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Journal of Receptors and Signal Transduction Volume 27, 2007 - Issue 5-6
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Research Article

Disruption of the Plasma Membrane Integrity by Cholesterol Depletion Impairs Effectiveness of TRH Receptor-Mediated Signal Transduction via Gq/G11α Proteins

PAVEL OSTASOV Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic; Department of Physiology, Faculty of Science, Charles University, 128 00, Prague, Czech Republic
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LENKA BOUROVA Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic; Department of Physiology, Faculty of Science, Charles University, 128 00, Prague, Czech Republic
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LUCIE HEJNOVA Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic; Department of Physiology, Faculty of Science, Charles University, 128 00, Prague, Czech Republic
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JIRI NOVOTNY Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic; Department of Physiology, Faculty of Science, Charles University, 128 00, Prague, Czech Republic
&
PETR SVOBODA Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic; Department of Physiology, Faculty of Science, Charles University, 128 00, Prague, Czech Republic
Pages 335-352 | Published online: 10 Oct 2008

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Radka Moravcova, Barbora Melkes & Jiri Novotny. (2018) TRH receptor mobility in the plasma membrane is strongly affected by agonist binding and by interaction with some cognate signaling proteins. Journal of Receptors and Signal Transduction 38:1, pages 20-26.
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Articles from other publishers (11)

Radka Trubacova, Zdenka Drastichova & Jiri Novotny. (2022) Biochemical and physiological insights into TRH receptor-mediated signaling. Frontiers in Cell and Developmental Biology 10.
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Franck Talmont, Chantal Lebrun & Jean-Marie Zajac. (2020) Agonist binding of human mu opioid receptors expressed in the yeast Pichia pastoris: Effect of cholesterol complementation. Neurochemistry International 132, pages 104588.
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Hana Ujcikova, Martina Hlouskova, Kristina Cechova, Katerina Stolarova, Lenka Roubalova & Petr Svoboda. (2017) Determination of μ-, δ- and κ-opioid receptors in forebrain cortex of rats exposed to morphine for 10 days: Comparison with animals after 20 days of morphine withdrawal. PLOS ONE 12:10, pages e0186797.
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Amol R Padol, Susanth V Sukumaran, Abdul Sadam, Manickam Kesavan, Kandasamy Arunvikram, Ankita D Verma, Vivek Srivastava, Manjit Panigrahi, Thakur Uttam Singh, Avinash G Telang, Santosh K Mishra & Subhashree Parida. (2017) Hypercholesterolemia impairs oxytocin-induced uterine contractility in late pregnant mouse. Reproduction 153:5, pages 565-576.
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Barbora Melkes, Lucie Hejnova & Jiri Novotny. (2016) Biased μ-opioid receptor agonists diversely regulate lateral mobility and functional coupling of the receptor to its cognate G proteins. Naunyn-Schmiedeberg's Archives of Pharmacology 389:12, pages 1289-1300.
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Jana Brejchova, Miroslava Vosahlikova, Lenka Roubalova, Marco Parenti, Mario Mauri, Oleksandr Chernyavskiy & Petr Svoboda. (2016) Plasma membrane cholesterol level and agonist-induced internalization of δ-opioid receptors; colocalization study with intracellular membrane markers of Rab family. Journal of Bioenergetics and Biomembranes 48:4, pages 375-396.
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Jana Brejchová, Jan Sýkora, Pavel Ostašov, Ladislav Merta, Lenka Roubalová, Jiří Janáček, Martin Hof & Petr Svoboda. (2015) TRH-receptor mobility and function in intact and cholesterol-depleted plasma membrane of HEK293 cells stably expressing TRH-R-eGFP. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848:3, pages 781-796.
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H. UJČÍKOVÁ, J. BREJCHOVÁ, M. VOŠAHLÍKOVÁ, D. KAGAN, K. DLOUHÁ, J. SÝKORA, L. MERTA, Z. DRASTICHOVÁ, J. NOVOTNÝ, P. OSTAŠOV, L. ROUBALOVÁ, M. PARENTI, M. HOF & P. SVOBODA. (2014) Opioid-Receptor (OR) Signaling Cascades in Rat Cerebral Cortex and Model Cell Lines: the Role of Plasma Membrane Structure. Physiological Research, pages S165-S176.
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Pavel Ostašov, Jan Sýkora, Jana Brejchová, Agnieszka Olżyńska, Martin Hof & Petr Svoboda. (2013) FLIM studies of 22- and 25-NBD-cholesterol in living HEK293 cells: Plasma membrane change induced by cholesterol depletion. Chemistry and Physics of Lipids 167-168, pages 62-69.
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Jana Brejchová, Jan Sýkora, Kateřina Dlouhá, Lenka Roubalová, Pavel Ostašov, Miroslava Vošahlíková, Martin Hof & Petr Svoboda. (2011) Fluorescence spectroscopy studies of HEK293 cells expressing DOR-Gi1α fusion protein; the effect of cholesterol depletion. Biochimica et Biophysica Acta (BBA) - Biomembranes 1808:12, pages 2819-2829.
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Mohammad Fallahi-Sichani & Jennifer J. Linderman. (2009) Lipid Raft-Mediated Regulation of G-Protein Coupled Receptor Signaling by Ligands which Influence Receptor Dimerization: A Computational Study. PLoS ONE 4:8, pages e6604.
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