4,980
Views
61
CrossRef citations to date
0
Altmetric
Research Article

Improving the topical ocular pharmacokinetics of lyophilized cyclosporine A-loaded micelles: formulation, in vitro and in vivo studies

, , , , &
Pages 888-899 | Received 14 Feb 2018, Accepted 25 Mar 2018, Published online: 10 Apr 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Ye Liu, Haonan Xu, Na Yan, Zhan Tang & Qiao Wang. (2023) Research progress of ophthalmic preparations of immunosuppressants. Drug Delivery 30:1.
Read now
Gary W Jerkins, Guruprasad R Pattar & Shane R Kannarr. (2020) A Review of Topical Cyclosporine A Formulations—A Disease-Modifying Agent for Keratoconjunctivitis Sicca. Clinical Ophthalmology 14, pages 481-489.
Read now
Dilshad Quereshi, Somali Dhal, Debasis Das, Biswaranjan Mohanty, Arfat Anis, Hamid Shaikh, Thi Thanh Hanh Nguyen, Doman Kim, Preetam Sarkar & Kunal Pal. (2020) Neem seed oil and gum arabic-based oil-in-water emulsions as potential ocular drug delivery system. Journal of Dispersion Science and Technology 41:13, pages 1911-1924.
Read now
Vrinda Gote, Michael Ansong & Dhananjay Pal. (2020) Prodrugs and nanomicelles to overcome ocular barriers for drug penetration. Expert Opinion on Drug Metabolism & Toxicology 16:10, pages 885-906.
Read now
Maria Aurora Grimaudo, Silvia Pescina, Cristina Padula, Patrizia Santi, Angel Concheiro, Carmen Alvarez-Lorenzo & Sara Nicoli. (2019) Topical application of polymeric nanomicelles in ophthalmology: a review on research efforts for the noninvasive delivery of ocular therapeutics. Expert Opinion on Drug Delivery 16:4, pages 397-413.
Read now
Fengyuan Sun, Zhou Zheng, Jie Lan, Xuefei Li, Mengshuang Li, Kaichao Song & Xianggen Wu. (2019) New micelle myricetin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment. Drug Delivery 26:1, pages 575-585.
Read now
Mengshuang Li, Jie Lan, Xuefei Li, Meng Xin, Hui Wang, Fan Zhang, Xiaohong Lu, Zengfang Zhuang & Xianggen Wu. (2019) Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery. Drug Delivery 26:1, pages 481-489.
Read now
Yan Shen, Yinglan Yu, Birendra Chaurasiya, Xiaolian Li, Ying Xu, Thomas J Webster, Jiasheng Tu & Runing Sun. (2018) Stability, safety, and transcorneal mechanistic studies of ophthalmic lyophilized cyclosporine-loaded polymeric micelles. International Journal of Nanomedicine 13, pages 8281-8296.
Read now

Articles from other publishers (53)

Karthikeyan Elumalai, Sivaneswari Srinivasan & Anandakumar Shanmugam. (2024) Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment. Biomedical Technology 5, pages 109-122.
Crossref
Ping Lu, Zhen Liang, Zhen Zhang, Jingjing Yang, Fei Song, Tianyang Zhou, Jingguo Li & Junjie Zhang. (2024) Novel nanomicelle butenafine formulation for ocular drug delivery against fungal keratitis: In Vitro and In Vivo study. European Journal of Pharmaceutical Sciences 192, pages 106629.
Crossref
Sanchit Arora, Sanat Kumar Dash, Dimple Dhawan, Prabhat Kumar Sahoo, Anil Jindal & Dalapathi Gugulothu. (2023) Freeze-drying revolution: unleashing the potential of lyophilization in advancing drug delivery systems. Drug Delivery and Translational Research.
