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Drug Delivery Volume 25, 2018 - Issue 1
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Research Article

Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis

A. R. TellegenDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; View further author information
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I. Rudnik-JansenDepartment of Orthopaedics, University Medical Centre Utrecht, Utrecht, The Netherlands; View further author information
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B. PouranDepartment of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands; View further author information
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H. M. de VisserDepartment of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands; View further author information
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H. H. WeinansDepartment of Orthopaedics, University Medical Centre Utrecht, Utrecht, The Netherlands; ;Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands; View further author information
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R. E. ThomasDepartment of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; View further author information
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M. J. L. KikDepartment of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; View further author information
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G. C. M. GrinwisDepartment of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; View further author information
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J. C. ThiesDSM Biomedical, Geleen, the Netherlands; View further author information
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N. WoikeDSM Biomedical, Geleen, the Netherlands; View further author information
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G. MihovDSM Biomedical, Geleen, the Netherlands; View further author information
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P. J. EmansDepartment of Orthopaedics, University Medical Centre Maastricht, Maastricht, The NetherlandsView further author information
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B. P. MeijDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; View further author information
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L. B. CreemersDepartment of Orthopaedics, University Medical Centre Utrecht, Utrecht, The Netherlands; View further author information
&
M. A. TryfonidouDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; Correspondence[email protected]
View further author information
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Pages 1438-1447 | Received 02 Apr 2018, Accepted 28 May 2018, Published online: 12 Jun 2018

