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Drug Delivery Volume 25, 2018 - Issue 1
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Research Article

Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2

Ao LiENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; ;Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Research Institution of Otorhinolaryngology, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing, China; View further author information
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Dan YouENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; View further author information
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Wenyan LiENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; View further author information
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Yingjie CuiKnowshine (Shanghai) Pharmaceuticals Inc, Shanghai, China; View further author information
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Yingzi HeENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; View further author information
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Wen LiENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; View further author information
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Yan ChenENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; View further author information
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Xiao FengKnowshine (Shanghai) Pharmaceuticals Inc, Shanghai, China; View further author information
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Shan SunENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2142-4307View further author information
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Renjie ChaiKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Institute of Life Sciences, Southeast University, Nanjing, China; ;Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China; Correspondence[email protected]
View further author information
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Huawei LiENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; ;Institutes of Biomedical Sciences and The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, ChinaCorrespondence[email protected]
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Pages 1033-1043 | Received 03 Feb 2018, Accepted 02 Apr 2018, Published online: 24 Apr 2018

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Yanji Qu, Shimin Zong, Zhe Wang, Peiyu Du, Yingying Wen, Hao Li, Nan Wu & Hongjun Xiao. (2023) The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells. Drug and Chemical Toxicology 46:2, pages 369-379.
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