Crossref
Ziyad Binkhathlan, Raisuddin Ali, Abdullah H. Alomrani, Mohd Abul Kalam, Aws Alshamsan & Afsaneh Lavasanifar. (2023) Role of Polymeric Micelles in Ocular Drug Delivery: An Overview of Decades of Research. Molecular Pharmaceutics 20:11, pages 5359-5382.
Crossref
Nazish Mumtaz, Muhammad Imran, Ayesha Javaid, Shoomaila Latif, Nazim Hussain & Liviu Mitu. (2023) Nanomaterials for Targeted Drug Delivery through Skin to Treat Various Diseases: Recent Trends and Future Perspective. Journal of Chemistry 2023, pages 1-21.
Crossref
Srushti Shah & Vandana Patel. (2023) Targeting Posterior Eye Infections with Colloidal Carriers: The Case of Ganciclovir. International Journal of Pharmaceutics, pages 123427.
Crossref
Ruijun Cai, Ling Zhang & Hao Chi. (2023) Recent development of polymer nanomicelles in the treatment of eye diseases. Frontiers in Bioengineering and Biotechnology 11.
Crossref
Syed Nazrin Ruhina Rahman, Neha Agarwal, Abhinab Goswami, Amoolya Sree, Aishwarya Jala, Animith Venuganti, Apurba Deka, Roshan M. Borkar, Vivek Singh, Dipankar Das & Tamilvanan Shunmugaperumal. (2023) Studies on spray dried topical ophthalmic emulsions containing cyclosporin A (0.05% w/w): systematic optimization, in vitro preclinical toxicity and in vivo assessments. Drug Delivery and Translational Research 13:6, pages 1654-1674.
Crossref
Haijie Han, Su Li, Mingyu Xu, Yueyang Zhong, Wenjie Fan, Jingwei Xu, Tinglian Zhou, Jian Ji, Juan Ye & Ke Yao. (2023) Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives. Advanced Drug Delivery Reviews 196, pages 114770.
Crossref
Kevin Y. Wu, Maxine Joly-Chevrier, Dania Akbar & Simon D. Tran. (2023) Overcoming Treatment Challenges in Posterior Segment Diseases with Biodegradable Nano-Based Drug Delivery Systems. Pharmaceutics 15:4, pages 1094.
Crossref
R. Manasa & Mahesh Shivananjappa. 2023. Advances in Novel Formulations for Drug Delivery. Advances in Novel Formulations for Drug Delivery 279 307 .
Kevin Y. Wu, Said Ashkar, Shrieda Jain, Michael Marchand & Simon D. Tran. (2023) Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma. Polymers 15:6, pages 1373.
Crossref
Sankha Bhattacharya, Vipan Kumar Parihar & Bhupendra G. Prajapati. (2023) Unveiling the therapeutic potential of cabozantinib-loaded poly D,L-lactic-co-glycolic acid and polysarcosine nanoparticles in inducing apoptosis and cytotoxicity in human HepG2 hepatocellular carcinoma cell lines and in vivo anti-tumor activity in SCID female mice. Frontiers in Oncology 13.
Crossref
Adaeze Linda Onugwu, Chinekwu Sherridan Nwagwu, Obinna Sabastine Onugwu, Adaeze Chidiebere Echezona, Chinazom Precious Agbo, Stella Amarachi Ihim, Prosper Emeh, Petra Obioma Nnamani, Anthony Amaechi Attama & Vitaliy V. Khutoryanskiy. (2023) Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases. Journal of Controlled Release 354, pages 465-488.
Crossref
Garima Rawat, Shital Kolhe, Dhwani Rana, Sagar Salave & Derajram Benival. (2023) Exploring the Therapeutic Potential of Cyclosporine for Ophthalmic Indications by Novel Carrier Systems. Critical Reviews™ in Therapeutic Drug Carrier Systems 40:5, pages 1-45.
Crossref
Honey Goel, Nitu Dogra, Richu Singla & Sushama Talegaonkar. 2023. Nanotechnology in Ophthalmology. Nanotechnology in Ophthalmology 49 66 .
