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Drug Delivery Volume 25, 2018 - Issue 1
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Research Article

Licorice root extract and magnesium isoglycyrrhizinate protect against triptolide-induced hepatotoxicity via up-regulation of the Nrf2 pathway

Qin-You TanClinical Pharmacy and Pharmacology Research Institute, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; ;Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; ;China-USA Lipids in Health and Disease Research Center, Guilin Medical University, Guilin, PR China; View further author information
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Qian HuClinical Pharmacy and Pharmacology Research Institute, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; View further author information
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Sheng-Nan ZhuClinical Pharmacy and Pharmacology Research Institute, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; ;Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; ;China-USA Lipids in Health and Disease Research Center, Guilin Medical University, Guilin, PR China; View further author information
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Lu-Lu JiaClinical Pharmacy and Pharmacology Research Institute, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; View further author information
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Juan XiaoLaboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; ;China-USA Lipids in Health and Disease Research Center, Guilin Medical University, Guilin, PR China; View further author information
,
Hua-Zhen SuClinical Pharmacy and Pharmacology Research Institute, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; View further author information
,
Shao-Yuan HuangClinical Pharmacy and Pharmacology Research Institute, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; View further author information
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Jing ZhangClinical Pharmacy and Pharmacology Research Institute, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; ;Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; Correspondence[email protected]
View further author information
&
Junfei JinLaboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, PR China; ;China-USA Lipids in Health and Disease Research Center, Guilin Medical University, Guilin, PR China; ;Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin Medical University, Guilin, PR ChinaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-9237-9024View further author information
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Pages 1213-1223 | Received 22 Mar 2018, Accepted 01 May 2018, Published online: 23 May 2018

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Sophia Seen. (2021) Chronic liver disease and oxidative stress – a narrative review. Expert Review of Gastroenterology & Hepatology 15:9, pages 1021-1035.
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Ranjana Bhandari, Japneet Kaur, Simerpreet Kaur & Anurag Kuhad. (2021) The Nrf2 pathway in psychiatric disorders: pathophysiological role and potential targeting. Expert Opinion on Therapeutic Targets 25:2, pages 115-139.
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Xin-Yi Liu, Wen-Jun Pei, Ye-Zhen Wu, Fang-Li Ren, Si-Yu Yang & Xiu Wang. (2021) Transdermal delivery of triptolide–phospholipid complex to treat rheumatoid arthritis. Drug Delivery 28:1, pages 2127-2136.
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Jiarui Zhang, Rui Zhao, Dongliang Xing, Jing Cao, Yan Guo, Liang Li, Yanan Sun, Linli Tian & Ming Liu. (2020) Magnesium Isoglycyrrhizinate Induces an Inhibitory Effect on Progression and Epithelial–Mesenchymal Transition of Laryngeal Cancer via the NF-κB/Twist Signaling. Drug Design, Development and Therapy 14, pages 5633-5644.
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Qian-Qian Shan, Xiao-Jing Jiang, Fang-Yuan Wang, Zi-Xuan Shu & Shuang-Ying Gui. (2019) Cubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide. Drug Delivery 26:1, pages 490-498.
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Dongxiao Cui, Dingqiao Xu, Shijun Yue, Chaoqun Yan, Wenjuan Liu, Ruijia Fu, Wenfu Ma & Yuping Tang. (2023) Recent advances in the pharmacological applications and liver toxicity of triptolide. Chemico-Biological Interactions 382, pages 110651.
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Wen Gao, Yichang Zhao, Lin Guo, Yikun Wang, Hui Gong, Bikui Zhang & Miao Yan. (2023) Comparative effectiveness of glycyrrhizic acid preparations aimed at improving liver function of patients with chronic hepatitis B: A network meta-analysis of 53 randomized controlled trials. Phytomedicine 116, pages 154883.
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Jing Song, Guan-Nan He & Long Dai. (2023) A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes. Biomedicine & Pharmacotherapy 162, pages 114705.
