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Drug Delivery Volume 26, 2019 - Issue 1
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Research Article

A 3D CFD model of the interstitial fluid pressure and drug distribution in heterogeneous tumor nodules during intraperitoneal chemotherapy

Margo Steuperaerta Biofluid, Tissue and Solid Mechanics for Medical Applications (bioMMeda), Department of Electronics and Information Systems, Ghent University, Ghent, Belgium; Correspondence[email protected]
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Charlotte Debbauta Biofluid, Tissue and Solid Mechanics for Medical Applications (bioMMeda), Department of Electronics and Information Systems, Ghent University, Ghent, Belgium; ORCID Iconhttps://orcid.org/0000-0003-1962-238XView further author information
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Charlotte Carlierb Departement of GI Surgery and Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium; View further author information
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Olivier De Weverc Department of Human Structure and Repair, Ghent University, Ghent, Belgium; ORCID Iconhttps://orcid.org/0000-0002-5453-760XView further author information
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Benedicte Descampsd Infinity (iMinds-IBiTech-MEDISIP), Department of Electronics and Information Systems, Ghent University, Ghent, BelgiumORCID Iconhttps://orcid.org/0000-0001-8879-1772View further author information
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Christian Vanhoved Infinity (iMinds-IBiTech-MEDISIP), Department of Electronics and Information Systems, Ghent University, Ghent, BelgiumORCID Iconhttps://orcid.org/0000-0002-3988-5980View further author information
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Wim Ceelenb Departement of GI Surgery and Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium; ORCID Iconhttps://orcid.org/0000-0001-7692-4419View further author information
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Patrick Segersa Biofluid, Tissue and Solid Mechanics for Medical Applications (bioMMeda), Department of Electronics and Information Systems, Ghent University, Ghent, Belgium; ORCID Iconhttps://orcid.org/0000-0003-3870-3409View further author information
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Pages 404-415 | Received 27 Dec 2018, Accepted 25 Feb 2019, Published online: 31 Mar 2019

Citations (28)

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Daan R. Löke, Roxan F. C. P. A. Helderman, Nicolaas A. P. Franken, Arlene L. Oei, Pieter J. Tanis, Johannes Crezee & H. Petra Kok. (2021) Simulating drug penetration during hyperthermic intraperitoneal chemotherapy. Drug Delivery 28:1, pages 145-161.
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Wim Ceelen, Helena Braet, Gabrielle van Ramshorst, Wouter Willaert & Katrien Remaut. (2020) Intraperitoneal chemotherapy for peritoneal metastases: an expert opinion. Expert Opinion on Drug Delivery 17:4, pages 511-522.
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Mohsen Rezaeian, Hamidreza Heidari, Kaamran Raahemifar & Madjid Soltani. (2023) Image-Based Modeling of Drug Delivery during Intraperitoneal Chemotherapy in a Heterogeneous Tumor Nodule. Cancers 15:20, pages 5069.
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Ramesh Paudyal, Eve LoCastro, Marsha Reyngold, Richard Kinh Do, Amaresha Shridhar Konar, Jung Hun Oh, Abhay Dave, Kenneth Yu, Karyn A. Goodman & Amita Shukla-Dave. (2021) Longitudinal Monitoring of Simulated Interstitial Fluid Pressure for Pancreatic Ductal Adenocarcinoma Patients Treated with Stereotactic Body Radiotherapy. Cancers 13:17, pages 4319.
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Brittany P. Rickard, Christina Conrad, Aaron J. Sorrin, Mustafa Kemal Ruhi, Jocelyn C. Reader, Stephanie A. Huang, Walfre Franco, Giuliano Scarcelli, William J. Polacheck, Dana M. Roque, Marcela G. del Carmen, Huang-Chiao Huang, Utkan Demirci & Imran Rizvi. (2021) Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response. Cancers 13:17, pages 4318.
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Wim Ceelen, Jesse Demuytere & Ignace de Hingh. (2021) Hyperthermic Intraperitoneal Chemotherapy: A Critical Review. Cancers 13:13, pages 3114.
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Linda Feldbrügge, Felix Gronau, Andreas Brandl, Timo Alexander Auer, Alan Oeff, Peter Thuss-Patience, Johann Pratschke & Beate Rau. (2021) Systemic Chemotherapy Including Ramucirumab in Combination With Pressurized Intra-Peritoneal Aerosol Chemotherapy Is a Safe Treatment Option for Peritoneal Metastasis of Gastric Cancer. Frontiers in Oncology 10.
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Wim Ceelen, Robert G. Ramsay, Vignesh Narasimhan, Alexander G. Heriot & Olivier De Wever. (2020) Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases. Trends in Cancer 6:3, pages 236-246.
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Pejman Shojaee, Hanieh Niroomand-Oscuii, Mostafa Sefidgar & Lida Alinezhad. (2020) Effect of nanoparticle size, magnetic intensity, and tumor distance on the distribution of the magnetic nanoparticles in a heterogeneous tumor microenvironment. Journal of Magnetism and Magnetic Materials 498, pages 166089.
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Giorgi Nadiradze, Philipp Horvath, Yaroslav Sautkin, Rami Archid, Frank-Jürgen Weinreich, Alfred Königsrainer & Marc A. Reymond. (2019) Overcoming Drug Resistance by Taking Advantage of Physical Principles: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC). Cancers 12:1, pages 34.
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