Mrunali R. Patel, Mayank N. Jain & Rashmin B. Patel. 2023. Nanotechnology in Ophthalmology. Nanotechnology in Ophthalmology 215 225 .
Tian-Zuo Wang, Xin-Xin Liu, Si-Yu Wang, Yan Liu, Xin-Yang Pan, Jing-Jie Wang & Kai-Hui Nan. (2022) Engineering Advanced Drug Delivery Systems for Dry Eye: A Review. Bioengineering 10:1, pages 53.
Crossref
Noriaki Nagai & Hiroko Otake. (2022) Novel drug delivery systems for the management of dry eye. Advanced Drug Delivery Reviews 191, pages 114582.
Crossref
Dongyang Gao, Zhuoli Da, Kan Yang & Yuanyuan Shi. (2022) Comparison of seven cyclosporine A formulations for dry eye disease: A systematic review and network meta-analysis. Frontiers in Pharmacology 13.
Crossref
Martina Ghezzi, Ilaria Ferraboschi, Andrea Delledonne, Silvia Pescina, Cristina Padula, Patrizia Santi, Cristina Sissa, Francesca Terenziani & Sara Nicoli. (2022) Cyclosporine-loaded micelles for ocular delivery: Investigating the penetration mechanisms. Journal of Controlled Release 349, pages 744-755.
Crossref
Onyinye Uwaezuoke, Lisa C. Du Toit, Pradeep Kumar, Naseer Ally & Yahya E. Choonara. (2022) Linoleic Acid-Based Transferosomes for Topical Ocular Delivery of Cyclosporine A. Pharmaceutics 14:8, pages 1695.
Crossref
Raquel Gregorio Arribada, Francine Behar-Cohen, Andre Luis Branco de Barros & Armando Silva-Cunha. (2022) The Use of Polymer Blends in the Treatment of Ocular Diseases. Pharmaceutics 14:7, pages 1431.
Crossref
K.D. Patel, L. Barrios Silva, Y. Park, T. Shakouri, Z. Keskin-Erdogan, P. Sawadkar, K.J. Cho, J.C. Knowles, D.Y.S. Chau & H.-W. Kim. (2022) Recent advances in drug delivery systems for glaucoma treatment. Materials Today Nano 18, pages 100178.
Crossref
Ranjit De, Manoj Kumar Mahata & Kyong‐Tai Kim. (2022) Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles. Advanced Science 9:10.
Crossref
Emine Kahraman, M. Ezgi Durgun, Sevgi Güngör & Yıldız Özsoy. 2022. Polymeric Micelles for Drug Delivery. Polymeric Micelles for Drug Delivery 115 143 .
Hamed Morad, Kamyar Jounaki, Mojtaba Ansari, Salar Sadeghian-Abadi, Hossein Vahidi & Hamed Barabadi. 2022. Pharmaceutical Nanobiotechnology for Targeted Therapy. Pharmaceutical Nanobiotechnology for Targeted Therapy 187 225 .
Nagendra Bhuwane, Ishwari Choudhary, Shweta Ramkar, Narayan Hemnani, Abhishek K. Sah & Preeti K. Suresh. 2022. Macrophage Targeted Delivery Systems. Macrophage Targeted Delivery Systems 415 436 .
Alexander Vaneev, Victoria Tikhomirova, Natalia Chesnokova, Ekaterina Popova, Olga Beznos, Olga Kost & Natalia Klyachko. (2021) Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye. International Journal of Molecular Sciences 22:22, pages 12368.
Crossref
Zhiguo Li, Minting Liu, Lingjie Ke, Li-Juan Wang, Caisheng Wu, Cheng Li, Zibiao Li & Yun-Long Wu. (2021) Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years. Nanoscale Advances 3:18, pages 5240-5254.