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Liwei Mao, Wei Wu, Miao Wang, Jianmin Guo, Hui Li, Shihua Zhang, Jiake Xu & Jun Zou. (2021) Targeted treatment for osteoarthritis: drugs and delivery system. Drug Delivery 28:1, pages 1861-1876.
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Peinan Li, Haokun Li, Xiaohong Shu, Moli Wu, Jia Liu, Tangna Hao, Hongxia Cui & Lianjie Zheng. (2020) Intra-articular delivery of flurbiprofen sustained release thermogel: improved therapeutic outcome of collagenase II-induced rat knee osteoarthritis. Drug Delivery 27:1, pages 1034-1043.
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Imke Rudnik-Jansen, Karin Schrijver, Nina Woike, Anna Tellegen, Sabine Versteeg, Pieter Emans, George Mihov, Jens Thies, Niels Eijkelkamp, Marianna Tryfonidou & Laura Creemers. (2019) Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model. Drug Delivery 26:1, pages 226-236.
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Guangxin Wang, Xin-an Zhang, Leonid Kapilevich & Mingjie Hu. (2023) Recent advances in polymeric microparticle-based drug delivery systems for knee osteoarthritis treatment. Frontiers in Bioengineering and Biotechnology 11.
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Jing-Han Song, Ming-Yi Liu, Yu-Xuan Ma, Qian-Qian Wan, Jing Li, Xiao-Ou Diao & Li-Na Niu. (2023) Inflammation-associated ectopic mineralization. Fundamental Research 3:6, pages 1025-1038.
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A.R. Tellegen, I. Rudnik-Jansen, L. Utomo, S. Versteeg, M. Beukers, R. Maarschalkerweerd, D. van Zuilen, N.J. van Klaveren, K. Houben, E. Teske, P.R. van Weeren, N. Karssemakers-Degen, G. Mihov, J. Thies, N. Eijkelkamp, L.B. Creemers, B.P. Meij & M.A. Tryfonidou. (2023) Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients. Osteoarthritis and Cartilage 31:3, pages 351-362.
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Angelos Kaspiris, Argyris C. Hadjimichael, Ioanna Lianou, Ilias D. Iliopoulos, Dimitrios Ntourantonis, Dimitra Melissaridou, Olga D. Savvidou, Evangelia Papadimitriou & Efstathios Chronopoulos. (2023) Subchondral Bone Cyst Development in Osteoarthritis: From Pathophysiology to Bone Microarchitecture Changes and Clinical Implementations. Journal of Clinical Medicine 12:3, pages 815.
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Yang Lei, Qingfei Zhang, Gaizheng Kuang, Xiaochen Wang, Qihui Fan & Fangfu Ye. (2022) Functional biomaterials for osteoarthritis treatment: From research to application. Smart Medicine 1:1.
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Bruno U. K. Steiner & Barbara A. Konkle. (2022) Exploring a potential role for selective COX‐2 inhibitors for the prevention of hemophilic arthropathy. Haemophilia 28:6.
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Mirella J.J. Haartmans, Ufuk Tan Timur, Kaj S. Emanuel, Marjolein M.J. Caron, Ralph M. Jeuken, Tim J.M. Welting, Gerjo J.V.M. van Osch, Ron M.A. Heeren, Berta Cillero-Pastor & Pieter J. Emans. (2022) Evaluation of the Anti-Inflammatory and Chondroprotective Effect of Celecoxib on Cartilage Ex Vivo and in a Rat Osteoarthritis Model . CARTILAGE 13:3, pages 194760352211155.
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Michael Dirauf, Irina Muljajew, Christine Weber & Ulrich S. Schubert. (2022) Recent advances in degradable synthetic polymers for biomedical applications ‐ Beyond polyesters. Progress in Polymer Science 129, pages 101547.
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Shuyan Han & Jun Wu. (2022) Recent Advances of Poly(ester amide)s-Based Biomaterials. Biomacromolecules 23:5, pages 1892-1919.
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Kelly Warmink, Jaqueline L. Rios, Devin R. van Valkengoed, Nicoline M. Korthagen & Harrie Weinans. (2022) Sprague Dawley Rats Show More Severe Bone Loss, Osteophytosis and Inflammation Compared toWistar Han Rats in a High-Fat, High-Sucrose Diet Model of Joint Damage. International Journal of Molecular Sciences 23:7, pages 3725.
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Katrin Agnes Muenzebrock, Valerie Kersten, Jacqueline Alblas, Joao Pedro Garcia & Laura B. Creemers. (2022) The Added Value of the “Co” in Co-Culture Systems in Research on Osteoarthritis Pathology and Treatment Development. Frontiers in Bioengineering and Biotechnology 10.
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A.W. Hsia, E.H. Jbeily, M.E. Mendez, H.C. Cunningham, K.K. Biris, H. Bang, C.A. Lee, G.G. Loots & B.A. Christiansen. (2021) Post-traumatic osteoarthritis progression is diminished by early mechanical unloading and anti-inflammatory treatment in mice. Osteoarthritis and Cartilage 29:12, pages 1709-1719.
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Thomas A Perry, Xia Wang, Michael Nevitt, Christina Abdelshaheed, Nigel Arden & David J Hunter. (2021) Association between current medication use and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative. Rheumatology 60:10, pages 4624-4632.
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Jie Zhao, Zhenyue Wang, Huaibao Xue & Zhan Yang. (2021) Clinical efficacy of repeated intra‑articular pulsed radiofrequency for the treatment of knee joint pain and its effects on inflammatory cytokines in synovial fluid of patients. Experimental and Therapeutic Medicine 22:4.
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Long Chen, Yuanzheng Wang, Li Sun, Jerry Yan & Hai‐Quan Mao. (2021) Nanomedicine Strategies for Anti‐Inflammatory Treatment of Noninfectious Arthritis. Advanced Healthcare Materials 10:11, pages 2001732.
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Jiho Nam, Dong-Won Seol, Choong-Gu Lee, Gabbine Wee, Siyoung Yang & Cheol-Ho Pan. (2021) Obtusifolin, an Anthraquinone Extracted from Senna obtusifolia (L.) H.S.Irwin & Barneby, Reduces Inflammation in a Mouse Osteoarthritis Model. Pharmaceuticals 14:3, pages 249.
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Mahdi Rahimi, Gholamreza Charmi, Krzysztof Matyjaszewski, Xavier Banquy & Joanna Pietrasik. (2021) Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis. Acta Biomaterialia 123, pages 31-50.
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Carlisle R. DeJulius, Shubham Gulati, Karen A. Hasty, Leslie J. Crofford & Craig L. Duvall. (2020) Recent Advances in Clinical Translation of Intra‐Articular Osteoarthritis Drug Delivery Systems. Advanced Therapeutics 4:1, pages 2000088.
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Bo Liu, Chenchen Ji, Yijie Shao, Ting Liang, Jiaheng He, Huaye Jiang, Guangdong Chen & Zongping Luo. (2020) Etoricoxib decreases subchondral bone mass and attenuates biomechanical properties at the early stage of osteoarthritis in a mouse model. Biomedicine & Pharmacotherapy 127, pages 110144.
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Marianna A. Tryfonidou, Geert de Vries, Wim E. Hennink & Laura B. Creemers. (2020) “Old Drugs, New Tricks” – Local controlled drug release systems for treatment of degenerative joint disease. Advanced Drug Delivery Reviews 160, pages 170-185.
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Anna R. Tellegen, Aileen J. Dessing, Kaat Houben, Frank M. Riemers, Laura B. Creemers, Simon C. Mastbergen, Björn P. Meij, Alberto Miranda‐Bedate & Marianna A. Tryfonidou. (2019) Dog as a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter. Journal of Orthopaedic Research 37:12, pages 2550-2560.
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Farhad Md. Hossain, Yunkyung Hong, Yunho Jin, Jeonghyun Choi & Yonggeun Hong. (2019) Physiological and Pathological Role of Circadian Hormones in Osteoarthritis: Dose-Dependent or Time-Dependent?. Journal of Clinical Medicine 8:9, pages 1415.
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Song Xue, Libo Zhu, Cong Wang, Yafei Jiang, Haiming Lu, Yu Liu, Qing Shao, Bao Xue, Weilin Sang & Jinzhong Ma. (2019) CDK9 attenuation exerts protective effects on catabolism and hypertrophy in chondrocytes and ameliorates osteoarthritis development. Biochemical and Biophysical Research Communications 517:1, pages 132-139.
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Dongyun Liu, Yuguang Wang, Lili Li, Han Zhao, Liangliang Li, Yan Liu, Hong Jiang, Xianghong Li & Rui Zhang. (2019) Celecoxib Protects Hyperoxia-Induced Lung Injury via NF-κB and AQP1. Frontiers in Pediatrics 7.
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