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Research Article

Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFRβ

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Pages 167-173 | Received 10 Mar 2016, Accepted 12 Jun 2016, Published online: 12 Jul 2016

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Segün Doğru, Ekrem Yaşar & Akın Yeşilkaya. (2022) Uric acid can enhance MAPK pathway-mediated proliferation in rat primary vascular smooth muscle cells via controlling of mitochondria and caspase-dependent cell death. Journal of Receptors and Signal Transduction 42:3, pages 293-301.
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Shuo Zhang, Lin Liu, Yu-Qing Huang, Kenneth Lo, Songtao Tang & Ying-Qing Feng. (2020) The association between serum uric acid levels and ischemic stroke in essential hypertension patients. Postgraduate Medicine 132:6, pages 551-558.
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Nurgül Oğuz, Mustafa Kırça, Arzu Çetin & Akın Yeşilkaya. (2017) Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells. Journal of Receptors and Signal Transduction 37:5, pages 500-505.
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Articles from other publishers (26)

Youqian Zhang, Zitian Tang, Ling Tong, Yang Wang & Lin Li. (2023) Serum uric acid and risk of diabetic neuropathy: a genetic correlation and mendelian randomization study. Frontiers in Endocrinology 14.
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Alma Čypienė, Silvija Gimžauskaitė, Egidija Rinkūnienė, Eugenijus Jasiūnas, Aleksandras Laucevičius, Ligita Ryliškytė & Jolita Badarienė. (2023) Effect of Alcohol Consumption Habits on Early Arterial Aging in Subjects with Metabolic Syndrome and Elevated Serum Uric Acid. Nutrients 15:15, pages 3346.
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Yong Zhuang, Huibin Huang, Xin Hu, Jinying Zhang & Qingyan Cai. (2022) Serum uric acid and diabetic peripheral neuropathy: a double-edged sword. Acta Neurologica Belgica 123:3, pages 857-863.
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Kaiyue Li, Kongwei Li, Qingmei Yao, Xiaorong Shui, Jing Zheng, Yuan He & Wei Lei. (2023) The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor. Heliyon 9:5, pages e16097.
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Mustafa KIRÇA. (2022) THE EFFECT OF ANGIOTENSIN II ON VASCULAR SMOOTH MUSCLE CELL PROLIFERATION IN HIGH GLUCOSE MEDIA. Kocatepe Tıp Dergisi 23:4, pages 399-405.
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Sidar Copur, Atalay Demiray & Mehmet Kanbay. (2022) Uric acid in metabolic syndrome: Does uric acid have a definitive role?. European Journal of Internal Medicine 103, pages 4-12.
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Zicen Fang, Zhenhui Luo, Yanying Ji, Rihong Yang, Jintian Gao & Nana Zhang. (2022) A network pharmacology technique used to investigate the potential mechanism of Ligustilide's effect on atherosclerosis. Journal of Food Biochemistry 46:7.
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Amany A. Azouz, Hany A. Omar, Fatema Hersi, Fares E.M. Ali & Asmaa Mohammed M. Hussein Elkelawy. (2022) Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways. Life Sciences 288, pages 120154.
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Yoshitaka Kimura, Daisuke Tsukui & Hajime Kono. (2021) Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis. International Journal of Molecular Sciences 22:22, pages 12394.
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Yousuf Waheed, Fan Yang & Dong Sun. (2021) Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease. The Korean Journal of Internal Medicine 36:6, pages 1281-1293.
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Fei Liu, Simei Hui, Tesfaldet H. Hidru, Yinong Jiang, Ying Zhang, Yan Lu, Haichen Lv, Sharen Lee, Yunlong Xia & Xiaolei Yang. (2021) The Prevalence, Distribution, and Extent of Subclinical Atherosclerosis and Its Relation With Serum Uric Acid in Hypertension Population. Frontiers in Cardiovascular Medicine 8.