Crossref
Faryal jahan, Shahiq uz Zaman, Rabia Arshad, Tanveer A. Tabish, Abbas Ali Naseem & Gul Shahnaz. (2021) Mapping the potential of thiolated pluronic based nanomicelles for the safe and targeted delivery of vancomycin against staphylococcal blepharitis. Journal of Drug Delivery Science and Technology 61, pages 102220.
Crossref
Uta Gehlsen, Sebastian Siebelmann & Philipp Steven. (2021) Tolerance and Adherence to Cationic 0.1% Cyclosporine in Ocular Graft-versus-Host Disease. Ophthalmic Research 64:1, pages 77-84.
Crossref
Sheetal Devi, Shailendra Bhatt, Vipin Saini, Manish Kumar & Aman Deep. (2020) A Review on Polymeric Nano Micelles Based Delivery to the Posterior Segment of the Eye. Nanoscience & Nanotechnology-Asia 10:5, pages 591-601.
Crossref
Subramanian Natesan, Sai H.S. Boddu, Venkateshwaran Krishnaswami & Moyad Shahwan. (2020) The Role of Nano-ophthalmology in Treating Dry Eye Disease. Pharmaceutical Nanotechnology 8:4, pages 258-289.
Crossref
Belén Begines, Tamara Ortiz, María Pérez-Aranda, Guillermo Martínez, Manuel Merinero, Federico Argüelles-Arias & Ana Alcudia. (2020) Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects. Nanomaterials 10:7, pages 1403.
Crossref
Meltem Ezgi DurgunSevgi GüngörYıldız Özsoy. (2020) Micelles: Promising Ocular Drug Carriers for Anterior and Posterior Segment Diseases. Journal of Ocular Pharmacology and Therapeutics 36:6, pages 323-341.
Crossref
Roseline Mazet, Josias B. G. Yaméogo, Denis Wouessidjewe, Luc Choisnard & Annabelle Gèze. (2020) Recent Advances in the Design of Topical Ophthalmic Delivery Systems in the Treatment of Ocular Surface Inflammation and Their Biopharmaceutical Evaluation. Pharmaceutics 12:6, pages 570.
Crossref
Meltem E. Durgun, Emine Kahraman, Sevgi Güngör & Yıldız Özsoy. (2020) Optimization and Characterization of Aqueous Micellar Formulations for Ocular Delivery of an Antifungal Drug, Posaconazole. Current Pharmaceutical Design 26:14, pages 1543-1555.
Crossref
Clotilde Jumelle, Shima Gholizadeh, Nasim Annabi & Reza Dana. (2020) Advances and limitations of drug delivery systems formulated as eye drops. Journal of Controlled Release 321, pages 1-22.
Crossref
Wan Sun, Xiaonan Shi, Chen Chen, Yan‐Ping Zhu, Zhengyu Liu & Bolin Zhu. (2020) Palladium‐Catalyzed Cascade Cyclization/Alkynylation of Alkene‐Tethered Carbamoyl Chlorides with Terminal Alkynes: Synthesis of Alkyne‐Functionalized Oxindoles. Asian Journal of Organic Chemistry 9:4, pages 575-578.
Crossref
Eleonora Terreni, Patrizia Chetoni, Silvia Tampucci, Susi Burgalassi, Ali Al-kinani, Raid Alany & Daniela Monti. (2020) Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A. Pharmaceutics 12:3, pages 253.
Crossref
Syed Nazrin Ruhina Rahman, Datta Maroti Pawde, Oly Katari, Victor Hmingthansanga & Tamilvanan Shunmugaperumal. (2019) Systematic Optimization, In Vitro Drug Release, and Preliminary Nonclinical Toxicity Assessment of Nonphospholipid-Based Topical Ophthalmic Emulsions Containing 0.05 or 0.1% w/w Cyclosporin A for Dry-Eye Syndrome Management. AAPS PharmSciTech 21:2.