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Wenyue Chen, Hua Luo, Zhangfeng Zhong, Jinchao Wei & Yitao Wang. (2023) The safety of Chinese medicine: A systematic review of endogenous substances and exogenous residues. Phytomedicine 108, pages 154534.
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Yanli Wang, Qiaomin Wu, Jinfeng Liu & Ruxiu Liu. (2022) The Effect of the Tongyang Huoxue Recipe (TYHX) on the Ito/IKur in Ischemia/Reperfusion Sinoatrial Node Cells. Cardiovascular Therapeutics 2022, pages 1-11.
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Lulu Jia, Shengnan Zhu, Mingfei Zhu, Lingyue Huang, Siyuan Xu, Yuqin Luo, Juan Xiao, Huazhen Su, Shaoyuan Huang & Qinyou Tan. (2022) Triptolide Inhibits the Biological Processes of HUVECs and HepG2 Cells via the Serine Palmitoyltransferase Long Chain Base Subunit 2/Sphingosine-1-Phosphate Signaling Pathway. Disease Markers 2022, pages 1-19.
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Fei Liu, Xin Tang, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Shumao Cui & Wei Chen. (2022) Ethanol Extract of Licorice Alleviates HFD-Induced Liver Fat Accumulation in Association with Modulation of Gut Microbiota and Intestinal Metabolites in Obesity Mice. Nutrients 14:19, pages 4180.
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Yalith Lyzet Arancibia‐Hernández, Ana Karina Aranda‐Rivera, Alfredo Cruz‐Gregorio & José Pedraza‐Chaverri. (2022) Antioxidant/anti‐inflammatory effect of Mg 2+ in coronavirus disease 2019 (COVID‐19) . Reviews in Medical Virology 32:5.
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Rong Chen, Xiangwei Li, Zhibo Sun, Junyi Yin, Xiaowei Hu, Jingwen Deng & Xinghui Liu. (2022) Intra-bone marrow injection of magnesium isoglyrrhizinate inhibits inflammation and delays osteoarthritis progression through the NF-κB pathway. Journal of Orthopaedic Surgery and Research 17:1.
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Yeqing Hu, Qiguo Wu, Yulin Wang, Haibo Zhang, Xueying Liu, Hua Zhou & Tao Yang. (2022) The molecular pathogenesis of triptolide-induced hepatotoxicity. Frontiers in Pharmacology 13.
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Min Yan, Yinyin Yan, Zhenqiang Zhang, Guoqiang Wang, Wenbo Shi, Mengyuan Jiang, Junwei Zhao, Xiangxiang Wu & Huahui Zeng. (2022) The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy. Frontiers in Pharmacology 13.
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Juntong Li, Yan Gao, Liyuan Cui, Hongyuan He, Jianyong Zheng, Shu Mo, Xin Zhou, Shifeng Chu, Xiaoyun Sun, Naihong Chen & Hong Wang. (2022) Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway. Journal of Pharmacy and Pharmacology 74:5, pages 730-739.
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Zhiwen Cao, Bin Liu, Li Li, Peipei Lu, Lan Yan & Cheng Lu. (2022) Detoxification strategies of triptolide based on drug combinations and targeted delivery methods. Toxicology 469, pages 153134.
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Hulinyue Peng, Longtai You, Chunjing Yang, Kaixin Wang, Manting Liu, Dongge Yin, Yuchen Xu, Xiaoxv Dong, Xingbin Yin & Jian Ni. (2022) Ginsenoside Rb1 Attenuates Triptolide-Induced Cytotoxicity in HL-7702 Cells via the Activation of Keap1/Nrf2/ARE Pathway. Frontiers in Pharmacology 12.
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Soo Ji Woo, Min Gyeong Jeong, Eun Ji Jeon, Mi Young Do & Na Young Kim. (2022) Antiparasitic potential of ethanolic extracts of Carpesii Fructus against Miamiensis avidus in hirame natural embryo cell line and their effects on immune response- and biotransformation-related genes. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 251, pages 109214.