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Shuai Huo, Hongxin Wang, Meixia Yan, Peng Xu, Tingting Song, Chuang Li, Ruimin Tian, Xiaoling Chen, Kun Bao, Ying Xie, Ping Xu, Weimin Zhu, Fengsong Liu, Wei Mao & Chen Shao. (2021) Urinary Proteomic Characteristics of Hyperuricemia and Their Possible Links with the Occurrence of Its Concomitant Diseases. ACS Omega 6:14, pages 9500-9508.
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Rong Tang, Xiaoqing Peng, Yan Wang, Xiaohong Zhou & Hong Liu. (2021) Network Pharmacology-Based Investigation of the Mechanism of Action of Plantaginis Herba in Hyperuricemia Treatment. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-8.
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Boyang Xiang, Xiaoya Zhao & Xiang Zhou. (2021) Cardiovascular benefits of sodium-glucose cotransporter 2 inhibitors in diabetic and nondiabetic patients. Cardiovascular Diabetology 20:1.
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Federica Piani, Arrigo F. G. Cicero & Claudio Borghi. (2021) Uric Acid and Hypertension: Prognostic Role and Guide for Treatment. Journal of Clinical Medicine 10:3, pages 448.
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Michael Toprover, Binita Shah, Cheongeun Oh, Talia F. Igel, Aaron Garza Romero, Virginia C. Pike, Fatmira Curovic, Daisy Bang, Deana Lazaro, Svetlana Krasnokutsky, Stuart D. Katz & Michael H. Pillinger. (2020) Initiating guideline-concordant gout treatment improves arterial endothelial function and reduces intercritical inflammation: a prospective observational study. Arthritis Research & Therapy 22:1.
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Nikolas Rapp, Pieter Evenepoel, Peter Stenvinkel & Leon Schurgers. (2020) Uremic Toxins and Vascular Calcification–Missing the Forest for All the Trees. Toxins 12:10, pages 624.
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Pan Jing, Min Shi, Liang Ma & Ping Fu. (2020) Mechanistic Insights of Soluble Uric Acid-related Kidney Disease. Current Medicinal Chemistry 27:30, pages 5056-5066.
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Fu-Shun Yen, Chih-Cheng Hsu, Hsin-Lun Li, James Cheng-Chung Wei & Chii-Min Hwu. (2020) Urate-Lowering Therapy May Prevent the Development of Coronary Artery Disease in Patients With Gout. Frontiers in Medicine 7.
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Bingqing Zhang, Mengyuan Duan, Bo Long, Baozhong Zhang, Dongmei Wang, Yun Zhang, Jialin Chen, Xiaoming Huang, Yang Jiao, Lei Zhu & Xuejun Zeng. (2019) Urate transport capacity of glucose transporter 9 and urate transporter 1 in cartilage chondrocytes. Molecular Medicine Reports.
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Shuangshuang Zhang, Yong Wang, Jinsong Cheng, Ning Huangfu, Ruochi Zhao, Zhenyu Xu, Fuxing Zhang, Wenyuan Zheng & Dandan Zhang. (2019) Hyperuricemia and Cardiovascular Disease. Current Pharmaceutical Design 25:6, pages 700-709.
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Min Tao, Xiaoling Pi, Xiaoyan Ma, Yingfeng Shi, Yuzhen Zhang, Hongwei Gu, Yongbin Chi, Shougang Zhuang & Na Liu. (2019) Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study. BMJ Open 9:3, pages e025453.
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Canan Topçuoğlu. (2018) Is There a Prognostic Significance of Serum Uric Acid Levels in Cardiac Dysfunction?. Ankara Medical Journal.
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Xiaojie Zhang, Qing Lu, Zhuojun Zhang, Yongle Chen, Yanan Wang, Youngshi Wang, Zheng Li & Lindi Jiang. (2018) Value of three-dimensional speckle tracking echocardiography to assess left ventricular function in hyperuricemia patients. Clinical Rheumatology 37:9, pages 2539-2545.
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Barbara Nieradko-Iwanicka. (2018) What is the role of angiotensin receptor blockers in treatment of hyperuricemia coexisting with arterial hypertension?. Rheumatology 56:2, pages 106-110.
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Seong-Kyu Kim. (2018) Interrelationship of Uric Acid, Gout, and Metabolic Syndrome: Focus on Hypertension, Cardiovascular Disease, and Insulin Resistance. Journal of Rheumatic Diseases 25:1, pages 19.
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