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Research Article

Constitutive Activity of Muscarinic Acetylcholine Receptors

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Pages 61-85 | Published online: 10 Oct 2008

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Jun-Min Liao & Yeng-Tseng Wang. (2019) In silico studies of conformational dynamics of Mu opioid receptor performed using gaussian accelerated molecular dynamics. Journal of Biomolecular Structure and Dynamics 37:1, pages 166-177.
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GUSTAVO BRUGES, ADOLFO BORGES, SINAI SÁNCHEZ DE VILLARROEL, ITALA LIPPO DE BÉCEMBERG, GISELA FRANCIS DE TOBA, FABIOLA PLÁCERES, RAMONA GONZÁLEZ DE ALFONZO & MARCELO J. ALFONZO. (2007) Coupling of M3 Acetylcholine Receptor to Gq16 Activates a Natriuretic Peptide Receptor Guanylyl Cyclase. Journal of Receptors and Signal Transduction 27:2-3, pages 189-216.
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Articles from other publishers (27)

Amit Chaudhary & Ashutosh Mani. (2022) Aβ peptides stabilize GPCRs in inactive form and trigger inverse agonism in Alzheimer's disease. Biochimie 201, pages 75-78.
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Joyce A. Nieva, Bernd Krock, Urban Tillmann, Jan Tebben, Christian Zurhelle & Ulf Bickmeyer. (2020) Gymnodimine A and 13-desMethyl Spirolide C Alter Intracellular Calcium Levels via Acetylcholine Receptors. Toxins 12:12, pages 751.
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Yair Ben-Chaim, Chava Broide & Hanna Parnas. (2019) The coupling of the M2 muscarinic receptor to its G protein is voltage dependent. PLOS ONE 14:10, pages e0224367.
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Ethan S. Burstein. (2019) Should inverse agonists be defined by pharmacological mechanism or clinical effect?. CNS Spectrums 24:4, pages 349-351.
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Yinglong Miao & J. Andrew McCammon. (2018) Mechanism of the G-protein mimetic nanobody binding to a muscarinic G-protein-coupled receptor. Proceedings of the National Academy of Sciences 115:12, pages 3036-3041.
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Yeng-Tseng Wang & Yang-Hsiang Chan. (2017) Understanding the molecular basis of agonist/antagonist mechanism of human mu opioid receptor through gaussian accelerated molecular dynamics method. Scientific Reports 7:1.
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Łukasz JaremkoMariusz JaremkoKarin GillerStefan BeckerMarkus Zweckstetter. (2015) Conformational Flexibility in the Transmembrane Protein TSPO. Chemistry – A European Journal 21:46, pages 16555-16563.
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Kalli Kappel, Yinglong Miao & J. Andrew McCammon. (2015) Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor. Quarterly Reviews of Biophysics 48:4, pages 479-487.
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Alena Randáková, Eva Dolejší, Vladimír Rudajev, Pavel Zimčík, Vladimír Doležal, Esam E. El-Fakahany & Jan Jakubík. (2015) Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms. Pharmacological Research 97, pages 27-39.
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Kevin MacDonald, Michael J. Kimber, Tim A. Day & Paula Ribeiro. (2015) A constitutively active G protein-coupled acetylcholine receptor regulates motility of larval Schistosoma mansoni. Molecular and Biochemical Parasitology 202:1, pages 29-37.
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Deeptankar DeMazumderDavid A. KassBrian O’RourkeGordon F. Tomaselli. (2015) Cardiac Resynchronization Therapy Restores Sympathovagal Balance in the Failing Heart by Differential Remodeling of Cholinergic Signaling. Circulation Research 116:10, pages 1691-1699.
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Yinglong Miao, Alisha D. Caliman & J. Andrew McCammon. (2015) Allosteric Effects of Sodium Ion Binding on Activation of the M3 Muscarinic G-Protein-Coupled Receptor. Biophysical Journal 108:7, pages 1796-1806.
