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Drug Delivery Volume 25, 2018 - Issue 1
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Research Article

Bispecific antibodies (anti-mPEG/anti-HER2) for active tumor targeting of docetaxel (DTX)-loaded mPEGylated nanocarriers to enhance the chemotherapeutic efficacy of HER2-overexpressing tumors

Chia-Yu SuSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC; View further author information
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Michael ChenPh.D. Program in Clinical Drug Development of Chinese Herbal Medicine, Taipei Medical University, Taipei, Taiwan, ROC; View further author information
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Ling-Chun ChenDepartment of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu, Taiwan, ROC; View further author information
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Yuan-Soon HoGraduate Institute of Medical Sciences, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ROC; View further author information
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Hsiu-O HoSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC; View further author information
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Shyr-Yi LinDepartment of Primary Care Medicine, Taipei Medical University Hospital, Taipei, Taiwan, ROC; ;Department of General Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC; ;TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan, ROC; View further author information
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Kuo-Hsiang ChuangPh.D. Program in Clinical Drug Development of Chinese Herbal Medicine, Taipei Medical University, Taipei, Taiwan, ROC; ;Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan, ROCCorrespondence[email protected]
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Ming-Thau SheuSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC; Correspondence[email protected]
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Pages 1066-1079 | Received 24 Feb 2018, Accepted 16 Apr 2018, Published online: 02 May 2018

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Wei-Jie Cheng, Shyr-Yi Lin, Michael Chen, Ling-Chun Chen, Hsiu-O Ho, Kuo-Hsiang Chuang & Ming-Thau Sheu. (2021) Active Tumoral/Tumor Environmental Dual-Targeting by Non-Covalently Arming with Trispecific Antibodies or Dual-Bispecific Antibodies on Docetaxel-Loaded mPEGylated Nanocarriers to Enhance Chemotherapeutic Efficacy and Minimize Systemic Toxicity. International Journal of Nanomedicine 16, pages 4017-4030.
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Chuan Zhang, Yujuan Zhang, Maolin Liang, Xiumin Shi, Yan Jun, Longfei Fan, Kai Yang, Feng Wang, Wei Li & Ran Zhu. (2022) Near-infrared upconversion multimodal nanoparticles for targeted radionuclide therapy of breast cancer lymphatic metastases. Frontiers in Immunology 13.
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Fatemeh Movahedi, Jie Liu, Bing Sun, Pei Cao, Luyao Sun, Christopher Howard, Wenyi Gu & Zhi Ping Xu. (2022) PD-L1-Targeted Co-Delivery of Two Chemotherapeutics for Efficient Suppression of Skin Cancer Growth. Pharmaceutics 14:7, pages 1488.
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Shun‐Yu Wu, Fu‐Gen Wu & Xiaoyuan Chen. (2022) Antibody‐Incorporated Nanomedicines for Cancer Therapy. Advanced Materials 34:24.
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Wei-Jie Cheng, Kuo-Hsiang Chuang, Yu-Ju Lo, Michael Chen, Yi-Jou Chen, Steve R. Roffler, Hsiu-O Ho, Shyr-Yi Lin & Ming-Thau Sheu. (2022) Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy. Journal of Controlled Release 344, pages 235-248.
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Lei Huang, Ruiqin Wang, Kun Xie, Jingming Zhang, Fei Tao, Chenyu Pi, Yan Feng, Hua Gu & Jianmin Fang. (2021) A HER2 target antibody drug conjugate combined with anti-PD-(L)1 treatment eliminates hHER2+ tumors in hPD-1 transgenic mouse model and contributes immune memory formation. Breast Cancer Research and Treatment 191:1, pages 51-61.
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Michael Chen, Ming-Thau Sheu, Tian-Lu Cheng, Steve R. Roffler, Shyr-Yi Lin, Yi-Jou Chen, Yi-An Cheng, Jing-Jy Cheng, Hsin-Yu Chang, Tung-Yun Wu, An-Pei Kao, Yuan-Soon Ho & Kuo-Hsiang Chuang. (2022) A novel anti-tumor/anti-tumor-associated fibroblast/anti-mPEG tri-specific antibody to maximize the efficacy of mPEGylated nanomedicines against fibroblast-rich solid tumor. Biomaterials Science 10:1, pages 202-215.
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Sunaina Saha, Diana D'souza & Vaishali Y. Londhe. (2021) Exploring the concepts of various nano-formulations loaded with herbal drugs moieties against breast cancer using PRISMA analysis. Journal of Drug Delivery Science and Technology 66, pages 102865.
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Xiu-Fang Li, Chen-Fu Liu & Guo-Wu Rao. (2021) Monoclonal Antibodies, Small Molecule Inhibitors and Antibody-drug Conjugates as HER2 Inhibitors. Current Medicinal Chemistry 28:17, pages 3339-3360.
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Justin T. Huckaby, Tim M. Jacobs, Zhongbo Li, Robert J. Perna, Anting Wang, Nathan I. Nicely & Samuel K. Lai. (2020) Structure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers. Communications Chemistry 3:1.
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Gautam Kumar, Krishnadas Nandakumar, Srinivas Mutalik & Chamallamudi Mallikarjuna Rao. (2020) Biologicals to direct nanotherapeutics towards HER2-positive breast cancers. Nanomedicine: Nanotechnology, Biology and Medicine 27, pages 102197.
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Robert M. Hughes & Jitka A.I. Virag. (2020) Harnessing the Power of Eph/ephrin Biosemiotics for Theranostic Applications. Pharmaceuticals 13:6, pages 112.
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Shreffler, Pullan, Dailey, Mallik & Brooks. (2019) Overcoming Hurdles in Nanoparticle Clinical Translation: The Influence of Experimental Design and Surface Modification. International Journal of Molecular Sciences 20:23, pages 6056.
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Christina L. Parker, Morgan D. McSweeney, Andrew T. Lucas, Timothy M. Jacobs, Daniel Wadsworth, William C. Zamboni & Samuel K. Lai. (2019) Pretargeted delivery of PEG-coated drug carriers to breast tumors using multivalent, bispecific antibody against polyethylene glycol and HER2. Nanomedicine: Nanotechnology, Biology and Medicine 21, pages 102076.
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Yi-An Cheng, I-Ju Chen, Yu-Cheng Su, Kai-Wen Cheng, Yun-Chi Lu, Wen-Wei Lin, Yuan-Chin Hsieh, Chien-Han Kao, Fang-Ming Chen, Steve R. Roffler & Tian-Lu Cheng. (2019) Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer. Biomaterials Science 7:8, pages 3404-3417.
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Jianan Bai, Ye Tian, Fangzhou Liu, Xiaolin Li, Yun Shao, Xintong Lu, Jintian Wang, Guoqin Zhu, Bingyan Xue, Min Liu, Ping Hu, Na He & Qiyun Tang. (2019) Octreotide-Conjugated Core-Cross-Linked Micelles with pH/Redox Responsivity Loaded with Etoposide for Neuroendocrine Neoplasms Therapy and Bioimaging with Photoquenching Resistance. ACS Applied Materials & Interfaces 11:20, pages 18111-18122.
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Madeline T. Olson, Quan P. Ly & Aaron M. Mohs. (2018) Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation. Molecular Imaging and Biology 21:2, pages 200-218.
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