Advanced search
Publication Cover
Drug Delivery Volume 25, 2018 - Issue 1
Submit an article Journal homepage
5,244
Views
44
CrossRef citations to date
0
Altmetric
Research Article

Doxorubicin conjugated with a trastuzumab epitope and an MMP-2 sensitive peptide linker for the treatment of HER2-positive breast cancer

Yiwen YouSchool of Pharmacy, Nanjing Medical University, Nanjing, China; View further author information
,
Zhiyuan XuSchool of Pharmacy, Nanjing Medical University, Nanjing, China; View further author information
&
Yun ChenSchool of Pharmacy, Nanjing Medical University, Nanjing, China; ;State Key Laboratory of Reproductive Medicine, Nanjing, ChinaCorrespondence[email protected]
View further author information
Pages 448-460 | Received 02 Nov 2017, Accepted 29 Jan 2018, Published online: 06 Feb 2018

Citations (44)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Yanqiu Zhang, Lianjun Peng, Jiahui Chu, Ming Zhang, Lizhu Sun, Bin Zhong & Qiyong Wu. (2018) pH and redox dual-responsive copolymer micelles with surface charge reversal for co-delivery of all-trans-retinoic acid and paclitaxel for cancer combination chemotherapy. International Journal of Nanomedicine 13, pages 6499-6515.
Read now

Articles from other publishers (43)

Pratiksha Tiwari, Krishna Yadav, Ravi Prakash Shukla, Shalini Gautam, Disha Marwaha, Madhu Sharma & Prabhat Ranjan Mishra. (2023) Surface modification strategies in translocating nano-vesicles across different barriers and the role of bio-vesicles in improving anticancer therapy. Journal of Controlled Release 363, pages 290-348.
Crossref
Asal Golchin, Masoumeh Maleki, Forough Alemi, Faezeh Malakoti & Bahman Yousefi. (2023) Autophagy‐targeted nanoparticles in breast carcinoma: A systematic review. Cell Biology International 47:11, pages 1767-1781.
Crossref
Akanksha Behl & Anil K. Chhillar. (2023) Nano-Based Drug Delivery of Anticancer Chemotherapeutic Drugs Targeting Breast Cancer. Recent Patents on Anti-Cancer Drug Discovery 18:3, pages 325-342.
Crossref
Marco Zambra, Ivan Ranđelović, Francesco Talarico, Adina Borbély, Laura Svajda, József Tóvári, Gábor Mező, Lizeth Bodero, Sveva Colombo, Federico Arrigoni, Elettra Fasola, Silvia Gazzola & Umberto Piarulli. (2023) Optimizing the enzymatic release of MMAE from isoDGR-based small molecule drug conjugate by incorporation of a GPLG-PABC enzymatically cleavable linker. Frontiers in Pharmacology 14.
Crossref
Huiqun Huang, Ronghui Liu, Jie Yang, Jing Dai, Shuhao Fan, Jiang Pi, Yubo Wei & Xinrong Guo. (2023) Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy. Pharmaceutics 15:7, pages 1868.
Crossref
Carina Hey Pui Cheung, Tin Hang Chong, Tongyao Wei, Han Liu & Xuechen Li. (2023) Guanidine Additive Enabled Intermolecular ortho‐ Phthalaldehyde‐Amine‐Thiol Three‐Component Reactions for Modular Constructions . Angewandte Chemie International Edition 62:10.
Crossref
Carina Hey Pui Cheung, Tin Hang Chong, Tongyao Wei, Han Liu & Xuechen Li. (2023) Guanidine Additive Enabled Intermolecular ortho‐ Phthalaldehyde‐Amine‐Thiol Three‐Component Reactions for Modular Constructions . Angewandte Chemie 135:10.
Crossref
Shurong Liu, Ye Tian, Sujun Jiang & Zihua Wang. (2023) A Novel Homodimer Peptide–Drug Conjugate Improves the Efficacy of HER2-Positive Breast Cancer Therapy. International Journal of Molecular Sciences 24:5, pages 4590.