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Gurleen Kour, Syed Assim Haq, Bijender Kumar Bajaj, Prem N. Gupta & Zabeer Ahmed. (2021) Phytochemical add-on therapy to DMARDs therapy in rheumatoid arthritis: In vitro and in vivo bases, clinical evidence and future trends. Pharmacological Research 169, pages 105618.
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Mohamed A. Nassan, Mohamed M. Soliman, Adil Aldhahrani, Fayez Althobaiti & Adel Q. Alkhedaide. (2021) Ameliorative impacts of Glycyrrhiza glabra root extract against nephrotoxicity induced by gentamicin in mice . Food Science & Nutrition 9:7, pages 3405-3413.
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Christian Bailly & Gérard Vergoten. (2020) Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?. Pharmacology & Therapeutics 214, pages 107618.
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Gérard Vergoten & Christian Bailly. (2020) Analysis of glycyrrhizin binding to protein HMGB1. Medicine in Drug Discovery 7, pages 100058.
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Yan-Zi Yang, Zhi-Hong Liu, Shan-Chun Wang, Xi-Quan Zhang, Hong-Jiang Xu, Ling Yang & Ling-Dong Kong. (2020) Magnesium isoglycyrrhizinate alleviates fructose-induced liver oxidative stress and inflammatory injury through suppressing NOXs. European Journal of Pharmacology 883, pages 173314.
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Shifeng Chu, Ziquan Niu, Qingxin Guo, Haozhi Bi, Xinyu Li, Fangfang Li, Zhao Zhang, Wenbin He, Peng Cao, Naihong Chen & Xiaoyun Sun. (2020) Combination of monoammonium glycyrrhizinate and cysteine hydrochloride ameliorated lipopolysaccharide/galactosamine-induced acute liver injury through Nrf2/ARE pathway. European Journal of Pharmacology 882, pages 173258.
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Ziqiao Yuan, Zihang Yuan, Muhammad Hasnat, Haoran Zhang, Peishi Liang, Lixin Sun, Zhenzhou Jiang & Luyong Zhang. (2020) A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- B and NF- B-mediated cellular FLICE-inhibitory protein. Acta Pharmaceutica Sinica B 10:5, pages 861-877.
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Yujie Yang, Lei Liu, Xiqian Zhang, Xuehua Jiang & Ling Wang. (2019) Tanshinone IIA prevents rifampicin‐induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2. Liver International 40:1, pages 141-154.
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Ji Pan, Feihai Shen, Kang Tian, Manhong Wang, Yue Xi, Jia Li & Zhiying Huang. (2019) Triptolide induces oxidative damage in NRK-52E cells through facilitating Nrf2 degradation by ubiquitination via the GSK-3β/Fyn pathway. Toxicology in Vitro 58, pages 187-194.
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Tu-Shuai Li, Li Chen, Shan-Chun Wang, Yan-Zi Yang, Hong-Jiang Xu, Hong-Mei Gu, Xiao-Juan Zhao, Ping Dong, Ying Pan, Zhan-Qiang Shang, Xi-Quan Zhang & Ling-Dong Kong. (2019) Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1. Biochemical Pharmacology 166, pages 139-152.
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Xiaojiaoyang Li, Rong Sun & Runping Liu. (2019) Natural products in licorice for the therapy of liver diseases: Progress and future opportunities. Pharmacological Research 144, pages 210-226.
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PENGJUAN XU, YOUYOU LI, ZHICHAO YU, LIN YANG, RONG SHANG & ZIHANG YAN. (2019) Protective Effect of Vitamin C on Triptolide-induced Acute Hepatotoxicity in Mice through mitigation of oxidative stress. Anais da Academia Brasileira de Ciências 91:2.
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Fangchao Mei, Jia Yu, Man Li, Mingwei Xiang, Yupu Hong, Yu Zhou, Yundong You, He Xia, Hongzhong Jin & Weixing Wang. (2019) Magnesium isoglycyrrhizinate alleviates liver injury in obese rats with acute necrotizing pancreatitis. Pathology - Research and Practice 215:1, pages 106-114.
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