kumar, Gajendra Kumar Gaurav & Raj Kumar Arya. (2022) Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives. Drug Delivery and Translational Research 13:2, pages 400-418.
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Wei Wang, Ying Li, Huimei Wang & Xiuhua Zhao. (2022) The Preparation of Apigenin Nanoparticles and the Study of Their Anti-Inflammatory and Anti-Tumor Activities In Vitro. Separations 10:1, pages 16.
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Mahima Verma, Shireen Fatima & Irfan Ahmad Ansari. (2022) Phytofabricated Nanoparticle Formulation for Cancer Treatment: A Comprehensive Review. Current Drug Metabolism 23:10, pages 818-826.
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Moein Adel, Masoumeh Zahmatkeshan, Abolfazl Akbarzadeh, Navid Rabiee, Sepideh Ahmadi, Peyman Keyhanvar, Seyed Mahdi Rezayat & Alexander Marcus Seifalian. (2022) Chemotherapeutic effects of Apigenin in breast cancer: Preclinical evidence and molecular mechanisms; enhanced bioavailability by nanoparticles. Biotechnology Reports 34, pages e00730.
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Rahul Kumar, Amit K. Thakur, Pranava Chaudhari & Nilanjana Banerjee. (2021) Particle Size Reduction Techniques of Pharmaceutical Compounds for the Enhancement of Their Dissolution Rate and Bioavailability. Journal of Pharmaceutical Innovation 17:2, pages 333-352.
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Bin Li, Yi Hu, Ting Wu, Ying Feng, Cuiping Jiang, Hongzhi Du & Shan Lu. (2022) Apigenin-oxymatrine binary co-amorphous mixture: Enhanced solubility, bioavailability, and anti-inflammatory effect. Food Chemistry 373, pages 131485.
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Syed Sarim Imam, Sultan Alshehri, Mohammad A. Altamimi, Raed Khalid Hassan Almalki, Afzal Hussain, Sarah I. Bukhari, Wael A. Mahdi & Wajhul Qamar. (2022) Formulation of Chitosan-Coated Apigenin Bilosomes: In Vitro Characterization, Antimicrobial and Cytotoxicity Assessment. Polymers 14:5, pages 921.
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Ameeduzzafar Zafar, Nabil K. Alruwaili, Syed Sarim Imam, Omar Awad Alsaidan, Mohammed Muqtader Ahmed, Mohd Yasir, Musarrat Husain Warsi, Ali Alquraini, Mohammed M. Ghoneim & Sultan Alshehri. (2022) Development and Optimization of Hybrid Polymeric Nanoparticles of Apigenin: Physicochemical Characterization, Antioxidant Activity and Cytotoxicity Evaluation. Sensors 22:4, pages 1364.
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Shan Hong, Vermont P. Dia, Seung Joon Baek & Qixin Zhong. (2022) Nanoencapsulation of apigenin with whey protein isolate: Physicochemical properties, in vitro activity against colorectal cancer cells, and bioavailability. LWT 154, pages 112751.
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Rahul Kumar, Sanjay Kumar, Pranava Chaudhari & Amit K. Thakur. (2021) Liquid antisolvent recrystallization and solid dispersion of flufenamic acid with polyvinylpyrrolidone K-30. International Journal of Chemical Reactor Engineering 19:7, pages 663-671.
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Cheng Tang, Kun Meng, Xiaoming Chen, Hua Yao, Junqiong Kong, Fusu Li, Haiyan Yin, Mingji Jin, Hao Liang & Qipeng Yuan. (2021) Preparation, Characterization, and In Vivo Evaluation of Amorphous Icaritin Nanoparticles Prepared by a Reactive Precipitation Technique. Molecules 26:10, pages 2913.
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Rui Tian, Hui Wang, Yi Xiao, Pengyue Hu, Ruofei Du, Xiufeng Shi, Zhengtao Wang & Yan Xie. (2020) Fabrication of Nanosuspensions to Improve the Oral Bioavailability of Total Flavones from Hippophae rhamnoides L. and their Comparison with an Inclusion Complex. AAPS PharmSciTech 21:7.
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Catheleeya Mekjaruskul & Bungorn Sripanidkulchai. (2020) Kaempferia parviflora Nanosuspension Formulation for Scalability and Improvement of Dissolution Profiles and Intestinal Absorption. AAPS PharmSciTech 21:2.
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Qi-Yao Wei, Kai-Ming He, Jin-Ling Chen, Yan-Ming Xu & Andy T. Y. Lau. (2019) Phytofabrication of Nanoparticles as Novel Drugs for Anticancer Applications. Molecules 24:23, pages 4246.
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Francesco Lai, Michele Schlich, Rosa Pireddu, Anna Maria Fadda & Chiara Sinico. (2019) Nanocrystals as Effective Delivery Systems of Poorly Water-soluble Natural Molecules. Current Medicinal Chemistry 26:24, pages 4657-4680.
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Shanshan Zhang, Sajid Asghar, Feng Yu, Zhipeng Chen, Ziyi Hu, Qineng Ping, Feng Shao & Yanyu Xiao. (2019) BSA Nanoparticles Modified with N -Acetylcysteine for Improving the Stability and Mucoadhesion of Curcumin in the Gastrointestinal Tract . Journal of Agricultural and Food Chemistry 67:33, pages 9371-9381.
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Lu Wang, Chen Zhong, Yuangang Zu, Xiuhua Zhao, Yiping Deng, Weiwei Wu, Xiaoli Sun, Lingling Wang & Mingfang Wu. (2019) Preparation and characterization of luteolin nanoparticles for enhance bioavailability and inhibit liver microsomal peroxidation in rats. Journal of Functional Foods 55, pages 57-64.
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