Crossref
Shalini Mani, Geeta Swargiary, Sasha Gulati, Simmi Gupta & Divya Jindal. (2023) Molecular docking and ADMET studies to predict the anti-breast cancer effect of aloin by targeting estrogen and progesterone receptors. Materials Today: Proceedings 80, pages 2378-2384.
Crossref
Nazan GÖKŞEN TOSUN, Özlem KAPLAN, Seçil ERDEN TAYHAN, Cemil ALKAN & İsa GÖKÇE. (2022) A new approach to breast cancer therapy: targeted nanocarrier systemsMeme kanseri tedavisinde yeni bir yaklaşım: hedefledirilmiş nanotaşıyıcı sistemler. International Journal of Chemistry and Technology 6:2, pages 81-92.
Crossref
Sana Kalave, Namita Hegde & Kapil Juvale. (2022) Applications of Nanotechnology-based Approaches to Overcome Multi-drug Resistance in Cancer. Current Pharmaceutical Design 28:38, pages 3140-3157.
Crossref
Samuel E. Collyer, Gary D. Stack & John J. Walsh. (2022) Selective Delivery of Clinically Approved Tubulin Binding Agents through Covalent Conjugation to an Active Targeting Moiety. Current Medicinal Chemistry 29:31, pages 5179-5211.
Crossref
Li Zhao, Jiawen Xu, Yao Tong, Pengyu Gong, Fucheng Gao, Hui Li & Yanyan Jiang. (2022) Injectable “cocktail” hydrogel with dual‐stimuli‐responsive drug release, photothermal ablation, and drug‐antibody synergistic effect. SmartMat.
Crossref
Louis Jolivet, Imène Ait Mohamed Amar, Catherine Horiot, Fanny Boursin, Cyril Colas, Stéphanie Letast, Caroline Denevault-Sabourin, Emilie Allard-Vannier, Nicolas Joubert & Nicolas Aubrey. (2022) Intra-Domain Cysteines (IDC), a New Strategy for the Development of Original Antibody Fragment–Drug Conjugates (FDCs). Pharmaceutics 14:8, pages 1524.
Crossref
Sandra Megantara, Nasrul Wathoni, Ahmed Fouad Abdelwahab Mohammed, Cecep Suhandi, Maryam H. Ishmatullah & Melisa F. F. D. Putri. (2022) In Silico Study: Combination of α-Mangostin and Chitosan Conjugated with Trastuzumab against Human Epidermal Growth Factor Receptor 2. Polymers 14:13, pages 2747.
Crossref
Nesrine Ebrahim, Hajir A. Al Saihati, Ola Mostafa, Amira Hassouna, Sameh Abdulsamea, Eman Abd El Aziz M. El Gebaly, Nashwa Hassan Abo-Rayah, Dina Sabry, Mohamed El-Sherbiny, Abdelmonem G. Madboly, Noha Ibrahim Hussien, Raja El Hasnaoui Saadani, Hasnaa Ali Ebrahim, Omnia A. M. Badr, Nehal M. Elsherbiny & Rabab F. Salim. (2022) Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway. International Journal of Molecular Sciences 23:11, pages 5967.
Crossref
Liu Xu, Shan Xu, Tangyong Xiang, Heng Liu, Linwei Chen, Baoping Jiang, Junhong Yao, Hongliu Zhu, Rongfeng Hu & Zhipeng Chen. (2022) Multifunctional building elements for the construction of peptide drug conjugates. Engineered Regeneration 3:1, pages 92-109.
Crossref
Ana Isabel Fraguas-Sánchez, Irene Lozza & Ana Isabel Torres-Suárez. (2022) Actively Targeted Nanomedicines in Breast Cancer: From Pre-Clinal Investigation to Clinic. Cancers 14:5, pages 1198.
Crossref
Indu Pal Kaur, Joga Singh, Sumit Goel, Srishti Jain, Aagamjit Singh, Chitvan Pandit, Prasanna Alluri, Udit Soni, Ravi Pratap Barnwal, Alka Bhatia & Gurpal Singh. 2022. Unraveling the Complexities of Metastasis. Unraveling the Complexities of Metastasis 105 124 .