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Uli Hacksell, Ethan S. Burstein, Krista McFarland, Roger G. Mills & Hilde Williams. (2014) On the Discovery and Development of Pimavanserin: A Novel Drug Candidate for Parkinson’s Psychosis. Neurochemical Research 39:10, pages 2008-2017.
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Yinglong Miao, Sara E. Nichols & J. Andrew McCammon. (2014) Mapping of Allosteric Druggable Sites in Activation-Associated Conformers of the M2 Muscarinic Receptor. Chemical Biology & Drug Design 83:2, pages 237-246.
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Yinglong Miao, Sara E. Nichols & J. Andrew McCammon. (2014) Free energy landscape of G-protein coupled receptors, explored by accelerated molecular dynamics. Physical Chemistry Chemical Physics 16:14, pages 6398.
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J.-N. Ma & E. S. Burstein. (2013) The Protease Activated Receptor 2 (PAR2) Polymorphic Variant F240S Constitutively Activates PAR2 Receptors and Potentiates Responses to Small-Molecule PAR2 Agonists. Journal of Pharmacology and Experimental Therapeutics 347:3, pages 697-704.
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Yinglong Miao, Sara E. Nichols, Paul M. Gasper, Vincent T. Metzger & J. Andrew McCammon. (2013) Activation and dynamic network of the M2 muscarinic receptor. Proceedings of the National Academy of Sciences 110:27, pages 10982-10987.
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Edward C. Hulme. (2013) GPCR activation: a mutagenic spotlight on crystal structures. Trends in Pharmacological Sciences 34:1, pages 67-84.
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C. Hoffmann, S. Nuber, U. Zabel, N. Ziegler, C. Winkler, P. Hein, C. H. Berlot, M. Bunemann & M. J. Lohse. (2012) Comparison of the Activation Kinetics of the M3 Acetylcholine Receptor and a Constitutively Active Mutant Receptor in Living Cells. Molecular Pharmacology 82:2, pages 236-245.
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Richard M. Eglen. 2012. Muscarinic Receptors. Muscarinic Receptors 3 28 .
Monica S. Guzman, Xavier De Jaeger, Sanda Raulic, Ivana A. Souza, Alex X. Li, Susanne Schmid, Ravi S. Menon, Raul R. Gainetdinov, Marc G. Caron, Robert Bartha, Vania F. Prado & Marco A. M. Prado. (2011) Elimination of the Vesicular Acetylcholine Transporter in the Striatum Reveals Regulation of Behaviour by Cholinergic-Glutamatergic Co-Transmission. PLoS Biology 9:11, pages e1001194.
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Rouslan Moukhametzianov, Tony Warne, Patricia C. Edwards, Maria J. Serrano-Vega, Andrew G. W. Leslie, Christopher G. Tate & Gebhard F. X. Schertler. (2011) Two distinct conformations of helix 6 observed in antagonist-bound structures of a β 1 -adrenergic receptor . Proceedings of the National Academy of Sciences 108:20, pages 8228-8232.
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Fernando Ochoa-Cortés, Luz María García-Hernández, Rosa Espinosa-Luna, Marcela Miranda-Morales, Luis M. Montaño & Carlos Barajas-López. (2010) Functional interactions between nicotinic and P2X receptors in celiac ganglia neurons. Autonomic Neuroscience 154:1-2, pages 59-65.
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Doreen Thor, Diana Le Duc, Rainer Strotmann & Torsten Schöneberg. (2009) Luciferase activity under direct ligand-dependent control of a muscarinic acetylcholine receptor. BMC Biotechnology 9:1.
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Jan Jakubík, Alena Randáková, Esam E El-Fakahany & Vladimír Doležal. (2009) Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors. BMC Pharmacology 9:1.
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Ilaria Peretto, Paola Petrillo & Bruno P. Imbimbo. (2009) Medicinal chemistry and therapeutic potential of muscarinic M3 antagonists. Medicinal Research Reviews 29:6, pages 867-902.
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Evelin L. Schaeffer & Wagner F. Gattaz. (2008) Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme. Psychopharmacology 198:1, pages 1-27.
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