Crossref
Maryam Koopaie. 2020. Nanoengineered Biomaterials for Advanced Drug Delivery. Nanoengineered Biomaterials for Advanced Drug Delivery 525 559 .
Yingying Zhang, Chen Chen, Jinghui Zhao & Guiyan Liu. (2019) Rhodium‐Catalyzed Cascade Radical Cyclization of 1,6‐Enynes with Br−CX 3 : Access to Bromine‐Containing Trihalomethylated Pyrrolidines . Asian Journal of Organic Chemistry 8:12, pages 2249-2256.
Crossref
Aws Alshamsan, Mohd Abul Kalam, Mohammad Reza Vakili, Ziyad Binkhathlan, Mohammad Raish, Raisuddin Ali, Turki A. Alturki, Nazila Safaei Nikouei & Afsaneh Lavasanifar. (2019) Treatment of endotoxin-induced uveitis by topical application of cyclosporine a-loaded PolyGel™ in rabbit eyes. International Journal of Pharmaceutics 569, pages 118573.
Crossref
Pescina, Lucca, Govoni, Padula, Favero, Cantù, Santi & Nicoli. (2019) Ex Vivo Conjunctival Retention and Transconjunctival Transport of Poorly Soluble Drugs Using Polymeric Micelles. Pharmaceutics 11:9, pages 476.
Crossref
Yu-Kai Kuo, I-Chan Lin, Li-Nien Chien, Tzu-Yu Lin, Ying-Ting How, Ko-Hua Chen, Gregory J. Dusting & Ching-Li Tseng. (2019) Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits. Journal of Clinical Medicine 8:8, pages 1227.
Crossref
Mengjie Guo, Dongdong Sun, Zhimin Fan, Yuxia Yuan, Miaomiao Shao, Jianhao Hou, Yuqi Zhu, Rongfang Wei, Yan Zhu, Jinjun Qian, Fei Li, Ye Yang & Chunyan Gu. (2019) Targeting MK2 Is a Novel Approach to Interfere in Multiple Myeloma. Frontiers in Oncology 9.
Crossref
Di Chen, Shunhua Zhang, Ailing Bian, Jing Hong, Yingping Deng, Mingchang Zhang, Wei Chen, Yan Shao & Jialiang Zhao. (2019) Efficacy and safety of 0.05% cyclosporine ophthalmic emulsion in treatment of Chinese patients with moderate to severe dry eye disease: A 12-week, multicenter, randomized, double-masked, placebo-controlled phase III clinical study. Medicine 98:31, pages e16710.
Crossref
Astrid Subrizi, Eva M. del Amo, Viktor Korzhikov-Vlakh, Tatiana Tennikova, Marika Ruponen & Arto Urtti. (2019) Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties. Drug Discovery Today 24:8, pages 1446-1457.
Crossref
Ozgur Esim, Sevinc Kurbanoglu, Ayhan Savaser, Sibel A. Ozkan & Yalcin Ozkan. 2019. New Developments in Nanosensors for Pharmaceutical Analysis. New Developments in Nanosensors for Pharmaceutical Analysis 273 301 .
Maren Kasper, Doris Gabriel, Michael Möller, Dirk Bauer, Lena Wildschütz, Herve Courthion, Marta Rodriguez-Aller, Martin Busch, Michael R.R. Böhm, Karin Loser, Solon Thanos, Robert Gurny & Arnd Heiligenhaus. (2018) Cyclosporine A-Loaded Nanocarriers for Topical Treatment of Murine Experimental Autoimmune Uveoretinitis. Molecular Pharmaceutics 15:7, pages 2539-2547.
Crossref
Yongpeng Huang, Bo Chen, Hui Tang, Xiang-yan Meng, Hui Zhong, Yun-yang Song & Zhi-yun Zou. (2022) A Rapid and Sensitive Hplc-Dad Method for the Determination of Cyclosporine a. SSRN Electronic Journal.
Crossref