Mengjun Shu, Feng Gao, Min Zeng, Chulang Yu, Xue Wang, Renhua Huang, Jianhua Yang, Yanjie Su, Nantao Hu, Zhihua Zhou, Ke Liu, Zhi Yang, Hongtao Tan & Lin Xu. (2021) Microwave-Assisted Chitosan-Functionalized Graphene Oxide as Controlled Intracellular Drug Delivery Nanosystem for Synergistic Antitumour Activity. Nanoscale Research Letters 16:1.
Crossref
Aman Gour, Suman Ramteke & Narendra Kumar Jain. (2021) Pharmaceutical Applications of Quantum Dots. AAPS PharmSciTech 22:7.
Crossref
Yanan Li, Cangang Zhang, Guo Li, Guowei Deng, Hui Zhang, Yongbing Sun & Feifei An. (2021) Protease-triggered bioresponsive drug delivery for the targeted theranostics of malignancy. Acta Pharmaceutica Sinica B 11:8, pages 2220-2242.
Crossref
Leonidas Gkionis, Harmesh Aojula, Lynda K. Harris & Annalisa Tirella. (2021) Microfluidic-assisted fabrication of phosphatidylcholine-based liposomes for controlled drug delivery of chemotherapeutics. International Journal of Pharmaceutics 604, pages 120711.
Crossref
Kamila Butowska, Anna Woziwodzka, Agnieszka Borowik & Jacek Piosik. (2021) Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies. Materials 14:9, pages 2135.
Crossref
Xing-Yu Wang, Yi-Hui Wang, Zhen Song, Xin-Yuan Hu, Ji-Ping Wei, Jun Zhang & Huai-Song Wang. (2021) Recent progress in functional peptides designed for tumor-targeted imaging and therapy. Journal of Materials Chemistry C 9:11, pages 3749-3772.
Crossref
Bethany M. Cooper, Jessica Iegre, Daniel H. O' Donovan, Maria Ölwegård Halvarsson & David R. Spring. (2021) Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs). Chemical Society Reviews 50:3, pages 1480-1494.
Crossref
Leonidas Gkionis, Eleni Kavetsou, Alexandros Kalospyros, Dimitris Manousakis, Miguel Garzon Sanz, Sam Butterworth, Anastasia Detsi & Annalisa Tirella. (2020) Investigation of the cytotoxicity of bioinspired coumarin analogues towards human breast cancer cells. Molecular Diversity 25:1, pages 307-321.
Crossref
Mona Alas, Azam Saghaeidehkordi & Kamaljit Kaur. (2020) Peptide–Drug Conjugates with Different Linkers for Cancer Therapy. Journal of Medicinal Chemistry 64:1, pages 216-232.
Crossref
Huijuan Jin, Xiaojie Gao, Li Xiao, Huimin He, Sinan Cheng, Caixia Zhang, Yifan Hou, Fengying Song, Xiaorong Su, Qian Gao, Zheng Lu, Ruina Yang, Xigui Song, Jin Yang, Wei Duan & Yingchun Hou. (2020) Screening and identification of a specific peptide binding to breast cancer cells from a phage-displayed peptide library. Biotechnology Letters 43:1, pages 153-164.
Crossref
Li Chen, Guanya Chen, Zebin Yang, Hao Wang, Ning Liu, Yuxuan Liu, Kaiyi Fang, Yuguo Song & Xingang Guan. (2020) Enhanced cancer treatment by an acid-sensitive cytotoxic peptide-doxorubicin conjugate. Journal of Drug Delivery Science and Technology 60, pages 102048.
Crossref
Leonidas Gkionis, Richard A. Campbell, Harmesh Aojula, Lynda K. Harris & Annalisa Tirella. (2020) Manufacturing drug co-loaded liposomal formulations targeting breast cancer: Influence of preparative method on liposomes characteristics and in vitro toxicity. International Journal of Pharmaceutics 590, pages 119926.
