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Drug Delivery Volume 28, 2021 - Issue 1
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Research Article

Triglyceride-mimetic prodrugs of scutellarin enhance oral bioavailability by promoting intestinal lymphatic transport and avoiding first-pass metabolism

Xinran Wanga School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
,
Cai Zhangb Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
,
Ning Hana School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
,
Juyuan Luoa School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
,
Shuofeng Zhanga School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
,
Chunguo Wangb Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
,
Zhanhong Jiaa School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
&
Shouying Dua School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, ChinaCorrespondence[email protected]
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Pages 1664-1672 | Received 23 Jun 2021, Accepted 19 Jul 2021, Published online: 02 Aug 2021

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Bin Zheng, Fei Pan, Minfei Shi, Cuiping He, Beibei He, Rongrong Wang, Guolian Ren, Shuang Yang & Shuqiu Zhang. (2024) 2-Monoacylglycerol Mimetic Liposomes to Promote Intestinal Lymphatic Transport for Improving Oral Bioavailability of Dihydroartemisinin. International Journal of Nanomedicine 19, pages 5273-5295.
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Jie Xiao, Wenni Tian, Haonan Wang, Meimiao Chen, Qingrong Huang, Man Zhang, Muwen Lu, Mingyue Song & Yong Cao. (2024) Updated design strategies for oral delivery systems: maximized bioefficacy of dietary bioactive compounds achieved by inducing proper digestive fate and sensory attributes. Critical Reviews in Food Science and Nutrition 64:3, pages 817-836.
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Yuexuan Cheng, Chunhong Zhong, Shujing Yan, Chunli Chen & Xiaoli Gao. (2023) Structure Modification: a Successful Tool for Prodrug Design. Future Medicinal Chemistry 15:4, pages 379-393.
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Takayuki Yoshida, Hiroyuki Kojima, Kazuhiro Sako & Hiromu Kondo. (2022) Drug delivery to the intestinal lymph by oral formulations. Pharmaceutical Development and Technology 27:2, pages 175-189.
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Articles from other publishers (7)

Abdelrahman Y. Sherif, Gamaleldin I. Harisa & Fars K. Alanazi. (2024) The Chimera of TPGS and Nanoscale Lipid Carriers as Lymphatic Drug Delivery Vehicles to Fight Metastatic Cancers. Current Drug Delivery 21:4, pages 525-543.
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Mingyang Zhang, Yifan Miao, Can Zhao, Tong Liu, Xiyan Wang, Zixuan Wang, Wenxin Zhong, Zhonggui He, Chutong Tian & Jin Sun. (2024) Fine-tuning the activation behaviors of ternary modular cabazitaxel prodrugs for efficient and on-target oral anti-cancer therapy. Asian Journal of Pharmaceutical Sciences 19:2, pages 100908.
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Xinyu Zhang, Tong Yin, Yincang Wang, Jiazhe Du, Jinjin Dou & Xiwu Zhang. (2024) Effects of scutellarin on the mechanism of cardiovascular diseases: a review. Frontiers in Pharmacology 14.
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Shujing Yan, Yuexuan Cheng, Liangyun Li, Chunhong Zhong, Chunli Chen & Xiaoli Gao. (2023) Lipid-based formulations: A promising approach for poorly soluble drug delivery via the intestinal lymphatic system. Journal of Drug Delivery Science and Technology 87, pages 104770.
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Hongyan Lu, Yikun Gao, Jianmin Chen, Jing Chai, Ansheng Li, Tongtong Sun, Yuling Mao, Ye He, Qinfu Zhao, Jinghai Zhang & Siling Wang. (2023) A novel oral biomimetic delivery system enhancing both the mucosal and systemic immunity of influenza virus vaccine. Chemical Engineering Journal 470, pages 144371.
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Lisha Cai, Xiaoling Xu & Wei Chen. (2022) The Current State of the Art in PARP Inhibitor-Based Delivery Nanosystems. Pharmaceutics 14:8, pages 1647.
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Tim Quach, Luojuan Hu, Sifei Han, Shea F. Lim, Danielle Senyschyn, Preeti Yadav, Natalie L. Trevaskis, Jamie S. Simpson & Christopher J. H. Porter. (2022) Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport. Frontiers in Pharmacology 13.
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