Crossref
Olufunke Olorundare, Adejuwon Adeneye, Akinyele Akinsola, Sunday Soyemi, Alban Mgbehoma, Ikechukwu Okoye, James M. Ntambi & Hasan Mukhtar. (2020) African Vegetables (Clerodendrum volubile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats. Oxidative Medicine and Cellular Longevity 2020, pages 1-15.
Crossref
Youbei Qiao, Chunjing Zhan, Chaoli Wang, Xuetao Shi, Jingcheng Yang, Xin He, Erlong Ji, Zhe Yu, Changjiao Yan & Hong Wu. (2020) MMP-2 sensitive poly(malic acid) micelles stabilized by π–π stacking enable high drug loading capacity. Journal of Materials Chemistry B 8:37, pages 8527-8535.
Crossref
Kamila Butowska, Krzysztof Żamojć, Mateusz Kogut, Witold Kozak, Dariusz Wyrzykowski, Wiesław Wiczk, Jacek Czub, Jacek Piosik & Janusz Rak. (2020) The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide–Doxorubicin Binding to DNA. International Journal of Molecular Sciences 21:18, pages 6923.
Crossref
Nicolas Joubert, Alain Beck, Charles Dumontet & Caroline Denevault-Sabourin. (2020) Antibody–Drug Conjugates: The Last Decade. Pharmaceuticals 13:9, pages 245.
Crossref
Lushan Wang, Ning Wang, Runshi Zhang, Dong Dong, Rui Liu, Lufang Zhang, Wei Ji, Man Yu, Fei Zhang, Ruifang Niu & Yunli Zhou. (2020) TGFβ regulates NK1R-Tr to affect the proliferation and apoptosis of breast cancer cells. Life Sciences 256, pages 117674.
Crossref
Kinga Piorecka, David Smith, Jan Kurjata, Maciej Stanczyk & Wlodzimierz A. Stanczyk. (2020) Synthetic routes to nanoconjugates of anthracyclines. Bioorganic Chemistry 96, pages 103617.
Crossref
Alain Beck, Charles Dumontet & Nicolas Joubert. (2020) Les immunoconjugués en oncologie. médecine/sciences 35:12, pages 1043-1053.
Crossref
Ilona Pysz, Paolo Andriollo & David E. Thurston. 2019. Cytotoxic Payloads for Antibody – Drug Conjugates. Cytotoxic Payloads for Antibody – Drug Conjugates 137 165 .
Piumi Y. Liyanage, Sajini D. Hettiarachchi, Yiqun Zhou, Allal Ouhtit, Elif S. Seven, Cagri Y. Oztan, Emrah Celik & Roger M. Leblanc. (2019) Nanoparticle-mediated targeted drug delivery for breast cancer treatment. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1871:2, pages 419-433.
Crossref
Li Xiao, Ni Ma, Huimin He, Jinmei Li, Sinan Cheng, Qian Yang, Yifan Hou, Fengying Song, Huijuan Jin, Xiaorong Su, Jing Dong, Ruiye Zuo, Xigui Song, Wei Duan & Yingchun Hou. (2019) Development of a novel drug targeting delivery system for cervical cancer therapy. Nanotechnology 30:7, pages 075604.
Crossref
Mengting Liu, Wenjuan Ma, Qianshun Li, Dan Zhao, Xiaoru Shao, Qian Huang, Liying Hao & Yunfeng Lin. (2018) Aptamer‐targeted DNA nanostructures with doxorubicin to treat protein tyrosine kinase 7‐positive tumours . Cell Proliferation 52:1.
Crossref
Nicolas Aubrey, Emilie Allard-Vannier, Camille Martin, Francesca Bryden, Stéphanie Letast, Cyril Colas, Zineb Lakhrif, Nils Collinet, Isabelle Dimier-Poisson, Igor Chourpa, Marie-Claude Viaud-Massuard & Nicolas Joubert. (2018) Site-Specific Conjugation of Auristatins onto Engineered scFv Using Second Generation Maleimide to Target HER2-positive Breast Cancer in Vitro . Bioconjugate Chemistry 29:11, pages 3516-3521.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.